EKS-AIM-00340
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00340
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.46.6E-135276525250
StatusUnreviewed
Ensembl ProteinENSAMEP00000012975
UniProt AccessionG1M0W5;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000012309ENSAMEP00000012975ENSAMET00000013519
OrganismAiluropoda melanoleuca
Functional Description
Protein Length542
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRCSLEP AENTHGGGGG AFPTSQTPSK PASADGHRGP STAFPSAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTPLP 120
LLREGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180
FLVRESETTK GAYCLSVSDF DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS 240
KHADGLCHRL TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR 300
VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK 360
GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK VADFGLARLI 420
EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELTTKGRV PYPGMVNREV 480
LDQVERGYRM PCPPECPESL HDLMCQCWRK EPEERPTFEY LQAFLEDYFT STEPQYQPGE 540
NL 542
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAAC GGCGCTGCAG CCTGGAGCCT 60
GCTGAGAACA CCCACGGTGG TGGCGGGGGT GCCTTCCCCA CCTCACAGAC ACCCAGCAAG 120
CCAGCCTCCG CTGATGGCCA CCGAGGCCCC AGTACGGCCT TCCCCTCCGC AGCTGCCGAG 180
CCCAAGCTGT TCGGGGGCTT CAACTCGTCA GACACAGTCA CCTCCCCGCA GAGGGCGGGG 240
CCGCTGGCTG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TCGGACAGAG 300
ACCGACCTGT CCTTCAAGAA AGGGGAGCGG CTCCAGATTG TCAACAACAC CCCTCTCCCC 360
CTCCTTAGAG AGGGTGACTG GTGGCTGGCC CACTCGCTCA GCACGGGACA GACGGGTTAC 420
ATCCCCAGCA ACTATGTGGC GCCCTCCGAC TCTATCCAGG CCGAGGAGTG GTACTTTGGC 480
AAGATCACCA GACGGGAGTC GGAGCGGTTA CTGCTCAATG CGGAGAACCC GAGAGGGACC 540
TTCCTAGTGC GAGAAAGTGA GACCACGAAA GGTGCCTACT GCCTCTCCGT GTCTGATTTC 600
GACAACGCCA AGGGCCTCAA CGTGAAGCAC TACAAGATCC GCAAGCTGGA CAGCGGCGGC 660
TTCTATATCA CCTCCCGCAC CCAGTTCAAC AGTCTGCAGC AGCTGGTGGC TTACTACTCC 720
AAGCATGCTG ACGGCCTCTG CCACCGCCTC ACCACTGTGT GCCCCACGTC CAAGCCCCAG 780
ACTCAGGGCC TGGCCAAGGA TGCCTGGGAG ATCCCTCGGG AGTCCCTGCG GCTGGAGGTC 840
AAGCTGGGCC AAGGCTGTTT CGGAGAGGTG TGGATGGGGA CCTGGAATGG AACCACCAGG 900
GTGGCCATCA AAACCCTGAA GCCAGGCACG ATGTCTCCGG AGGCCTTCCT GCAGGAGGCC 960
CAGGTCATGA AGAAACTGAG GCACGAGAAG CTGGTGCAGC TATATGCGGT GGTGTCTGAG 1020
GAGCCTATCT ACATCGTCAC GGAGTACATG AGCAAGGGGA GTCTGCTGGA CTTTCTCAAG 1080
GGGGAGACCG GCAAGTACCT GCGGCTGCCT CAGCTGGTGG ACATGGCTGC TCAGATCGCC 1140
TCAGGCATGG CCTACGTGGA ACGGATGAAC TATGTCCACC GGGACCTCCG TGCTGCCAAC 1200
ATCCTGGTTG GAGAAAACCT TGTGTGCAAA GTGGCTGACT TTGGGCTGGC TCGGCTCATC 1260
GAAGACAACG AGTACACGGC GCGGCAAGGT GCCAAATTCC CCATCAAGTG GACAGCTCCA 1320
GAAGCGGCCC TCTACGGCCG GTTCACCATC AAGTCAGATG TATGGTCCTT TGGGATCCTG 1380
CTGACAGAGC TCACGACAAA GGGACGGGTG CCCTACCCTG GGATGGTCAA CCGTGAGGTG 1440
CTGGACCAGG TGGAGCGGGG CTACCGGATG CCCTGCCCGC CCGAGTGTCC CGAGTCCCTG 1500
CATGACCTCA TGTGCCAGTG CTGGCGGAAG GAGCCGGAGG AACGGCCCAC CTTCGAGTAC 1560
CTGCAGGCCT TCCTGGAAGA CTACTTCACG TCCACCGAGC CCCAGTACCA GCCTGGAGAG 1620
AACCTA 1626
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 276   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  335
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 336   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  394
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 395   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  454
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 455   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  514
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 515   RPTFEYLQAFL  525
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013