EKS-AIM-00083

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00083

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	456.9	4.3E-137	2293	2619	327

Status

Unreviewed

Ensembl Protein

ENSAMEP00000013271

UniProt Accession

G1M1R0;

Protein Name

Protein Synonyms/Alias

Gene Name

ATR

Gene Synonyms/Alias

ATR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000012578	ENSAMEP00000013271	ENSAMET00000013828

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

2644

Protein Sequence
(FASTA)

MGDHGLELAS MIPALRELGS ASPEEYNTVV QKPRQILCQF IDRILTDVNV VALELVKKTD 60

SQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKGSCI EFSNWIITRL LRIAATPSCH 120

MLHKKICEVV CSLLFLFKSK SPAIFGVLTK ELLHLFEDVI YLHRKNAMGH FVEWPVVVSR 180

FLSQLDEHVG YLQPAPLQFT NMQNLEFIEV TLLTVLIRIV AIVFFRRQEL FLWQIGCVLL 240

EYGSPKVKSL AISLLTELFE LGGLPAQPAS TFFSSFLGLL KHLVEMDADQ LKLYEEPLSK 300

LIRTLFPFAA EAYRNIEPVY LNMLLEKLCV MFEDGVLMRL KSDLLKAALC HLLQYFLKYV 360

PAGYESALQV RKVYVRNICR VLVDVLGFQV DAEYLLGPLY AALKMESMEI IEEVQCQIQQ 420

ENLSSNSDGI SAKRRRLSSS LNSSKRPPKQ TEEIKHVDMS KKSILWSALK QKAESLQIFL 480

EYGSLKNPVI ATLEGITVVL QLTALCTVHC SHQNMDCHNF KDSQQKYKKK PSIEVTWMSL 540

DFYTKVLKSC RSLLESVQKP DLEAIIDKVV KIYDALIYIH VKTSFEDHIL EDLCGMLSLP 600

WIHSHSDDGS LKLTTFATNL LGLSQRISDS YSPQAQSRCV FLLTLFPRRI FLEWRTAIYS 660

WALQSSHEVI RASCVNGFFI LLQQQNSCNR VPKILIDKVK DDSDTVKKEF ASILGQLICT 720

LHGMFYLTSS LTEPFSEHGH IDLFCKSLKV TSQHECSSSQ LKASLCKPFL FLMKKKTPSP 780

VKLAFIDNLY HLCKHLDFRE DETDVKTVLG TLLNLMEDPD KDVRVAFSGN IKHILESLDS 840

EDGFIKELFV LRMKEAYTHA QISRNNELKD TLILTTGDIG RAAKGDLVPF ALLHLLHCLL 900

SKSASVSGAA YTEIRALVAA KSVKLQNFFS QYKKPICQFL VESLHSSQMT ALPSTPCQNA 960

EMRKQDVAHQ REMALNTLSE IANVFDFPDL NRFLTRTLQV LLPDLAAKAS PAASALIRTL 1020

GKQLNVNRRE ILINNFKYIF SHLVCSCSKD ELERALHYLK NETEIELGSL LRQDFQGLHN 1080

ELLLRIGEHY QQVFNGLSIL ASFASSDDPY QGPREITSPE LMADYLQPKL LGILAFFNMQ 1140

LLSSSVGIED KKMALNSLMS LMKLMGPKHV SSVRVKMMTT LRTGLRFKDD FPELCCRAWD 1200

CFVRCLDHAY LGSLLSHVIV ALLPLIHIQP EETAAIFHYL IIENRDAVQD FLHEIYFLPD 1260

HPELKKIKAV LQEYRKETSE STDLQTTLQL SMKAIQHENV DVRIHALTSL KETLYKNQEK 1320

LIKYATDSET VEPVISQLVT VLLKGCQDAN SQARLLCGEC LGELGAIDPG RLDFSTSESQ 1380

GKDFTFVTGV EDSSFAFGLL MELTRAYLAY ADNSRAQDSA AYAIQELLSI YDCREMQTDG 1440

PGHQLWRRFP EHVREILEPH LNTRYKSSQK STDWSGVKKP IYLSKLGNNF AEWSASWAGY 1500

LITKVRHDLA SKIFTCCSIM MKHDFKVTIY LLPHILVYVL LGCNQEDQQE VYAEIMAVLK 1560

HDDRHIISTQ DSASDLCQLS TQTVFSMLDH LTQWARHKFQ ALNAEKFPQS KSNRDKVDSV 1620

VSTADYEDYQ SVTRFLDLIP QDTLAVASFR SKAYTRAVMH FESFITEKKQ NIQEHLGFLQ 1680

KLYAAMHEPD GVAGVSAIRK AEPSLKEQIL EHESIGLLRD ATACYDRAIQ LEPDQIIHYH 1740

GVVKSMLGLG QLSTVITQVN GVHANRSEWT DELNTYRVEA AWKLSQWDLV ENYLAADGKS 1800

TTWSVRLGQL LLSAKKRDTT AFYDTLKLVR AEQIVPLSAA SFERGSYQRG YEYIVRLHML 1860

CELEHSIKPL FHRSPGDSSQ EDSLNWVARL EMTQNSYRAK EPILALRRAL LSLNKRPDYN 1920

EMVGECWLQS ARVARKAGHH QTAYNALLNA GESRLAELYV ERAKWLWSKG DVHQALIVLQ 1980

KGVELCFPEN KTPTESKNML IHGRAMLLVG RFMEETANFE SNAVMKKYKD VTLFLPEWED 2040

GHFYLAKYYD KLMPMVTDNK MEKQGDLIRY IVLHFGRSLQ YGNQFIYQSM PRMLSLWLDF 2100

GAKAYEWEKA GRSDRVQMRN DLAKINKVIT EHTNHLAPYQ FLTAFSQLIS RICHSHDEVF 2160

VVLMEIIAKV FLAYPQQAMW MMTAVSKSSY PMRVNRCKEI LNKAIHMKKS LEKFIGDATR 2220

LTDKLLELCN KPVDGSSSTL SMSTHFKMLK KLVEEPTFSE ILIPLQSVMI PTLPSIPGAH 2280

ANHEPFPGHW AYIASFDDMV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME 2340

FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 2400

MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPVFHEWF LRTFPDPTSW YSSRSAYCRS 2460

TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV 2520

NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET 2580

GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW 2640

TPYM 2644

Nucleotide Sequence
(FASTA)

ATGGGCGACC ACGGCCTGGA GCTGGCGTCT ATGATCCCCG CTCTGCGGGA GTTGGGCAGT 60

GCCAGTCCAG AGGAATATAA TACAGTTGTA CAGAAGCCAA GACAAATTTT ATGTCAGTTT 120

ATTGACCGAA TACTTACAGA TGTCAATGTT GTTGCTCTAG AACTTGTAAA GAAAACTGAC 180

TCTCAGCCAA CCTCTGTGAT GTTGCTTGAT TTCATCCAAC ATATAATGAA GTCCTCCCCA 240

CTTATGTTTG TAAATGTGAA TGGAAGCCAA GGGCAAAATG AGGCCAAAGG CAGTTGTATT 300

GAATTCAGTA ATTGGATCAT AACAAGACTT CTGCGGATTG CAGCAACTCC ATCCTGTCAT 360

ATGTTACACA AGAAAATCTG TGAAGTTGTC TGCTCATTGT TATTTCTTTT TAAAAGCAAG 420

AGCCCTGCAA TTTTTGGAGT ACTGACAAAG GAATTACTAC ATCTTTTTGA AGATGTGATT 480

TACCTCCACA GAAAAAATGC AATGGGACAC TTTGTGGAAT GGCCAGTGGT AGTTAGCCGA 540

TTTTTAAGTC AATTAGATGA ACATGTGGGA TATTTACAAC CAGCTCCTTT GCAATTCACG 600

AACATGCAAA ATTTAGAATT TATTGAAGTC ACTTTATTAA CAGTTCTTAT TCGTATTGTT 660

GCAATTGTGT TTTTTAGAAG GCAAGAACTC TTTCTTTGGC AGATAGGTTG TGTTCTGCTA 720

GAGTATGGTA GTCCAAAAGT TAAATCCTTA GCAATTAGCC TTTTAACTGA ACTCTTTGAG 780

CTTGGAGGAT TACCAGCACA ACCAGCCAGC ACTTTCTTCA GCTCATTTTT AGGATTATTA 840

AAACATCTTG TAGAAATGGA TGCTGACCAG TTGAAACTCT ATGAAGAACC ATTATCAAAG 900

CTGATAAGAA CACTGTTCCC CTTTGCAGCA GAAGCTTATA GAAATATTGA ACCTGTCTAT 960

TTAAATATGC TGCTAGAAAA ACTCTGTGTC ATGTTTGAAG ATGGTGTGCT TATGCGGCTT 1020

AAGTCTGATT TGCTAAAAGC AGCTTTGTGC CACTTACTGC AGTATTTCCT TAAATATGTG 1080

CCAGCTGGGT ATGAATCTGC TCTACAAGTC AGGAAGGTTT ATGTGAGAAA CATTTGTAGA 1140

GTTCTTGTGG ATGTGCTTGG ATTTCAGGTA GATGCAGAGT ATTTGTTGGG CCCACTTTAT 1200

GCAGCCTTAA AAATGGAAAG TATGGAAATC ATTGAGGAGG TTCAATGCCA AATTCAACAG 1260

GAAAACCTGA GCAGTAATAG TGATGGGATA TCAGCCAAAA GGCGTCGACT CAGCTCATCT 1320

CTAAACTCTT CCAAAAGACC ACCAAAACAG ACTGAGGAAA TTAAACATGT GGATATGAGC 1380

AAGAAGAGCA TATTATGGAG TGCCCTGAAA CAGAAAGCTG AGTCCCTTCA GATTTTCCTT 1440

GAATATGGTA GTCTAAAGAA TCCTGTTATT GCAACTTTGG AAGGAATCAC TGTTGTCCTA 1500

CAGCTGACTG CTCTGTGTAC TGTTCATTGT TCTCATCAAA ACATGGACTG CCATAATTTC 1560

AAGGACAGTC AACAGAAATA TAAGAAGAAA CCTTCAATAG AGGTAACTTG GATGTCTTTG 1620

GATTTTTACA CAAAAGTGCT TAAGAGCTGT AGGAGTTTGT TAGAATCTGT TCAGAAGCCC 1680

GACCTGGAGG CAATTATTGA TAAAGTGGTG AAAATATATG ATGCTCTGAT TTATATTCAC 1740

GTGAAAACTT CTTTTGAAGA TCATATTCTG GAAGATTTAT GTGGAATGCT CTCACTTCCA 1800

TGGATTCATT CCCATTCTGA TGATGGCTCT TTAAAGTTGA CCACGTTTGC CACTAATCTT 1860

TTAGGATTAA GCCAGAGGAT TTCAGATAGC TACTCACCAC AGGCACAGTC ACGGTGTGTG 1920

TTTCTTCTAA CTTTGTTTCC GAGAAGAATA TTCCTTGAAT GGAGAACAGC AATTTATAGC 1980

TGGGCCCTAC AGAGCTCCCA TGAAGTAATC CGAGCTAGTT GTGTTAATGG ATTTTTTATC 2040

TTATTGCAGC AGCAGAATTC ATGTAACAGA GTTCCCAAGA TTCTTATAGA TAAAGTCAAA 2100

GATGATTCTG ACACTGTCAA GAAAGAATTT GCCTCTATTC TTGGTCAGCT TATCTGTACG 2160

CTTCATGGCA TGTTTTATTT GACAAGTTCT TTAACAGAAC CTTTCTCTGA ACATGGACAT 2220

ATTGACCTCT TCTGTAAAAG CCTTAAAGTC ACTTCTCAAC ATGAATGTTC ATCTTCTCAA 2280

CTAAAAGCTT CTCTTTGCAA ACCTTTCCTT TTCCTAATGA AAAAAAAAAC ACCTAGTCCA 2340

GTGAAACTTG CTTTCATAGA TAATCTATAT CATCTTTGTA AGCACCTTGA TTTTAGAGAA 2400

GATGAAACAG ATGTGAAAAC AGTTCTTGGA ACTTTATTAA ATTTAATGGA AGATCCAGAC 2460

AAGGATGTGA GAGTGGCTTT TAGTGGAAAT ATCAAGCATA TATTGGAATC TTTGGACTCT 2520

GAAGATGGAT TTATAAAAGA GCTTTTTGTC TTAAGAATGA AGGAAGCATA TACACATGCT 2580

CAAATCTCAA GAAATAATGA GTTGAAGGAT ACCTTGATTC TTACAACAGG GGATATTGGA 2640

AGGGCAGCAA AAGGAGATTT GGTACCTTTT GCACTTTTGC ATTTATTGCA TTGTTTATTA 2700

TCGAAGTCAG CATCTGTCTC TGGAGCAGCA TATACAGAAA TCAGAGCTCT GGTTGCAGCT 2760

AAGAGTGTTA AACTGCAAAA CTTTTTCAGC CAGTATAAGA AACCCATCTG TCAGTTTTTA 2820

GTAGAATCCC TCCATTCCAG TCAGATGACA GCACTTCCTA GTACTCCATG CCAGAATGCT 2880

GAGATGCGGA AACAAGATGT GGCTCACCAG AGAGAAATGG CTTTAAATAC CTTGTCTGAA 2940

ATTGCCAATG TTTTTGACTT TCCTGATCTT AATCGTTTCC TTACTAGGAC ATTACAAGTT 3000

CTGCTCCCTG ACCTTGCCGC CAAAGCAAGC CCTGCAGCTT CTGCTCTCAT TCGAACTTTA 3060

GGAAAACAAT TAAATGTCAA TCGTAGAGAG ATTTTAATAA ATAACTTCAA ATATATTTTT 3120

TCTCATTTGG TCTGTTCCTG TTCCAAGGAT GAATTAGAAC GTGCCCTTCA TTATCTGAAG 3180

AATGAAACAG AAATTGAACT GGGGAGTCTA TTGAGACAAG ATTTCCAAGG ATTGCATAAT 3240

GAATTATTGC TACGTATTGG AGAACACTAT CAACAGGTTT TCAATGGTTT GTCAATACTT 3300

GCCTCATTTG CATCTAGTGA TGATCCATAT CAGGGCCCCA GAGAGATCAC ATCACCTGAA 3360

TTAATGGCTG ATTATTTGCA ACCTAAGTTA TTGGGCATTT TGGCCTTTTT TAACATGCAG 3420

TTACTGAGCT CCAGTGTTGG CATTGAAGAT AAGAAAATGG CTTTGAACAG TTTGATGTCT 3480

TTGATGAAGT TGATGGGACC AAAACACGTC AGTTCTGTGA GGGTGAAGAT GATGACCACG 3540

CTAAGAACTG GCCTGAGATT CAAGGATGAT TTTCCCGAAT TGTGTTGTAG AGCTTGGGAT 3600

TGCTTTGTTC GTTGCCTGGA TCATGCTTAT CTTGGGTCCC TTCTCAGTCA TGTGATAGTA 3660

GCTTTGTTAC CTCTCATACA CATCCAGCCT GAAGAAACTG CAGCCATATT TCACTACCTC 3720

ATAATTGAAA ACAGGGATGC TGTACAAGAT TTTCTTCATG AAATATATTT TTTACCTGAT 3780

CATCCAGAAT TAAAAAAGAT AAAAGCAGTT CTACAGGAAT ACAGAAAGGA GACCTCAGAG 3840

AGTACAGATC TTCAGACAAC TCTACAATTA TCCATGAAAG CAATTCAACA TGAAAATGTA 3900

GATGTTCGTA TTCATGCTCT TACGAGTTTG AAGGAAACTT TATATAAAAA TCAGGAAAAA 3960

CTGATAAAAT ATGCAACAGA TAGTGAAACA GTGGAACCTG TTATCTCACA GTTGGTGACA 4020

GTGCTTTTGA AAGGTTGCCA AGATGCAAAT TCTCAAGCTC GGTTGCTCTG TGGGGAATGT 4080

TTAGGGGAAT TGGGGGCAAT AGATCCAGGT CGACTAGATT TTTCAACAAG TGAAAGCCAA 4140

GGAAAAGATT TTACATTTGT GACTGGAGTA GAAGATTCAA GCTTTGCCTT TGGATTGTTG 4200

ATGGAACTAA CAAGAGCTTA CCTTGCATAT GCAGATAATA GCCGGGCTCA AGATTCAGCT 4260

GCTTACGCCA TTCAGGAGTT ACTTTCTATT TATGACTGTA GAGAGATGCA GACCGATGGC 4320

CCAGGCCATC AGTTGTGGAG GAGATTTCCT GAGCATGTTC GGGAAATCCT GGAACCTCAT 4380

CTAAATACTA GATATAAGAG TTCTCAGAAG TCAACAGATT GGTCTGGAGT AAAGAAGCCA 4440

ATTTACTTAA GTAAATTAGG TAATAACTTT GCAGAATGGT CAGCATCTTG GGCAGGTTAT 4500

CTTATAACAA AGGTTCGGCA TGATCTTGCC AGTAAAATCT TCACCTGCTG TAGCATTATG 4560

ATGAAACATG ATTTCAAGGT GACCATCTAT CTTCTTCCAC ATATTCTAGT GTATGTCTTG 4620

TTGGGTTGTA ATCAAGAAGA TCAGCAAGAG GTTTATGCAG AAATTATGGC AGTTCTAAAG 4680

CATGATGATC GACATATCAT AAGTACCCAA GACAGTGCAT CTGATCTGTG TCAACTCAGT 4740

ACACAGACTG TCTTCTCCAT GCTTGACCAT CTCACACAAT GGGCAAGGCA CAAATTTCAG 4800

GCACTGAATG CAGAGAAATT TCCACAAAGC AAATCAAACA GAGATAAAGT AGACTCAGTA 4860

GTATCTACTG CGGATTATGA AGACTATCAG AGTGTAACTC GTTTTCTAGA CCTCATACCT 4920

CAGGATACCC TGGCAGTAGC TTCCTTTCGC TCCAAAGCAT ACACACGAGC TGTAATGCAC 4980

TTTGAATCAT TTATTACAGA AAAGAAACAA AATATTCAAG AACATCTTGG ATTTTTACAG 5040

AAATTGTACG CTGCTATGCA TGAACCAGAT GGAGTGGCTG GAGTAAGCGC AATTCGAAAG 5100

GCAGAACCAT CTCTCAAAGA ACAGATCCTT GAACATGAAA GCATTGGCTT ACTGAGGGAT 5160

GCCACTGCTT GTTATGACAG GGCTATTCAG CTAGAACCAG ACCAGATCAT TCATTATCAT 5220

GGTGTAGTGA AGTCCATGTT AGGTCTTGGT CAGTTGTCTA CCGTAATCAC TCAGGTGAAT 5280

GGAGTACATG CTAACAGGTC TGAATGGACA GATGAATTAA ACACATACAG AGTGGAAGCA 5340

GCTTGGAAAT TGTCACAGTG GGATTTGGTG GAAAACTATT TGGCAGCAGA TGGGAAATCT 5400

ACAACATGGA GTGTCAGACT GGGACAGCTA TTATTATCAG CCAAAAAAAG AGATACCACA 5460

GCTTTTTATG ACACACTGAA ACTAGTGAGA GCAGAACAAA TTGTACCTCT TTCAGCTGCA 5520

AGCTTCGAAA GAGGCTCTTA TCAACGAGGA TATGAATATA TTGTAAGATT GCACATGTTG 5580

TGTGAGTTGG AGCATAGCAT CAAACCACTT TTTCACCGTT CGCCAGGTGA CAGTTCTCAA 5640

GAAGATTCTC TAAACTGGGT AGCTCGACTA GAAATGACCC AGAATTCCTA CAGAGCCAAG 5700

GAGCCCATCC TGGCTCTCCG GAGAGCTTTA TTAAGCCTCA ACAAAAGACC AGATTACAAT 5760

GAAATGGTTG GAGAATGCTG GCTACAGAGT GCCAGAGTAG CTAGAAAAGC TGGTCACCAC 5820

CAGACAGCCT ATAATGCTCT CCTTAATGCT GGAGAATCAC GGCTTGCTGA ACTGTATGTG 5880

GAAAGGGCAA AGTGGCTGTG GTCCAAGGGT GATGTTCATC AGGCACTAAT TGTTCTTCAG 5940

AAGGGTGTTG AATTATGTTT TCCTGAAAAT AAAACCCCAA CTGAGAGTAA GAACATGTTA 6000

ATCCATGGTC GAGCTATGCT ACTAGTGGGC CGATTTATGG AAGAAACAGC TAACTTTGAG 6060

AGCAATGCAG TTATGAAAAA ATATAAGGAT GTGACCTTGT TCCTGCCAGA GTGGGAGGAT 6120

GGGCATTTTT ACCTTGCCAA GTATTATGAC AAATTGATGC CCATGGTCAC AGACAACAAA 6180

ATGGAAAAGC AGGGTGATCT CATTCGGTAT ATAGTTCTTC ATTTTGGCAG ATCTCTACAA 6240

TATGGAAACC AATTCATATA TCAGTCAATG CCACGAATGT TATCACTATG GCTTGATTTT 6300

GGTGCTAAGG CATATGAATG GGAAAAAGCT GGCCGTTCTG ATCGTGTACA AATGAGAAAT 6360

GATTTAGCTA AAATAAACAA GGTTATCACA GAGCACACAA ATCACTTAGC ACCATATCAG 6420

TTTTTGACTG CTTTTTCGCA GTTGATCTCC CGAATTTGTC ATTCTCATGA TGAAGTTTTT 6480

GTTGTCTTGA TGGAAATTAT AGCCAAAGTG TTCCTGGCCT ATCCTCAACA AGCAATGTGG 6540

ATGATGACAG CTGTGTCAAA GTCTTCTTAT CCCATGCGTG TGAACAGATG CAAGGAAATC 6600

CTAAATAAAG CTATTCATAT GAAAAAATCC TTAGAAAAAT TTATTGGAGA TGCAACTCGC 6660

CTAACAGATA AACTTTTGGA ATTGTGCAAT AAACCGGTGG ATGGAAGTAG TTCCACATTA 6720

AGCATGAGCA CTCATTTTAA AATGCTTAAA AAGCTGGTAG AAGAACCAAC ATTTAGTGAA 6780

ATCCTCATTC CTTTACAATC AGTCATGATA CCTACTCTTC CATCAATTCC GGGTGCCCAT 6840

GCTAACCATG AGCCATTTCC TGGGCATTGG GCCTATATTG CAAGCTTCGA TGATATGGTG 6900

GAAATTCTTG CTTCTCTTCA GAAACCAAAG AAGATCTCTT TGAAAGGATC AGATGGAAAG 6960

TTCTACATCA TGATGTGTAA GCCAAAAGAT GACCTGAGAA AGGATTGTAG ACTAATGGAA 7020

TTCAATTCCT TGATTAATAA GTGCTTAAGA AAAGATGCAG AATCTCGTAG AAGAGAACTT 7080

CATATCCGAA CATATGCAGT TATTCCCCTG AATGATGAAT GTGGTATTAT TGAATGGGTT 7140

AACAACACTG CTGGCTTGAG ACCTATTCTG ACCAAACTAT ATAAGGAAAA GGGAGTTTAT 7200

ATGACAGGAA AAGAACTTCG CCAGTGTATG CTACCAAAAT CCGCAGCTTT GTCTGAAAAA 7260

CTCAAAGTAT TCCGAGAATT TCTCCTACCC AGGCATCCTC CTGTTTTTCA TGAGTGGTTT 7320

CTGAGGACAT TCCCTGATCC TACATCATGG TACAGTAGCA GATCAGCATA CTGTCGTTCC 7380

ACCGCAGTTA TGTCAATGGT TGGTTATATC CTGGGGCTTG GAGACCGTCA TGGTGAAAAC 7440

ATTCTCTTTG ATTCTTTGAC TGGTGAATGT GTACATGTGG ATTTCAACTG TCTCTTCAAT 7500

AAGGGAGAAA CCTTTGAAGT TCCAGAAATT GTTCCATTTC GACTGACTCA TAATATGGTT 7560

AATGGAATGG GTCCTATGGG AACAGAAGGT CTTTTTCGAA GGGCTTGTGA AGTTACAATG 7620

AGGCTGATGC GAGATCAGAG AGAGCCTTTA ATGAGTGTCT TAAAAACTTT TCTACATGAT 7680

CCTCTTGTGG AATGGAGTAA ACCAGTGAAA GGGCATTCCA AAGCACCACT GAATGAAACC 7740

GGGGAGGTTG TCAATGAAAA GGCCAAGACC CATGTTCTTG ACATTGAGCA GCGACTGCAA 7800

GGTGTAATCA AGACCCGAAA TAGAGTGACA GGGCTGCCGT TATCTATCGA AGGACATGTG 7860

CATTACCTTA TACAAGAAGC TACTGATGAA AACTTACTGT GCCAAATGTA CCTTGGTTGG 7920

ACCCCATATA TGTGA 7935

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         ia+fd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 2293  IASFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2352

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 2353  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2404

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 2405  ELRQCMLPKSAALSEKLKVFREFLLPRHPP-VFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2463

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 2464  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2522

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k++ +et+e

Q: 2523  MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAPLNETGE  2582

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 2583  VVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGH  2619

         ********************************99987

Domain Sequence
(FASTA)

IASFDDMVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KSAALSEKLK VFREFLLPRH PPVFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180

LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240

RRACEVTMRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAPLNETGE VVNEKAKTHV 300

LDIEQRLQGV IKTRNRVTGL PLSIEGH 327

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0001741	; C:XY body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

aml:100464897

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013