EKS-AIM-00161
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00161
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC478.46.2E-144333591259
StatusUnreviewed
Ensembl ProteinENSAMEP00000012443
UniProt AccessionG1LZD5;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000011747ENSAMEP00000012443ENSAMET00000012976
OrganismAiluropoda melanoleuca
Functional Description
Protein Length666
Protein Sequence
(FASTA)
ANDSTASQDV ANRFARKGAL RQKNVHEVKD HKFIARFFKQ PTFCSHCTDF IWGFGKQGFQ 60
CQVCCFVVHK RCHEFVTFSC PGADKGPDTD DPRSKHKFKI HTYGSPTFCD HCGSLLYGLI 120
HQGMKCDTCD MNVHKQCVIN VPSLCGMDHT EKRGRIYLKA EVTDEKLHVT VRDAKNLIPM 180
DPNGLSDPYV KLKLIPDPKN ESKQKTKTIR STLNPQWNES FTFKLKPSDK DRRLSVEIWD 240
WDRTTRNDFM GSLSFGVSEL MKMPASGWYK LLNQEEGEYY NVPIPEGDEE GNVELRQKFE 300
KAKLGPAGNK VISPSEDRRQ PSNNLDRVKL TDFNFLMVLG KGSFGKVMLA DRKGTEELYA 360
IKILKKDVVI QDDDVECTMV EKRVLALLDK PPFLTQLHSC FQTVDRLYFV MEYVNGGDLM 420
YHIQQVGKFK EPQAVFYAAE ISIGLFFLHK RGIIYRDLKL DNVMLDSEGH IKIADFGMCK 480
EHMMDGVTTR TFCGTPDYIA PEIIAYQPYG KSVDWWAYGV LLYEMLAGQP PFDGEDEDEL 540
FQSIMEHNVS YPKSLSKEAV SICKGLMTKH PGKRLGCGPE GERDVREHAF FRRIDWEKLE 600
NREIQPPFKP KVCGKGAENF DKFFTRGQPV LTPPDQLVIA NIDQSDFEGF SYVNPQFVHP 660
ILQSAV 666
Nucleotide Sequence
(FASTA)
GCCAACGACT CCACGGCGTC TCAGGACGTG GCCAACCGCT TCGCCCGCAA AGGGGCGCTG 60
AGGCAGAAGA ACGTGCATGA GGTGAAGGAC CACAAATTCA TCGCCCGCTT CTTCAAGCAG 120
CCCACCTTCT GCAGCCACTG CACCGACTTC ATCTGGGGGT TTGGGAAACA AGGCTTCCAG 180
TGCCAAGTTT GCTGTTTTGT GGTTCACAAG AGGTGCCATG AATTTGTCAC TTTTTCTTGT 240
CCGGGTGCGG ATAAGGGACC CGACACCGAC GACCCAAGAA GCAAGCACAA GTTTAAAATC 300
CACACTTATG GAAGCCCCAC CTTCTGTGAT CACTGTGGGT CCTTGCTGTA TGGACTTATC 360
CATCAAGGGA TGAAATGTGA CACCTGCGAC ATGAACGTGC ACAAACAGTG CGTGATCAAC 420
GTGCCCAGCC TCTGCGGGAT GGACCACACG GAGAAGAGGG GCCGGATCTA CCTGAAGGCG 480
GAGGTCACCG ACGAGAAGCT CCACGTCACC GTACGAGATG CAAAAAATCT AATTCCTATG 540
GATCCAAATG GGCTTTCAGA TCCTTATGTG AAGCTGAAAC TTATTCCTGA TCCCAAGAAT 600
GAGAGCAAAC AGAAAACCAA AACCATCCGC TCCACACTGA ACCCCCAGTG GAATGAGTCC 660
TTTACATTCA AATTAAAACC TTCGGATAAA GACCGACGGC TGTCCGTAGA AATCTGGGAC 720
TGGGATCGAA CAACTAGGAA TGATTTCATG GGGTCCCTCT CCTTTGGAGT CTCGGAGCTG 780
ATGAAGATGC CAGCCAGCGG ATGGTACAAG CTGCTTAACC AAGAGGAAGG TGAGTACTAC 840
AACGTGCCCA TTCCGGAAGG GGACGAAGAA GGCAACGTGG AGCTCAGGCA GAAATTCGAG 900
AAAGCCAAGC TTGGCCCAGC TGGGAACAAA GTAATCAGTC CTTCAGAAGA CAGAAGACAA 960
CCTTCCAACA ACCTGGACAG AGTGAAACTC ACCGACTTCA ATTTCCTCAT GGTGCTGGGG 1020
AAGGGGAGTT TTGGAAAGGT GATGCTTGCT GACCGGAAGG GCACAGAGGA ACTGTATGCT 1080
ATCAAAATCC TGAAGAAGGA TGTGGTGATT CAGGATGACG ACGTGGAGTG CACCATGGTG 1140
GAGAAGCGAG TCCTAGCCCT CCTGGACAAG CCGCCGTTCC TGACACAGCT ACACTCCTGC 1200
TTCCAGACAG TGGATCGGCT GTACTTCGTC ATGGAATACG TCAATGGCGG GGACCTCATG 1260
TACCACATTC AGCAAGTAGG AAAATTTAAG GAACCACAAG CAGTATTTTA TGCGGCAGAG 1320
ATTTCCATTG GATTGTTCTT TCTTCATAAA AGAGGAATCA TTTACAGGGA TCTGAAGTTA 1380
GATAATGTCA TGCTGGATTC AGAAGGGCAT ATCAAGATTG CCGATTTTGG GATGTGCAAG 1440
GAACACATGA TGGACGGAGT CACAACCAGG ACCTTCTGTG GGACGCCAGA TTACATCGCC 1500
CCAGAGATAA TCGCCTATCA GCCGTATGGA AAATCTGTGG ACTGGTGGGC CTATGGCGTC 1560
CTGTTGTATG AAATGCTAGC TGGGCAGCCT CCCTTTGATG GTGAAGATGA AGACGAGCTG 1620
TTTCAGTCCA TAATGGAGCA TAACGTTTCT TATCCCAAGT CCTTGTCCAA GGAGGCCGTT 1680
TCCATCTGCA AGGGACTGAT GACCAAACAC CCAGGCAAGC GGCTGGGTTG CGGGCCGGAG 1740
GGGGAGAGGG ACGTGCGGGA ACATGCCTTC TTCCGGAGGA TCGACTGGGA GAAACTCGAG 1800
AACAGGGAGA TCCAGCCACC CTTCAAGCCC AAAGTGTGTG GCAAAGGCGC AGAAAACTTT 1860
GACAAGTTCT TCACGCGAGG GCAGCCTGTC TTGACACCAC CTGATCAGCT GGTCATTGCT 1920
AACATAGACC AGTCTGATTT CGAGGGGTTC TCGTATGTCA ACCCCCAGTT TGTGCACCCC 1980
ATCTTACAGA GCGCAGTA 1998
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 333   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  392
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 393   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  452
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 453   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  512
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p 
Q: 513   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPG  572
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 573   KRLGCGPEGERDVREHAFF  591
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPG 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-OCP-00107
EKS-ORN-00212
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00207
Gene Ontology
GO:0005829; C:cytosol
GO:0030425; C:dendrite
GO:0005783; C:endoplasmic reticulum
GO:0005739; C:mitochondrion
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0001750; C:photoreceptor outer segment
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004698; F:calcium-dependent protein kinase C activity
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0008270; F:zinc ion binding
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0002062; P:chondrocyte differentiation
GO:0000188; P:inactivation of MAPK activity
GO:0050930; P:induction of positive chemotaxis
GO:0035556; P:intracellular signal transduction
GO:0008285; P:negative regulation of cell proliferation
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0030593; P:neutrophil chemotaxis
GO:0045766; P:positive regulation of angiogenesis
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0045785; P:positive regulation of cell adhesion
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0050729; P:positive regulation of inflammatory response
GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0001934; P:positive regulation of protein phosphorylation
GO:0006937; P:regulation of muscle contraction
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330; P:regulation of platelet aggregation
GO:0002026; P:regulation of the force of heart contraction
GO:0070555; P:response to interleukin-1
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013