EKS-AIM-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	426.3	4.2E-128	54	306	253

Status

Unreviewed

Ensembl Protein

ENSAMEP00000015034

UniProt Accession

G1M6R4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014232	ENSAMEP00000015034	ENSAMET00000015652

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MSAAATAGKL ARAPADPGKA GGPGVAAPGA PAAAPPPAKE IPEVLVDPRS RRRYLRGRFL 60

GKGGFAKCFE ISDADTKEVF AGKIVPKSLL LKPHQKEKMS MEISIHRSLA HQHIVGFHGF 120

FEDNDFVFVV LELCRRRSLL ELHKRRKALT EPEARYYLRQ IVLGCQYLHR NRVIHRDLKL 180

GNLFLNEDLE VKIGDFGLAT KVEYDGERKK TLCGTPNYIA PEVLSKKGHS FEVDVWSIGC 240

IMYTLLVGKP PFETSCLKET YLRIKKNDYS IPKHINPVAA SLIQKMLQTD PTARPTIHEL 300

LNDEFFTSGY IPARLPITCL TIAPRFSIAP SSLDPSNRKP LTVLNKGTEN PMPERPREKE 360

EPVVRETSEA VDCHLGDMLQ QLHSVNASKP SERGLVRQEE AEDPACIPIF WVSKWVDYSD 420

KYGLGYQLCD NSVGVLFNDS TRLILYNDGD SLQYIERDGT ESYLTVSSHP NSLMKKITLL 480

KYFRNYMSEH LLKAGANITP REGDELARLP YLRTWFRTRS AIILHLSNGC VQINFFQDHT 540

KLILCPLMAA VTYIDERRDF RTYRLSLLEE YGCSKELASR LRYARTMVDK LLSSRSASNR 600

LKASS 605

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CGGCAACTGC AGGGAAGCTG GCGCGGGCAC CAGCCGACCC AGGGAAAGCT 60

GGGGGCCCCG GAGTTGCAGC TCCCGGGGCT CCGGCGGCCG CACCGCCGCC GGCGAAAGAG 120

ATCCCGGAGG TCCTAGTGGA CCCGCGCAGC CGGCGGCGCT ACCTGCGGGG ACGCTTTCTG 180

GGGAAGGGCG GCTTTGCTAA GTGCTTCGAG ATCTCGGACG CCGACACCAA GGAGGTGTTC 240

GCGGGCAAGA TCGTGCCTAA GTCGCTGCTG CTCAAGCCGC ACCAGAAGGA GAAGATGTCC 300

ATGGAGATAT CCATTCACCG CAGCCTCGCC CATCAGCACA TCGTAGGCTT CCACGGCTTT 360

TTCGAGGACA ACGACTTCGT GTTCGTGGTG TTGGAGCTCT GCCGCCGGAG GTCTCTCCTG 420

GAGCTGCACA AGCGGAGAAA AGCACTGACC GAGCCCGAAG CCCGCTACTA CCTTCGGCAG 480

ATTGTCCTTG GCTGCCAGTA TCTGCACCGA AACCGGGTTA TTCACCGGGA CCTCAAGCTC 540

GGCAACCTTT TCCTGAATGA GGATCTGGAG GTGAAAATAG GGGATTTTGG ACTGGCAACC 600

AAAGTGGAGT ATGACGGGGA ACGCAAGAAG ACCCTGTGCG GGACTCCTAA TTACATAGCT 660

CCTGAGGTGC TGAGCAAGAA AGGGCACAGT TTCGAGGTGG ACGTGTGGTC CATTGGGTGT 720

ATCATGTATA CACTGTTAGT GGGCAAACCA CCTTTTGAGA CCTCTTGCCT TAAAGAGACC 780

TACCTTCGGA TCAAGAAGAA TGACTACAGT ATTCCCAAGC ACATCAACCC TGTGGCCGCC 840

TCCCTCATCC AGAAGATGCT TCAGACAGAT CCTACTGCCC GCCCCACCAT TCACGAGCTG 900

CTCAATGACG AGTTCTTTAC TTCCGGCTAC ATCCCCGCCC GACTACCCAT CACCTGTCTC 960

ACCATTGCAC CTCGGTTTTC CATTGCTCCC AGTAGTCTGG ACCCCAGCAA CCGGAAGCCT 1020

CTCACTGTCC TCAATAAAGG CACAGAGAAC CCCATGCCCG AGCGGCCCCG GGAAAAAGAG 1080

GAGCCAGTGG TCCGGGAGAC CAGTGAGGCG GTTGACTGCC ACCTGGGCGA CATGCTGCAG 1140

CAGCTACACA GCGTCAATGC GTCCAAGCCC TCAGAGCGGG GGCTGGTGAG GCAAGAGGAG 1200

GCTGAGGATC CTGCCTGCAT CCCCATCTTC TGGGTTAGCA AGTGGGTGGA CTATTCGGAC 1260

AAGTACGGCC TCGGGTACCA GCTGTGCGAC AACAGCGTGG GGGTGCTCTT CAACGACTCA 1320

ACACGCCTGA TCCTCTACAA TGACGGCGAC AGCCTGCAGT ACATAGAGCG CGATGGCACA 1380

GAGTCCTACC TCACTGTGAG CTCCCATCCT AACTCCCTGA TGAAGAAGAT CACCCTCCTG 1440

AAGTATTTCC GGAACTACAT GAGTGAACAC TTGCTGAAGG CGGGGGCCAA TATCACACCT 1500

CGGGAAGGCG ATGAGCTCGC CCGGCTACCC TACCTGCGCA CCTGGTTTCG CACCCGCAGC 1560

GCCATCATCC TGCACCTCAG CAATGGCTGT GTACAGATCA ACTTTTTCCA GGACCATACC 1620

AAACTCATCC TCTGCCCATT GATGGCAGCC GTGACCTATA TCGATGAGAG GCGGGACTTC 1680

CGCACGTACC GCCTGAGCCT GCTGGAGGAG TACGGCTGCT CCAAGGAGCT GGCCAGCCGG 1740

CTCCGCTACG CCCGCACCAT GGTGGACAAG CTGCTGAGCT CCCGCTCGGC CTCCAACCGT 1800

CTCAAGGCCT CCTCGTAG 1818

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 54    YLRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  113

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 114   IVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  173

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 174   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  233

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk++ys+P+++++ a+sli+k+l+++P++

Q: 234   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNDYSIPKHINPVAASLIQKMLQTDPTA  293

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 294   RPTIHELLNDEFF  306

         ************8

Domain Sequence
(FASTA)

YLRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

IVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNDYSIPK HINPVAASLI QKMLQTDPTA 240

RPTIHELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000942	; C:condensed nuclear chromosome outer kinetochore
GO:0030496	; C:midbody
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007092	; P:activation of mitotic anaphase-promoting complex activity
GO:0051297	; P:centrosome organization
GO:0000910	; P:cytokinesis
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0001578	; P:microtubule bundle formation
GO:0043066	; P:negative regulation of apoptotic process
GO:0045736	; P:negative regulation of cyclin-dependent protein kinase activity
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0031648	; P:protein destabilization
GO:0071168	; P:protein localization to chromatin
GO:0016567	; P:protein ubiquitination
GO:0090007	; P:regulation of mitotic anaphase
GO:0043393	; P:regulation of protein binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013