EKS-AIM-00036

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00036

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	436.0	4.4E-131	37	303	267

Status

Unreviewed

Ensembl Protein

ENSAMEP00000014979

UniProt Accession

G1M6K9;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK1

Gene Synonyms/Alias

VRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014202	ENSAMEP00000014979	ENSAMET00000015596

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

446

Protein Sequence
(FASTA)

MPRVKAAQAG RQGPGKRRLA EHFAAGEIIT DMMKKEWKLG SPIGQGGFGC IYLADMNSSK 60

SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD 120

KNGKSYRFMI MDRFGSDLQK IYEANARRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180

SNLLLSYKNP DQVYLVDYGL AYRYCPDGIH KEYKEDPKRC HDGTIEFTSI DAHNGVAPSR 240

RGDLEILGYC MIQWLSGHLP WEDNLKDPNY VRDSKIRYRD NIADLMDKCF PERSKPDEIA 300

KYMETVKLLD YAEKPLYQNL RDTLLQGLRA IGSKDDGKLD LSLMENGGLR AKSITKKIFI 360

CNKRKKGIEE STESSVEDME CSEVQTEEAI KTRSEESRGA VHGSLSQPEA SSSSYDSEWE 420

QKALINDLNF FVFSLQGSKT RKRVQK 446

Nucleotide Sequence
(FASTA)

ATGCCTCGTG TAAAAGCAGC TCAAGCTGGA AGACAGGGCC CTGGAAAGAG ACGACTTGCA 60

GAACACTTTG CAGCTGGGGA GATAATCACT GACATGATGA AGAAGGAGTG GAAACTAGGA 120

TCGCCCATTG GCCAGGGTGG CTTCGGTTGT ATATATCTTG CTGATATGAA TTCTTCAAAA 180

TCGGTGGGCA GCGATGCACC TTGTGTTGTA AAAGTGGAGC CCAGTGACAA CGGACCTCTC 240

TTTACTGAAC TGAAGTTCTA CCAGCGAGCT GCCAAACCAG AGCAAATTCA GAAGTGGATT 300

CGTACCCATA AACTGAAGTA CCTGGGTGTT CCTAAGTATT GGGGGTCGGG CCTACATGAT 360

AAAAATGGAA AGAGCTACAG GTTTATGATA ATGGATCGCT TTGGGAGTGA CCTTCAGAAA 420

ATATATGAAG CAAATGCCAG AAGGTTTTCT CGGAAAACTG TCTTGCAGCT AAGCTTGAGA 480

ATTCTGGATA TTCTGGAATA TATTCACGAG CATGAGTATG TACACGGAGA TATCAAGGCC 540

TCAAATCTTC TTTTGAGCTA CAAGAATCCC GACCAGGTGT ACTTGGTAGA TTACGGCCTT 600

GCTTACCGGT ATTGCCCAGA TGGAATTCAT AAAGAATACA AAGAAGACCC CAAAAGATGT 660

CACGATGGCA CTATTGAATT CACCAGCATT GATGCGCACA ATGGTGTTGC CCCGTCAAGA 720

CGTGGTGATT TGGAAATCCT TGGTTATTGC ATGATCCAGT GGCTTAGTGG CCATCTTCCT 780

TGGGAGGATA ATTTGAAAGA TCCCAACTAT GTTAGAGATT CCAAAATTAG ATATAGAGAT 840

AATATTGCAG ATTTGATGGA CAAATGTTTT CCTGAGAGAA GCAAGCCAGA TGAGATTGCT 900

AAATACATGG AAACAGTGAA ATTACTGGAC TATGCCGAGA AACCTCTTTA TCAGAACTTG 960

CGAGACACTC TTTTGCAAGG ACTGAGAGCT ATAGGAAGCA AGGATGACGG CAAGCTGGAC 1020

CTCAGCCTCA TGGAGAACGG GGGCTTGAGA GCAAAGTCAA TAACGAAGAA AATCTTTATA 1080

TGTAACAAGC GCAAGAAAGG AATTGAGGAG AGCACCGAAT CCAGTGTTGA AGATATGGAA 1140

TGCTCAGAGG TCCAGACAGA AGAGGCCATA AAAACTCGAA GTGAGGAGTC CCGAGGAGCA 1200

GTGCATGGAA GCCTGTCTCA GCCAGAGGCT AGCAGCAGCA GCTATGACAG TGAGTGGGAG 1260

CAAAAAGCTT TAATTAATGA TTTGAATTTC TTTGTTTTTT CTCTTCAAGG TTCAAAAACC 1320

AGAAAGAGAG TCCAGAAGTA A 1341

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wklg++ig+ggfG+iyla  +++k++++da +vvkvep++nGpLf+elkfyqraak+eqi

Q: 37    WKLGSPIGQGGFGCIYLAdmNSSKSVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI  96

         9*****************9999**************************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n++r+s+ktvlq

Q: 97    QKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANARRFSRKTVLQ  156

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycp+g hkeyked

Q: 157   LSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPDGIHKEYKED  216

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGt+efts+DaH+GvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp++v+++k

Q: 217   PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGHLPWEDNLKDPNYVRDSKI  276

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

         ++ d++++l++k+++++s++ e+aky+

Q: 277   RYRDNIADLMDKCFPERSKPDEIAKYM  303

         **************************8

Domain Sequence
(FASTA)

WKLGSPIGQG GFGCIYLADM NSSKSVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60

QKWIRTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA RRFSRKTVLQ 120

LSLRILDILE YIHEHEYVHG DIKASNLLLS YKNPDQVYLV DYGLAYRYCP DGIHKEYKED 180

PKRCHDGTIE FTSIDAHNGV APSRRGDLEI LGYCMIQWLS GHLPWEDNLK DPNYVRDSKI 240

RYRDNIADLM DKCFPERSKP DEIAKYM 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013