EPS-AIM-00036

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00036

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	90.0	2.2E-25	57	332	276

Status

Unreviewed

Ensembl Protein

ENSAMEP00000011454

UniProt Accession

G1LWK3;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000010877	ENSAMEP00000011454	ENSAMET00000011941
ENSAMEG00000010877	ENSAMEP00000011461	ENSAMET00000011948

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SAPNRSYSAD GKGTESHPPE DSWLKFRSEN 60

NCFLYGVFNG YDGNRVTSFV AQRLSAELLL GQLSAEHTEA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKVLER EISGGAMAVV AVLLNSKLYV 180

ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGVICGQEST 240

RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHGD TFASGGERAK FCPRHEDMTL 360

LVRNFGYPLG EMSQPAPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQLVNG 420

AHSASTLDEA TPTLTNQSPT LTLQSTTTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP 480

YVDFAEFYRL WSVDHGEQSV MTAP 504

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CCTGCTGCAG AGTGAGCAGC AGCCGAGCTG GACAGATGAC 60

CTGCCGCTCT GCCACCTCTC CGGGGTCGGT TCGGCCCCCA ACCGCAGCTA CTCTGCTGAT 120

GGCAAAGGCA CTGAGAGCCA CCCACCGGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC 180

AACTGCTTCC TGTACGGGGT CTTCAATGGC TATGACGGCA ACCGAGTAAC CAGCTTCGTG 240

GCCCAGCGGT TGTCCGCCGA GCTCCTGCTG GGCCAGCTCA GTGCTGAGCA CACCGAGGCG 300

GATGTGCGGC GCGTGCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCC 360

ATCGATGATG CGTTGGCTGA GAAGGCAAGC CTCCAGTCCC AGCTGCCAGA GGGTGTCCCT 420

CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTCGAAA GACTCAAGGT GCTGGAGAGG 480

GAGATTTCGG GAGGAGCCAT GGCTGTTGTG GCGGTCCTTC TCAACAGCAA GCTCTACGTT 540

GCCAATGTCG GTACAAATCG TGCCCTTTTA TGCAAATCCA CGGTGGATGG GCTGCAGGTG 600

ACACAGCTGA ACGTGGACCA CACCACGGAG AACGAGGACG AGCTCTTCCG CCTCTCCCAG 660

CTGGGTTTGG ATGCAGGAAA GATCAAGCAA GTGGGGGTCA TCTGTGGGCA GGAGAGCACC 720

AGGCGCATCG GGGATTACAA GGTCAAATAT GGCTACACGG ACATCGACCT ACTCAGCGCT 780

GCCAAGTCCA AGCCGATTAT CGCGGAGCCC GAAATCCACG GTGCGCAGCC CCTGGACGGG 840

GTGACTGGCT TCCTGGTGCT GATGTCGGAG GGGCTCTACA AGGCTCTGGA GGCCGCCCAC 900

GGGCCTGGGC AGGCCAACCA GGAGATCGCC GCCATGATCG ACACGGAGTT CGCCAAGCAG 960

ACGTCGCTGG ATGCCGTGGC CCAGGCCGTG GTGGACCGAG TGAAGCGCAT CCACGGGGAC 1020

ACCTTCGCCA GTGGCGGCGA GCGTGCCAAG TTCTGCCCGA GGCACGAGGA CATGACCCTG 1080

CTGGTGAGGA ACTTTGGCTA CCCGCTGGGT GAGATGAGCC AGCCCGCACC GTCCCCGGCC 1140

CCAGCTGCAG GAGGACGCGT GTACCCCGTC TCCGTGCCGT ACTCCAGCGC CCAGAGCACC 1200

AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGCT GGTCAATGGG 1260

GCCCACAGCG CTTCCACCCT GGACGAAGCC ACTCCCACCC TTACCAACCA GAGCCCGACC 1320

CTGACGCTGC AGTCCACCAC CACGCACACG CAGAGCAGCA GCTCCAGCTC GGACGGGGGC 1380

CTCTTCCGCT CCCGGCCCGC CCACTCTCTC CCGCCTGGCG AGGATGGCCG CGTCGAACCT 1440

TACGTGGACT TTGCTGAGTT TTACCGCCTC TGGAGCGTGG ACCATGGCGA GCAGAGTGTG 1500

ATGACGGCAC CA 1512

Domain Profile

S: 29    pekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstde  88

         +++++   ++gv++G  g++v++f++++l+  l     s e +e++v+++l +aF  +++

Q: 57    RSENN-CFLYGVFNGYDGNRVTSFVAQRLSAELLLGQLSAEHTEADVRRVLLQAFDVVER  115

         44444.589********************976655555599*******************

S: 89    el................................kvleeksldidk..sGstavvalikd  114

          +                                k+le+ +  +++   G+ avva++ +

Q: 116   SFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKVLEREisGGAMAVVAVLLN  175

         **************************999999996666665555556699**********

S: 115   sklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdgaR  167

         sklyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 176   SKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--V  233

         ****************9663366699*********************8777777664..4

S: 168   vlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDGl  212

         ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s Gl

Q: 234   ICG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVLMSEGL  292

         555.69************************999*******98765155555*********

S: 213   wdvvs........neeavslvrdvlekkeaeqeaakkLvk  244

         ++ ++        n+e+ +++     k+++++++a+ +v+

Q: 293   YKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVD  332

         **98633333333566666665555567777777777666

Domain Sequence
(FASTA)

RSENNCFLYG VFNGYDGNRV TSFVAQRLSA ELLLGQLSAE HTEADVRRVL LQAFDVVERS 60

FLESIDDALA EKASLQSQLP EGVPQHQLPP QYQKILERLK VLEREISGGA MAVVAVLLNS 120

KLYVANVGTN RALLCKSTVD GLQVTQLNVD HTTENEDELF RLSQLGLDAG KIKQVGVICG 180

QESTRRIGDY KVKYGYTDID LLSAAKSKPI IAEPEIHGAQ PLDGVTGFLV LMSEGLYKAL 240

EAAHGPGQAN QEIAAMIDTE FAKQTSLDAV AQAVVD 276

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013