EKS-AIM-00038

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00038

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	354.2	4.0E-106	162	427	266

Status

Unreviewed

Ensembl Protein

ENSAMEP00000014260

UniProt Accession

D2H7T9;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

VRK3

Gene Synonyms/Alias

PANDA_006247;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000013521	ENSAMEP00000014260	ENSAMET00000014859

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MITFCPDCGK SIKAAFKFCP YCGKPLSAEE HEGSQTFLRP IRSSFGGSRR QSNTSPEIPS 60

KKVKWSGSVT FPSSSLCLDG DSSGSEDTMR SKGSWSRPPT PKSSPQATRR SPQATKRSPQ 120

ATKRSPQATK RSPQTLKRSR VTTSLEALPT GTLMRDKSGR HWKLGPLQTR DDQGILYEAE 180

ALSSFACKSS QKQTFSLKLD AKDGRLFNEQ NFFQRAAKPL QVNKWKKLNA IPLLAIPTCV 240

GFGIHQDKYR FLVFPMLGRS LQSALDDSPR HVMSVKCVFQ MACRLLDALE FLHENEYVHG 300

NVTAENIFVN PEDLSQVMLA GYGFAFRYAP GGRHVAYVEG SRSPHEGDLE FISLDLHRGC 360

GPSRRSDLET LGYCLLKWLY GFLPWTKCLP NIEAIMKLKQ KFLENPETLV GHCSRWICPS 420

ETLQEYMKVV MNLEYDEKPP YTMLRNNLEA LLQDLRVSAY DPVDLQMVP 469

Nucleotide Sequence
(FASTA)

ATGATCACCT TCTGTCCAGA CTGTGGCAAA AGTATCAAAG CAGCATTCAA ATTCTGCCCC 60

TACTGTGGAA AACCTTTGTC TGCAGAGGAG CATGAAGGGT CCCAGACCTT TCTCAGACCA 120

ATTAGGTCAT CCTTCGGAGG CTCAAGGAGA CAGAGCAACA CCAGTCCTGA GATCCCTTCC 180

AAGAAAGTGA AATGGTCTGG CTCAGTCACC TTCCCCTCAT CCTCCCTTTG CTTGGATGGT 240

GACAGTTCTG GGTCTGAAGA TACCATGAGA TCCAAAGGGT CCTGGAGCAG ACCCCCAACC 300

CCCAAAAGCA GCCCGCAGGC GACCAGGCGA AGCCCGCAGG CAACCAAGAG AAGCCCTCAG 360

GCGACCAAGA GAAGCCCACA GGCAACCAAG AGAAGCCCGC AGACACTGAA GCGGAGCCGG 420

GTGACTACCT CGCTTGAGGC TCTACCCACA GGGACGCTGA TGAGAGACAA GAGTGGGCGG 480

CACTGGAAGC TGGGACCCCT CCAGACCAGG GACGACCAGG GCATTCTCTA TGAAGCTGAG 540

GCTCTCTCCT CCTTCGCCTG CAAGTCAAGT CAGAAACAAA CGTTCTCACT TAAACTTGAT 600

GCCAAGGATG GGCGCTTGTT CAACGAGCAG AACTTCTTCC AGCGGGCCGC CAAGCCTTTG 660

CAAGTGAACA AGTGGAAGAA GCTGAACGCA ATCCCCCTAC TGGCCATCCC CACCTGCGTC 720

GGTTTTGGCA TTCACCAGGA CAAGTACAGG TTCTTGGTGT TTCCCATGCT GGGGAGGAGC 780

CTTCAGTCGG CCCTGGATGA CAGCCCAAGG CATGTAATGT CGGTGAAGTG TGTGTTCCAG 840

ATGGCCTGCC GGCTGCTGGA TGCCCTGGAG TTCCTTCATG AGAATGAGTA TGTCCATGGA 900

AATGTGACAG CTGAGAACAT CTTTGTGAAT CCAGAGGACC TGAGCCAGGT GATGCTGGCA 960

GGCTATGGCT TCGCCTTCCG CTATGCCCCC GGCGGCAGAC ACGTGGCCTA CGTGGAAGGC 1020

AGCAGGAGCC CACATGAGGG GGATCTCGAG TTCATTAGCC TTGACCTGCA CAGGGGATGT 1080

GGGCCCTCCC GCCGCAGTGA CCTCGAGACC CTGGGCTACT GTTTGTTGAA GTGGCTGTAT 1140

GGGTTCCTGC CGTGGACAAA GTGCCTTCCC AACATCGAGG CTATCATGAA GCTGAAACAG 1200

AAGTTTCTTG AAAACCCGGA GACCCTCGTG GGACACTGCA GTCGCTGGAT CTGTCCCTCA 1260

GAGACCCTGC AGGAGTACAT GAAGGTGGTG ATGAACCTTG AGTATGACGA GAAGCCTCCC 1320

TACACCATGC TGAGGAACAA TCTAGAAGCC CTGCTGCAGG ACCTGCGGGT ATCTGCTTAC 1380

GACCCTGTGG ACCTCCAGAT GGTTCCATAG 1410

Domain Profile

S: 1     wklgkkigkggfGeiyla.....ltckkeekdaklvvkvepkenGpLfvelkfyqraakk  55

         wklg  ++++++G++y+a     ++ck +++++++++k+++k+ G+Lf+e++f+qraak+

Q: 162   WKLGPLQTRDDQGILYEAealssFACK-SSQKQTFSLKLDAKD-GRLFNEQNFFQRAAKP  219

         9*****************998866665.567899********9.****************

S: 56    eqikkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkr.lsek  114

          q++kwkk + ++ll+iPt++++G+h+   +kyRflv+p lgr+Lq++l++++++ +s k

Q: 220   LQVNKWKKLNAIPLLAIPTCVGFGIHQ---DKYRFLVFPMLGRSLQSALDDSPRHvMSVK  276

         ***************************...*************************8999*

S: 115   tvlqlavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhke  174

         +v+q+a+rlld+le+lHeneYvHg+++A+n+++++e+ sqv+L++yG+a+ry+p+g+h++

Q: 277   CVFQMACRLLDALEFLHENEYVHGNVTAENIFVNPEDLSQVMLAGYGFAFRYAPGGRHVA  336

         ************************************************************

S: 175   ykedkrraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvq  234

         y+e++r++H+G+lef+slD+H+G++psrRsDle+LgYcllkWl+g+LPW+++l++ e+++

Q: 337   YVEGSRSPHEGDLEFISLDLHRGCGPSRRSDLETLGYCLLKWLYGFLPWTKCLPNIEAIM  396

         ************************************************************

S: 235   kakekfldelpellkkllkkkssseelakyl  265

         k k+kfl+++++l+ ++ ++  +se+l++y+

Q: 397   KLKQKFLENPETLVGHCSRWICPSETLQEYM  427

         ******************************7

Domain Sequence
(FASTA)

WKLGPLQTRD DQGILYEAEA LSSFACKSSQ KQTFSLKLDA KDGRLFNEQN FFQRAAKPLQ 60

VNKWKKLNAI PLLAIPTCVG FGIHQDKYRF LVFPMLGRSL QSALDDSPRH VMSVKCVFQM 120

ACRLLDALEF LHENEYVHGN VTAENIFVNP EDLSQVMLAG YGFAFRYAPG GRHVAYVEGS 180

RSPHEGDLEF ISLDLHRGCG PSRRSDLETL GYCLLKWLYG FLPWTKCLPN IEAIMKLKQK 240

FLENPETLVG HCSRWICPSE TLQEYM 266

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR026870	; Zinc_ribbon_dom.

Pfam

PF00069	; Pkinase; 1.
PF13240	; zinc_ribbon_2; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013