EKS-AIM-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.5	5.8E-136	197	484	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000015117

UniProt Accession

G1M6Z7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014338	ENSAMEP00000015117	ENSAMET00000015738

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

495

Protein Sequence
(FASTA)

IFKYYEINLH NIFYILKLSA LHFPGLKCVC LLCDSSNFTC QTEGACWASV MLANGKEQVI 60

KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TAEASPNAPK LGPMELTVVI 120

TVPLCLLSMA AVLTIWACQG RPCTNRKKKR QNVEEPLSEC NLVNAGKTLK DLIYDVTASG 180

SGSGLPLLVQ RTIARTIVLQ EIVGKGRFGE VWHGRWCGED VAVKIFSSRD ERSWFREAEI 240

YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSEYHELGSL YDYLNRNIVT VAGMVKLALS 300

IASGLAHLHM EIVGTQGKPA IAHRDIKSKN ILVKKCETCA IADLGLAVKH DSVLNTIDIP 360

QNPKVGTKRY MAPEMLDDTM NVNIFESFKR ADIYSVGLVY WEIARRCSVG GIVEEYQLPY 420

YDMVPSDPSI EEMRKVVCDQ KFRPSIPNQW QSCEALRVMG RIMRECWYAN GAARLTALRI 480

KKTISQLCVK EDCKA 495

Nucleotide Sequence
(FASTA)

ATATTCAAGT ATTATGAAAT AAATTTGCAC AATATTTTCT ATATCTTAAA GCTTTCTGCC 60

TTACACTTTC CAGGATTGAA GTGTGTATGT CTTTTGTGTG ACTCTTCAAA CTTTACCTGC 120

CAAACCGAGG GAGCATGCTG GGCGTCAGTT ATGCTGGCCA ATGGAAAAGA GCAGGTGATC 180

AAGTCCTGCG TCTCTCTCCC AGAACTCAAT GCTCAAGTCT TCTGTCATAG TTCCAACAAT 240

GTTACCAAAA CGGAGTGCTG CTTCACAGAC TTTTGCAACA ACATAACCCT GCACCTTCCA 300

ACAGCTGAAG CATCTCCAAA TGCCCCCAAA CTCGGACCCA TGGAGCTGAC CGTTGTTATT 360

ACTGTGCCAC TTTGCCTCCT GTCCATGGCA GCCGTGCTGA CGATCTGGGC ATGCCAAGGT 420

CGACCATGCA CAAACAGGAA GAAAAAGAGA CAGAATGTGG AGGAACCCCT CTCTGAGTGC 480

AATCTGGTAA ATGCTGGAAA AACTCTAAAA GATCTGATTT ACGATGTGAC TGCCTCTGGA 540

TCTGGCTCTG GTCTACCTCT GTTGGTTCAA AGAACAATTG CAAGGACCAT CGTACTTCAG 600

GAGATAGTGG GAAAAGGTAG ATTTGGTGAG GTCTGGCATG GAAGATGGTG TGGGGAAGAT 660

GTGGCTGTAA AAATCTTCTC CTCCAGAGAT GAAAGATCTT GGTTTCGAGA GGCAGAAATT 720

TATCAGACGG TTATGCTGAG ACATGAAAAC ATACTTGGTT TCATTGCTGC TGACAACAAA 780

GATAATGGAA CTTGGACTCA ACTTTGGCTT GTCTCCGAAT ACCATGAACT GGGTTCCTTA 840

TATGACTATT TGAATAGAAA CATAGTGACT GTGGCTGGCA TGGTCAAACT GGCCCTTTCG 900

ATAGCTAGTG GTCTGGCCCA CCTACATATG GAAATTGTTG GCACACAAGG TAAACCTGCT 960

ATTGCTCATC GAGATATAAA ATCAAAGAAT ATCTTAGTGA AAAAATGTGA AACTTGTGCC 1020

ATAGCCGACT TGGGGCTGGC TGTGAAGCAT GATTCGGTAC TGAACACAAT TGACATACCT 1080

CAGAACCCTA AAGTGGGAAC CAAAAGGTAT ATGGCTCCTG AAATGCTTGA TGATACAATG 1140

AATGTGAATA TCTTTGAGTC CTTCAAACGA GCTGACATCT ATTCTGTTGG TCTGGTTTAT 1200

TGGGAAATAG CACGAAGGTG TTCAGTTGGA GGAATTGTTG AGGAGTACCA GTTGCCTTAT 1260

TATGACATGG TGCCTTCAGA TCCCTCAATA GAGGAAATGA GGAAGGTTGT TTGTGACCAG 1320

AAGTTTCGAC CAAGTATCCC AAACCAGTGG CAAAGCTGTG AAGCACTCCG AGTTATGGGG 1380

AGAATAATGC GGGAGTGTTG GTATGCCAAT GGGGCAGCCC GCCTAACGGC CCTTCGTATT 1440

AAGAAGACTA TCTCTCAACT TTGTGTCAAA GAAGACTGCA AAGCCTAA 1488

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 197   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  256

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 257   ADNKDNGTWTQLWLVSEYHELGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQ  316

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 317   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSVLNTIDIPQNPKVGTKRYMAPE  374

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 375   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  433

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 434   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  484

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE LGSLYDYLNR NIVTVAGMVK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSVLNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013