EKS-AIM-00160
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00160
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC481.47.4E-14568326259
StatusUnreviewed
Ensembl ProteinENSAMEP00000014940
UniProt AccessionG1M6H5;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000014177ENSAMEP00000014945ENSAMET00000015560
ENSAMEG00000014177ENSAMEP00000014940ENSAMET00000015554
OrganismAiluropoda melanoleuca
Functional Description
Protein Length397
Protein Sequence
(FASTA)
FKLLSQEEGE YFNVPVPPEG SEGNEELRQK FERAKISQGT KAPEEKTTNT ISKLDNNGNR 60
DRMKLTDFNF LMVLGKGSFG KVMLSERKGT DELYAVKILK KDVVIQDDDV ECTMVEKRVL 120
ALPGKPPFLT QLHSCFQTMD RLYFVMEYVN GGDLMYHIQQ VGRFKEPHAV FYAAEIAIGL 180
FFLQSKGIIY RDLKLDNVML DSEGHIKIAD FGMCKENIWD GVTTKTFCGT PDYIAPEIIA 240
YQPYGKSVDW WAFGVLLYEM LAGQAPFEGE DEDELFQSIM EHNVAYPKSM SKEAVAICKG 300
LMTKHPGKRL GCGPEGERDI KEHAFFRYID WEKLERKEIQ PPYKPKARDK RDTSNFDKEF 360
TRQPVELTPT DKLFIMNLDQ NEFAGFSYTN PEFVINV 397
Nucleotide Sequence
(FASTA)
TTTAAGCTGC TGAGCCAGGA GGAAGGCGAA TACTTCAATG TGCCTGTGCC GCCGGAAGGA 60
AGCGAAGGCA ATGAAGAGCT GCGGCAGAAA TTCGAGAGGG CCAAGATCAG TCAGGGGACC 120
AAGGCTCCAG AAGAAAAGAC GACCAACACC ATATCCAAAC TTGACAACAA CGGGAACAGA 180
GACCGAATGA AACTGACCGA TTTTAACTTC CTGATGGTGC TCGGGAAAGG AAGCTTTGGA 240
AAGGTCATGC TCTCTGAGCG AAAAGGCACG GACGAGCTCT ATGCCGTGAA GATCCTGAAG 300
AAGGACGTCG TGATCCAGGA TGACGATGTG GAGTGCACGA TGGTGGAGAA GCGGGTGCTG 360
GCCCTGCCTG GGAAGCCGCC ATTCCTGACC CAACTGCATT CCTGCTTCCA GACCATGGAC 420
CGCCTGTACT TTGTGATGGA GTATGTGAAC GGGGGCGACC TCATGTACCA CATCCAACAA 480
GTCGGCCGGT TTAAGGAGCC TCATGCTGTA TTTTACGCTG CAGAAATTGC CATCGGTCTG 540
TTCTTCTTAC AGAGCAAGGG CATCATTTAC CGTGACCTCA AACTTGACAA TGTGATGCTG 600
GATTCAGAGG GCCACATCAA GATTGCTGAT TTTGGCATGT GCAAAGAAAA CATCTGGGAT 660
GGGGTGACCA CCAAGACATT CTGTGGCACT CCAGACTACA TCGCCCCTGA GATCATTGCC 720
TACCAGCCCT ATGGGAAGTC TGTGGATTGG TGGGCCTTCG GAGTCCTGCT GTACGAAATG 780
TTGGCTGGGC AGGCACCCTT TGAAGGGGAG GATGAGGATG AGCTCTTCCA GTCCATCATG 840
GAACACAATG TGGCTTACCC CAAGTCCATG TCCAAGGAAG CTGTGGCCAT CTGCAAAGGG 900
CTGATGACCA AACACCCGGG CAAACGTCTG GGTTGCGGAC CCGAAGGTGA ACGTGACATC 960
AAGGAGCATG CGTTTTTCCG GTATATTGAT TGGGAGAAAC TTGAACGCAA AGAGATTCAG 1020
CCCCCGTATA AGCCAAAAGC CAGAGACAAG CGAGACACCT CCAACTTCGA CAAAGAGTTC 1080
ACCAGACAGC CTGTGGAACT CACGCCTACC GATAAACTCT TCATCATGAA CTTGGACCAA 1140
AATGAATTTG CTGGCTTCTC CTATACTAAC CCAGAGTTTG TCATTAATGT GTAG 1194
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 68    FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  127
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 128   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  187
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 188   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  247
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 248   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  307
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 308   KRLGCGPEGERDIKEHAFF  326
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0003682; F:chromatin binding
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0042113; P:B cell activation
GO:0050853; P:B cell receptor signaling pathway
GO:0006816; P:calcium ion transport
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0035556; P:intracellular signal transduction
GO:0010829; P:negative regulation of glucose transport
GO:0045766; P:positive regulation of angiogenesis
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013