EKS-AIM-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.51.8E-151618877260
StatusUnreviewed
Ensembl ProteinENSAMEP00000015457
UniProt AccessionG1M7Y7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000014567ENSAMEP00000015457ENSAMET00000016100
OrganismAiluropoda melanoleuca
Functional Description
Protein Length990
Protein Sequence
(FASTA)
MELRALLCWA SLAAALESVL ETLLNTKLET ADLKWVTFPQ VEGQWEELSG LDEEQHSVRT 60
YEVCDVQRAP GLAHWLRTGW VPRRGAVHVY ATLRFTMLEC LSLSRAGRSC KETFTVFYFE 120
SDADTATAFT PAWMENPYIK VDTVAAEHLT RKRPGAEATG KVNVKTLRLG PLTKAGFYLA 180
FQDQGACMAL LSLHLFYKKC AQLTVNLTHF PETVPRELVV PVAGSCVADA VPTPGPSPSL 240
YCREDGQWAE QPVTGCSCAP GFEAAEGNTR CRACAQGTFK PLSGEGACQP CPANSHSSTI 300
GSPVCQCRNG YFRARTDFRG APCTAPPSAP RSVVPRLNGS SLRLEWSAPL ESGGREDLTY 360
ALRCRECRPG GSCTPCGGDL TFDPGPRDLV EPWVAVRGLR PDFTYTFEVT ALNGVSSLAT 420
GPVPFEAVNV TTDREVPPPV SDIRVTRSSP SSLSLAWAVP RAPSGAVLDY EVKYHEKGTE 480
GPSSVRFLKT SENWAELRGL KRGASYLVQV RARSEAGYGP FGQEHHSQTQ LDENESWREQ 540
LALIAGTAVV GVVLVLVVIV IAVLCLRKQS NGREAEYSDK HGQYLIGHGT KVYIDPFTYE 600
DPNEAVREFA KEIDVSYVKI EEVIGAGEFG EVCRGRLKAP GKKESCVAIK TLKGGYTERQ 660
RREFLSEASI MGQFEHPNII RLEGVVTNSV PVMILTEFME NGALDSFLRL NDGQFTVIQL 720
VGMLRGIASG MRYLAEMSYV HRDLAARNIL VNSNLVCKVS DFGLSRFLEE NSSDPTYTSS 780
LGGKIPIRWT APEAIAFRKF TSASDAWSYG IVMWEVMSFG ERPYWDMSNQ DVINAIEQDY 840
RLPPPPDCPT SLHQLMLDCW QKDRNARPRF PQVVSALDKM IRNPASLKIV ARENGGASHP 900
LLDQRQPHYS AFGSVGEWLR AIKMGRYEES FAAAGFGSFE LVSQISAEDL LRIGVTLAGH 960
QKKILASVQH MKSQAKPGAP GGSGAPAPQY 990
Nucleotide Sequence
(FASTA)
ATGGAACTAC GGGCTCTGCT TTGCTGGGCT TCGCTCGCCG CCGCCTTAGA ATCTGTCTTA 60
GAGACCCTAT TGAACACAAA ACTGGAAACT GCCGATCTAA AGTGGGTCAC GTTCCCTCAG 120
GTGGAGGGGC AGTGGGAGGA GCTGAGCGGC CTGGACGAGG AGCAGCACAG CGTCCGGACC 180
TACGAGGTGT GCGACGTGCA GCGCGCGCCA GGCCTGGCCC ACTGGCTGCG CACTGGCTGG 240
GTCCCGCGCC GAGGAGCCGT CCACGTGTAC GCCACGCTTC GCTTCACCAT GCTCGAGTGC 300
CTCTCGCTGT CGCGGGCTGG GCGCTCTTGC AAGGAGACCT TCACCGTCTT CTACTTCGAG 360
AGCGATGCTG ACACGGCCAC AGCCTTCACG CCAGCCTGGA TGGAGAACCC CTACATCAAG 420
GTGGACACAG TGGCCGCCGA GCACTTGACC CGGAAGCGCC CTGGGGCCGA GGCAACGGGC 480
AAGGTGAACG TCAAGACACT GCGTCTGGGC CCGCTCACCA AGGCTGGCTT CTACCTGGCC 540
TTCCAGGACC AGGGTGCCTG CATGGCCCTG CTTTCCCTGC ATCTCTTCTA CAAGAAATGC 600
GCCCAGCTGA CCGTGAACCT CACGCATTTC CCGGAGACCG TGCCTCGGGA GCTCGTGGTG 660
CCCGTGGCAG GGAGCTGTGT GGCTGACGCC GTCCCTACCC CCGGCCCCAG CCCCAGCCTC 720
TACTGCCGGG AGGATGGCCA GTGGGCCGAG CAGCCGGTCA CGGGGTGCAG CTGTGCTCCA 780
GGGTTCGAGG CCGCCGAGGG GAACACCCGG TGCCGAGCCT GCGCCCAAGG CACCTTCAAG 840
CCCTTGTCTG GCGAGGGGGC CTGCCAGCCG TGCCCAGCCA ACAGCCACTC CAGCACCATT 900
GGCTCACCCG TCTGCCAGTG CCGCAACGGG TACTTCCGGG CCCGGACGGA CTTCCGGGGT 960
GCACCCTGTA CTGCGCCACC CTCTGCTCCA AGAAGTGTGG TTCCCCGTCT GAACGGCTCT 1020
TCCCTGCGCC TGGAGTGGAG TGCCCCCCTC GAGTCTGGGG GCCGAGAGGA TCTCACGTAC 1080
GCGCTGCGCT GCAGGGAGTG CCGCCCCGGG GGGTCCTGCA CACCCTGCGG AGGAGACCTG 1140
ACCTTCGACC CTGGCCCCCG GGACCTTGTG GAGCCCTGGG TAGCAGTTCG CGGGCTGCGT 1200
CCAGATTTCA CCTATACCTT CGAGGTCACC GCCTTGAACG GGGTGTCGTC CTTAGCCACC 1260
GGGCCCGTCC CGTTTGAGGC TGTGAATGTC ACCACTGACC GTGAGGTACC GCCCCCCGTG 1320
TCTGACATCC GGGTGACACG GTCATCACCC AGCAGCTTGA GCCTGGCATG GGCTGTTCCC 1380
CGGGCACCCA GCGGGGCCGT GCTGGACTAC GAGGTCAAGT ACCACGAGAA GGGCACAGAG 1440
GGCCCCAGCA GCGTGCGGTT CCTGAAGACG TCGGAAAACT GGGCAGAGCT GCGGGGGCTG 1500
AAGCGGGGAG CCAGCTACCT GGTCCAGGTG CGGGCACGCT CCGAGGCTGG CTACGGGCCC 1560
TTCGGCCAGG AGCACCACAG CCAGACCCAG CTGGACGAGA ACGAGAGCTG GCGGGAGCAG 1620
CTGGCCCTGA TCGCAGGCAC GGCCGTCGTG GGTGTGGTGC TGGTCCTGGT GGTCATTGTC 1680
ATTGCTGTTC TCTGTCTCAG GAAGCAGAGC AACGGGAGGG AAGCCGAGTA CTCGGACAAG 1740
CACGGACAGT ATCTCATCGG GCACGGTACT AAGGTCTACA TCGACCCCTT CACTTACGAA 1800
GACCCTAATG AGGCTGTGAG GGAATTTGCG AAAGAGATCG ATGTCTCCTA CGTCAAGATT 1860
GAGGAGGTGA TCGGCGCAGG CGAGTTTGGC GAGGTGTGCC GGGGGCGGCT CAAGGCCCCG 1920
GGGAAGAAAG AGAGCTGTGT GGCCATCAAG ACCCTGAAAG GGGGCTACAC GGAGCGGCAG 1980
CGGCGGGAGT TCCTGAGTGA GGCCTCCATC ATGGGCCAGT TCGAGCACCC CAACATCATC 2040
CGCCTGGAGG GCGTGGTCAC CAACAGCGTA CCTGTCATGA TCCTCACCGA GTTCATGGAG 2100
AACGGCGCCC TGGACTCCTT CCTGCGGCTG AACGATGGGC AGTTCACCGT CATCCAGCTG 2160
GTGGGCATGC TGCGGGGCAT TGCCTCGGGC ATGCGGTACC TTGCCGAGAT GAGCTACGTG 2220
CACCGAGACC TGGCCGCCCG CAACATCCTG GTCAACAGCA ACCTTGTCTG CAAGGTGTCC 2280
GACTTCGGGC TTTCCCGGTT CCTGGAGGAG AACTCTTCTG ATCCCACCTA CACGAGCTCT 2340
CTGGGTGGAA AGATTCCCAT CCGATGGACA GCCCCTGAGG CCATTGCCTT CCGGAAGTTC 2400
ACATCTGCTA GTGACGCCTG GAGCTATGGA ATTGTGATGT GGGAGGTCAT GTCATTTGGG 2460
GAGCGGCCAT ACTGGGACAT GAGCAATCAG GATGTGATCA ATGCCATTGA ACAGGACTAC 2520
CGGCTGCCCC CGCCCCCAGA CTGCCCCACT TCCCTGCACC AGCTCATGCT GGACTGTTGG 2580
CAGAAGGACC GGAATGCACG GCCCCGCTTC CCCCAGGTGG TCAGTGCCCT CGACAAGATG 2640
ATCCGGAACC CGGCCAGTCT CAAAATCGTG GCCAGGGAGA ACGGCGGGGC CTCACACCCA 2700
CTTCTGGATC AGCGGCAGCC TCACTACTCA GCTTTTGGCT CAGTGGGCGA GTGGCTTCGA 2760
GCCATCAAGA TGGGACGATA CGAAGAAAGT TTCGCAGCTG CTGGCTTTGG CTCCTTCGAA 2820
CTGGTCAGCC AGATCTCTGC AGAGGATCTG CTCCGAATTG GAGTCACTCT GGCGGGACAC 2880
CAGAAGAAAA TCCTGGCCAG TGTCCAGCAC ATGAAGTCCC AGGCCAAGCC TGGAGCCCCA 2940
GGCGGGTCGG GAGCACCAGC CCCCCAGTAC TGA 2973
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 618   VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP  677
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqftviqlvgmlrGiasgm+yl++m
Q: 678   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM  737
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 738   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  797
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 798   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML  857
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 858   DCWQKDRNARPRFPQVVSAL  877
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KAPGKKESCV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTV IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0007155; P:cell adhesion
GO:0002042; P:cell migration involved in sprouting angiogenesis
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013