EPS-AIM-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.0	1.7E-56	78	331	254

Status

Unreviewed

Ensembl Protein

ENSAMEP00000012267

UniProt Accession

D2HLV5;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E; PANDA_012503;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000011659	ENSAMEP00000012267	ENSAMET00000012790

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

NCPSFLAAAL ARATSDEVLQ SDLSAHYIAK ETDCTEGTVE IETMKLARSV FSKLHEICCS 60

WVKDFPLRRR PQLYYETSIH AIKNMRRKME DKHVCIPDFN MLFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNLVRQ EMFPHDPAEA LCRAFRVTDE RFVQKAARES LRCGTTGVVT 180

FIRGNMLHVA WVGDSQVMLV RKGQAVELMK PHKPDREDEK QRIEALGGCV VWFGAWRVNG 240

SLSVSRAIGD AEHKPYICGD ADSASTVLDG TEDYLILACD GFYDTVNPDE AVKVVSDHLK 300

ENNGDSSMVA HKLVASARDA GSSDNITVIV VFLRDMNKAV NVSEESDWTE NSFQGGQEDG 360

GDDKENHGEC KRPWPQHQCS APADLGYDGR VDSFTDRTSL SPGSQINVLE DPGYLDLTQI 420

EASKPYSAQF LPPIEMFGPG APKKANPINE LIMERKSVHS SLPEQSGAGE FPSFNLGSIG 480

QQIDRMESLS PVCPRLEDEQ FKFLGKRVSR LSHLSYHYSK RRHGFRFNPK LYSFMSAQEP 540

SHKIGTSLSS LIRSGKRTRV FRSFLPWRQN IWKGYSANMM RKLRKSNDIP DPGLPWSYKI 600

Nucleotide Sequence
(FASTA)

AATTGCCCTT CCTTTTTGGC TGCTGCTTTA GCCAGAGCCA CATCAGATGA AGTCCTCCAG 60

AGTGATCTTT CTGCACATTA CATCGCAAAG GAAACAGACT GCACAGAAGG GACTGTGGAG 120

ATTGAAACAA TGAAATTGGC CCGTTCTGTC TTCAGCAAAC TACACGAGAT TTGCTGCAGC 180

TGGGTGAAAG ACTTCCCTCT CCGCAGGAGA CCCCAGCTTT ATTATGAGAC ATCAATCCAT 240

GCCATCAAAA ACATGCGCAG GAAAATGGAA GACAAACATG TCTGCATTCC TGACTTTAAT 300

ATGCTCTTCA ACCTAGAGGA CCAGGAAGAA CAAGCCTACT TTGCAGTGTT TGATGGCCAT 360

GGGGGAGTGG ATGCTGCCAT TTATGCCTCC ATCCACCTGC ACGTTAATTT AGTACGCCAG 420

GAGATGTTCC CCCATGATCC TGCTGAGGCC CTGTGCCGGG CCTTCCGGGT CACTGATGAG 480

CGGTTTGTGC AGAAAGCAGC CAGGGAGAGT TTGAGATGTG GGACCACAGG CGTGGTGACT 540

TTCATCAGAG GGAACATGCT CCATGTGGCC TGGGTGGGGG ACTCCCAGGT CATGCTTGTG 600

AGAAAAGGCC AAGCTGTTGA GCTAATGAAG CCACACAAAC CGGACAGGGA GGATGAAAAG 660

CAGCGAATTG AGGCTCTTGG AGGTTGTGTG GTCTGGTTTG GTGCCTGGAG GGTGAATGGA 720

AGTCTGTCGG TCTCCAGAGC TATTGGAGAC GCTGAACATA AGCCATATAT CTGTGGGGAC 780

GCGGATTCTG CCTCTACTGT TTTGGATGGA ACCGAAGACT ACCTCATTCT GGCCTGTGAT 840

GGCTTCTATG ACACCGTGAA CCCTGACGAG GCAGTGAAAG TTGTGTCTGA CCACCTGAAG 900

GAGAATAATG GAGACAGTAG CATGGTTGCC CACAAATTAG TTGCATCAGC TCGTGATGCT 960

GGGTCAAGTG ATAACATCAC TGTTATTGTG GTATTCCTGA GGGACATGAA CAAAGCTGTA 1020

AATGTTAGTG AGGAATCAGA TTGGACAGAG AACTCTTTTC AAGGAGGGCA AGAAGACGGT 1080

GGGGATGATA AGGAGAATCA TGGAGAGTGC AAACGCCCTT GGCCTCAGCA CCAGTGCTCA 1140

GCACCAGCCG ATCTAGGCTA TGATGGGCGC GTGGATTCAT TCACTGATAG AACTAGCCTG 1200

AGCCCAGGGT CCCAAATCAA CGTGCTGGAA GACCCAGGCT ACCTAGATCT CACACAAATA 1260

GAAGCAAGCA AACCTTACAG TGCCCAGTTT TTGCCACCAA TTGAGATGTT TGGTCCTGGT 1320

GCACCAAAGA AAGCAAATCC TATTAATGAG CTAATAATGG AGAGAAAATC AGTTCATTCA 1380

TCATTGCCTG AACAGAGTGG TGCTGGAGAG TTTCCCTCTT TTAATTTGGG TTCAATAGGG 1440

CAGCAGATAG ACAGAATGGA GAGCTTGTCT CCTGTCTGTC CTAGGTTGGA AGATGAACAA 1500

TTTAAATTCC TGGGAAAGAG AGTTTCCAGA TTGTCTCATT TAAGCTATCA TTATTCAAAG 1560

AGACGGCACG GATTCAGGTT TAATCCAAAG TTGTATTCAT TTATGTCTGC TCAAGAGCCT 1620

TCCCACAAAA TAGGCACTAG TCTGTCCTCC CTTATTCGAA GTGGGAAGAG AACTAGGGTG 1680

TTCAGAAGTT TTCTGCCGTG GAGGCAAAAT ATTTGGAAAG GATATAGTGC AAACATGATG 1740

AGGAAGCTCA GAAAGAGTAA TGATATTCCA GACCCAGGTC TTCCCTGGAG CTATAAAATA 1800

TAA 1803

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 78    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  137

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 138   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  191

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 192   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  250

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 251   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  310

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 311   HKLVASARDAGSSDNITVIVV  331

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013