EKS-AIM-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.2	8.7E-106	283	534	252

Status

Unreviewed

Ensembl Protein

ENSAMEP00000012731

UniProt Accession

D2HEA3;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK3

Gene Synonyms/Alias

PAK3; PANDA_009116;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000012072	ENSAMEP00000012731	ENSAMET00000013271
ENSAMEG00000012072	ENSAMEP00000012732	ENSAMET00000013272

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

MSDSLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 60

KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS 120

NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP 180

LAPPVSEEED EEEEEEEDDN EPPPVIAPRP EHTKSIYTRS VLESIASPAA PNKEVTPPSA 240

ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA 300

LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL 360

AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD 420

FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE 480

NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL 540

SSLTPLIIAA KEAIKNSSR 559

Nucleotide Sequence
(FASTA)

ATGTCTGACA GTCTGGATAA CGAAGAGAAA CCCCCGGCTC CCCCGCTGAG AATGAACAGT 60

AACAACCGAG ATTCTTCGGC ACTCAACCAC AGCTCCAAAC CACTTCCCAT GGCCCCTGAA 120

GAGAAGAATA AGAAAGCCAG GCTTCGCTCT ATCTTCCCAG GAGGAGGGGA TAAAACCAAT 180

AAGAAGAAGG AGAAAGAACG CCCAGAGATC TCTCTTCCTT CAGACTTTGA ACATACGATT 240

CATGTGGGGT TTGACGCAGT CACCGGGGAG TTCACTCCAG ATCTCTATGG CTCACAGATG 300

TGCCCAGGGA AGCTCCCAGA GGGAATCCCT GAGCAGTGGG CACGGTTACT CCAAACCTCC 360

AACATAACAA AACTGGAACA GAAGAAGAAC CCACAAGCCG TCCTGGATGT TCTCAAATTC 420

TACGATTCCA AAGAAACGGT CAACAACCAG AAATACATGA GCTTTACGTC GGGAGATAAA 480

AGCGCACATG GATACATAGC AGCCCATCCC TCGAGTACAA AAACAGCATC AGAGCCTCCT 540

TTGGCCCCTC CTGTGTCTGA AGAAGAAGAT GAAGAAGAGG AAGAAGAAGA AGACGACAAT 600

GAGCCCCCAC CAGTTATCGC GCCGAGACCC GAGCACACGA AATCAATCTA CACTCGTTCT 660

GTGCTGGAAT CCATTGCTTC ACCGGCAGCA CCAAATAAAG AGGTCACACC ACCTTCTGCT 720

GAGAACGCCA ATTCCAGTAC TTTGTATAGA AACACAGATC GGCAAAGGAA AAAATCCAAG 780

ATGACTGATG AGGAGATCCT AGAGAAGCTA AGAAGCATTG TGAGTGTCGG TGACCCAAAG 840

AAAAAATACA CAAGATTTGA AAAAATAGGT CAAGGGGCGT CAGGTACTGT TTACACAGCG 900

CTAGACATTG CCACAGGACA AGAGGTGGCC ATAAAGCAGA TGAACCTTCA ACAGCAGCCC 960

AAAAAGGAAT TAATTATTAA TGAAATTCTG GTCATGAGGG AAAATAAGAA CCCCAATATT 1020

GTTAATTATT TAGATAGCTA CTTAGTGGGT GACGAACTAT GGGTAGTCAT GGAATACTTG 1080

GCAGGTGGCT CTCTGACTGA TGTGGTCACA GAAACCTGTA TGGATGAAGG CCAGATAGCA 1140

GCTGTCTGCA GAGAGTGCCT CCAAGCTCTG GATTTTTTGC ACTCAAACCA AGTGATCCAT 1200

AGAGACATAA AGAGTGACAA TATTCTTCTT GGGATGGATG GCTCTGTTAA ATTGACTGAT 1260

TTTGGGTTCT GCGCCCAGAT CACCCCTGAG CAAAGTAAAC GAAGCACTAT GGTGGGAACT 1320

CCCTACTGGA TGGCGCCTGA GGTTGTAACT CGAAAAGCCT ATGGTCCGAA AGTTGATATC 1380

TGGTCTCTGG GGATTATGGC GATCGAAATG GTGGAAGGTG AACCACCTTA CCTTAATGAA 1440

AATCCACTCA GGGCATTATA TCTGATAGCC ACTAATGGAA CCCCAGAGCT CCAGAATCCT 1500

GAGAGACTGT CGGCCGTGTT CCGTGACTTT TTAAATCGCT GTCTTGAGAT GGATGTGGAC 1560

AGGCGAGGAT CTGCCAAGGA GCTTTTGCAG CATCCATTTT TAAAATTAGC CAAGCCTCTC 1620

TCCAGCCTGA CTCCTCTGAT TATCGCTGCA AAAGAAGCAA TTAAGAACAG CAGCCGCTAG 1680

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 283   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  342

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 343   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  399

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 400   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  457

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+

Q: 458   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  517

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 518   DVDRRGSAKELLQHPFL  534

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007409	; P:axonogenesis
GO:0016358	; P:dendrite development
GO:0030833	; P:regulation of actin filament polymerization

KEGG

aml:100481001

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013