EKS-AIM-00206
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00206
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKN543.19.5E-164612871260
StatusUnreviewed
Ensembl ProteinENSAMEP00000014182
UniProt AccessionG1M4B7;
Protein Name
Protein Synonyms/Alias
Gene NamePKN1
Gene Synonyms/Alias PKN1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000013411ENSAMEP00000014182ENSAMET00000014781
OrganismAiluropoda melanoleuca
Functional Description
Protein Length939
Protein Sequence
(FASTA)
TRPHLPQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR 60
RAASLGPVEL LLRGSSRRLD LLHQQLQELY AHVVLPDPTA AARDAPQSPG AGSQACLATN 120
LSRVAGLEKQ LAIELKVKQG AENMIQTYSN GSTKDRKLLL TAQQMLQDSK TKIDIIRMQL 180
RRALQTGQLE SQAVPDEAQG SPDLGAVELR IEELRHHFRV EHAVAEGAKN VLRLLSAGKA 240
PDRKAVSEAQ EKLMESNQKL GLLREALERR LGELPADHPK GRLLREELAA ASSAAFSARL 300
AGPFPPMHYS TLCKPAPLTG TLEVRVVGCK DLPETIPWNP SPSVGGPGTP DSRTTFLSRP 360
ARGLYSRSGS LSGRSSLKVE AESTSDVSTV LKLDNTVVGQ TSWKPCGPSA WDQSFTLELE 420
RARELELAVF WRDQRGLCAL KFLKLEDFLD NERHEVQLDM EPQGCLLAEV TFRNPVIERI 480
PRLRRQKKIF SKQQGKTFQR ARQMNIDVAT WVRLLRRLIP NATGTGTFSP GASPGPEARS 540
TGDISVEKLN LGADLESLPQ KSPLGPPSSP SSLSSPIQET ATIPELPSET QETPGSTLCS 600
PLRKSPLTLE DFKFLAVLGR GHFGKVLLSE FRPSGELFAI KALKKGDIVA RDEVESLMCE 660
KRILAAVTRA GHPFLVNLFG CFQTPEHVCF VMEYSAGGDL MLHIHSDVFS EPRAIFYSAC 720
VVLGLQFLHE HKIVYRDLKL DNLLLDTEGY VKIADFGLCK EGMGYGDRTS TFCGTPEFLA 780
PEVLTDTSYT RAVDWWGLGV LLYEMLVGES PFPGDDEEEV FDSIVNDEVR YPRFLSAEAI 840
GIMRRLLRRN PERRLGSSER DAEDVKKQPF YRTLGWDTLL ARRLPPPFVP TLSGRTDVSN 900
FDEEFTGEAP TLSPPRDARP LTATEQAAFQ DFDFVAGGC 939
Nucleotide Sequence
(FASTA)
ACCAGGCCCC ATCTCCCGCA GAGCGAGCCG CGCAGCTGGT CCCTGCTGGA GCAGCTGGGC 60
CTGGCAGGGG CGGACCTGGC GGCTCCTGGG GTGCAGCAGC AGCTGGAGCT CGAGCGGGAG 120
CGGCTGCGGC GCGAGATCCG CAAGGAGCTG AAGCTGAAGG AGGGCGCCGA GAACCTGCGG 180
CGGGCCGCCA GCCTCGGCCC AGTGGAGCTG CTGCTGCGCG GCTCGTCCCG CCGGCTCGAC 240
CTGCTGCACC AGCAGCTGCA GGAGCTCTAC GCCCACGTGG TGCTGCCGGA CCCCACGGCC 300
GCTGCACGAG ATGCCCCCCA GTCCCCTGGT GCAGGTAGCC AGGCTTGCTT GGCCACCAAC 360
CTGAGCCGCG TGGCCGGCCT GGAGAAGCAG CTGGCCATCG AGCTGAAGGT GAAGCAGGGG 420
GCGGAAAACA TGATCCAGAC ATACAGCAAT GGCAGCACCA AGGACCGGAA GCTGCTGCTG 480
ACGGCCCAGC AGATGCTGCA GGACAGTAAG ACGAAGATCG ACATCATCCG CATGCAGCTC 540
CGCCGTGCGC TGCAGACCGG CCAGCTGGAG AGCCAGGCGG TCCCAGACGA GGCCCAAGGG 600
AGTCCAGACC TGGGGGCCGT GGAGCTGCGC ATCGAGGAGC TGAGGCACCA CTTCCGAGTG 660
GAGCACGCCG TGGCCGAGGG TGCCAAGAAC GTGCTCCGCC TGCTCAGCGC AGGCAAGGCC 720
CCGGACCGCA AGGCTGTCAG CGAGGCCCAG GAGAAGCTAA TGGAGTCCAA CCAGAAGCTG 780
GGGCTGCTGC GCGAGGCTCT GGAGCGGCGG CTCGGGGAGT TACCCGCAGA CCATCCGAAG 840
GGGCGGCTGC TGCGCGAGGA GCTTGCTGCG GCCTCCTCTG CAGCCTTCAG TGCTCGCCTG 900
GCTGGACCCT TCCCCCCCAT GCACTATAGC ACCCTGTGCA AACCCGCGCC ACTCACAGGA 960
ACCCTGGAGG TACGTGTGGT AGGCTGCAAG GACCTTCCAG AGACCATCCC CTGGAACCCC 1020
TCACCCTCGG TGGGGGGGCC CGGGACCCCT GACAGCCGCA CCACCTTCCT GAGCCGCCCA 1080
GCCCGGGGCC TTTACAGCCG AAGTGGAAGC CTCAGTGGCC GGAGCAGCCT CAAAGTGGAA 1140
GCCGAGAGCA CCAGCGACGT CAGCACTGTG CTCAAATTGG ATAACACAGT GGTGGGGCAG 1200
ACATCCTGGA AGCCATGTGG CCCCAGCGCC TGGGACCAGA GCTTCACTCT GGAGCTGGAA 1260
AGGGCTCGGG AACTGGAGTT GGCCGTGTTC TGGCGGGACC AACGGGGCCT GTGTGCCCTC 1320
AAATTCCTGA AGTTGGAGGA TTTCTTGGAC AACGAGAGGC ATGAGGTGCA GCTGGACATG 1380
GAACCCCAGG GCTGCCTGCT GGCCGAGGTT ACCTTCCGCA ACCCTGTCAT TGAGAGGATA 1440
CCCCGGCTCC GAAGGCAAAA GAAAATTTTT TCCAAGCAAC AAGGGAAAAC ATTTCAGCGC 1500
GCCAGGCAGA TGAACATTGA TGTTGCCACC TGGGTGCGGC TGCTTCGAAG ACTCATCCCC 1560
AATGCCACGG GCACAGGCAC CTTCAGCCCT GGGGCTTCTC CAGGACCCGA GGCCCGGTCC 1620
ACAGGTGATA TATCTGTGGA GAAGCTGAAC CTCGGGGCTG ACTTGGAGAG CTTGCCCCAG 1680
AAGAGTCCTC TGGGTCCTCC TTCCAGCCCC TCGAGCCTGA GTTCCCCAAT CCAGGAAACT 1740
GCCACCATCC CTGAGCTGCC TTCAGAGACC CAGGAGACCC CAGGCTCTAC CCTGTGCAGC 1800
CCTCTGAGGA AGTCACCCCT GACCCTCGAG GATTTCAAAT TCCTGGCAGT GCTGGGCCGG 1860
GGTCACTTTG GGAAGGTGCT GCTTTCCGAA TTCCGGCCCA GTGGGGAGCT GTTCGCCATC 1920
AAGGCTTTGA AGAAAGGCGA CATTGTGGCC CGAGATGAGG TTGAAAGCCT GATGTGTGAG 1980
AAGCGGATCT TGGCGGCAGT GACCAGAGCT GGACACCCCT TCCTGGTGAA CCTGTTCGGC 2040
TGTTTCCAGA CACCCGAGCA CGTGTGCTTC GTGATGGAGT ACTCAGCCGG CGGGGACCTG 2100
ATGTTGCACA TTCACAGTGA CGTGTTCTCG GAGCCTCGCG CCATCTTTTA TTCAGCCTGT 2160
GTGGTGCTGG GGTTGCAGTT TCTCCATGAA CACAAGATCG TGTACAGGGA CCTGAAGTTG 2220
GACAATTTGC TCCTGGACAC CGAGGGCTAT GTCAAGATCG CAGACTTTGG CCTCTGCAAG 2280
GAGGGGATGG GCTATGGGGA CCGGACCAGC ACATTCTGTG GGACCCCGGA GTTCCTGGCC 2340
CCTGAGGTGC TGACAGACAC ATCTTACACG CGGGCCGTGG ACTGGTGGGG CCTGGGCGTG 2400
CTGCTCTATG AGATGCTGGT TGGTGAGTCC CCATTCCCAG GGGACGACGA GGAGGAGGTG 2460
TTTGACAGCA TAGTCAATGA TGAGGTTCGC TACCCACGCT TCCTGTCAGC TGAAGCCATT 2520
GGCATCATGC GCAGGCTGCT GCGGAGGAAT CCAGAACGGA GGTTGGGGTC CAGCGAGAGG 2580
GATGCAGAGG ATGTGAAAAA GCAGCCCTTC TATAGGACAC TGGGTTGGGA CACTCTGCTG 2640
GCCCGGCGCT TGCCACCTCC CTTCGTGCCC ACGCTGTCAG GCCGCACTGA TGTCAGCAAC 2700
TTCGACGAGG AGTTCACAGG GGAGGCCCCC ACGCTGAGCC CGCCCCGCGA CGCGCGGCCC 2760
CTCACGGCCA CAGAGCAGGC AGCCTTCCAG GACTTCGACT TCGTGGCTGG GGGCTGCTAG 2820
Domain Profile
S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60
         f++lavlgrghfgkvllse++++gel+aikalkkgdi+ardevesl+cekril+av++++
Q: 612   FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTRAG  671
         89**********************************************************
S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120
         hpflvnl++cfqt ehvcfvmey+aggdlmlhih+dvfsepra+fy+acvvlglqflhe+
Q: 672   HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEH  731
         ************************************************************
S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180
         kivyrdlkldnllldtegyvkiadfglckeg+gygdrtstfcgtpeflapevlt+tsytr
Q: 732   KIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTR  791
         ************************************************************
S: 181   avdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsveaieilrrllrknp  240
         avdwwglgvllyemlvgespfpgddeeevfdsivndevryprfls+eai+i+rrllr+np
Q: 792   AVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNP  851
         ************************************************************
S: 241   ekrlgaserdaedvkkqpff  260
         e+rlg+serdaedvkkqpf+
Q: 852   ERRLGSSERDAEDVKKQPFY  871
         ******************97
Domain Sequence
(FASTA)
FKFLAVLGRG HFGKVLLSEF RPSGELFAIK ALKKGDIVAR DEVESLMCEK RILAAVTRAG 60
HPFLVNLFGC FQTPEHVCFV MEYSAGGDLM LHIHSDVFSE PRAIFYSACV VLGLQFLHEH 120
KIVYRDLKLD NLLLDTEGYV KIADFGLCKE GMGYGDRTST FCGTPEFLAP EVLTDTSYTR 180
AVDWWGLGVL LYEMLVGESP FPGDDEEEVF DSIVNDEVRY PRFLSAEAIG IMRRLLRRNP 240
ERRLGSSERD AEDVKKQPFY 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>
EKS-ANC-00213
EKS-BOT-00222
EKS-CAE-00188
EKS-CAJ-00223
EKS-CAF-00225
EKS-CAP-00246
EKS-CII-00131
EKS-FEC-00204
EKS-GOG-00213
EKS-HOS-00223
EKS-ICT-00212
EKS-LOA-00215
EKS-MAM-00224
EKS-MOD-00221
EKS-MUM-00225
EKS-MUP-00220
EKS-MYL-00224
EKS-NOL-00206
EKS-OTG-00228
EKS-PAT-00212
EKS-POA-00216
EKS-PTV-00190
EKS-RAN-00220
EKS-SAH-00209
EKS-TAR-00285
Gene Ontology
GO:0032154; C:cleavage furrow
GO:0016023; C:cytoplasmic membrane-bounded vesicle
GO:0005768; C:endosome
GO:0030496; C:midbody
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0003682; F:chromatin binding
GO:0035402; F:histone kinase activity (H3-T11 specific)
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0010631; P:epithelial cell migration
GO:0006972; P:hyperosmotic response
GO:2000145; P:regulation of cell motility
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 3.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00239; C2; 1.
SM00742; Hr1; 3.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013