EKS-AIM-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	482.8	2.3E-145	90	344	255

Status

Unreviewed

Ensembl Protein

ENSAMEP00000014254

UniProt Accession

D2HVX2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB; PANDA_016569;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000013506	ENSAMEP00000014254	ENSAMET00000014853

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

397

Protein Sequence
(FASTA)

MAAYKELPCN QYTGTTALQK LEGFASRLFH RHSKSTAHDQ KTALENDSLH FSEHTALWDR 60

SMKEFLAKAK EDFLKKWENP APNNAGLEDF ERKKTLGTGS FGRVMLVKHK ATEQYYAMKI 120

LDKQKVVKLK QIEHTLNEKR ILQAVNFPFL VRLEYSFKDN SNLYMVMEYV PGGEMFSHLR 180

RIGRFSEPHA RFYAAQIVLT FEYLHSLDLI YRDLKPENLL IDHQGYIQVT DFGFAKRVKG 240

RTWTLCGTPE YLAPEIILSK GYNKAVDWWA LGVLIYEMAA GYPPFFADQP IQIYEKIVSG 300

KVRFPSHFSS DLKDLLRNLL QVDLTKRFGN LKNGVSDIKT HKWFATTDWI AIYQRKVEAP 360

FIPKFRGSGD TSNFDDYEEE DIRVSITEKC AKEFCEF 397

Nucleotide Sequence
(FASTA)

ATGGCAGCTT ATAAAGAACT ACCCTGTAAC CAGTATACAG GTACAACTGC TCTTCAGAAA 60

TTGGAAGGTT TTGCTAGCCG ATTATTTCAT AGACATTCTA AAAGTACTGC ACATGATCAG 120

AAAACTGCTC TGGAAAATGA CAGCCTTCAT TTCTCTGAAC ATACTGCTTT ATGGGACAGA 180

TCAATGAAAG AGTTTCTAGC CAAAGCCAAA GAAGACTTTC TTAAAAAATG GGAAAATCCT 240

GCTCCGAATA ATGCTGGACT GGAGGATTTT GAAAGGAAAA AAACCCTTGG AACAGGTTCA 300

TTTGGAAGAG TCATGTTGGT GAAACATAAA GCCACTGAAC AGTATTATGC CATGAAGATC 360

TTAGATAAGC AGAAGGTTGT TAAACTGAAG CAAATAGAGC ATACCTTGAA TGAGAAAAGA 420

ATATTACAGG CAGTGAATTT TCCTTTTCTT GTTCGACTGG AGTACTCTTT TAAGGATAAT 480

TCTAATTTAT ACATGGTTAT GGAATATGTC CCTGGGGGTG AAATGTTTTC CCATCTAAGA 540

AGAATTGGAA GGTTCAGTGA ACCCCATGCA CGGTTCTATG CAGCTCAGAT AGTGCTAACA 600

TTCGAGTACC TCCATTCACT AGACCTCATC TACAGAGATC TAAAACCTGA AAATCTCTTA 660

ATTGACCACC AAGGGTATAT CCAGGTTACA GACTTTGGGT TTGCCAAAAG AGTTAAAGGC 720

AGAACTTGGA CATTATGTGG CACTCCAGAA TATTTGGCTC CAGAGATAAT CCTCAGCAAG 780

GGCTACAATA AGGCAGTGGA TTGGTGGGCA TTAGGTGTGT TAATCTATGA AATGGCAGCT 840

GGCTACCCCC CATTCTTTGC AGACCAACCA ATTCAGATTT ATGAAAAGAT TGTTTCTGGA 900

AAGGTCCGAT TCCCATCGCA CTTCAGTTCA GATCTCAAGG ACCTTCTAAG GAACCTGCTG 960

CAGGTGGATT TGACGAAGCG GTTTGGAAAC CTGAAGAATG GTGTGAGTGA TATAAAAACT 1020

CACAAGTGGT TTGCCACCAC AGATTGGATT GCTATTTACC AGAGGAAGGT TGAAGCACCA 1080

TTCATACCAA AGTTCAGAGG CTCTGGAGAT ACCAGCAACT TCGATGACTA TGAAGAAGAA 1140

GATATCCGCG TCTCTATAAC AGAAAAATGT GCAAAAGAGT TTTGTGAATT TTAA 1194

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 90    FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  149

         799*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l++sfkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 150   LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  209

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 210   IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  269

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 270   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG  329

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 330   NLKNGVSDIKTHKWF  344

         **************9

Domain Sequence
(FASTA)

FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVRLEYSFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240

NLKNGVSDIK THKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding

KEGG

aml:100469628

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013