EKS-AIM-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	419.5	4.4E-126	137	390	254

Status

Unreviewed

Ensembl Protein

ENSAMEP00000014046

UniProt Accession

D2I0I7;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

FRK

Gene Synonyms/Alias

PANDA_018676;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000013338	ENSAMEP00000014052	ENSAMET00000014638
ENSAMEG00000013338	ENSAMEP00000014046	ENSAMET00000014632

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

408

Protein Sequence
(FASTA)

TLPLRQNRMQ ILHLSLFRWF FGAIKRTDAE KQLLYSENQT GAFLIRESES QKGDFALSVL 60

DEKVVKHYRI RRLDEGGFFL TQRRTFASLN EFVDYYTKTS NGLCVQLGKP CVKIQVPVPF 120

DLSYKTVDQW EIDRNSIQLL KRLGSGQFGE VWEGLWNNTT SVAVKTLKPG SMDPNDFLRE 180

AQIMKNLRHP KLIQLYAVCT LEDPIYIITE LMRHGSLQEY LQNDAGTKIH LTQQVDMAAQ 240

VASGMAYLES QNYIHRDLAA RNVLVGEHNI YKVADFGLAR VFKVDNEDIY ESKHEIKLPV 300

KWTAPEAIRA NKFSIKSDVW SFGILLYEII TYGKMPYSGM TGAQVIQMLG QNYRLPQPPN 360

CPPQFYNIMW ECWNAEPKER PTFEKLHWKL EDYFETDFSF SDTDNFVR 408

Nucleotide Sequence
(FASTA)

ACGTTACCTC TCAGACAGAA TAGAATGCAG ATTTTACATC TGTCTCTTTT TAGGTGGTTC 60

TTTGGAGCAA TCAAGAGAAC AGATGCAGAA AAACAACTAT TATATTCAGA AAATCAGACT 120

GGTGCCTTTC TAATCAGAGA AAGTGAAAGC CAGAAAGGAG ATTTCGCCCT TTCAGTTTTA 180

GATGAAAAGG TTGTGAAACA CTACAGAATC AGAAGACTGG ATGAAGGAGG GTTTTTCCTT 240

ACCCAGAGAA GAACCTTTGC ATCGTTGAAT GAATTTGTAG ACTACTACAC CAAGACAAGT 300

AATGGCCTGT GTGTCCAGCT GGGAAAACCA TGTGTAAAGA TACAAGTGCC AGTGCCTTTT 360

GATTTGTCGT ATAAAACCGT GGACCAGTGG GAGATAGACC GCAACTCCAT ACAGCTTCTG 420

AAGCGATTAG GATCTGGTCA GTTTGGCGAA GTGTGGGAAG GCCTGTGGAA CAATACCACT 480

TCGGTAGCAG TAAAAACATT AAAACCAGGT TCAATGGATC CAAATGACTT CCTGAGGGAA 540

GCACAGATAA TGAAGAATCT AAGACATCCA AAGCTTATCC AGCTTTATGC TGTTTGCACT 600

TTAGAAGATC CAATTTATAT TATTACAGAG TTGATGAGAC ATGGAAGTCT GCAAGAATAT 660

CTCCAAAATG ATGCTGGAAC AAAAATCCAT CTGACTCAGC AGGTAGATAT GGCCGCGCAG 720

GTTGCCTCTG GGATGGCTTA TCTGGAGTCC CAGAACTACA TTCACAGAGA TCTGGCTGCC 780

AGAAATGTCC TGGTTGGCGA ACATAATATC TACAAAGTTG CAGATTTTGG ACTTGCAAGG 840

GTTTTTAAGG TAGATAATGA AGACATCTAT GAATCCAAAC ACGAAATAAA GCTGCCAGTG 900

AAGTGGACTG CGCCCGAAGC CATTCGCGCT AATAAATTCA GCATTAAGTC CGATGTGTGG 960

TCATTTGGAA TCCTTCTTTA TGAAATCATT ACTTATGGCA AAATGCCTTA TAGTGGCATG 1020

ACAGGTGCTC AGGTAATCCA GATGTTGGGT CAAAACTATA GACTCCCTCA GCCACCTAAC 1080

TGTCCACCAC AATTCTACAA CATCATGTGG GAGTGTTGGA ACGCAGAGCC TAAGGAACGG 1140

CCAACATTTG AGAAACTGCA TTGGAAACTT GAAGACTATT TTGAAACAGA CTTTTCGTTT 1200

TCAGATACAG ATAACTTCGT AAGATGA 1227

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 137   IQLLKRLGSGQFGEVWEGLWNNTTSVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  196

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 197   AVCTLEDPIYIITELMRHGSLQEYLQNDAGTKIHLTQQVDMAAQVASGMAYLESQNYIHR  256

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+ +kf+ik

Q: 257   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRANKFSIK  316

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p +cp ++y+++ ecw+++

Q: 317   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLGQNYRLPQPPNCPPQFYNIMWECWNAE  376

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfe+l+++l

Q: 377   PKERPTFEKLHWKL  390

         **********9986

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTSVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG TKIHLTQQVD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRANKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLGQNYRLP QPPNCPPQFY NIMWECWNAE 240

PKERPTFEKL HWKL 254

Keyword

ATP-binding; Kinase; Nucleotide-binding; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

aml:100471968

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013