EKS-AIM-00028
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00028
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak325.23.5E-978961166271
StatusUnreviewed
Ensembl ProteinENSAMEP00000012301
UniProt AccessionG1LYZ3;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000011557ENSAMEP00000012301ENSAMET00000012827
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1186
Protein Sequence
(FASTA)
AVKSMPLCHW GATTRDSRPD GDGAQPMATR GGLKVLLHWA GPGGGDPWVT FSEATLTAEE 60
VCIHIAQKVG ITPSCLNLFA LFDAQAQVWL PPNHVLEISR DMSLTLYFRM RFYFRNWHGT 120
NPQEPAVYRC GPPGAKSSSE QAEQGMQLLD PASFEYLFEQ GKHEFVNDVA SLWELSSEEE 180
IHHFKNESLG MAFLHLCHLA LCHGVPLEKV AKKISFKDCI PRSFRQQIRR HNALTRLRLR 240
NIFRRFVRAF QPGHVSQQVI MVKYLATLEQ LAPRFGTERV PVCRLQLPAQ AGGEPYYIRD 300
GGQAPPEPGP DLAPGPPTHE VLVTGTGGIQ WRPVQAEGPR GDGSSRNPHA GPTGKKTKAP 360
EVVNQPADRP REAPWAYFCD FRDITHVVLK ERHVSIHCQD NKSLELTLPS RAAALSLVSL 420
VDGYFRLTAD SSHYLCHEVA PPRLVMSIQE GIHGPLLEPF VLAKLRAEDG LYLVHWSASH 480
LNRLILTVAQ REQAPGTQHM HLRKFPIELQ AGVFTLEGWD RSFPSVRELR AALQGCSLRA 540
GDDCFSLRRC CLPWPGEISN LIIMRGPRAS TGPPNLSQLS FHRVCRDDIT QLSHLGQGTR 600
TNVYEGILRV GGRSPEEGMA DGEDPPTPSG DRGQELRVVL KVLDPSHHDI ALAFYETASL 660
MSQVSHVHLA FVHGICVHGS ENIMVTEYVE HGPLDVWLRR EKGHTPVAWK VAVAQQLASA 720
LSYLEDKNLV HGNVCGRNIL LARLGLAEGT SPFIKLSDPG VGLGALSREE RVERIPWIAP 780
ECLSGGANSL TTAADKWGFG ATLLEICFDG EAPLQGRGPS EKECFYQKQH RLPQPSCPEL 840
ATLTSQCLTY EPAQRPSFRT ILRDLTQLQP QNLADVLAVN PDSPASDPTV FHKRYLKKIR 900
DLGEGHFGKV SLYCYDPTND GTGEMVAVKA LKADCSPQLR TGWRREIDIL RTLYHKHIVK 960
YKGCCEDPGE KSVQLVMEYV PLGSLRDYLP RHSVGLAQLL LFAQQICEGM AYLHGQHYVH 1020
RDLAARNVLL DNDRLVKLGD FGLTKAVPEG HEYYRVREDG DSPVFWYAPE CLKECKFYYA 1080
SDVWSFGVTL YELLTYCDSS QSPPSKFIEL IGLTQGQMTV LRLTELLERG ERLPRPERCP 1140
CEIYLLMKNC WEAEASFRPT FQNLIPILKT AQEKYQGQAA SVFNVC 1186
Nucleotide Sequence
(FASTA)
GCTGTCAAAA GCATGCCTCT GTGCCATTGG GGTGCCACCA CCAGGGACAG CAGGCCTGAT 60
GGCGATGGAG CTCAGCCCAT GGCCACCAGG GGAGGCCTGA AGGTCCTTCT GCACTGGGCT 120
GGCCCTGGTG GCGGGGACCC CTGGGTCACC TTCAGCGAAG CCACACTGAC CGCAGAGGAG 180
GTCTGCATCC ACATTGCACA AAAAGTTGGT ATCACTCCGT CCTGCCTCAA TCTCTTTGCT 240
CTCTTCGATG CCCAGGCTCA GGTCTGGCTG CCCCCAAACC ATGTCTTGGA GATCTCCAGA 300
GACATGAGCC TGACGTTGTA TTTCCGCATG AGGTTTTATT TCCGGAACTG GCACGGCACA 360
AACCCTCAGG AACCGGCTGT GTACCGCTGT GGGCCCCCAG GGGCCAAGTC TTCCTCAGAA 420
CAGGCAGAGC AGGGGATGCA ATTGCTGGAC CCAGCCTCCT TTGAGTACCT CTTTGAGCAG 480
GGCAAGCATG AGTTTGTGAA TGACGTGGCA TCACTGTGGG AGCTGTCGAG TGAGGAGGAG 540
ATCCACCATT TTAAGAACGA GAGTCTGGGC ATGGCCTTTC TGCACCTCTG CCACCTGGCT 600
CTCTGCCATG GCGTCCCCCT GGAGAAGGTG GCCAAGAAGA TCAGCTTCAA GGACTGCATC 660
CCGCGCTCCT TCCGTCAGCA GATCCGGCGG CACAACGCGC TGACGCGTCT ACGCTTGCGG 720
AACATCTTCC GCAGGTTCGT GCGGGCCTTC CAGCCGGGCC ACGTCTCGCA GCAGGTCATC 780
ATGGTCAAGT ACCTGGCCAC GCTCGAGCAG CTGGCACCCC GCTTCGGCAC GGAGCGTGTG 840
CCCGTGTGCC GCCTGCAGCT ACCGGCCCAG GCCGGTGGGG AGCCCTACTA CATCCGGGAC 900
GGCGGGCAGG CTCCCCCAGA GCCCGGGCCG GACTTGGCCC CCGGACCCCC CACTCATGAG 960
GTGCTGGTGA CGGGCACGGG TGGCATCCAG TGGCGGCCGG TACAGGCAGA GGGTCCCAGA 1020
GGCGATGGCA GCAGCAGGAA TCCCCATGCT GGCCCAACTG GGAAGAAAAC CAAGGCCCCA 1080
GAGGTGGTCA ACCAGCCAGC AGACAGGCCT CGGGAAGCGC CATGGGCCTA CTTCTGCGAC 1140
TTCCGGGATA TCACGCACGT GGTGCTGAAA GAACGCCACG TCAGCATCCA CTGTCAGGAC 1200
AACAAGAGCC TGGAGCTGAC CCTGCCTTCC CGGGCCGCAG CCCTGTCCTT GGTGTCGCTG 1260
GTGGACGGCT ATTTCCGCCT GACCGCCGAC TCGAGCCACT ACCTGTGCCA CGAGGTGGCT 1320
CCTCCGCGGC TGGTGATGAG CATCCAGGAG GGTATCCACG GACCCCTGCT GGAGCCGTTT 1380
GTGCTGGCCA AGCTGCGGGC GGAGGATGGT CTCTACCTCG TGCACTGGAG CGCCAGCCAC 1440
CTCAACCGCC TCATCCTCAC CGTGGCCCAG CGTGAGCAGG CACCGGGCAC ACAGCACATG 1500
CACCTGCGTA AATTCCCCAT TGAGCTGCAG GCGGGGGTCT TCACGCTGGA GGGCTGGGAC 1560
CGGTCCTTTC CCAGCGTGCG CGAGCTGCGA GCCGCCCTGC AGGGTTGTTC CCTGCGGGCT 1620
GGCGATGACT GTTTCTCCCT GCGCCGCTGC TGCCTACCGT GGCCGGGAGA GATCTCCAAC 1680
CTCATCATCA TGCGGGGGCC TCGGGCCAGC ACGGGCCCCC CCAACCTCAG CCAGCTCAGC 1740
TTCCACCGGG TCTGCCGGGA TGACATCACC CAGCTCTCCC ACTTGGGCCA AGGCACAAGG 1800
ACCAATGTGT ATGAGGGCAT CTTACGAGTG GGGGGCAGAA GCCCCGAGGA GGGCATGGCA 1860
GACGGTGAGG ACCCCCCCAC GCCCAGTGGG GACCGTGGGC AAGAGCTCCG AGTGGTACTC 1920
AAGGTGCTGG ACCCCAGTCA CCATGACATC GCCCTGGCCT TCTACGAGAC AGCCAGCCTC 1980
ATGAGCCAGG TGTCCCACGT GCACCTGGCC TTCGTGCACG GCATCTGCGT GCACGGCTCT 2040
GAGAACATCA TGGTGACGGA GTACGTGGAG CACGGGCCCC TGGATGTGTG GCTGCGGCGA 2100
GAGAAGGGCC ACACGCCTGT GGCCTGGAAG GTGGCGGTAG CCCAGCAGCT GGCCAGCGCC 2160
CTCAGCTACC TGGAAGACAA GAACCTGGTT CATGGTAATG TGTGTGGCCG GAACATTCTG 2220
CTGGCACGAC TGGGGCTGGC GGAGGGCACC AGCCCCTTCA TCAAGCTGAG TGACCCCGGT 2280
GTGGGCCTGG GCGCCCTTTC CAGGGAGGAG CGGGTGGAGC GGATCCCCTG GATAGCCCCC 2340
GAGTGTCTCT CTGGTGGAGC CAACAGCCTA ACCACCGCAG CCGATAAATG GGGCTTTGGT 2400
GCCACACTCC TGGAGATCTG CTTCGACGGG GAGGCCCCTC TGCAGGGCCG TGGCCCCTCT 2460
GAGAAAGAGT GTTTCTACCA GAAGCAGCAC CGGCTTCCTC AGCCCTCCTG CCCGGAGCTG 2520
GCCACACTCA CCAGCCAGTG CCTGACCTAT GAACCAGCTC AGCGGCCCTC CTTCCGCACC 2580
ATCCTGCGTG ACCTCACTCA ACTGCAGCCC CAGAATCTTG CTGACGTCTT GGCTGTGAAC 2640
CCCGACTCGC CTGCGTCGGA CCCCACCGTT TTCCACAAGC GCTATTTGAA AAAGATCCGG 2700
GATCTGGGCG AGGGTCATTT CGGCAAGGTC AGTCTGTACT GCTACGACCC CACGAACGAC 2760
GGCACTGGCG AGATGGTGGC CGTGAAGGCC CTCAAGGCGG ACTGCAGCCC CCAGCTGCGC 2820
ACCGGCTGGA GGCGGGAGAT CGACATCCTG CGCACGCTCT ACCACAAGCA CATCGTCAAG 2880
TACAAGGGCT GCTGCGAGGA CCCAGGAGAG AAGTCGGTGC AGCTCGTCAT GGAGTACGTG 2940
CCCCTGGGAA GCCTGCGCGA CTACCTGCCG CGGCACAGCG TTGGACTCGC GCAGCTGCTT 3000
CTCTTCGCTC AGCAGATCTG TGAGGGCATG GCCTACCTTC ACGGACAGCA CTACGTGCAC 3060
CGAGACCTGG CTGCCCGCAA CGTGCTGCTG GACAACGACA GGCTGGTCAA ACTTGGGGAC 3120
TTTGGCCTGA CCAAGGCTGT GCCTGAGGGC CATGAATACT ACCGCGTGCG CGAGGACGGG 3180
GACAGCCCCG TATTCTGGTA TGCCCCAGAG TGCCTGAAGG AGTGTAAGTT CTACTATGCG 3240
TCCGACGTCT GGTCCTTCGG GGTCACCCTG TACGAGCTGC TGACCTACTG TGACTCCAGC 3300
CAGAGCCCCC CCTCGAAATT CATCGAGCTC ATAGGCCTCA CCCAGGGGCA GATGACGGTG 3360
CTGAGGCTCA CTGAGTTGCT GGAACGAGGG GAGAGGCTGC CCCGGCCAGA GAGATGTCCT 3420
TGTGAGATCT ATCTCCTCAT GAAGAACTGC TGGGAGGCAG AGGCTTCATT CCGTCCCACC 3480
TTCCAGAACC TCATACCCAT TCTCAAGACC GCCCAGGAGA AATACCAAGG CCAGGCCGCC 3540
TCAGTGTTCA ATGTGTGCTG A 3561
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk +++++ ++++ re++il++l+h
Q: 896   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCSPQLRTGWRREIDILRTLYH  955
         6899********************************************************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         +hivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL
Q: 956   KHIVKYKGCCEDPGEKsvQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  1013
         ****************9********************..*********************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         + +++vhrd+aarnvL+++++       vkl+d+gl+kav+++ eYy vre++ds+++w+
Q: 1014  HGQHYVHRDLAARNVLLDNDRL------VKLGDFGLTKAVPEGhEYYRVREDGDSPVFWY  1067
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219
         apecl+e+k +++asdvWsFgvtlyellt c++++sp         l     +       
Q: 1068  APECLKECK-FYYASDVWSFGVTLYELLTyCDSSQSPpskfieligL-----Tqgqmtvl  1121
         *********.****************************999555443.....45555588
S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         r++elle++erlp+p+ cp+e++ lm+nc+++e+s+rp+F++++ 
Q: 1122  RLTELLERGERLPRPErCPCEIYLLMKNCWEAEASFRPTFQNLIP  1166
         *****************************************9975
Domain Sequence
(FASTA)
LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC SPQLRTGWRR EIDILRTLYH 60
KHIVKYKGCC EDPGEKSVQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHG 120
QHYVHRDLAA RNVLLDNDRL VKLGDFGLTK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180
KFYYASDVWS FGVTLYELLT YCDSSQSPPS KFIELIGLTQ GQMTVLRLTE LLERGERLPR 240
PERCPCEIYL LMKNCWEAEA SFRPTFQNLI P 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-DAR-00045
EKS-EQC-00392
EKS-FEC-00030
EKS-GAM-00233
EKS-GAA-00049
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-LOA-00031
EKS-MAM-00032
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORN-00049
EKS-ORC-00032
EKS-ORL-00046
EKS-OTG-00034
EKS-PAT-00030
EKS-POA-00029
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-TAR-00049
EKS-XET-00032
EKS-XIM-00047
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013