EKS-AIM-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.0	8.6E-104	542	798	257

Status

Unreviewed

Ensembl Protein

ENSAMEP00000011525

UniProt Accession

G1LWS2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000010924	ENSAMEP00000011525	ENSAMET00000012016

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1234

Protein Sequence
(FASTA)

DVVVLEVSSS LAQPSLFYHL GVRESFSMTN NVLLCSQADL PDLQALREDV FQKNSDCVGS 60

YTLIPYVVTA TGRVLCGDAG LLRGLADGLV QAGVGTEALL TPLVGRLARL LETTPTDSCG 120

YFRETIRQDI RRARERFCGQ QLRLELARLQ RRLDSVELLS PDIIMNLLLS YRDVQDYSAI 180

IELVETLQAL PTCDVAEQHN VCFHYTFALN RRNRPGDREK ALAVLLPLVQ SEGSVAPDLY 240

CMCGRVYKDM FFSSGFQDAG HREQAYHWYR KAFDLEPSLH SGINAAVLLI AAGQRFEDSE 300

ELRLIGMKLG CLLARKGCVE KMQYYWDVGF YLGAQILAND LTQVALAAEQ LYKLNAPIWY 360

LVSMMETFLL YQHFRPTLEL PEGPPHCAHF WLHFLLQSCQ PLKTACPQGD QCLVRPPKVL 420

VLEMNKVLLP ARLEIQGTDP VSAVTLSLLE PESQDVPSSW TFPVASICGV SSSKRDERCC 480

FLYALPPAQD VQLCFPSVGH CQWFCGLIQA LVTNPDSTAP AEEAEGVGEV LEFDYEYAET 540

GERLVLGKGT YGVVYAGRER HTRVRIAIKE IPERDSRFSQ PLHEEIALHK RLRHKNIVRY 600

LGSASQGGYL KIFMEEVPGG SLSSLLRSVW GPLQDNESTI SFYTRQILQG LGYLHDNRIV 660

HRDIKGDNVL INTFSGLLKI SDFGTSKRLA GITPCTETFT GTLQYMAPEI IDQGPRGYGK 720

AADIWSLGCT VIEMATGRPP FHELGSPQAA MFQVGMYKVH PPMPTSLSAE AQAFLLRTFE 780

PDPRLRASAQ ALLGDPFLQP GKRSRSPGSP RHALLPTGNI QVEGVGTLGT HPVPRSAASV 840

METPASSVAA SVSGFSPFSS CGVSIKVKAE PGFKPWGGGG RTVLPPVPEE PGAEEPTSPE 900

ESSGLSLLHQ ESKRRAMLAA VLEQERRALA DVLCPKQEQG PHLGRNHVEQ LLRCLGAHIH 960

TPNRRRLAQE LRALQGQLRA QGLGPALLHG PLFAFPDAVK QILRRRQIRP HWMFVLDSLL 1020

SRAVRVALAV LGPGVWGCPK WASFPCRSSP QSLGLAEVET EEVPLRSEES SKEEEPQSKQ 1080

QETLVQLSRL PGEPEQAPPS PVVQLGLLRA ETDRLRDVLA EKERECQALV QQALQRVNGE 1140

ARTCTLATEP PGEGTWLGNI HSKSALTVDQ GLVQWLQELN VDSGTIQMNQ LLNHSFSLHT 1200

LLTCATRDDL IYTRIRGGMV CRIWRAILAQ RARS 1234

Nucleotide Sequence
(FASTA)

GACGTGGTGG TGCTGGAGGT GAGCAGCTCC CTGGCACAGC CCTCTCTGTT CTACCACCTT 60

GGTGTGCGGG AGAGCTTCAG CATGACCAAC AACGTGCTCC TCTGCTCCCA GGCTGACCTC 120

CCTGACCTGC AGGCCCTTCG GGAGGATGTT TTCCAGAAGA ACTCGGACTG TGTTGGCAGC 180

TACACGCTGA TCCCCTATGT GGTGACAGCC ACTGGTCGGG TGCTGTGCGG TGATGCGGGC 240

CTCCTGAGGG GCCTGGCTGA TGGGCTGGTA CAGGCCGGGG TGGGCACTGA GGCCCTGCTA 300

ACGCCCCTGG TGGGCCGGCT GGCCCGCCTG CTAGAGACCA CGCCCACGGA CTCTTGTGGC 360

TACTTCCGGG AGACCATCCG GCAGGACATC CGGCGGGCCC GGGAGCGGTT CTGCGGGCAG 420

CAGCTTCGGC TGGAGCTGGC TCGCCTGCAG CGGAGACTGG ACAGCGTGGA GCTGCTGAGC 480

CCCGACATCA TCATGAACCT GCTGCTGTCC TACCGCGATG TGCAGGACTA CTCAGCCATC 540

ATCGAGCTGG TGGAGACACT GCAGGCCTTG CCCACCTGTG ACGTGGCCGA GCAGCACAAC 600

GTCTGCTTCC ACTACACGTT CGCCCTCAAC CGGAGGAACC GGCCTGGGGA CCGGGAGAAG 660

GCACTGGCTG TGCTGCTGCC ACTGGTCCAG AGTGAGGGCT CTGTGGCGCC TGACCTCTAC 720

TGCATGTGCG GCCGTGTCTA CAAGGACATG TTCTTCAGCT CTGGCTTCCA GGATGCTGGG 780

CACCGGGAAC AGGCCTATCA CTGGTATCGC AAGGCTTTCG ACTTAGAGCC CAGCCTCCAC 840

TCGGGCATCA ACGCGGCTGT GCTGCTCATT GCTGCTGGGC AGCGCTTTGA GGACTCTGAG 900

GAGCTCCGGC TCATCGGCAT GAAGCTGGGC TGCCTGTTGG CCCGGAAAGG CTGCGTGGAG 960

AAGATGCAGT ATTACTGGGA TGTAGGGTTC TACCTGGGAG CGCAGATCCT CGCCAATGAC 1020

CTCACCCAGG TGGCGCTGGC CGCAGAGCAG CTGTACAAAC TCAACGCTCC CATATGGTAC 1080

CTGGTGTCCA TGATGGAAAC CTTCCTGCTG TACCAGCACT TCAGACCCAC CCTGGAGCTT 1140

CCCGAAGGAC CCCCACACTG TGCCCACTTT TGGCTGCACT TCTTGCTACA GTCCTGTCAG 1200

CCACTCAAGA CGGCCTGTCC CCAAGGGGAC CAGTGCTTGG TGAGGCCGCC TAAGGTGCTG 1260

GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAGGCTCG AGATTCAGGG TACTGATCCT 1320

GTGAGTGCAG TGACCCTGAG CCTGCTGGAG CCCGAAAGCC AGGACGTTCC CTCCAGCTGG 1380

ACCTTCCCAG TGGCCTCCAT CTGCGGGGTC AGCTCCTCGA AGCGGGATGA GCGCTGCTGC 1440

TTCCTCTACG CGCTCCCCCC GGCTCAGGAC GTGCAGCTGT GCTTCCCCAG CGTAGGGCAC 1500

TGCCAGTGGT TCTGCGGCCT GATCCAAGCC TTGGTGACGA ATCCGGATTC CACGGCGCCC 1560

GCGGAGGAGG CGGAGGGCGT GGGGGAGGTG CTGGAGTTTG ATTATGAGTA CGCGGAGACG 1620

GGCGAGCGGC TGGTGCTGGG CAAGGGCACC TACGGGGTGG TGTACGCGGG CCGCGAGCGG 1680

CACACGCGGG TGCGCATAGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 1740

CCCCTGCACG AAGAGATAGC TCTGCACAAA CGCCTTCGCC ACAAGAACAT CGTGCGCTAC 1800

CTGGGCTCGG CCAGCCAGGG CGGCTACCTC AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 1860

AGCCTGTCCT CCCTGCTGCG GTCAGTGTGG GGACCCCTGC AGGACAACGA GAGCACCATC 1920

AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTCGGCTACC TGCATGACAA CCGCATAGTG 1980

CATCGAGACA TCAAGGGGGA CAATGTGCTG ATCAACACCT TCAGCGGGCT GCTCAAGATC 2040

TCTGACTTCG GCACCTCCAA GAGGCTGGCA GGCATCACGC CTTGCACTGA GACCTTCACA 2100

GGGACCCTAC AGTATATGGC GCCAGAAATC ATTGACCAGG GCCCACGAGG GTATGGGAAG 2160

GCAGCTGACA TCTGGTCACT GGGCTGCACT GTTATCGAGA TGGCCACAGG TCGCCCACCC 2220

TTCCATGAGC TGGGGAGCCC GCAGGCTGCC ATGTTTCAGG TGGGCATGTA CAAGGTGCAT 2280

CCGCCAATGC CCACTTCTCT GTCAGCGGAG GCCCAAGCCT TCCTTCTCCG AACTTTTGAG 2340

CCAGACCCCC GCCTCCGAGC CAGTGCTCAA GCACTGCTGG GGGACCCCTT CCTGCAGCCC 2400

GGGAAGAGGA GCCGCAGCCC TGGCTCCCCC CGACATGCAC TGCTGCCCAC AGGTAATATA 2460

CAGGTGGAGG GAGTGGGCAC ACTGGGCACC CACCCAGTCC CCCGAAGCGC TGCCTCAGTT 2520

ATGGAGACAC CAGCCAGCTC CGTGGCCGCC TCAGTGTCAG GCTTCTCTCC CTTTTCCTCC 2580

TGTGGGGTGA GCATCAAAGT AAAAGCAGAG CCAGGATTCA AACCCTGGGG TGGAGGTGGC 2640

CGGACGGTGT TGCCCCCGGT GCCCGAGGAA CCCGGGGCCG AGGAGCCCAC GTCCCCCGAG 2700

GAGAGTTCTG GGCTCAGCCT GCTGCACCAG GAGAGCAAGC GCCGGGCCAT GCTGGCCGCC 2760

GTGCTGGAGC AGGAGCGGCG CGCGCTCGCG GACGTCCTGT GCCCCAAGCA GGAGCAGGGG 2820

CCCCATCTGG GCAGGAATCA TGTGGAACAG CTACTGCGCT GCCTCGGGGC GCACATCCAC 2880

ACTCCCAACC GCCGGCGGCT AGCCCAGGAG CTGCGGGCGC TGCAGGGGCA GCTGCGGGCC 2940

CAAGGCCTCG GGCCTGCGCT TCTGCACGGA CCGCTCTTCG CCTTCCCGGA TGCGGTGAAG 3000

CAGATTCTCC GACGGCGCCA GATCCGCCCA CACTGGATGT TCGTGCTGGA CTCGCTGCTC 3060

AGTAGAGCTG TGCGGGTAGC CCTGGCTGTG CTGGGCCCAG GTGTCTGGGG GTGTCCCAAA 3120

TGGGCGTCCT TTCCCTGCCG GAGCTCACCC CAATCACTTG GATTGGCAGA GGTGGAGACG 3180

GAGGAGGTCC CACTGAGGTC AGAGGAGTCG AGTAAAGAAG AGGAACCCCA GTCCAAGCAG 3240

CAGGAGACCT TGGTCCAGCT CAGCCGGCTC CCGGGGGAAC CAGAGCAGGC ACCCCCGTCC 3300

CCCGTAGTGC AGCTGGGCCT CTTGCGAGCA GAGACTGACA GGCTCCGAGA TGTCCTGGCT 3360

GAGAAAGAAC GGGAGTGCCA GGCCCTGGTG CAGCAGGCGC TACAACGGGT GAACGGGGAG 3420

GCCAGAACCT GTACCCTGGC CACAGAGCCC CCAGGTGAGG GGACTTGGCT GGGCAACATT 3480

CACAGCAAGT CTGCTCTTAC GGTGGACCAG GGCCTGGTGC AGTGGCTACA GGAACTGAAC 3540

GTGGATTCAG GCACCATCCA GATGAACCAG CTGCTGAACC ACAGCTTCAG CCTCCATACC 3600

CTACTGACCT GTGCCACTCG AGATGACCTC ATCTACACCC GCATCAGGGG AGGGATGGTA 3660

TGCCGCATCT GGAGAGCCAT CTTGGCACAG CGAGCGAGAT CC 3702

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya+++ +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n

Q: 542   ERLVLGKGTYGVVYAGRERHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  596

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl yLH+

Q: 597   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLQdnESTISFYTRQILQGLGYLHD  656

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 657   NRIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  713

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++

Q: 714   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPTSLSAEAQA  773

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 774   FLLRTFEPDPRLRASAQALLGDPFL  798

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRERH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQILQGL GYLHDNRIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPTSLSAEA QAFLLRTFEP 240

DPRLRASAQA LLGDPFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013