EKS-AIM-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK315.03.9E-94161396236
StatusUnreviewed
Ensembl ProteinENSAMEP00000013251
UniProt AccessionG1M1P0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000012574ENSAMEP00000013251ENSAMET00000013808
OrganismAiluropoda melanoleuca
Functional Description
Protein Length892
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60
GGPSPSPGGE PPAEPFANSV LQLHEQDAGG PGGASGSPES RASRVRADEV RLQCQSGSGF 120
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
HLPVPSGCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 600
PHEPGGPGSP GGLGGGPSGW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
GAGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGDVVGL LGTGREGTAG 720
RGGSRAGSQH LTPAAMLYRA AVTRSQKRGI SSEEEEGEVD SEVELPSSQR WPQGLNMRQS 780
LSTFSSENPS DGEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDPPASEV 840
VPGPEPSSRP IPHQDLPREG QGPPSEDSDC DSTELDNSNS GEALQPPASL PP 892
Nucleotide Sequence
(FASTA)
ATGGCCTGCC TCCACGAGAC CCGCACACCC TCCCCTTCCT TCGGGGGCTT CGTGTCCACC 60
CTCAGCGAGG CGTCCATGCG CAAGCTCGAC CCGGACACTT CCGACTGCAC CCCGGAGAAG 120
GACCTGACGC CCACCCAGTG TGTACTTCGA GACGTAGTGC CGCTCGGCGG GCAGGGCGGG 180
GGCGGACCCA GCCCCTCCCC GGGGGGAGAG CCGCCCGCTG AGCCTTTTGC CAACAGTGTC 240
CTGCAGCTCC ACGAGCAGGA TGCAGGGGGC CCCGGGGGAG CCTCTGGGTC CCCTGAGAGT 300
CGGGCGTCCC GAGTTCGGGC CGATGAGGTG CGGCTGCAGT GCCAGAGCGG CAGCGGCTTC 360
CTGGAAGGGC TCTTCGGCTG CCTGCGCCCC GTCTGGACCA TGATCGGCAA GGCCTACTCC 420
ACGGAGCACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA GATCCTGGAC 480
CTGCAGTGGG TGGGCTCAGG GGCCCAGGGC GCTGTCTTCC TGGGGCGCTT CCACGGGGAG 540
GAGGTGGCTG TGAAGAAGGT ACGGGACCTG AAGGAGACGG ACATCAAGCA CCTGCGAAAG 600
CTGAAGCACC CCAACATCAT CACCTTCAAG GGCGTGTGCA CCCAGGCTCC CTGCTACTGC 660
ATCCTGATGG AGTTCTGCGC CCAGGGCCAG CTGTATGAGG TACTGCGGGC CGGCCGCCCT 720
GTCACCCCTT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CCGGTGGCAT GAACTACCTG 780
CACCTGCACA AGATTATCCA TAGAGACCTC AAGTCCCCCA ACATGCTAAT CACGTACGAC 840
GATGTGGTGA AGATCTCCGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCCGCAA CGAGCCCGTG 960
TCCGAGAAGG TCGACATCTG GTCCTTTGGC GTGGTGCTGT GGGAACTGCT GACTGGTGAG 1020
ATCCCCTACA AAGATGTGGA CTCCTCAGCC ATCATCTGGG GTGTGGGGAG CAACAGTCTC 1080
CATCTGCCTG TGCCCTCCGG CTGCCCCGAC GGCTTCAAAA TCCTGCTTCG CCAGTGCTGG 1140
AACAGCAAAC CAAGAAATCG TCCCTCATTC CGCCAGATCC TGCTGCACCT GGACATCGCC 1200
TCGGCTGACG TCCTCTCCAC GCCCCAGGAG ACTTACTTTA AGTCCCAGGC AGAGTGGCGC 1260
GAAGAGGTAA AGCTGCACTT TGAAAAAATT AAGTCAGAAG GGACTTGTCT GCACCGCCTA 1320
GAAGAGGAGC TGGTGATGCG GCGGAGGGAA GAGCTCAGAC ACGCCCTGGA CATCAGGGAG 1380
CACTACGAAC GGAAGCTGGA GCGGGCCAAC AACCTGTACA TGGAGCTCAA CGCGCTCATG 1440
CTGCAGCTCG AGCTCAAGGA GCGGGAGCTG CTCAGGAGGG AACAAGCTTT GGAGCGGAGA 1500
TGCCCAGGTC TGCTGAAGTC ACACCCTTCC CGAGGCCTCC TGCATGGGAA CACGATGGAG 1560
AAGCTCATCA AGAAGAGGAA CGTCCCACAG AAACTGTCAC CCCACAGTAA AAGGCCGGAT 1620
ATCCTCAAGA CTGAATCTTT GCTGCCTAAA CTTGATGCTG CCCTGAGTGG GGTGGGGCTT 1680
CCCGGGTGTC CTAAGGGCCC CCCCTCACCA GGACGGAGTC GTCGTGGCAA GACTCGTCAC 1740
CGCAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 1800
CCCCATGAAC CTGGGGGACC AGGAAGCCCA GGGGGGCTAG GAGGGGGACC CTCAGGCTGG 1860
GAGGCCTGCC CTCCAGCCCT GCGTGGGCTC CATCATGACC TCCTGCTCCG AAAAATGTCG 1920
TCGTCGTCCC CAGATCTGCT GTCAGCAGCA CTGGGAGCCC GGGGCCGAGG GGCCACAGGG 1980
GGAGCTGGGG ATCCTGGCTC ACCGCCTCCA GCCCGGGGAG ACACCCCGCC AAGTGAGGGC 2040
TCAGCACCTG GCTCCACCAG CCCAGATTCA CCTGGGGGAG CCAAAGGGGA GCCACCTCCA 2100
CCAGTAGGGC CTGGTGACGT TGTGGGGCTA CTGGGAACTG GAAGGGAAGG GACGGCGGGA 2160
CGGGGAGGAA GCCGGGCTGG GTCCCAGCAC TTGACCCCAG CTGCAATGCT GTACAGGGCT 2220
GCTGTCACCC GGAGCCAGAA ACGTGGCATC TCGTCAGAGG AAGAGGAAGG CGAGGTGGAC 2280
AGTGAAGTGG AGCTGCCCTC GAGCCAGAGG TGGCCTCAGG GCCTGAACAT GCGCCAGTCA 2340
CTGTCCACCT TCAGCTCCGA GAACCCATCT GACGGGGAGG AGGGCACAGC CAGCGAGCCC 2400
TCCCCCAGTG GCACACCTGA AGTTGGCAGT ACCAACACCG ACGAACGGCC AGACGAGCGG 2460
TCTGATGACA TGTGTTCCCA GGGCTCAGAA ATCCCACTGG ACCCGCCTGC GTCGGAGGTG 2520
GTTCCTGGCC CCGAACCCAG CTCCCGACCC ATCCCACACC AGGACCTACC CAGAGAGGGG 2580
CAGGGCCCTC CCAGTGAGGA CTCAGACTGT GACAGCACCG AACTGGACAA CTCCAACAGT 2640
GGTGAAGCCT TGCAGCCTCC AGCCTCCCTC CCTCCATGA 2679
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps cp+ +k L+++cwn++p+
Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSGCPDGFKILLRQCWNSKPR  385
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 386   NRPSFRQILLH  396
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSGCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00369
EKS-BOT-00381
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DAR-00760
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013