EKS-AIM-00343
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00343
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src439.43.7E-132241490250
StatusUnreviewed
Ensembl ProteinENSAMEP00000014252
UniProt AccessionG1M4J6;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000013465ENSAMEP00000014252ENSAMET00000014851
ENSAMEG00000013465ENSAMEP00000014263ENSAMET00000014862
OrganismAiluropoda melanoleuca
Functional Description
Protein Length505
Protein Sequence
(FASTA)
RMGCMKSKFL QDRGKVSKTE PSTNPHSPVY VPDPTSTSKR RPDNGNNIPP GSTDAGPDDI 60
IVIALYDYEA IHHEDLSFQK GDQMVVLEES GEWWKARSLA TRKEGYIPSN YVARVNSLET 120
EEWFFKGISR KDAERQLLAP GNVLGSFMIR DSETTKGSYS LSVRDYDPQL RDAVKHYKIR 180
TLDSGGFYVS PRSTFGTLQE LVAHYKKGSD GLCQKLTVPC VSSKPQKPWE KDAWEIPRES 240
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 300
AVVTEEPIYI ITEFMAKGSL LDFLKSPEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 360
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 420
SFGILLMEIV TYGRIPYPGM TNPEVIRALE RGYRMPRPEH CPEELYNIMT RCWKNRPEER 480
PTFEYIQSVL DDFYTATESQ YQQQP 505
Nucleotide Sequence
(FASTA)
AGGATGGGGT GCATGAAGTC CAAATTCCTC CAGGACAGAG GCAAGGTCTC AAAAACTGAG 60
CCCAGCACCA ACCCACACAG CCCTGTGTAC GTGCCAGATC CCACGTCTAC CAGCAAGCGG 120
CGTCCTGACA ACGGCAACAA CATCCCACCA GGGTCCACGG ATGCAGGTCC TGATGACATC 180
ATTGTGATCG CCCTGTATGA TTACGAGGCC ATTCACCATG AAGACCTCAG TTTCCAGAAG 240
GGAGATCAGA TGGTGGTCCT GGAAGAGTCT GGGGAGTGGT GGAAGGCTCG ATCCCTGGCC 300
ACCCGGAAAG AAGGCTACAT CCCAAGCAAC TACGTCGCCC GAGTTAACTC TCTGGAGACA 360
GAGGAGTGGT TCTTCAAGGG CATCAGCAGG AAGGATGCAG AGCGCCAACT CCTGGCCCCA 420
GGCAACGTGC TGGGCTCCTT CATGATCCGG GACAGCGAGA CCACCAAAGG AAGCTACTCC 480
TTGTCTGTGC GAGACTATGA CCCCCAGCTC AGGGACGCGG TGAAACATTA CAAGATCCGG 540
ACCCTGGACA GTGGCGGCTT CTACGTCTCC CCGCGGAGCA CCTTCGGCAC GCTGCAGGAG 600
CTGGTGGCCC ACTACAAGAA GGGGAGTGAT GGACTGTGCC AGAAGCTGAC AGTGCCCTGC 660
GTATCCTCCA AGCCCCAGAA ACCATGGGAG AAAGATGCCT GGGAGATACC CCGGGAATCC 720
CTCAAGCTGG AGAAGAAACT TGGAGCTGGG CAGTTTGGGG AAGTCTGGAT GGCCACCTAC 780
AACAAGCACA CCAAGGTGGC TGTGAAGACG ATGAAGCCAG GGAGCATGTC CGTGGAGGCC 840
TTCCTGGCGG AGGCCAACCT CATGAAGACT CTGCAGCATG ACAAGCTGGT GAAGCTGCAC 900
GCAGTGGTCA CAGAGGAGCC CATCTACATC ATCACCGAGT TCATGGCCAA AGGGAGCCTG 960
CTGGACTTCC TGAAGAGCCC GGAGGGCAGC AAGCAGCCTT TGCCCAAGCT CATCGACTTC 1020
TCAGCTCAGA TTGCAGAAGG TATGGCCTTC ATCGAGCAGA GGAACTACAT TCACCGAGAC 1080
CTCCGAGCTG CCAACATCCT GGTCTCTGCG TCCCTGGTGT GTAAGATCGC CGACTTTGGC 1140
CTGGCACGTG TCATCGAGGA CAATGAGTAC ACGGCTCGGG AAGGGGCCAA GTTCCCCATC 1200
AAGTGGACAG CTCCCGAAGC CATCAACTTT GGCTCTTTCA CCATCAAGTC AGACGTCTGG 1260
TCCTTTGGTA TTCTGCTGAT GGAGATCGTC ACCTATGGCC GGATCCCTTA CCCAGGGATG 1320
ACGAACCCTG AGGTGATCCG GGCGCTGGAG CGCGGGTACC GCATGCCTCG ACCCGAGCAC 1380
TGCCCCGAGG AGCTCTACAA CATTATGACG CGCTGCTGGA AGAACCGCCC TGAGGAGCGG 1440
CCCACCTTCG AATATATCCA GAGCGTGCTG GACGACTTCT ACACGGCCAC GGAGAGCCAG 1500
TACCAACAGC AGCCGTGA 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 241   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makGslldflk+ eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 301   AVVTE-EPIYIITEFMAKGSLLDFLKSPEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 360   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  419
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGmtn ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 420   WSFGILLMEIVTYGRIPYPGMTNPEVIRALERGYRMPRPEHCPEELYNIMTRCWKNRPEE  479
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 480   RPTFEYIQSVL  490
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGSL LDFLKSPEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM TNPEVIRALE RGYRMPRPEH CPEELYNIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013