EKS-AIM-00215

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00215

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	429.1	6.1E-129	46	306	261

Status

Unreviewed

Ensembl Protein

ENSAMEP00000012111

UniProt Accession

D2HER6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK3

Gene Synonyms/Alias

MAPKAPK3; PANDA_009306;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000011487	ENSAMEP00000012111	ENSAMET00000012628

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MDGETAEEQG DPVPPPGAPC GPGSAGAPAL GGRREPKKYA VTDDYQLSKQ VLGLGVNGKV 60

LECFHRRTGQ KCALKLLYDS PKARQEVDHH WQASGGPHIV RILDVYENMH HGKRCLLIVM 120

ECMEGGELFS RIQERGDQAF TEREAAEIMR DIGTAIQFLH SQNIAHRDVK PENLLYTSKE 180

KDAVLKLTDF GFAKETTQNA LQTPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG 240

FPPFYSNTGQ AISPGMKRRI RLGQYGFPNP EWSEVSEDAK QLIRLLLKTD PTERLTITQF 300

MNHPWINQSM VVPQTPLHTA RVLQEDRDHW DEVKEEMTSA LATMRVDYDQ VQIKDLKTSN 360

NRLLNKRRKK QAGGSSASQG CHNQ 384

Nucleotide Sequence
(FASTA)

ATGGATGGCG AGACAGCAGA GGAGCAAGGA GACCCTGTGC CCCCGCCAGG TGCACCCTGC 60

GGACCCGGCT CAGCCGGTGC TCCTGCCCTC GGGGGGCGGC GGGAGCCCAA GAAGTATGCA 120

GTGACCGATG ACTACCAGTT GTCCAAGCAG GTGCTGGGCC TGGGTGTGAA CGGCAAGGTG 180

CTGGAGTGCT TCCACAGGCG CACTGGGCAG AAATGTGCTC TGAAGCTCCT GTACGACAGC 240

CCCAAGGCCC GGCAGGAGGT GGACCACCAC TGGCAGGCGT CGGGGGGCCC GCACATTGTG 300

CGCATCCTGG ACGTGTACGA GAACATGCAC CACGGCAAGC GCTGTCTCCT CATCGTCATG 360

GAGTGCATGG AAGGTGGTGA GCTCTTCAGC CGGATTCAGG AGCGTGGCGA CCAGGCTTTC 420

ACTGAGAGAG AAGCTGCAGA GATCATGCGG GATATCGGCA CTGCCATCCA GTTCCTGCAT 480

AGCCAGAACA TTGCCCACCG AGATGTCAAG CCTGAAAACC TGCTGTACAC GTCCAAGGAG 540

AAAGATGCAG TACTAAAGCT CACCGACTTT GGCTTTGCCA AGGAGACCAC CCAAAATGCC 600

CTGCAGACAC CCTGCTACAC TCCCTATTAC GTAGCTCCCG AGGTCTTGGG TCCAGAGAAG 660

TATGACAAAT CGTGTGACAT GTGGTCCCTG GGCGTCATCA TGTACATCCT CCTGTGTGGC 720

TTCCCGCCCT TCTACTCCAA CACGGGCCAG GCCATCTCCC CAGGGATGAA GAGGCGGATC 780

CGCCTAGGCC AGTATGGCTT CCCCAACCCA GAGTGGTCGG AGGTTTCTGA AGATGCCAAG 840

CAGCTGATCC GCCTGCTACT GAAGACAGAC CCCACAGAGA GGCTGACCAT CACGCAGTTC 900

ATGAACCATC CCTGGATCAA CCAATCAATG GTGGTGCCGC AGACCCCGCT CCACACGGCC 960

CGAGTGCTGC AGGAGGATAG AGACCACTGG GATGAGGTCA AGGAGGAGAT GACCAGTGCC 1020

CTGGCGACCA TGCGTGTGGA CTACGACCAG GTGCAGATCA AGGACCTGAA GACGTCTAAC 1080

AACCGATTGC TCAACAAGCG GAGGAAGAAG CAGGCAGGCG GCTCCTCAGC CTCACAGGGC 1140

TGCCACAACC AATAG 1155

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         +l+++vlG G++gkvlec++++tg+k+alk+l+d++k+r+ev++h+qasg ++iv+++dv

Q: 46    QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDV  105

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en+++++++ll+v+e++eGGel+sriqer  +afte+ea+e+++di++a++flhs+nia

Q: 106   YENMHHGKRCLLIVMECMEGGELFSRIQERgdQAFTEREAAEIMRDIGTAIQFLHSQNIA  165

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+skek+a++kl+Dfg+ake +++++l+tpc+t++yvaPevl++ek

Q: 166   HRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTPYYVAPEVLGPEK----  220

         *****************************7.7899*********************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcG+pPfys++g+ais+++k+ri+ g+y fP++eWsevse+a

Q: 221   -YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDA  279

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir lLk+dp+erlti++++nhpw+

Q: 280   KQLIRLLLKTDPTERLTITQFMNHPWI  306

         **************************8

Domain Sequence
(FASTA)

QLSKQVLGLG VNGKVLECFH RRTGQKCALK LLYDSPKARQ EVDHHWQASG GPHIVRILDV 60

YENMHHGKRC LLIVMECMEG GELFSRIQER GDQAFTEREA AEIMRDIGTA IQFLHSQNIA 120

HRDVKPENLL YTSKEKDAVL KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC 180

DMWSLGVIMY ILLCGFPPFY SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRL 240

LLKTDPTERL TITQFMNHPW I 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0044351	; P:macropinocytosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032496	; P:response to lipopolysaccharide
GO:0006950	; P:response to stress
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

aml:100484361

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013