EKS-AIM-00344
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00344
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.62.2E-130261509249
StatusUnreviewed
Ensembl ProteinENSAMEP00000011599
UniProt AccessionD2GWJ1;
Protein Name
Protein Synonyms/Alias
Gene NameFGR
Gene Synonyms/Alias FGR; PANDA_001178;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000010994ENSAMEP00000011599ENSAMET00000012092
OrganismAiluropoda melanoleuca
Functional Description
Protein Length526
Protein Sequence
(FASTA)
MGCVFCKKSE PALKEDVGLE RDFRGGGAAD RYGPDPTRAR TVSSFAHIPN YNFPTQSTTP 60
AFLDGGTIRA ISGTGVTLFI ALYDYEARTE DDLTFTKGEK FHILNNTEGD WWEARSLSSG 120
QTGYIPSNYV APVDSIQAEE WYFGKIGRKD AERQLLSPGN PRGAFLIRES ETTKGAYSLS 180
IRDWDQARGD HVKHYKIRKL DTGGYYITTR AQFDSVQELV QHYIEVNDGL CHLLTAACTT 240
MKPQTMGLAK DAWEISRSSI ALERRLGTGC FGDVWLGMWN GSTKVAVKTL KPGTMSPKAF 300
LAEAQIMKML RHDKLVQLYA VVSEEPIYIV TEFMCHGSLL EFLKDRQGQD LTLPQLVDMA 360
AQVAEGMAYM ERMNYIHRDL RAANILVGER LVCKIADFGL ARLIEDDEYN PQQGAKFPIK 420
WTAPEAALFG RFTIKSDVWS FGILLTELIS KGRVPYPGMN NREVLEQVEH GYHMPCPPGC 480
PVSLYEAMEQ TWRLDPEERP TFEYLQSFLE DYFTSTEPQY QPGDQT 526
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTCCGAG CCGGCGCTCA AGGAGGATGT TGGCCTGGAA 60
AGGGACTTCA GGGGCGGTGG GGCTGCGGAC CGCTATGGCC CTGACCCTAC TCGGGCCCGG 120
ACTGTGTCCT CCTTTGCCCA TATCCCAAAT TACAACTTCC CCACTCAGTC CACCACCCCG 180
GCCTTCCTCG ATGGGGGCAC CATCAGGGCC ATCTCAGGGA CTGGGGTGAC CCTGTTCATC 240
GCCTTGTATG ACTATGAGGC CCGGACAGAG GATGACCTCA CCTTCACCAA GGGTGAGAAG 300
TTCCACATCC TGAACAACAC TGAGGGTGAC TGGTGGGAAG CCCGGTCTCT CAGCTCTGGA 360
CAAACTGGCT ATATTCCCAG CAACTACGTC GCCCCTGTGG ACTCCATCCA GGCTGAAGAG 420
TGGTACTTTG GAAAGATTGG GAGAAAGGAT GCAGAGAGGC AGCTGCTCTC CCCTGGGAAC 480
CCCCGGGGGG CTTTTCTTAT TCGTGAGAGT GAGACTACCA AAGGTGCCTA CTCCCTGTCC 540
ATCCGGGATT GGGACCAGGC CAGAGGCGAC CACGTGAAGC ATTACAAAAT CCGCAAGCTG 600
GACACGGGTG GCTACTACAT CACCACACGG GCCCAGTTCG ACTCAGTGCA GGAGCTCGTG 660
CAGCACTACA TTGAGGTGAA CGACGGGCTA TGCCACCTGC TCACAGCGGC CTGCACCACC 720
ATGAAGCCGC AGACAATGGG CCTGGCCAAG GACGCTTGGG AGATCAGCCG CAGCTCCATC 780
GCGCTCGAGC GCCGGCTGGG CACCGGCTGC TTTGGGGACG TGTGGCTGGG CATGTGGAAC 840
GGCAGCACGA AGGTGGCGGT GAAGACCCTG AAGCCGGGAA CCATGTCCCC GAAGGCCTTC 900
CTGGCGGAGG CGCAGATCAT GAAGATGCTG CGACACGACA AGCTGGTGCA GCTGTACGCG 960
GTGGTGTCGG AGGAACCCAT CTACATCGTG ACCGAGTTCA TGTGCCACGG TAGCTTGCTG 1020
GAGTTCCTCA AGGACCGGCA AGGCCAGGAT TTGACACTGC CCCAGTTGGT GGACATGGCA 1080
GCCCAGGTGG CCGAGGGCAT GGCCTACATG GAACGCATGA ACTACATCCA CCGCGACCTG 1140
AGGGCAGCCA ACATCCTTGT TGGGGAACGG CTGGTGTGCA AGATCGCTGA CTTCGGCCTG 1200
GCCCGTCTCA TTGAGGATGA TGAGTACAAC CCCCAGCAAG GGGCCAAGTT CCCCATCAAG 1260
TGGACAGCCC CGGAGGCTGC TCTCTTTGGT AGATTCACCA TCAAGTCAGA TGTGTGGTCC 1320
TTTGGGATCC TGCTCACTGA ACTCATCAGC AAGGGCCGAG TCCCCTACCC AGGCATGAAT 1380
AACCGGGAAG TGTTGGAACA GGTGGAGCAT GGCTACCACA TGCCATGCCC CCCAGGCTGC 1440
CCAGTATCCC TGTACGAAGC CATGGAGCAG ACCTGGCGTC TGGACCCAGA GGAGAGGCCT 1500
ACCTTCGAGT ACCTGCAGTC CTTCCTTGAG GACTACTTCA CCTCCACAGA ACCCCAGTAC 1560
CAACCTGGGG ATCAGACATA A 1581
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afl+eaqi+k lrh+klv+lya
Q: 261   ALERRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKAFLAEAQIMKMLRHDKLVQLYA  320
         789*********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vvse ePiyivte+m +Gsll+flk+++g+ l+lp+lvd+aaqvaeGmay+e++n+ihrd
Q: 321   VVSE-EPIYIVTEFMCHGSLLEFLKDRQGQDLTLPQLVDMAAQVAEGMAYMERMNYIHRD  379
         ***9.*******************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lvge+lv+k+adfGlarlieddey++++gak+PikWtaPea+ +g+ftiksdvW
Q: 380   LRAANILVGERLVCKIADFGLARLIEDDEYNPQQGAKFPIKWTAPEAALFGRFTIKSDVW  439
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGillte+++kG+vPypGm+n+evleqve+gy++p+p  cp +lye+++++w+ dpeer
Q: 440   SFGILLTELISKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEAMEQTWRLDPEER  499
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe+lq++l
Q: 500   PTFEYLQSFL  509
         *******986
Domain Sequence
(FASTA)
ALERRLGTGC FGDVWLGMWN GSTKVAVKTL KPGTMSPKAF LAEAQIMKML RHDKLVQLYA 60
VVSEEPIYIV TEFMCHGSLL EFLKDRQGQD LTLPQLVDMA AQVAEGMAYM ERMNYIHRDL 120
RAANILVGER LVCKIADFGL ARLIEDDEYN PQQGAKFPIK WTAPEAALFG RFTIKSDVWS 180
FGILLTELIS KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PVSLYEAMEQ TWRLDPEERP 240
TFEYLQSFL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
EKS-TUT-00101
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
aml:100467541;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013