EKS-AIM-00153
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00153
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.61.2E-148454707254
StatusUnreviewed
Ensembl ProteinENSAMEP00000011288
UniProt AccessionG1LW37;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA1
Gene Synonyms/Alias RPS6KA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000010620ENSAMEP00000011288ENSAMET00000011768
OrganismAiluropoda melanoleuca
Functional Description
Protein Length767
Protein Sequence
(FASTA)
LRNSGPWGGL GLRGSGGRMF CEQQGGAAPG AGRLCSSPAE MWAPLQQTFS EHENGQASGE 60
EAGLQPSKDE GILKEISITH HVKAGSEKAD PSHFELLKVL GQGSFGKVFL VRKVTRPDSG 120
HLYAMKVLKK ATLKVRDRVR TKMERDILAD VNHPFVVKLH YAFQTEGKLY LILDFLRGGD 180
LFTRLSKEVM FTEEDVKFYL AELALGLDHL HHLGIIYRDL KPENILLDEE GHIKLTDFGL 240
SKEAIDHEKK AYSFCGTVEY MAPEVVNRQG HTHSADWWSY GVLMFEMLTG SLPFQGKDRK 300
ETMTLILKAK LGMPQFLSTE AQSLLRALFK RNPANRLGSG PDGAEEIKRH AFYSTIDWNK 360
LYRREIKPPF KPAVAQPDDT FYFDTEFTSR TPRDSPGIPP SAGAHQLFRG FSFVATGLLE 420
DDGKPRATQA PLHSVVQKLH GKFRIERHNW GIFETIGVGS YSVCKRCVHK ATNMEYAVKV 480
IDKSKRDPSE EIEILLRYGQ HPNIITLKDV YDDGKHVYLV TELMRGGELL DKILRQKFFS 540
EREASFVLHT ISKTVEYLHS QGVVHRDLKP SNILYVDESG NPECLRICDF GFAKQLRAEN 600
GLLMTPCYTA NFVAPEVLKR QGYDEGCDIW SLGILLYTML AGYTPFANGP SDTPEEILTR 660
IGSGKFTLSG GNWNTVSETA KDLVSKMLHV DPHQRLTAKQ VLQHPWITQK DKLPQSQLSH 720
QDLQLVKGAM AATYSALNSS KPTPQLKPIE SSILAQRRVR KLPSTTL 767
Nucleotide Sequence
(FASTA)
CTGCGGAACA GCGGCCCCTG GGGAGGATTA GGATTAAGGG GCTCAGGGGG CAGGATGTTC 60
TGCGAGCAGC AGGGAGGAGC TGCTCCAGGG GCAGGGAGGT TATGTAGTTC CCCTGCGGAG 120
ATGTGGGCTC CTCTTCAGCA GACCTTTTCT GAGCATGAGA ATGGACAGGC TTCAGGGGAA 180
GAAGCTGGAC TTCAGCCGTC CAAGGATGAG GGCATCCTCA AGGAGATCTC CATCACGCAC 240
CACGTCAAGG CTGGCTCTGA GAAGGCCGAC CCATCCCATT TTGAGCTGCT CAAGGTTCTG 300
GGCCAGGGAT CCTTTGGCAA AGTCTTCCTG GTGCGGAAGG TCACCCGACC TGATAGTGGG 360
CACCTGTATG CCATGAAGGT TCTCAAGAAG GCAACGCTGA AAGTGCGTGA CCGCGTTCGG 420
ACCAAGATGG AGAGAGACAT CCTAGCTGAT GTGAACCACC CGTTTGTGGT GAAGCTGCAC 480
TATGCCTTCC AGACTGAGGG AAAGCTCTAT CTTATTCTGG ACTTCCTGCG TGGCGGGGAC 540
CTCTTCACGC GGCTCTCTAA AGAGGTGATG TTCACGGAGG AGGACGTGAA GTTTTACCTG 600
GCTGAGCTGG CCTTGGGCCT GGACCACCTG CACCACCTGG GTATCATCTA CAGGGACCTC 660
AAGCCTGAAA ACATCCTTCT GGATGAGGAG GGCCACATCA AACTCACTGA CTTTGGCCTA 720
AGCAAGGAGG CCATTGACCA TGAGAAAAAA GCCTATTCCT TCTGCGGGAC AGTGGAGTAC 780
ATGGCCCCCG AGGTCGTCAA CCGCCAGGGC CACACCCATA GTGCAGACTG GTGGTCCTAT 840
GGGGTGTTGA TGTTTGAGAT GCTGACGGGC TCCCTGCCCT TCCAGGGGAA GGACCGGAAG 900
GAGACCATGA CACTGATTCT GAAGGCGAAG CTAGGCATGC CCCAGTTTCT GAGCACGGAA 960
GCCCAGAGCC TCCTGCGGGC CCTGTTCAAG CGGAATCCTG CCAACCGGCT CGGCTCCGGC 1020
CCTGATGGGG CAGAGGAAAT CAAGCGGCAT GCCTTCTACT CTACCATTGA CTGGAATAAG 1080
CTATACCGTC GTGAGATCAA GCCACCCTTC AAGCCGGCCG TGGCTCAGCC TGATGACACC 1140
TTCTACTTTG ACACTGAGTT CACATCCCGC ACACCCAGGG ACTCCCCAGG CATCCCCCCC 1200
AGCGCTGGCG CCCATCAGCT GTTCCGTGGT TTCAGCTTCG TGGCCACTGG CCTGCTGGAG 1260
GACGATGGCA AGCCTCGGGC CACACAGGCA CCACTGCACT CAGTGGTTCA GAAGCTCCAT 1320
GGGAAATTCA GAATTGAGAG GCACAACTGG GGCATCTTTG AGACGATTGG TGTGGGCTCC 1380
TACTCCGTGT GCAAGCGCTG TGTCCATAAG GCTACCAATA TGGAGTATGC TGTCAAGGTC 1440
ATCGACAAGA GCAAGCGGGA TCCCTCAGAA GAGATTGAGA TTCTTCTGCG ATATGGGCAG 1500
CACCCCAACA TCATCACTCT GAAAGATGTG TACGATGATG GCAAACACGT GTATCTGGTG 1560
ACGGAGCTGA TGCGGGGTGG GGAGCTGCTA GACAAGATCT TGAGGCAGAA ATTCTTCTCA 1620
GAGCGGGAGG CCAGCTTTGT CCTGCACACC ATCAGCAAAA CCGTGGAGTA CCTGCACTCC 1680
CAGGGGGTTG TTCACAGGGA CCTCAAGCCC AGCAACATCC TGTACGTGGA CGAGTCTGGG 1740
AACCCCGAGT GCCTGCGCAT CTGTGACTTT GGCTTCGCCA AGCAGCTGCG TGCCGAGAAC 1800
GGGCTCCTCA TGACGCCCTG CTACACTGCC AACTTTGTGG CACCCGAGGT GCTCAAACGC 1860
CAGGGCTACG ATGAGGGCTG TGACATCTGG AGCCTGGGCA TCCTGCTGTA TACCATGCTG 1920
GCTGGATACA CTCCATTCGC CAATGGACCC AGTGACACAC CGGAGGAAAT CCTGACCCGG 1980
ATCGGCAGTG GGAAGTTCAC CCTGAGTGGG GGAAATTGGA ACACAGTTTC AGAGACAGCC 2040
AAGGACCTGG TGTCCAAGAT GCTGCATGTG GACCCCCACC AGCGCCTCAC AGCTAAGCAG 2100
GTCCTGCAGC ACCCATGGAT CACCCAGAAA GACAAGCTCC CTCAGAGCCA GCTGTCCCAC 2160
CAGGACCTGC AGCTTGTGAA GGGAGCCATG GCAGCTACCT ACTCTGCCCT CAACAGCTCC 2220
AAGCCCACCC CTCAGCTGAA GCCCATCGAG TCATCGATCC TGGCCCAGCG GCGGGTGAGG 2280
AAGCTGCCGT CCACCACCCT GTGA 2304
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkdvydd  64
         e++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkdvydd
Q: 454   ETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDD  513
         79**********************************************************
S: 65    gkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpeni  124
         gk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlkp+ni
Q: 514   GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNI  573
         ************************************************************
S: 125   lyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlwslG  184
         lyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+wslG
Q: 574   LYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLG  633
         ************************************************************
S: 185   vllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvsklltvdpa  244
         +llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+vdp+
Q: 634   ILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPH  693
         ************************************************************
S: 245   krlkleqllkhswl  258
         +rl+++q+l+h+w+
Q: 694   QRLTAKQVLQHPWI  707
         *************8
Domain Sequence
(FASTA)
ETIGVGSYSV CKRCVHKATN MEYAVKVIDK SKRDPSEEIE ILLRYGQHPN IITLKDVYDD 60
GKHVYLVTEL MRGGELLDKI LRQKFFSERE ASFVLHTISK TVEYLHSQGV VHRDLKPSNI 120
LYVDESGNPE CLRICDFGFA KQLRAENGLL MTPCYTANFV APEVLKRQGY DEGCDIWSLG 180
ILLYTMLAGY TPFANGPSDT PEEILTRIGS GKFTLSGGNW NTVSETAKDL VSKMLHVDPH 240
QRLTAKQVLQ HPWI 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00160
EKS-CAE-00123
EKS-CAJ-00166
EKS-CAF-00167
EKS-CAP-00160
EKS-DAR-00450
EKS-EQC-00159
EKS-ERE-00040
EKS-FEC-00151
EKS-GAG-00138
EKS-GAA-00191
EKS-GOG-00161
EKS-HOS-00166
EKS-LAC-00172
EKS-LOA-00161
EKS-MAM-00159
EKS-MAE-00059
EKS-MEG-00129
EKS-MIM-00076
EKS-MOD-00160
EKS-MUM-00165
EKS-MUP-00163
EKS-MYL-00171
EKS-NOL-00154
EKS-ORN-00201
EKS-ORC-00148
EKS-ORL-00188
EKS-OTG-00166
EKS-PAT-00151
EKS-PES-00143
EKS-POA-00157
EKS-PRC-00043
EKS-RAN-00158
EKS-SAH-00155
EKS-SUS-00142
EKS-TAG-00190
EKS-TAR-00208
EKS-TEN-00200
EKS-XET-00151
EKS-XIM-00195
Gene Ontology
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013