EKS-AIM-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	509.5	1.8E-153	470	752	283

Status

Unreviewed

Ensembl Protein

ENSAMEP00000014966

UniProt Accession

G1M6J6;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014119	ENSAMEP00000014966	ENSAMET00000015582

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

810

Protein Sequence
(FASTA)

PLVWAVGLPW CLPGGGCQAP RIPVLGVPAL GSSVLSTEAP GPELGQQEQL VFGSGDTVEL 60

SCHSPAGGPT GPSVWVKDGV GLVPSDRILV GPQRLQVLNA SHEDAGAYSC RQRLTQRVLC 120

HFSVRVTDAP SSGDDEDGED EAEDTAGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP 180

TPSISWLKNG KEFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT 240

LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE VNGSKVGPDG 300

TPYVTVLKTA GANTTDKELE VLSLRNVTFE DAGEYTCLAG NSIGFSHHSA WLVVLPAEEE 360

LVEAGEAGSV YAGVLSYGVG FLLFILVVAA VTLCRLRTPP KKGLGSPTVH KVSRFPLKRQ 420

VSLESNSSMN SNTPLVRIAR LSSGEGPALA NVSELELPAD PKWELSRARL TLGKPLGEGC 480

FGQVVMAEER GGRGGLWQGG LDRAGQWRLT PSVRADDATD KDLSDLVSEM EMMKMIGRHK 540

NIINLLGACT QGGPLYVLVE YAAKGNLREY LRARRPPGMD YSFDTCKLPE EQLTCKDLVS 600

CAYQVARGME YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL 660

PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP 720

ANCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRILTVTS TDEYLDLSVP FEQYSPGGQD 780

TPSSSSSGDD SVFAHDLLPP APPGSGGPRT 810

Nucleotide Sequence
(FASTA)

CCGCTTGTCT GGGCAGTGGG CCTGCCATGG TGCCTCCCGG GGGGGGGGTG CCAGGCGCCC 60

AGGATTCCTG TTTTGGGGGT GCCTGCCTTA GGGTCATCTG TGCTCTCTAC AGAGGCCCCG 120

GGACCTGAGC TTGGCCAGCA GGAGCAGCTG GTCTTTGGCA GTGGGGACAC TGTGGAGCTG 180

AGCTGCCATT CGCCTGCCGG TGGTCCCACG GGGCCCAGCG TCTGGGTCAA GGACGGTGTG 240

GGGCTGGTTC CCTCAGACCG CATCCTGGTG GGGCCGCAGC GGCTGCAGGT GCTCAATGCC 300

TCCCATGAGG ACGCCGGGGC CTACAGCTGC CGGCAGCGGC TCACCCAACG CGTTCTCTGC 360

CACTTCAGCG TGCGCGTGAC AGATGCTCCG TCGTCTGGAG ACGACGAAGA CGGGGAGGAT 420

GAGGCTGAAG ATACAGCAGG GGCCCCCTAC TGGACACGGC CCGAGCGGAT GGACAAGAAG 480

CTGCTGGCGG TGCCTGCCGC CAACACCGTG CGCTTCCGGT GCCCGGCCGC CGGCAACCCC 540

ACGCCATCCA TCTCCTGGCT GAAGAACGGC AAGGAGTTCC GAGGCGAGCA CCGCATCGGG 600

GGCATCAAGC TGCGGCACCA GCAGTGGAGC CTGGTCATGG AGAGCGTGGT GCCCTCCGAC 660

CGCGGGAACT ACACGTGTGT CGTGGAGAAC AAGTTCGGCA GCATCCGGCA GACCTACACC 720

CTGGACGTGC TGGAGCGCTC TCCGCACCGG CCCATCCTGC AGGCCGGGCT GCCCGCCAAT 780

CAGACGGCCG TGCTGGGCAG CGACGTGGAG TTCCACTGCA AGGTGTACAG TGACGCGCAG 840

CCCCACATCC AGTGGCTCAA GCACGTGGAG GTGAACGGCA GCAAAGTGGG GCCCGATGGC 900

ACCCCCTACG TCACCGTGCT CAAGACGGCG GGCGCTAACA CCACCGACAA GGAGCTAGAG 960

GTGCTGTCCT TGCGCAATGT CACCTTTGAG GACGCGGGGG AGTACACGTG TCTGGCGGGC 1020

AATTCTATCG GGTTTTCCCA TCACTCTGCG TGGCTGGTGG TGCTGCCAGC CGAGGAGGAG 1080

CTGGTGGAGG CTGGTGAGGC TGGCAGCGTG TACGCGGGAG TCCTCAGCTA TGGGGTGGGC 1140

TTCCTCCTCT TCATCCTGGT GGTGGCGGCC GTGACACTGT GCCGCCTGCG CACGCCCCCG 1200

AAGAAGGGTC TGGGCTCGCC CACCGTGCAC AAGGTCTCCC GCTTCCCGCT CAAGCGACAG 1260

GTGTCCTTGG AGTCCAACTC GTCCATGAAC TCCAACACGC CACTGGTGCG CATTGCCCGG 1320

CTGTCTTCTG GGGAGGGCCC TGCGCTGGCC AACGTCTCCG AGCTGGAGTT GCCTGCTGAC 1380

CCCAAGTGGG AGCTGTCCCG GGCCCGGCTG ACCCTGGGTA AGCCTCTTGG GGAGGGCTGC 1440

TTCGGCCAAG TGGTCATGGC GGAGGAAAGG GGAGGGAGGG GAGGGCTGTG GCAGGGGGGC 1500

CTGGACAGGG CCGGGCAGTG GCGCCTGACA CCCTCCGTCC GCGCAGACGA CGCCACGGAC 1560

AAGGACCTCT CGGACCTGGT GTCTGAGATG GAGATGATGA AGATGATCGG CCGGCACAAG 1620

AACATCATCA ACCTGCTGGG GGCCTGCACC CAGGGCGGGC CCCTGTACGT GCTGGTGGAG 1680

TACGCGGCCA AGGGCAACCT GAGGGAGTAC CTGCGGGCAC GGCGGCCCCC GGGCATGGAC 1740

TACTCCTTCG ACACCTGCAA GCTGCCGGAG GAGCAGCTCA CCTGCAAGGA CCTGGTGTCC 1800

TGCGCCTACC AGGTGGCCCG CGGCATGGAG TACCTGGCCT CGCAGAAGTG CATCCACAGG 1860

GACCTGGCCG CACGCAATGT GCTGGTGACG GAGGACAACG TGATGAAGAT TGCGGACTTC 1920

GGCCTGGCCC GTGACGTGCA CAACCTTGAC TACTACAAAA AGACCACCAA CGGCCGGCTG 1980

CCCGTGAAGT GGATGGCGCC TGAGGCCTTG TTTGACCGCG TCTACACCCA CCAGAGTGAC 2040

GTCTGGTCCT TTGGGGTCCT GCTGTGGGAG ATCTTCACCC TGGGGGGCTC GCCATACCCC 2100

GGCATCCCCG TGGAGGAGCT CTTCAAGCTG CTGAAGGAGG GTCACCGCAT GGACAAGCCG 2160

GCCAACTGCA CACACGACCT GTACATGATT ATGCGGGAGT GTTGGCACGC GGTGCCCTCC 2220

CAGAGGCCCA CCTTCAAGCA GCTGGTGGAG GACCTGGACC GCATCCTCAC CGTGACGTCC 2280

ACGGATGAGT ACCTGGACCT GTCCGTGCCT TTCGAGCAGT ACTCGCCAGG CGGCCAGGAC 2340

ACCCCCAGCT CCAGCTCCTC GGGGGACGAC TCTGTGTTTG CCCATGACCT GCTGCCTCCA 2400

GCCCCACCTG GCAGTGGGGG CCCGCGGACG TGA 2433

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaig....ldkdkekk..evtvavkmlkedatdkdladlvse  54

         l+lgk+lGeG+fGqvv+ae  g    l +   ++  +  ++  +  +datdkdl+dlvse

Q: 470   LTLGKPLGEGCFGQVVMAEERGgrggLWQGGLDRagQWRLTPSVRADDATDKDLSDLVSE  529

         79*****************8752222444333331134455556679*************

S: 55    mevlkliGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskas  114

         me++k+iG+hkniinllGactq+Gplyv+veyaakGnlre+lrarrp+g+++s d++k +

Q: 530   MEMMKMIGRHKNIINLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGMDYSFDTCKLP  589

         ************************************************************

S: 115   eeqltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvhei  174

         eeqlt+kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++

Q: 590   EEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL  649

         ************************************************************

S: 175   dyykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfk  234

         dyykkttnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfk

Q: 650   DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFK  709

         ************************************************************

S: 235   llkeGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         llkeGhrm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 710   LLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  752

         *****************************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEE RGGRGGLWQG GLDRAGQWRL TPSVRADDAT DKDLSDLVSE 60

MEMMKMIGRH KNIINLLGAC TQGGPLYVLV EYAAKGNLRE YLRARRPPGM DYSFDTCKLP 120

EEQLTCKDLV SCAYQVARGM EYLASQKCIH RDLAARNVLV TEDNVMKIAD FGLARDVHNL 180

DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS DVWSFGVLLW EIFTLGGSPY PGIPVEELFK 240

LLKEGHRMDK PANCTHDLYM IMRECWHAVP SQRPTFKQLV EDL 283

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0009898	; C:internal side of plasma membrane
GO:0005764	; C:lysosome
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0061144	; P:alveolar secondary septum development
GO:0060385	; P:axonogenesis involved in innervation
GO:0060349	; P:bone morphogenesis
GO:0051216	; P:cartilage development
GO:0022010	; P:central nervous system myelination
GO:0090102	; P:cochlea development
GO:0048546	; P:digestive tract morphogenesis
GO:0072148	; P:epithelial cell fate commitment
GO:0060113	; P:inner ear receptor cell differentiation
GO:0070307	; P:lens fiber cell development
GO:0002089	; P:lens morphogenesis in camera-type eye
GO:0000165	; P:MAPK cascade
GO:0002009	; P:morphogenesis of an epithelium
GO:0043066	; P:negative regulation of apoptotic process
GO:0048712	; P:negative regulation of astrocyte differentiation
GO:0050680	; P:negative regulation of epithelial cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597	; P:positive regulation of cell differentiation
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518	; P:positive regulation of phospholipase activity
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0042511	; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777	; P:protein autophosphorylation
GO:0048678	; P:response to axon injury
GO:0035019	; P:somatic stem cell maintenance
GO:0021762	; P:substantia nigra development

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013