EKS-AIM-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	428.0	2.4E-128	112	431	320

Status

Unreviewed

Ensembl Protein

ENSAMEP00000013365

UniProt Accession

G1M204;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1B

Gene Synonyms/Alias

DYRK1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000012685	ENSAMEP00000013365	ENSAMET00000013923

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

629

Protein Sequence
(FASTA)

MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 60

EVYYAKKKRR AQQAPPQDDS STKKEKKVLN HGYDDDNHDY IVRSGERWLE RYEIDSLIGK 120

GSFGQVVKAY DHQTQELVAI KIIKNKKAFL NQAQIELRLL ELMNQHDTEM KYYIVHLKRH 180

FMFRNHLCLV FELLSYNLYD LLRNTHFRGV SLNLTRKLAQ QLCTALLFLA TPELSIIHCD 240

LKPENILLCN PKRSAIKIVD FGSSCQLGQR IYQYIQSRFY RSPEVLLGTP YDLAIDMWSL 300

GYILVEMHTG EPLFSGSNEV DQMNRIVEVL GIPPAPMLDQ APKARKYFER LPGGRWTLPR 360

TKELRKVLLF PRVCLPAPLG VQTGRPRGRW AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 420

SPLGALQHGF FRCAADEATN TGPAGSSAST SPTPLDTCPS SSTASSISSS GGSSGSSSDN 480

WNYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGAGA 540

QLPPQPRCLG RPPSPTSPPP PELMDVSLVG GPPDCSPPHP APASQHPAAS ALRTRMTGGR 600

PPLPPPDNPA TLGSHLGLRG VPQSTAASS 629

Nucleotide Sequence
(FASTA)

ATGGCCGTCC CACCAGGCCA TGGTCCCTTC TCTGGCTTCC CGGGGCCCCA GGAGCACACG 60

CAGGTATTGC CTGATGTGCG GCTGTTGCCA CGGAGGCTGC CCCTGGCCTT CCGGGATGCG 120

ACCTCAGCCC CACTGCGCAA GCTCTCCGTG GACCTCATCA AGACCTACAA GCACATCAAT 180

GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CACCACCTCA GGACGACTCG 240

AGCACCAAGA AGGAGAAGAA GGTCCTGAAC CATGGTTACG ACGATGACAA CCACGATTAC 300

ATTGTGCGCA GTGGTGAGCG CTGGCTGGAG CGCTACGAGA TTGACTCACT CATCGGCAAA 360

GGCTCCTTTG GCCAGGTGGT AAAAGCCTAT GATCATCAGA CCCAGGAGCT GGTGGCCATC 420

AAGATCATCA AGAACAAAAA GGCCTTCCTG AACCAGGCCC AGATTGAGCT GCGGCTGCTG 480

GAGCTGATGA ACCAGCACGA CACAGAGATG AAGTACTACA TAGTGCACCT GAAGCGGCAC 540

TTCATGTTCC GGAACCACCT GTGCCTGGTA TTCGAGCTGC TCTCCTACAA CCTGTACGAC 600

CTCCTGCGCA ACACGCACTT CCGCGGCGTC TCGCTGAACC TGACGCGGAA GCTGGCGCAG 660

CAGCTCTGCA CAGCGCTGCT CTTCCTGGCC ACGCCCGAGC TCAGCATCAT TCACTGCGAC 720

CTCAAGCCCG AGAACATCCT GCTCTGCAAC CCCAAGCGCA GCGCCATCAA GATCGTGGAT 780

TTTGGCAGCT CCTGCCAGCT TGGCCAGCGG ATCTATCAGT ACATCCAGAG CCGCTTCTAC 840

CGGTCACCTG AGGTGCTCCT GGGCACACCC TACGACCTGG CCATTGACAT GTGGTCCCTG 900

GGCTACATCC TGGTGGAGAT GCACACCGGA GAGCCCCTCT TCAGTGGCTC CAATGAGGTG 960

GACCAGATGA ACCGGATTGT GGAGGTGCTG GGCATCCCAC CAGCCCCCAT GTTGGACCAG 1020

GCACCCAAGG CTCGCAAGTA CTTTGAACGG CTGCCTGGGG GTCGCTGGAC CCTACCAAGG 1080

ACAAAGGAAC TCAGGAAGGT GCTTCTGTTT CCCCGTGTGT GTCTCCCTGC CCCTCTGGGC 1140

GTGCAGACGG GCAGGCCCCG GGGCCGGTGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 1200

TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 1260

AGCCCACTGG GGGCTCTGCA GCATGGCTTC TTCCGCTGCG CGGCTGATGA GGCCACCAAC 1320

ACGGGCCCAG CAGGCAGCAG TGCCTCCACC TCGCCCACAC CCCTTGACAC CTGTCCCTCC 1380

TCCAGCACCG CCAGCTCCAT CTCCAGCTCT GGAGGCTCCA GCGGCTCCTC CAGTGACAAC 1440

TGGAACTACC GATACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCCAT CACTGACTGT 1500

GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GCCCCTGGGC AGGGGGTGAT 1560

GTGCCCCACA AGACACATCA GGCCCCTGCC TCCGCCTCGT CACTGCCAGG GGCCGGGGCC 1620

CAGTTACCCC CCCAACCCCG ATGCCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 1680

CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTCCAG ACTGCTCCCC ACCTCACCCA 1740

GCGCCTGCCT CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC AGGAGGTCGT 1800

CCACCCCTTC CACCCCCTGA TAACCCTGCC ACTCTGGGGT CTCACTTGGG CCTCCGTGGT 1860

GTACCCCAGA GCACGGCAGC CAGCTCATGA 1890

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k

Q: 112   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  171

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+

Q: 172   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  231

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 232   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  290

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlG +l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +l++a ka+k+f++

Q: 291   YDLAIDMWSLGYILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAPMLDQAPKARKYFER  350

         ************************************************************

S: 239   keapkyilktkksdrkkklvlnvkkaa...kkrkaplskelgealkekedkl.fkdllkr  294

             +++l ++k+ rk+ l   v   a    +   p  + +ge+ ++ +d+l f+dl+ r

Q: 351   LPGGRWTLPRTKELRKVLLFPRVCLPAplgVQTGRPRGRWAGEPGHSPADYLrFQDLVLR  410

         **********9999999888877765411157788999999*******************

S: 295   mleldpakRitpkealkhpfv  315

         mle++pa+Ri+p  al+h f+

Q: 411   MLEYEPAARISPLGALQHGFF  431

         *******************97

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60

YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180

DLAIDMWSLG YILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAPMLDQA PKARKYFERL 240

PGGRWTLPRT KELRKVLLFP RVCLPAPLGV QTGRPRGRWA GEPGHSPADY LRFQDLVLRM 300

LEYEPAARIS PLGALQHGFF 320

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0003713	; F:transcription coactivator activity
GO:0007520	; P:myoblast fusion
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013