EKS-AIM-00219
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00219
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl551.23.1E-166215466252
StatusUnreviewed
Ensembl ProteinENSAMEP00000015438
UniProt AccessionD2H3L6;
Protein Name
Protein Synonyms/Alias
Gene NameABL2
Gene Synonyms/Alias ABL2; PANDA_004303;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000014636ENSAMEP00000015438ENSAMET00000016081
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1109
Protein Sequence
(FASTA)
EALHRPYGCD VEPQALNEAI RWSSKENLLG ATESDPNLFV ALYDFVASGD NTLSITKGEK 60
LRVLGYNQNG EWSEVRSKNG QGWVPSNYIT PVNSLEKHSW YHGPVSRSAA EYLLSSLING 120
SFLVRESESS PGQLSISLRY EGRVYHYRIN TTTDGKVYVT AESRFSTLAE LVHHHSTVAD 180
GLVTTLHYPA PKCNKPTVYG VSPIHDKWEM ERTDITMKHK LGGGQYGEVY VGVWKKYSLT 240
VAVKTLKEDT MEVEEFLKEA AVMKEIKHPN LVQLLGVCTL EPPFYIVTEY MPYGNLLDYL 300
RECSREEVTA VVLLYMATQI SSAMEYLEKK NFIHRDLAAR NCLVGENHVV KVADFGLSRL 360
MTGDTYTAHA GAKFPIKWTA PESLAYNTFS IKSDVWAFGV LLWEIATYGM SPYPGIDLSQ 420
VYDLLEKGYR MEQPEGCPPK VYELMRACWK WSPADRPSFA ETHQAFETMF HDSSISEEVA 480
EELGRAASSS SVVPYLPRLP ILPSKTRTLK KQVENKENIE GAQDATENSA SSSAPGFLRG 540
AQAPSGSPAL PRKQRDKSPS SLLEDAKETC FTRDRKGGFF SSFMKKRNAP TPPKRSSSFR 600
EMENQPHKKY ELTGNFSSVA SLQHADGFSL TPAQQEANLV PPKCYGGSFA QRNLCNDDGG 660
GGGGSGTAGG GWSGITGFFT PRLIKKTLGL RAGKPTASDD TSKPFPRSNS TSSMSSGLPE 720
QDRMAMTLPR NCQRSKLQLE RTVSTSSQPE ENVDRANDMH PKKSEEGAAP SRERPKAKLL 780
PRGATALPLR TPSGDPAITE KDSPGAGVAG VAAAPKSKER NGGARLGMAG VPEDGEQTGW 840
SSPAKAAAAL PTTHNHKVPV LISPTLKHTP ADVQLIGTDS QGNKFKLLSE HQVTASGDKD 900
RPRRVKPKCA PPPPPVMRLL QHPSMCSDAT EEPSAPTAGQ PAPETQEGGK KAAPGAVPSG 960
GKAGRPVMPP PQVPLPASSI SPVKMANGTA GTKVALRKTK QAAEKISADK ISKEALLECA 1020
DLLSSAIVEP VPSSQLVDTG HQLLDYCSGY VDCIPQTRNK FAFREAVSKL ELSLQELQVS 1080
SAAAGVPGAN PVLNNLLSCV QEISDVVQR 1109
Nucleotide Sequence
(FASTA)
GAAGCTTTAC ACCGCCCCTA TGGTTGTGAT GTTGAACCCC AGGCACTGAA CGAAGCCATC 60
AGGTGGAGCT CCAAGGAGAA CTTACTTGGA GCCACTGAGA GTGACCCTAA TCTCTTTGTT 120
GCACTTTATG ATTTTGTAGC CAGCGGTGAT AACACACTCA GCATCACTAA AGGTGAAAAG 180
CTACGAGTCC TTGGTTATAA CCAGAATGGC GAGTGGAGTG AAGTTCGCTC CAAGAATGGA 240
CAAGGTTGGG TGCCAAGCAA CTACATCACC CCAGTGAACA GCTTGGAAAA ACATTCCTGG 300
TACCACGGAC CCGTGTCACG CAGTGCAGCA GAGTATCTAC TCAGCAGTCT AATCAATGGC 360
AGTTTCCTAG TGCGAGAAAG CGAGAGCAGC CCCGGGCAGC TGTCCATCTC GCTCAGGTAT 420
GAGGGGCGTG TGTATCACTA CAGGATCAAC ACCACCACAG ATGGCAAGGT GTACGTCACT 480
GCCGAGAGCC GCTTTAGCAC CCTGGCGGAG CTCGTGCACC ATCACTCCAC GGTGGCTGAT 540
GGGCTGGTGA CAACGTTACA CTACCCAGCA CCGAAGTGTA ATAAGCCCAC AGTCTATGGT 600
GTGTCCCCCA TCCATGACAA ATGGGAAATG GAACGAACGG ATATTACCAT GAAGCACAAA 660
CTTGGGGGTG GTCAGTATGG GGAAGTGTAT GTTGGCGTCT GGAAGAAATA CAGCCTTACG 720
GTTGCTGTGA AAACATTGAA GGAAGATACC ATGGAAGTGG AAGAGTTCCT GAAGGAAGCT 780
GCAGTGATGA AGGAAATCAA GCATCCTAAT CTGGTCCAAC TATTAGGTGT GTGTACTTTG 840
GAGCCACCAT TTTACATTGT GACTGAGTAC ATGCCATATG GCAATTTGCT TGATTATCTC 900
CGGGAATGCA GCCGAGAAGA GGTGACTGCA GTTGTCCTGC TGTATATGGC CACTCAGATC 960
TCTTCTGCAA TGGAGTATCT AGAGAAGAAG AATTTCATCC ATAGAGATCT TGCAGCCCGT 1020
AACTGCCTAG TGGGAGAAAA CCATGTGGTC AAAGTGGCTG ATTTTGGCTT AAGTAGATTG 1080
ATGACTGGAG ACACCTATAC TGCTCATGCT GGAGCCAAAT TTCCTATTAA ATGGACAGCA 1140
CCAGAGAGTC TTGCCTACAA TACCTTCTCA ATAAAATCTG ATGTCTGGGC TTTCGGAGTA 1200
CTGTTGTGGG AAATTGCTAC TTATGGAATG TCACCGTATC CAGGTATTGA CCTGTCTCAG 1260
GTGTATGATC TACTGGAAAA AGGATATCGA ATGGAACAAC CTGAAGGATG CCCCCCTAAG 1320
GTTTATGAAC TTATGAGAGC ATGCTGGAAG TGGAGCCCTG CCGACAGGCC CTCTTTTGCT 1380
GAAACACATC AAGCTTTTGA AACCATGTTC CATGACTCCA GCATTTCTGA AGAGGTGGCT 1440
GAAGAGCTTG GGAGAGCTGC CTCCTCGTCC TCGGTGGTTC CATACCTGCC CCGACTGCCT 1500
ATACTTCCTT CCAAGACGCG GACGCTGAAG AAACAGGTGG AGAATAAGGA GAACATTGAA 1560
GGGGCACAGG ACGCCACAGA AAATTCGGCT TCTAGTTCGG CACCAGGGTT CCTTAGAGGC 1620
GCACAGGCCC CCAGTGGGTC CCCAGCACTG CCTCGAAAAC AAAGAGACAA GTCACCCAGC 1680
AGCCTCTTGG AAGATGCCAA AGAGACATGC TTCACCAGGG ATAGGAAGGG AGGCTTCTTC 1740
AGCTCCTTCA TGAAAAAGAG AAATGCTCCC ACACCCCCCA AACGCAGCAG CTCCTTCCGA 1800
GAAATGGAGA ATCAGCCCCA CAAGAAATAT GAACTCACGG GTAACTTCTC ATCTGTTGCT 1860
TCTCTGCAGC ATGCTGATGG GTTCTCTCTC ACTCCTGCCC AGCAAGAGGC GAATCTGGTG 1920
CCACCCAAGT GCTATGGGGG GAGCTTTGCG CAGAGGAACC TATGTAATGA CGATGGCGGT 1980
GGGGGTGGGG GCAGTGGCAC TGCTGGGGGC GGGTGGTCTG GCATCACAGG CTTCTTTACA 2040
CCACGCTTAA TCAAAAAGAC ACTGGGCTTA CGAGCGGGGA AACCCACAGC CAGTGATGAC 2100
ACTTCCAAGC CTTTTCCAAG GTCAAACTCT ACATCTTCCA TGTCCTCAGG GCTTCCAGAG 2160
CAGGATAGGA TGGCAATGAC CCTTCCCAGG AACTGCCAGA GGTCCAAACT CCAGCTGGAA 2220
AGGACAGTGT CCACCTCTTC TCAGCCAGAA GAGAATGTAG ACAGGGCCAA TGACATGCAT 2280
CCAAAAAAAT CAGAGGAAGG TGCTGCTCCA AGCAGGGAGA GACCAAAAGC CAAACTTTTG 2340
CCCAGAGGAG CCACGGCTCT TCCTCTCAGA ACCCCCTCTG GGGATCCAGC CATTACAGAG 2400
AAGGACTCTC CAGGGGCAGG GGTGGCTGGA GTGGCAGCCG CCCCAAAGAG CAAGGAGAGG 2460
AACGGTGGGG CGCGACTCGG CATGGCTGGA GTCCCAGAGG ACGGCGAGCA GACGGGCTGG 2520
TCTTCTCCGG CCAAGGCTGC AGCAGCCCTC CCAACCACTC ACAACCACAA AGTGCCAGTC 2580
CTTATCTCAC CCACTCTGAA GCACACGCCA GCTGACGTGC AGCTCATTGG CACAGACTCT 2640
CAGGGCAATA AATTCAAACT CTTATCTGAG CATCAGGTCA CAGCCTCTGG AGACAAGGAC 2700
CGACCCCGAC GGGTAAAACC AAAGTGTGCC CCACCCCCAC CCCCAGTGAT GAGACTACTG 2760
CAGCATCCGT CCATGTGCTC AGACGCCACG GAAGAGCCAA GCGCCCCGAC TGCAGGACAG 2820
CCCGCGCCAG AAACACAGGA GGGAGGGAAA AAGGCCGCTC CGGGGGCAGT GCCCAGCGGT 2880
GGGAAAGCCG GGAGGCCGGT GATGCCTCCG CCTCAAGTTC CTCTGCCCGC ATCTTCCATC 2940
TCGCCAGTTA AAATGGCTAA CGGCACAGCA GGTACGAAAG TGGCTCTGAG AAAAACCAAA 3000
CAGGCAGCTG AGAAAATCTC AGCAGACAAA ATCAGCAAAG AGGCCCTGTT GGAATGTGCT 3060
GACCTCCTGT CCAGTGCCAT CGTGGAACCT GTGCCCAGCA GCCAGCTGGT GGACACCGGC 3120
CACCAGCTGC TCGACTACTG TTCAGGCTAC GTGGACTGCA TCCCTCAGAC GCGCAACAAG 3180
TTTGCCTTCC GAGAGGCTGT GAGCAAACTG GAGCTCAGCC TGCAGGAGCT GCAGGTGTCT 3240
TCAGCGGCTG CCGGGGTGCC TGGGGCCAAC CCTGTCCTTA ATAACTTATT GTCCTGTGTA 3300
CAGGAGATCA GCGACGTGGT GCAGAGGTAG 3330
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 215   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  274
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih
Q: 275   LGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIH  334
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd
Q: 335   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  394
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+
Q: 395   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  454
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfae+hqa+
Q: 455   DRPSFAETHQAF  466
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTLEPPF YIVTEYMPYG NLLDYLRECS REEVTAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240
DRPSFAETHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00229
EKS-BOT-00258
EKS-CAJ-00244
EKS-CAF-00246
EKS-CAP-00294
EKS-DAR-00594
EKS-EQC-00231
EKS-FEC-00245
EKS-GAG-00199
EKS-GOG-00257
EKS-HOS-00246
EKS-ICT-00226
EKS-LAC-00271
EKS-LOA-00269
EKS-MAM-00260
EKS-MEG-00205
EKS-MOD-00238
EKS-MUM-00243
EKS-MUP-00257
EKS-MYL-00238
EKS-NOL-00239
EKS-ORN-00336
EKS-ORA-00228
EKS-ORC-00245
EKS-ORL-00287
EKS-OTG-00265
EKS-PAT-00227
EKS-PES-00230
EKS-POA-00231
EKS-RAN-00273
EKS-SAH-00244
EKS-SUS-00224
EKS-TAG-00254
EKS-TEN-00296
EKS-TUT-00027
EKS-XET-00313
EKS-XIM-00329
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0051017; P:actin filament bundle assembly
GO:0071300; P:cellular response to retinoic acid
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0010976; P:positive regulation of neuron projection development
GO:0051353; P:positive regulation of oxidoreductase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013