EKS-AIM-00147
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00147
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK368.13.0E-11091352262
StatusUnreviewed
Ensembl ProteinENSAMEP00000012017
UniProt AccessionD2HLU3;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KB1
Gene Synonyms/Alias RPS6KB1; PANDA_012486;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000011391ENSAMEP00000012017ENSAMET00000012524
OrganismAiluropoda melanoleuca
Functional Description
Protein Length525
Protein Sequence
(FASTA)
MRRRRRRDGF YPVPDFQDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG 60
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF 120
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL 180
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC 240
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK 300
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL 360
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE 420
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG 480
VEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL 525
Nucleotide Sequence
(FASTA)
ATGAGGCGAC GACGGAGGCG GGACGGCTTT TACCCAGTGC CGGACTTCCA AGACAGGGAA 60
GCTGAGGACA TGGCAGGAGT GTTTGACATA GACCTGGACC AGCCAGAGGA CGCGGGCTCT 120
GAGGATGAGC TGGAGGAGGG GGGTCAGTTA AATGAAAGCA TGGACCATGG GGGAGTTGGA 180
CCATATGAAC TTGGCATGGA ACATTGTGAG AAATTTGAAA TTTCGGAAAC TAGTGTGAAC 240
AGAGGGCCAG AAAAAATCAG ACCAGAATGT TTTGAGCTAC TTCGGGTACT TGGTAAAGGG 300
GGCTATGGAA AGGTTTTTCA AGTACGAAAA GTAACAGGAG CAAATACTGG GAAAATATTT 360
GCCATGAAGG TGCTTAAAAA GGCAATGATA GTAAGAAATG CTAAAGATAC AGCTCATACA 420
AAAGCAGAAC GGAATATTCT GGAGGAAGTA AAGCATCCCT TCATTGTGGA TTTAATTTAT 480
GCCTTTCAGA CCGGTGGAAA ACTCTACCTC ATCCTTGAGT ATCTCAGCGG AGGAGAATTA 540
TTTATGCAGT TAGAAAGAGA GGGAATATTT ATGGAAGACA CAGCCTGCTT TTACTTGGCA 600
GAAATCTCCA TGGCTTTGGG GCATTTGCAT CAAAAGGGGA TCATCTACAG AGACCTGAAG 660
CCGGAGAATA TCATGCTTAA TCACCAAGGT CATGTGAAAC TAACAGACTT TGGACTATGC 720
AAAGAATCTA TTCATGATGG AACAGTCACA CACACATTTT GTGGAACAAT AGAATACATG 780
GCCCCTGAAA TCTTGATGAG AAGTGGCCAC AATCGTGCTG TGGATTGGTG GAGTTTGGGA 840
GCATTAATGT ATGACATGCT GACTGGAGCA CCCCCGTTCA CTGGGGAGAA TAGAAAGAAA 900
ACAATTGACA AAATCCTCAA ATGTAAACTC AATTTGCCTC CCTACCTCAC GCAAGAAGCC 960
AGAGATCTGC TTAAAAAGCT GCTGAAAAGA AATGCTGCTT CTCGGCTTGG AGCTGGTCCT 1020
GGGGATGCTG GAGAAGTTCA AGCTCATCCA TTCTTCAGGC ATATTAACTG GGAAGAACTG 1080
CTGGCTCGGA AGGTGGAGCC CCCCTTTAAA CCTCTGTTGC AATCTGAAGA GGATGTGAGT 1140
CAGTTTGATT CAAAGTTTAC ACGTCAGACA CCTGTTGACA GCCCAGATGA CTCAACTCTC 1200
AGTGAAAGTG CCAACCAGGT CTTTCTGGGT TTTACATATG TGGCTCCATC TGTACTTGAA 1260
AGTGTGAAAG AAAAATTTTC CTTTGAACCA AAAATCCGAT CACCTCGAAG ATTTATTGGC 1320
AGCCCACGAA CACCTGTCAG CCCGGTCAAA TTTTCTCCTG GGGATTTCTG GGGAAGAGGT 1380
GCTTCAGCCA GCACGGCAAA TCCTCAGACA CCTGTGGAAT ATCCCATGGA AACAAGTGGA 1440
GTAGAGCAGA TGGATGTGAC GATGAGTGGG GAAGCTTCAG CACCACTTCC AATACGACAG 1500
CCGAACTCCG GGCCATACAA AAAACAAGCT TTTCCCATGA TCTCCAAACG ACCAGAGCAC 1560
CTACGTATGA ATCTATGA 1578
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58
         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev
Q: 91    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  150
         89***********************************9999999****************
S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118
         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH
Q: 151   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  210
         ************************************************************
S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178
         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g
Q: 211   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  269
         *********************************9.9999999******************
S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238
         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k
Q: 270   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  325
         ****************************************..9*****..**********
S: 239   klLkkdpakRlga...taeeikehkfl  262
         klLk++ a+Rlga   +a e+++h+f+
Q: 326   KLLKRNAASRLGAgpgDAGEVQAHPFF  352
         *************9*9*********97
Domain Sequence
(FASTA)
FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60
KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120
QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180
NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240
NAASRLGAGP GDAGEVQAHP FF 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-ANC-00148
EKS-BOT-00154
EKS-CAE-00124
EKS-CAJ-00159
EKS-CAF-00162
EKS-CAP-00155
EKS-CHH-00022
EKS-DAR-00441
EKS-DRM-00075
EKS-EQC-00153
EKS-FEC-00145
EKS-GAG-00132
EKS-GAA-00182
EKS-HOS-00160
EKS-ICT-00151
EKS-LAC-00164
EKS-LOA-00154
EKS-MAM-00153
EKS-MEG-00122
EKS-MOD-00155
EKS-MUM-00159
EKS-MUP-00159
EKS-MYL-00163
EKS-NOL-00148
EKS-ORN-00191
EKS-ORA-00134
EKS-ORL-00181
EKS-OTG-00160
EKS-PAT-00145
EKS-PES-00137
EKS-POA-00151
EKS-RAN-00152
EKS-SAH-00149
EKS-SOA-00029
EKS-SUS-00135
EKS-TAG-00183
EKS-TAR-00200
EKS-TEN-00193
EKS-TUT-00147
EKS-VIP-00075
EKS-XET-00143
EKS-XIM-00186
EKS-SCP-00040
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007281; P:germ cell development
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0045948; P:positive regulation of translational initiation
GO:0043491; P:protein kinase B signaling cascade
GO:0031929; P:TOR signaling cascade
KEGG
aml:100484786;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016238; Ribosomal_S6_kinase.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013