EPS-AIM-00071

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00071

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	283.1	1.2E-84	123	293	171

Status

Unreviewed

Ensembl Protein

ENSAMEP00000012750

UniProt Accession

G1M090;

Protein Name

Protein Synonyms/Alias

Gene Name

TENC1

Gene Synonyms/Alias

TENC1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000012074	ENSAMEP00000012750	ENSAMET00000013290

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1406

Protein Sequence
(FASTA)

MKSSGPVERL LRALGRRDSS RASSRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC 60

RVCKVATHRK CEAKVTSSCQ ALPPAELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 120

LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 180

KRHDLSRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 240

IVSAYMHYSK ISAGADQALA TLTMRKFCED KVAAELQPSQ RRYISYFSGL LAGSIRMNSS 300

PLFLHYVLVP VLPAFEPGTG FQPFLKIYQS MQLVYTSGIY HIAGPGPQQL CISLEPALLL 360

KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPRLTFPK DQLDEAWADE RFPFQASVEF 420

VFSSSPEKIK GNTPRNEPSV SVDYNTAEPA VRWDSYENFN QHHEDSVDGS PTHTRGPLDG 480

SPYAQVQRAP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQG 540

GLGGCGVAGG GRGAGRETAI LDDEEQPPAG GGPHLGMYSG HRPGLSRHCS CRQGYREPCG 600

VPNGGYYRPE GTLERRRLAY GGYEGHPQGY AEASVEKRRL CRSLSEGPYP YPPELGKPAN 660

GDFGYRAPGY REVVILEDAG LPALCSCPAC DEKLALPTAA LYGLRLEREA GEGWAGEAGK 720

PLLHPVRPGH PLPLLVPACG HHHAPMPDYS CLKPPKVGDD GHEGCPYAVC PEGRYGHPGY 780

PALVTYGYGG AVPSYCPAYG RVPHSCGSPA EARAYSSSGA HSPRAGSVSP GSPPYPQSRK 840

LSYEIPAEEG GDRYPMPGHL APAGPLASAE SPEPASWREG PSGHSTLPRS PRDAPCSASS 900

ELSGPSTPLH TSSPVQGKES TRRQDSTSPT LVPTQRLSPG EALPSIPQGG AEKASELPAR 960

SGLELPAASP FSPTSPPSSP NDWPQEKSPG SRSDSASPRG PVPTTLPGLR HAPWQGLRDP 1020

PDSPDGSPLT PVPTQMPWLV ASSEPPQSSP TPAFPLAASY DINGPTQPPL PEKRHLLGPG 1080

QQPGPWGSEQ ASPPARGTSH HVTFAPLLPD NVPQPPEPPM QESQSNVKFV QDTSKFWYKP 1140

HLSRDQAIAL LKDKDPGAFL IRDSHSFQGA YGLALKVATP PPSAQPWKGD PLEQLVRHFL 1200

IETGPKGVKI KGCPSEPYFG SLSALVSQHS ISPLSLPCCL RIPSKEPLEE TPEAPVPANM 1260

STAADLLRQG AACSVLYLTS VETESLTGPQ AVARASSAAL SCSPRPTPAI VHFKVSAQGI 1320

TLTDNQRKLF FRRHYPVNSI TFSSTDPQDR RWANPDGTTS KIFGFVAKKP GSPWENVCHL 1380

FAELDPDQPA GAIVTFITKV LLGQRK 1406

Nucleotide Sequence
(FASTA)

ATGAAGTCCA GCGGCCCCGT GGAGAGGCTG CTCAGAGCCC TGGGGAGGAG GGACAGCAGC 60

CGGGCCAGCA GCAGGCCTAG GAAAGCTGAG CCACACAGCT TCCGGGAGAA GGTCTTCCGG 120

AAGAAGCCAC CAGTCTGCGC AGTGTGTAAG GTGACCATCG ATGGGACTGG CGTCTCATGC 180

AGAGTTTGCA AGGTGGCAAC ACACAGAAAA TGTGAAGCAA AGGTCACTTC GTCCTGTCAG 240

GCCTTGCCTC CTGCGGAGCT GCGGAGAAAC ACGGCCCCTG TGAGGCGCAT AGAGCACCTG 300

GGATCCACCA AGTCTCTGAA CCACTCCAAG CAGCGCAGCA CTCTGCCCAG GAGCTTCAGC 360

CTGGACCCGC TTATGGAGCG CCGCTGGGAC TTGGACCTCA CTTACGTGAC GGAGCGGATC 420

CTGGCCGCCG CCTTCCCCGC GCGGCCCGAC GAGCAGCGAC ACCGGGGCCA CCTGCGCGAG 480

CTGGCTCACG TGCTGCAATC CAAGCACCGC GACAAGTACC TGCTCTTCAA CCTTTCAGAG 540

AAAAGACATG ACCTGTCCCG CCTAAACCCT AAGGTCCAGG ACTTCGGCTG GCCTGAGCTG 600

CATGCACCGC CCCTGGACAA GCTGTGTTCC ATCTGCAAAG CCATGGAGAC GTGGCTCAGT 660

GCAGACCCAC AGCACGTAGT CGTGCTGTAC TGCAAGGGGA GCAAGGGCAA GCTCGGGGTC 720

ATCGTCTCCG CCTACATGCA CTACAGCAAG ATCTCTGCAG GGGCAGACCA GGCACTGGCC 780

ACGCTTACCA TGAGGAAGTT CTGCGAGGAC AAGGTGGCCG CGGAGCTGCA GCCCTCCCAG 840

CGCCGGTACA TCAGCTACTT TAGCGGCCTC CTGGCTGGCT CCATCAGAAT GAACAGCAGC 900

CCACTCTTCC TGCACTATGT GCTCGTGCCC GTGCTGCCAG CCTTTGAACC TGGCACCGGC 960

TTCCAGCCCT TCCTCAAGAT CTACCAGTCC ATGCAGCTGG TCTACACATC TGGAATCTAT 1020

CACATCGCAG GCCCTGGGCC CCAGCAGCTT TGCATCAGCC TGGAGCCAGC CCTCCTCCTC 1080

AAAGGCGATG TCATGGTGAC CTGCTATCAC AAGGGTGGCC GGGGGACAGA CCGGACCCTG 1140

GTGTTCCGAG TCCAGTTCCA CACATGCACC ATCCACGGGC CACGGCTCAC TTTCCCCAAG 1200

GACCAGCTGG ACGAGGCCTG GGCTGATGAG AGGTTCCCCT TCCAAGCCTC AGTGGAGTTC 1260

GTCTTCTCCT CCAGCCCTGA AAAGATCAAA GGCAACACCC CACGGAATGA GCCTTCGGTC 1320

TCTGTTGACT ACAACACCGC GGAGCCCGCC GTGCGCTGGG ACTCCTACGA GAACTTCAAT 1380

CAGCACCATG AGGACAGTGT GGACGGCTCC CCGACCCACA CCCGGGGACC TCTGGACGGC 1440

AGTCCTTATG CCCAGGTGCA GCGGGCCCCC CGCCAGACCC CGCCAGCGCC CTCTCCAGAG 1500

CCACCTCCAC CCCCCATGCT GTCTGTCAGC AGCGACTCAG GCCATTCGTC CACGCTGACC 1560

ACGGAGCCCG CTGCCGAGTC CCCTGGCCGG CCGCCCCCGA CAGCTGCCGA GCGGCAGGGG 1620

GGCCTGGGAG GCTGTGGAGT GGCCGGCGGG GGCCGGGGCG CTGGGCGTGA GACGGCCATC 1680

CTCGATGATG AAGAGCAGCC CCCCGCGGGC GGAGGCCCGC ACCTCGGAAT GTACTCAGGC 1740

CACAGACCTG GCCTCAGCCG CCACTGCTCC TGCCGCCAGG GCTACCGGGA GCCCTGCGGG 1800

GTCCCCAATG GGGGCTACTA CCGGCCAGAG GGAACCCTGG AGAGGCGGCG GCTGGCCTAT 1860

GGGGGCTACG AGGGGCACCC CCAGGGCTAC GCCGAGGCCT CTGTGGAGAA GAGGCGCCTC 1920

TGCCGATCAC TGTCCGAGGG CCCGTATCCC TACCCACCTG AGCTGGGGAA ACCAGCCAAT 1980

GGGGACTTCG GCTACCGGGC CCCAGGCTAC CGGGAGGTGG TGATCCTGGA GGACGCGGGG 2040

CTGCCTGCCC TCTGCTCGTG CCCCGCCTGT GACGAGAAGC TGGCGCTGCC CACCGCGGCC 2100

CTATATGGGC TGCGGCTGGA GAGGGAGGCC GGAGAGGGCT GGGCGGGCGA GGCGGGCAAG 2160

CCCCTCCTGC ACCCCGTGCG GCCAGGGCAC CCACTGCCCC TGCTCGTGCC GGCCTGCGGG 2220

CATCACCATG CCCCGATGCC CGACTACAGC TGCCTGAAGC CACCCAAGGT GGGCGACGAT 2280

GGGCATGAGG GCTGCCCCTA TGCCGTGTGC CCCGAAGGCA GGTATGGGCA TCCAGGGTAC 2340

CCTGCCCTGG TGACCTACGG CTATGGAGGA GCAGTTCCCA GTTACTGCCC GGCCTATGGC 2400

CGCGTGCCTC ATAGCTGTGG CTCTCCAGCT GAGGCCAGAG CGTACTCCAG TTCTGGCGCC 2460

CACTCCCCAC GGGCTGGCTC CGTGTCCCCA GGCAGCCCAC CCTACCCGCA GTCCAGGAAG 2520

CTGAGCTACG AGATCCCTGC GGAGGAGGGA GGGGACAGGT ACCCGATGCC TGGGCACCTG 2580

GCCCCAGCAG GACCCTTGGC ATCTGCAGAG TCACCTGAGC CAGCGTCCTG GAGGGAGGGC 2640

CCGAGCGGGC ACAGTACCCT GCCTCGGTCT CCCCGTGATG CTCCGTGCAG TGCCTCTTCT 2700

GAGCTGTCTG GGCCCTCCAC ACCCCTGCAC ACCAGCAGCC CAGTCCAGGG CAAGGAAAGC 2760

ACCCGACGGC AGGACAGCAC GTCCCCCACC TTGGTGCCCA CTCAGAGACT AAGTCCTGGC 2820

GAGGCCTTGC CATCTATTCC CCAGGGAGGC GCTGAAAAGG CTTCCGAGCT GCCAGCAAGA 2880

AGTGGGCTTG AGCTTCCGGC CGCTAGCCCC TTCTCCCCCA CCTCCCCCCC CAGCTCACCC 2940

AATGACTGGC CTCAGGAGAA GAGCCCGGGG AGCCGCTCGG ACAGTGCCAG TCCGAGGGGC 3000

CCCGTGCCCA CCACGCTGCC TGGCCTCCGC CATGCCCCCT GGCAGGGCCT TCGAGACCCC 3060

CCAGATAGTC CGGATGGGTC CCCCCTCACT CCTGTGCCTA CCCAGATGCC CTGGCTTGTG 3120

GCCAGCTCAG AGCCACCTCA GAGCTCACCC ACGCCTGCCT TCCCCCTGGC TGCCTCCTAT 3180

GACATCAATG GCCCCACCCA GCCCCCACTT CCCGAGAAAC GCCACTTGCT GGGACCTGGG 3240

CAACAGCCAG GACCCTGGGG CTCAGAGCAG GCATCACCAC CAGCCAGAGG CACCAGTCAC 3300

CATGTCACCT TTGCACCTCT GCTCCCGGAT AATGTCCCCC AGCCCCCAGA GCCCCCTATG 3360

CAAGAGAGCC AGAGCAATGT CAAGTTCGTC CAGGATACGT CCAAGTTCTG GTACAAACCG 3420

CACCTGTCCC GTGACCAAGC CATTGCCCTG CTGAAGGACA AGGATCCTGG GGCCTTCCTG 3480

ATCAGGGACA GTCATTCATT CCAAGGAGCC TATGGGCTGG CCCTCAAGGT GGCCACACCT 3540

CCACCCAGCG CCCAGCCCTG GAAAGGGGAC CCCTTGGAAC AACTTGTCCG CCATTTTCTC 3600

ATTGAAACTG GGCCCAAAGG GGTGAAGATC AAGGGTTGTC CCAGTGAGCC CTACTTTGGC 3660

AGCCTGTCCG CCCTGGTCTC CCAGCACTCC ATCTCCCCAC TGTCCCTGCC CTGCTGCCTG 3720

CGCATTCCCA GCAAAGAGCC TCTAGAAGAG ACCCCAGAGG CCCCAGTGCC CGCCAACATG 3780

AGCACAGCAG CAGACCTCCT CCGTCAGGGT GCCGCCTGCA GTGTGCTCTA CCTGACCTCA 3840

GTGGAGACAG AGTCGCTGAC GGGCCCCCAA GCAGTGGCCC GGGCCAGCTC GGCAGCTCTG 3900

AGCTGCAGCC CCCGGCCCAC CCCAGCCATC GTCCACTTCA AGGTCTCGGC CCAGGGCATT 3960

ACACTGACAG ACAATCAAAG GAAGCTCTTC TTTCGCCGTC ATTACCCAGT GAACAGCATC 4020

ACCTTCTCCA GCACCGATCC TCAGGACCGG AGATGGGCCA ACCCCGACGG GACCACCTCC 4080

AAGATCTTTG GTTTCGTGGC CAAGAAGCCG GGAAGCCCCT GGGAGAACGT GTGTCACCTC 4140

TTTGCAGAGC TTGACCCAGA TCAGCCTGCA GGCGCCATTG TCACCTTCAT CACCAAAGTC 4200

CTACTGGGCC AGAGAAAGTG A 4221

Domain Profile

S: 2     rltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcser  61

         +l+e+++dldltyvteri+a++fPa+++e+++r++lre++++l+skhr+ky+l+nl se+

Q: 123   PLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEK  181

         79******************************************************.***

S: 62    rydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvi  121

         r+dl++ln+kv++fg+++l+aP+l+kl+sick++++Wls+d+++vvvl+ckg+kg+lGvi

Q: 182   RHDLSRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGSKGKLGVI  241

         ************************************************************

S: 122   vcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         v+ay+++s+isa+ad+al+t+++r+++edkva++ qPsqrry+syfs+ll g

Q: 242   VSAYMHYSKISAGADQALATLTMRKFCEDKVAAELQPSQRRYISYFSGLLAG  293

         *************************************************976

Domain Sequence
(FASTA)

PLMERRWDLD LTYVTERILA AAFPARPDEQ RHRGHLRELA HVLQSKHRDK YLLFNLSEKR 60

HDLSRLNPKV QDFGWPELHA PPLDKLCSIC KAMETWLSAD PQHVVVLYCK GSKGKLGVIV 120

SAYMHYSKIS AGADQALATL TMRKFCEDKV AAELQPSQRR YISYFSGLLA G 171

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005925	; C:focal adhesion
GO:0005622	; C:intracellular
GO:0046872	; F:metal ion binding
GO:0019725	; P:cellular homeostasis
GO:0032963	; P:collagen metabolic process
GO:0035556	; P:intracellular signal transduction
GO:0001822	; P:kidney development
GO:0035264	; P:multicellular organism growth
GO:0048871	; P:multicellular organismal homeostasis
GO:0008285	; P:negative regulation of cell proliferation
GO:0014850	; P:response to muscle activity

KEGG

aml:100466592

;

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011993	; PH_like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR013625	; PTB.
IPR006020	; PTyr_interaction_dom.
IPR000980	; SH2.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF08416	; PTB; 1.
PF10409	; PTEN_C2; 1.
PF00017	; SH2; 1.

SMARTs

SM00109	; C1; 1.
SM00462	; PTB; 1.
SM00252	; SH2; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50001	; SH2; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013