EKS-AIM-00259

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00259

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	3.5E-136	208	495	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000015102

UniProt Accession

G1M6Y2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014318	ENSAMEP00000015102	ENSAMET00000015723

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MVDGVMILPV LMMIAFPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60

DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120

HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180

ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420

NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480

NPSARLTALR IKKTLTKIDN SLDKLKTDC 509

Nucleotide Sequence
(FASTA)

ATGGTAGATG GAGTGATGAT TCTTCCTGTG CTAATGATGA TTGCTTTCCC TTCCCCTAGT 60

ATGGAAGATG AGAAGCCCAA GGTGAACCCC AAACTTTACA TGTGTGTGTG TGAAGGCCTC 120

TCCTGTGGGA ATGAGGACCA TTGTGAAGGC CAGCAGTGCT TTTCCTCACT GAGCATAAAT 180

GATGGCTTCC ATGTCTACCA GAAAGGCTGC TTCCAGGTCT ACGAGCAGGG AAAGATGACC 240

TGTAAGACCC CACCATCACC TGGCCAAGCT GTGGAGTGCT GCCAAGGGGA CTGGTGTAAC 300

AGGAACATCA CGGCCCAGCT GCCCACTAAA GGGAAGTCCT TTCCTGGAAC GCAGAATTTC 360

CACTTGGAGG TCGGCCTCAT TATTCTGTCC GTAGTATTTG CAGTATGCCT TCTAGCTTGC 420

CTACTGGGAG TCGCTCTCCG AAAATTTAAA AGGCGCAACC AAGAACGACT CAATCCCAGA 480

GATGTGGAGT ACGGTACCAT CGAAGGGCTC ATCACCACCA ATGTTGGAGA CAGCACTTTA 540

GCCGATTTAC TGGATCATTC ATGTACATCA GGAAGCGGCT CTGGTCTCCC TTTTCTGGTA 600

CAAAGAACAG TGGCTCGTCA GATCACACTG TTGGAGTGTG TTGGCAAAGG CAGGTATGGT 660

GAGGTGTGGA GGGGCAGTTG GCAGGGGGAG AACGTCGCTG TGAAGATCTT CTCCTCCCGG 720

GATGAGAAGT CATGGTTCAG GGAAACAGAA TTGTACAACA CTGTAATGCT GAGGCATGAA 780

AATATTTTGG GTTTTATTGC TTCAGACATG ACATCAAGAC ACTCCAGTAC CCAGCTGTGG 840

TTAATCACAC ATTACCATGA AATGGGATCG TTGTATGACT ATCTTCAGCT CACTACTCTG 900

GATACTGTTA GCTGCCTGCG AATAGTGCTG TCCATAGCTA GTGGTCTCGC ACATTTGCAC 960

ATAGAGATAT TTGGGACCCA AGGGAAGCCA GCCATTGCTC ATCGAGATTT AAAGAGCAAA 1020

AACATCCTGG TTAAGAAGAA TGGACAGTGT TGCATAGCAG ATTTGGGCCT GGCAGTCATG 1080

CATTCCCAGA GTACCAATCA GCTTGATGTG GGGAACAACC CCCGTGTGGG CACCAAACGC 1140

TACATGGCCC CTGAAGTTCT AGATGAAACC ATCCAGGTGG ACTGTTTCGA TTCTTACAAG 1200

AGAGTGGATA TTTGGGCCTT TGGACTTGTC TTGTGGGAAG TGGCCAGGCG TATGGTCAGC 1260

AACGGTATCG TGGAGGATTA CAAGCCACCA TTTTACGACG TGGTTCCCAA TGACCCAAGT 1320

TTTGAAGATA TGAGAAAGGT GGTCTGTGTG GATCAACAGA GGCCAAACAT ACCCAATAGA 1380

TGGTTCTCAG ACCCGACATT AACCTCTCTG GCTAAGCTGA TGAAAGAATG CTGGTATCAA 1440

AATCCATCCG CAAGACTCAC AGCTCTGCGT ATCAAAAAGA CTTTGACCAA AATTGATAAT 1500

TCCCTAGACA AATTGAAAAC TGACTGT 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 328   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0003289	; P:atrial septum primum morphogenesis
GO:0030509	; P:BMP signaling pathway
GO:0060923	; P:cardiac muscle cell fate commitment
GO:0007368	; P:determination of left/right symmetry
GO:0003143	; P:embryonic heart tube morphogenesis
GO:0003197	; P:endocardial cushion development
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001702	; P:gastrulation with mouth forming second
GO:0007281	; P:germ cell development
GO:0001701	; P:in utero embryonic development
GO:0001707	; P:mesoderm formation
GO:0003183	; P:mitral valve morphogenesis
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0001755	; P:neural crest cell migration
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0051145	; P:smooth muscle cell differentiation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

aml:100476325

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013