EKS-AIM-00256

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00256

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	374.7	4.0E-112	11	347	337

Status

Unreviewed

Ensembl Protein

ENSAMEP00000013128

UniProt Accession

D2HMV6;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK4

Gene Synonyms/Alias

HIPK4; PANDA_012954;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000012476	ENSAMEP00000013128	ENSAMET00000013678

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

616

Protein Sequence
(FASTA)

MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLR 60

CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV 120

LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 180

YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH 240

AARKAHHFFK RNPHPDASNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA 300

SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHETTR 360

YYQLSLRGCR LSLQVEGKPP TPAVAAAEDG PPYYRLAEEE EAVGVGSVVG GRPFFCEEKA 420

PGVQRAIDQL DDLSLQEVGR GLWGETRVDV VPDMLAPLKA AAAGRRVPDS GPEPILAFYG 480

SRLAGRHKAR KAPAGSKSDS NFSNLIRLSQ ASPEDDGPCR GSSWAEGERR GASAEPPTLP 540

QRDGDGPDIK DMTMDADRPG PELFDPSSCP GEWLSEPDWT LEGVRGPRAQ GLPPRHTHPH 600

GPARATSFLQ HVGGHH 616

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCCAGTCCGA GACCGACTGC TATGACATCA TCGAGGTGCT GGGCAAGGGC 60

ACCTTCGGGG AGGTGGCCAA GGGCTGGCGG CGAAGCACAG GCGAGATGGT GGCCATCAAG 120

ATCCTCAAGA ATGACGCCTA CCGCAACCGC ATCATCAAGA ACGAGCTGAA GCTTCTGCGT 180

TGCATGAGGG GTCTGGACCC CGAGGAAGCC CACGTCATCC GCTTCCTCGA GTTCTTCCAC 240

GACGCCCTCA AGTTCTACCT GGTCTTCGAG CTGCTGGAGC AAAACCTTTT CGAATTCCAG 300

AAGGAGAACA ACTTCGCGCC CCTCCCTGCC CGCCACATCC GCACGGTCAC CCTGCAGGTG 360

CTTAGAGCCC TGGCCCGGCT CAAGGAGCTG GCGATCATCC ATGCTGATCT CAAGCCCGAA 420

AACATCATGC TGGTGGACCA GACGCGCTGC CCCTTCAGGG TCAAGGTGAT TGACTTCGGC 480

TCAGCCAGCA TTTTCAGCGA GGTGCGCTAC GTCAAGGAGC CATACATTCA GTCGCGCTTC 540

TACCGGGCCC CTGAGATTCT GCTGGGGCTA CCCTTCTGCG AGAAGGTGGA CGTGTGGTCC 600

CTGGGCTGTG TCATGGCCGA GCTGCACCTG GGCTGGCCCC TCTACCCGGG CAACAACGAG 660

TACGACCAGG TGCGCTACAT CTGTGAGACC CAAGGTTTGC CCAAGCCCCA CCTGCTGCAC 720

GCCGCCCGCA AGGCCCACCA CTTCTTCAAG CGCAACCCCC ACCCCGATGC CAGCAACCCC 780

TGGCAGCTCA AGTCCTCGGC CGACTACCTG GCTGAGACCA AGGTGCGCCC CCTGGAGCGC 840

CGCAAGTACA TGCTCAAGTC GCTGGACCAG ATTGAGACAG TGAACGGTGG CGGGGCAGCC 900

AGTCGGCTGA CCTTCCCGGA CCGCGAGGCG CTAGCGGAGC ACGCTGACCT CAAGAGCATG 960

GTAGAGCTGA TCAAGCGCAT GCTGACGTGG GAGTCGCATG AACGCATCAG CCCCAGCGCA 1020

GCCCTGCGCC ACCCCTTCGT GTCCATGCAG CAACTGCGCA GCGCCCACGA GACTACCCGC 1080

TACTACCAGC TCTCGCTGCG CGGCTGCCGC CTCTCGCTGC AGGTGGAGGG CAAGCCGCCC 1140

ACGCCGGCCG TGGCTGCTGC GGAAGACGGG CCGCCCTACT ACCGTCTGGC CGAGGAGGAG 1200

GAGGCCGTGG GCGTGGGCAG TGTGGTGGGT GGCAGGCCCT TCTTCTGCGA GGAGAAGGCG 1260

CCGGGCGTGC AAAGGGCCAT TGATCAGCTG GATGACCTGA GTCTGCAGGA GGTGGGGCGA 1320

GGGCTGTGGG GTGAGACCCG AGTCGACGTG GTTCCTGACA TGCTGGCCCC ACTCAAGGCA 1380

GCCGCCGCTG GCCGCCGAGT GCCCGACTCG GGCCCCGAGC CCATCCTGGC TTTCTACGGC 1440

AGCCGCCTGG CAGGTCGCCA CAAGGCCCGC AAGGCACCCG CGGGCTCCAA GTCTGACTCC 1500

AACTTCAGCA ACCTCATCCG GCTGAGCCAG GCCTCCCCTG AGGATGACGG GCCGTGCCGG 1560

GGCAGCAGCT GGGCAGAAGG AGAGCGCCGC GGGGCCTCCG CCGAGCCGCC CACGCTCCCG 1620

CAGCGGGATG GGGATGGACC AGACATCAAG GATATGACCA TGGATGCTGA CAGGCCGGGC 1680

CCTGAGCTCT TCGACCCCAG CAGCTGCCCT GGGGAATGGC TGAGTGAGCC AGACTGGACC 1740

CTGGAGGGTG TCAGGGGGCC ACGGGCCCAG GGGCTCCCAC CCCGCCACAC TCACCCGCAC 1800

GGTCCCGCCC GGGCCACCAG CTTTCTGCAG CACGTCGGGG GGCACCATTA A 1851

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         y+++ev+gkG+fg+V+k+++++t e+vaiki+kn++  +r +++E+++L++++  d+ee+

Q: 11    YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLRCMRGLDPEEA  70

         99*******************************************************988

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

          +v+r+le+f+   +++lvfell+qnL+e+ k+n+f++l+ +++r+++ q+l+aL+ Lke

Q: 71    -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKE  129

         .9**********************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqk..eiytyiqsrfYraPEiilg  176

         l+iiHaDlKPeNi+lv+++r++  vkviDFGs+s +s+   + ++yiqsrfYraPEi+lg

Q: 130   LAIIHADLKPENIMLVDQTRCPfrVKVIDFGSASIFSEVryVKEPYIQSRFYRAPEILLG  189

         *********************999**********99987447899***************

S: 177   lkydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff  236

         l+++e++D+WSlGcv+aEl++G+pL+pG+ne+dq+++i+e++glp+++ll++a+ka++ff

Q: 190   LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFF  249

         ************************************************************

S: 237   tkkeapkyilktk.............ksdrkkklvlnvkkaakkrkaplske.....lge  278

         +++ +p     ++                +++k++l+  +++++++  ++++      +e

Q: 250   KRNPHPDASNPWQlkssadylaetkvRPLERRKYMLKSLDQIETVNGGGAASrltfpDRE  309

         888887766665566669999988886667778888888888777655444311111578

S: 279   alkekedkl.fkdllkrmleldpakRitpkealkhpfv  315

         al+e++d + +++l+krml++++++Ri+p++al+hpfv

Q: 310   ALAEHADLKsMVELIKRMLTWESHERISPSAALRHPFV  347

         8888889888***************************7

Domain Sequence
(FASTA)

YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLR CMRGLDPEEA 60

HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV LRALARLKEL 120

AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL 180

PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AARKAHHFFK 240

RNPHPDASNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA SRLTFPDREA 300

LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFV 337

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

aml:100468010

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013