EKS-AIM-00414
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00414
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK453.03.3E-13645310266
StatusUnreviewed
Ensembl ProteinENSAMEP00000012262
UniProt AccessionG1LYV5;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2
Gene Synonyms/Alias ROCK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000011596ENSAMEP00000012262ENSAMET00000012783
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1407
Protein Sequence
(FASTA)
DGLNSLVLDL DFPALRKNKN IDNFLNRYEK IVKKIRGLQM KAEDYDVVKV IGRGAFGEVQ 60
LVRHKASQKV YAMKLLSKFE MIKRSDSAFF WEERDIMAFA NSPWVVQLFC AFQDDKYLYM 120
VMEFMPGGDL VNLMSNYDVP EKWAKFYTAE VVLALDAIHS MGLIHRDVKP DNMLLDKHGH 180
LKLADFGTCM KMDETGMVHC DTAVGTPDYI SPEVLKSQGG DGYYGRECDW WSVGVFLFEM 240
LVGILGDTPF YADSLVGTYS KIMDHKNSLC FPEDAEISKH AKNLICAFLT DREVRLGRNG 300
VEEIKQHPFF KNDQWNWDNI RETAAPVVPE LSSDIDSSNF DDIEDDKGDV ETFPIPKAFV 360
GNQLPFIGFT YYRENLLLGD SSSCRENDSV QSRKNEESQE IQKKLYTLEE HLSTEIQAKE 420
ELEQKCKSVN TRLEKVAKEL EEEITLRKNV ESALRQLERE KALLQHKNAE YQRKADHEAD 480
KKRNLENDVN SLKDQLEDLK KRNQNSQIST EKVNQLQRQL DETNALLRTE SDTAARLRKT 540
QAESSKQIQQ LESNNRDLQD KNCLLETAKL KLEKEFINLQ SVLESERRDR THGSEIINDL 600
QGRISGLEED LKNGKILLAK AETEKRQLQE RLTDLEKEKN NMEIDMTYQL KVIQQSLEQE 660
EAEHKATKAR LADKNKIYES IEEAKSEAMK AIEMEKKLSE ERTLKQKVEN LLLEAEKRCS 720
IFDCDLKQSQ QKINELLKQK DVLNEDVRNL TLKIEQETQK RCLTQNDLKM QTQQVNTLKM 780
SEKQLKQENN HLMEMKMSLE KQNAELRKER QDADGQMKEL QDQLEAEQYF STLYKTQVRE 840
LKEECEEKAK LCKELQQKKQ DLQEERDSLA AQLEITLTKA DSEQLARSIA EEQYSDLEKE 900
KIMKELEIKE MMARHKQELT EKDATIASLE ETNRTLTSDV ANLANEKEEL NNKLKDAQEQ 960
LSRLKDEEIS AAAIKAQFEK QLLTERTLKT QAVNKLAEIM NRKEPVKRGS DTDMRRKEKE 1020
NRKLHMELKS EREKLTQQMI KYQKELNEMQ AQIAEESQIR IELQMTLDSK DSDIEQLRSQ 1080
LQALHIGLDS SSIGSGPGDA EPDDGFPGCL VHITQSRTME SMSFTYQRSS TSLNVATKPS 1140
SSHLLLDSDS DSEEESLPYL PISSEPNGTE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK 1200
KILFYDSEQD KEQSNPYMVL DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK 1260
EQEFPVEPVG EKSNYICHKG HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC 1320
HKDHMDKKEE IIAPCKVYYD ISTAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR 1380
SSPRTSMKIQ QNQSIRRPSR QLAPNKP 1407
Nucleotide Sequence
(FASTA)
GATGGCTTAA ATTCCTTGGT CCTTGATTTG GATTTTCCTG CTTTGAGGAA AAACAAGAAT 60
ATAGATAATT TTTTAAATAG ATATGAGAAA ATTGTGAAAA AAATCAGAGG TCTACAGATG 120
AAGGCAGAAG ACTATGATGT TGTAAAAGTT ATCGGAAGAG GTGCTTTTGG TGAAGTGCAG 180
CTGGTTCGTC ATAAGGCATC ACAGAAGGTT TATGCTATGA AGCTTCTTAG TAAGTTTGAA 240
ATGATAAAAA GATCTGATTC TGCTTTTTTC TGGGAAGAAA GGGATATTAT GGCCTTTGCC 300
AACAGTCCCT GGGTGGTTCA GCTCTTTTGT GCTTTTCAAG ATGATAAGTA TCTGTACATG 360
GTAATGGAGT TCATGCCTGG TGGAGATCTT GTAAACCTTA TGAGTAACTA TGATGTACCT 420
GAAAAATGGG CCAAATTTTA TACTGCCGAA GTTGTTCTTG CTCTGGATGC CATACACTCC 480
ATGGGCTTAA TTCACAGAGA TGTAAAGCCT GACAACATGC TCTTGGATAA ACACGGACAT 540
CTAAAGTTGG CAGATTTTGG CACATGTATG AAGATGGATG AAACAGGCAT GGTGCATTGT 600
GATACAGCAG TTGGAACACC TGATTATATT TCACCTGAGG TTCTCAAATC ACAAGGGGGT 660
GATGGTTACT ATGGGCGAGA ATGTGATTGG TGGTCTGTGG GTGTTTTCCT TTTTGAAATG 720
CTGGTGGGAA TTTTAGGGGA TACTCCATTT TATGCAGATT CACTTGTAGG AACATATAGC 780
AAAATTATGG ATCATAAAAA CTCACTGTGT TTCCCTGAAG ATGCAGAAAT TTCTAAACAT 840
GCGAAGAATC TCATTTGCGC CTTCTTAACA GATAGGGAGG TACGACTTGG GAGAAATGGA 900
GTAGAAGAAA TCAAACAGCA TCCTTTCTTT AAGAATGATC AATGGAATTG GGATAACATA 960
AGAGAGACGG CGGCTCCTGT GGTACCTGAA CTCAGCAGTG ACATAGACAG CAGCAATTTT 1020
GATGACATTG AAGATGATAA AGGAGATGTA GAAACCTTCC CGATTCCTAA AGCTTTTGTG 1080
GGAAATCAGC TGCCTTTTAT AGGATTTACC TACTATAGAG AAAATTTGTT ATTAGGTGAC 1140
TCTTCATCTT GTAGAGAAAA TGATTCAGTA CAATCAAGGA AAAACGAAGA AAGTCAAGAG 1200
ATTCAGAAAA AATTATACAC ATTAGAAGAG CACCTTAGCA CTGAGATACA AGCCAAAGAG 1260
GAACTAGAGC AGAAGTGCAA ATCTGTTAAT ACTCGCCTTG AGAAAGTAGC AAAGGAACTA 1320
GAAGAAGAGA TTACTTTAAG GAAAAATGTG GAATCAGCAT TAAGACAATT AGAAAGAGAA 1380
AAGGCACTTC TTCAGCACAA AAATGCAGAA TATCAGCGGA AAGCTGATCA CGAAGCAGAC 1440
AAGAAACGAA ATTTGGAAAA TGATGTTAAC AGTTTAAAGG ATCAACTTGA AGATTTGAAA 1500
AAAAGAAATC AGAACTCTCA AATATCCACT GAGAAAGTGA ATCAGCTCCA GAGACAACTG 1560
GATGAAACCA ATGCTTTGCT GAGAACAGAA TCCGATACTG CAGCCCGGTT AAGAAAAACC 1620
CAAGCAGAAA GTTCAAAACA GATTCAGCAG CTGGAATCTA ACAATAGAGA TCTTCAAGAT 1680
AAAAATTGCC TGCTGGAGAC TGCCAAGTTA AAACTTGAAA AGGAATTTAT CAATCTTCAG 1740
TCAGTTCTAG AATCTGAAAG GAGAGACCGA ACCCACGGAT CTGAGATAAT TAATGACTTA 1800
CAAGGTAGAA TATCTGGCCT AGAAGAAGAT TTAAAGAATG GCAAAATCTT ACTGGCAAAA 1860
GCAGAGACGG AGAAGAGACA ACTACAGGAG AGACTTACCG ATTTGGAAAA GGAAAAGAAC 1920
AACATGGAAA TAGATATGAC GTACCAACTG AAAGTTATAC AGCAGAGCTT AGAACAAGAA 1980
GAAGCTGAGC ATAAGGCTAC AAAAGCACGG CTGGCAGATA AAAATAAAAT TTATGAATCC 2040
ATTGAAGAAG CAAAATCAGA AGCCATGAAA GCAATAGAAA TGGAGAAAAA GCTCTCAGAG 2100
GAAAGGACGT TAAAGCAAAA AGTGGAGAAC CTATTGCTGG AAGCTGAGAA GAGATGCTCT 2160
ATATTTGACT GTGACCTCAA GCAGTCACAG CAGAAAATAA ATGAACTTCT TAAGCAGAAA 2220
GATGTGCTAA ATGAGGATGT TAGAAATTTG ACATTAAAAA TAGAGCAGGA AACTCAGAAG 2280
CGCTGCCTTA CACAAAATGA CCTGAAGATG CAAACACAGC AAGTTAACAC ACTAAAAATG 2340
TCAGAAAAGC AGTTAAAACA AGAGAATAAT CATCTCATGG AAATGAAAAT GAGCTTGGAA 2400
AAGCAGAATG CTGAACTTCG AAAAGAACGT CAAGATGCAG ATGGGCAAAT GAAAGAACTT 2460
CAGGATCAGC TTGAAGCGGA GCAGTATTTC TCAACCCTCT ATAAAACACA GGTGAGGGAA 2520
CTTAAAGAAG AATGTGAAGA AAAGGCCAAA CTTTGTAAAG AATTACAACA GAAGAAACAG 2580
GACTTACAGG AGGAAAGGGA CTCCCTGGCT GCTCAACTGG AGATCACCTT GACCAAAGCA 2640
GATTCTGAGC AGCTGGCTCG TTCAATTGCT GAAGAGCAAT ATTCTGATTT GGAAAAAGAG 2700
AAAATCATGA AGGAGCTTGA GATCAAAGAG ATGATGGCTA GACACAAACA GGAACTCACT 2760
GAAAAAGATG CTACAATTGC ATCTCTTGAA GAAACGAACA GGACACTAAC TAGTGATGTT 2820
GCCAATCTTG CAAATGAGAA AGAAGAATTA AATAACAAAT TGAAAGATGC CCAAGAACAG 2880
CTGTCACGGC TGAAAGATGA GGAGATCAGC GCAGCCGCTA TTAAAGCACA GTTTGAGAAG 2940
CAGCTGCTCA CAGAGAGAAC ACTCAAAACT CAGGCTGTGA ATAAGTTGGC TGAGATCATG 3000
AATCGAAAAG AACCTGTCAA GCGTGGTAGT GACACTGATA TGCGGAGAAA AGAGAAAGAG 3060
AATAGAAAGC TACATATGGA GCTTAAATCT GAACGTGAAA AACTGACCCA GCAGATGATC 3120
AAGTATCAGA AAGAACTGAA TGAAATGCAG GCTCAAATAG CTGAAGAGAG CCAGATTCGA 3180
ATTGAACTGC AGATGACACT AGACAGTAAA GATAGTGACA TTGAGCAGCT GCGGTCACAG 3240
CTCCAGGCGT TGCATATTGG TCTGGATAGT TCCAGTATAG GCAGTGGACC AGGGGATGCT 3300
GAGCCCGATG ATGGATTTCC AGGGTGTCTA GTTCATATCA CTCAGTCACG CACTATGGAA 3360
TCCATGTCAT TCACCTACCA ACGTTCCTCT ACTTCTCTCA ATGTTGCCAC TAAGCCTTCC 3420
AGTTCTCATT TGCTTCTTGA CTCTGATTCT GACTCAGAAG AAGAATCTTT GCCTTACTTA 3480
CCTATTTCAT CGGAACCTAA TGGTACAGAA TCAAGACTAG AAGGATGGCT TTCATTGCCT 3540
GTACGAAACA ACACTAAGAA ATTTGGATGG GTTAAAAAGT ATGTGATTGT AAGCAGTAAG 3600
AAGATTCTTT TCTATGACAG TGAACAAGAT AAAGAACAAT CTAACCCTTA CATGGTTTTA 3660
GATATAGACA AATTATTTCA TGTCCGACCA GTTACACAGA CAGATGTATA TAGAGCGGAT 3720
GCTAAAGAAA TTCCAAGGAT ATTTCAGATT CTGTATGCCA ATGAAGGAGA AAGTAAGAAG 3780
GAACAAGAAT TTCCAGTGGA GCCAGTGGGA GAAAAATCAA ATTATATTTG CCATAAAGGA 3840
CATGAATTTA TTCCTACTCT CTATCATTTC CCAACCAACT GTGAGGCTTG TATGAAGCCA 3900
TTGTGGCATA TGTTTAAACC TCCCCCTGCT TTAGAGTGCC GGCGCTGCCA TATTAAATGT 3960
CATAAAGATC ACATGGACAA AAAGGAGGAG ATTATAGCGC CTTGCAAAGT TTATTACGAT 4020
ATTTCGACGG CAAAGAATCT ATTGTTGTTA GCAAATTCTA CAGAAGAGCA GCAGAAGTGG 4080
GTTAGTCGGT TGGTGAAAAA GATACCTAAA AAGCCTCCAG CCCCAGACCC TTTTGCACGG 4140
TCATCTCCTA GAACTTCGAT GAAGATACAG CAAAACCAGT CTATTAGACG GCCAAGTCGA 4200
CAGCTTGCCC CAAACAAACC A 4221
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 45    YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  104
         799*********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql++afqd+kyly+vme+++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g
Q: 105   VVQLFCAFQDDKYLYMVMEFMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  162
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+
Q: 163   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  221
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellv...getpfyaeslvetyskilnhkeslkfpedekvseea  237
         g+yg+ecdwws+Gv+l+e+lv   g+tpfya+slv tyski++hk+sl+fped+++s++a
Q: 222   GYYGRECDWWSVGVFLFEMLVgilGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHA  281
         *******************8733369**********************************
S: 238   kdlikklltsreerlgregiedlkkhpff  266
         k+li+++lt+re rlgr+g+e++k+hpff
Q: 282   KNLICAFLTDREVRLGRNGVEEIKQHPFF  310
         ****************************9
Domain Sequence
(FASTA)
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFCAFQD DKYLYMVMEF MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120
HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLFEMLVGI LGDTPFYADS LVGTYSKIMD HKNSLCFPED AEISKHAKNL 240
ICAFLTDREV RLGRNGVEEI KQHPFF 266
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00429
EKS-BOT-00443
EKS-CAJ-00447
EKS-CAF-00442
EKS-CAP-00477
EKS-CII-00252
EKS-CIS-00203
EKS-DRM-00209
EKS-EQC-00434
EKS-FEC-00423
EKS-GAG-00374
EKS-GAA-00538
EKS-GOG-00434
EKS-LAC-00457
EKS-LOA-00452
EKS-MAM-00442
EKS-MEG-00367
EKS-MOD-00431
EKS-MUM-00475
EKS-MUP-00434
EKS-MYL-00435
EKS-NOL-00404
EKS-ORN-00562
EKS-ORA-00388
EKS-ORC-00415
EKS-OTG-00448
EKS-PAT-00418
EKS-PES-00393
EKS-POA-00431
EKS-RAN-00456
EKS-SAH-00409
EKS-SUS-00392
EKS-TAG-00509
EKS-TEN-00556
EKS-VIP-00080
EKS-XET-00594
EKS-XIM-00554
Gene Ontology
GO:0031616; C:spindle pole centrosome
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0051298; P:centrosome duplication
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
GO:0016525; P:negative regulation of angiogenesis
GO:0001843; P:neural tube closure
GO:0010825; P:positive regulation of centrosome duplication
GO:0045616; P:regulation of keratinocyte differentiation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 1.
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013