EKS-AIM-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph480.21.1E-144660916257
StatusUnreviewed
Ensembl ProteinENSAMEP00000015553
UniProt AccessionG1M883;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000014652ENSAMEP00000015553ENSAMET00000016201
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1025
Protein Sequence
(FASTA)
RKGLGIICAS QSRRGQASSA RGGASPGLAC WVSSPAPHGR GRACEVLLPG LGLLGLGAPS 60
MVASAVNLLD TSTIHGDWGW LTYPSHGWDS INEVDESFQP IHTYQVCNVM SPNQNNWLRT 120
SWVPRDGARR VYAEIKFTLR DCNSMPGVLG TCKETFNLYY LESDRDLGAS TQESQFLKID 180
TIAADESFTG ADLGVRRLKL NTEVRGVGPL SKRGFYLAFQ DIGACLAILS LRIYYKKCPT 240
TVRNLAAFSE AVTGADSSSL VEVRGQCVRH SEERDTPKMY CSAEGAWLVP IGKCVCSAGY 300
EERRDACVAC ELGFYKSAAG DQLCARCPPH SHSAAPAAQA CRCDLSYYRA ALDPPSAACT 360
RPPSAPVNLI SSVNGTSVTL EWAPPLDPGG RNDITYNAVC RRCPWALGHC ETCGSGPRFV 420
PQQTSLVRAS LMVANLLAHM NYSFWIEAVN GVSDLSPEPR RAAVVNITTN QAAPSQVVVI 480
RQERAGQTSV SLLWQEPEQP NGIILEYEIK YYEKDKEMQS YSTLKAVTTR ATVSGLKPGT 540
RYMFQVRART SAGCGRFSQA MEVETGKPRE YETLSELPLL IGTETLALIT GLVVLLLLLI 600
CKKRHCGYSK AFQDSDEEKM QYQNGPGKIP EPQFYAEPHN YEEPGRTGRS FTREIEASRI 660
HIEKIIGSGE SGEVCYGRLQ VPGQRDVPVA IKALKPGYTE RQRRDFLSEA SIMGQFDHPN 720
IIRLEGVVTR GRLAMIVTEY MENGSLDAFL RTHDGQLTIM QLVGMLRGVG AGMCYLSDLG 780
YVHRDLAARN VLVDSNLVCK VSDFGLSRVL EDDPDAAYTT TGGKIPIRWT APEAIAFRTF 840
SSASDVWSFG VVMWEVLAYG ERPYWNMTNR DVISSVEEGY RLPAPMGCPR ALHQLMLDCW 900
HKDRAQRPRF SQIVGVLDAL IRSPESLRAT ATVNRCLTPT PALPKSSGPP GISPVTVGDW 960
LDSNRMGRYR DHFAAGGYSS LGMVLRMNAQ DVRALGITLM GHQKKILGSI QTMRAQLTST 1020
QGPHR 1025
Nucleotide Sequence
(FASTA)
AGGAAAGGCT TAGGAATTAT CTGTGCTTCT CAGAGCAGGA GAGGACAGGC CAGCAGTGCA 60
AGAGGGGGAG CGAGCCCAGG CCTGGCATGC TGGGTCTCCT CCCCAGCCCC CCACGGGAGG 120
GGGAGGGCAT GTGAGGTTCT GCTTCCTGGG CTCGGGCTGC TGGGGCTGGG GGCTCCATCT 180
ATGGTCGCCT CCGCGGTGAA CTTGCTGGAC ACGTCCACCA TCCACGGAGA CTGGGGCTGG 240
CTCACGTATC CATCTCATGG GTGGGACTCC ATCAACGAGG TGGACGAGTC CTTCCAGCCC 300
ATCCACACGT ACCAGGTGTG CAACGTCATG AGCCCCAACC AGAACAACTG GCTACGCACG 360
AGCTGGGTGC CCCGCGACGG TGCCCGGCGC GTCTACGCCG AGATCAAGTT CACCCTGCGT 420
GACTGCAACA GCATGCCCGG TGTGCTGGGC ACCTGTAAGG AGACCTTCAA TCTCTACTAC 480
CTGGAGTCGG ACCGCGACCT GGGCGCCAGC ACACAAGAAA GCCAGTTCCT CAAAATCGAC 540
ACCATTGCAG CCGACGAGAG CTTCACGGGT GCCGACCTGG GCGTTCGGCG CCTCAAGCTC 600
AACACGGAGG TGCGCGGCGT GGGCCCCCTC AGCAAGCGCG GCTTCTATCT GGCCTTCCAG 660
GACATCGGGG CGTGCCTCGC CATCCTGTCT CTCCGCATCT ATTACAAGAA GTGCCCCACT 720
ACGGTGCGCA ACCTGGCTGC CTTCTCGGAG GCAGTGACGG GGGCCGACTC GTCCTCGCTG 780
GTGGAGGTGC GGGGCCAGTG CGTGCGGCAC TCCGAGGAGC GGGACACGCC CAAGATGTAC 840
TGCAGCGCCG AAGGCGCGTG GCTGGTGCCC ATCGGCAAGT GCGTGTGCAG CGCCGGCTAC 900
GAGGAGCGGC GGGACGCCTG CGTGGCCTGT GAGCTGGGCT TCTACAAGTC GGCCGCTGGG 960
GACCAGCTCT GCGCCCGCTG CCCTCCCCAC AGTCACTCTG CGGCCCCTGC TGCCCAGGCC 1020
TGTCGCTGTG ACCTCAGCTA CTACCGCGCG GCCCTGGACC CACCCTCTGC AGCCTGCACC 1080
CGGCCACCCT CAGCACCGGT GAATCTGATC TCCAGCGTGA ACGGGACATC CGTGACCCTG 1140
GAATGGGCCC CTCCCCTGGA TCCAGGCGGC CGCAACGACA TTACCTACAA CGCGGTGTGC 1200
CGCCGCTGCC CTTGGGCGTT GGGCCACTGC GAGACCTGCG GGAGTGGCCC CCGCTTCGTG 1260
CCCCAGCAGA CAAGCCTGGT GCGGGCCAGT CTGATGGTGG CCAACCTGCT GGCCCACATG 1320
AACTACTCCT TCTGGATTGA GGCTGTCAAC GGTGTGTCCG ACCTGAGCCC CGAGCCCCGC 1380
CGGGCCGCTG TCGTCAACAT CACCACAAAC CAGGCAGCCC CGTCCCAGGT GGTGGTGATC 1440
CGTCAGGAGA GGGCTGGGCA GACCAGCGTC TCCCTGCTGT GGCAGGAGCC GGAACAGCCC 1500
AACGGCATCA TCCTGGAGTA TGAGATCAAG TACTACGAGA AGGACAAGGA GATGCAGAGC 1560
TACTCCACCC TCAAGGCTGT CACCACCAGG GCCACGGTCT CGGGCCTCAA GCCTGGCACC 1620
CGCTACATGT TCCAGGTCCG AGCCCGCACA TCCGCCGGCT GCGGCCGCTT CAGCCAGGCC 1680
ATGGAGGTGG AGACTGGGAA ACCCCGTGAG TACGAGACCC TCAGTGAGTT GCCGTTGTTA 1740
ATTGGGACTG AAACCCTGGC GCTCATCACG GGCCTGGTGG TGCTCCTGCT TCTGCTTATC 1800
TGCAAAAAGA GGCACTGCGG CTACAGCAAG GCCTTCCAGG ACTCGGACGA GGAGAAGATG 1860
CAGTATCAGA ACGGGCCGGG GAAGATCCCG GAGCCCCAGT TCTATGCAGA ACCCCACAAT 1920
TATGAGGAAC CAGGCCGGAC GGGCCGCAGT TTCACCCGAG AGATTGAAGC CTCCAGGATC 1980
CACATTGAGA AAATTATCGG CTCTGGGGAG TCCGGGGAAG TCTGCTACGG GCGGTTGCAG 2040
GTGCCGGGGC AGCGGGACGT GCCCGTGGCC ATCAAGGCCC TCAAACCTGG CTACACGGAG 2100
AGACAGCGGC GGGACTTTCT GAGTGAGGCA TCCATCATGG GTCAGTTTGA CCACCCCAAT 2160
ATCATCCGCC TCGAAGGTGT CGTCACCCGT GGCCGCCTGG CAATGATCGT GACCGAGTAC 2220
ATGGAGAATG GCTCTCTGGA CGCCTTCCTG CGGACTCACG ACGGGCAGCT CACCATCATG 2280
CAGCTGGTGG GCATGCTCAG GGGCGTGGGC GCCGGCATGT GCTACCTCTC GGACCTGGGC 2340
TACGTCCACC GCGACCTGGC CGCCCGCAAC GTCCTGGTTG ACAGCAACCT GGTGTGCAAG 2400
GTGTCTGATT TCGGGCTCTC CCGGGTACTG GAGGACGACC CCGACGCGGC CTACACCACC 2460
ACGGGAGGCA AGATCCCCAT CCGCTGGACA GCCCCCGAGG CCATCGCTTT CCGGACCTTC 2520
TCCTCAGCCA GCGACGTGTG GAGCTTTGGC GTGGTCATGT GGGAGGTGCT GGCCTACGGG 2580
GAGAGGCCCT ACTGGAACAT GACCAACCGT GATGTCATCA GCTCCGTGGA GGAGGGGTAC 2640
CGCCTGCCCG CGCCCATGGG CTGCCCCCGC GCCCTGCACC AGCTCATGCT GGACTGCTGG 2700
CACAAGGACA GGGCCCAGCG GCCTCGCTTT TCCCAGATTG TCGGCGTCCT TGATGCCCTC 2760
ATCCGGAGCC CTGAGAGTCT CAGGGCCACT GCCACTGTCA ACAGGTGCCT GACGCCCACC 2820
CCAGCTCTGC CCAAGTCCAG CGGCCCTCCT GGCATTTCCC CAGTCACCGT GGGGGACTGG 2880
CTGGACTCCA ACCGCATGGG CCGCTACCGA GATCACTTCG CCGCCGGCGG GTACTCCTCC 2940
CTGGGCATGG TGCTGCGTAT GAATGCTCAG GACGTGCGTG CCCTGGGCAT CACCCTCATG 3000
GGCCACCAGA AGAAGATCCT GGGCAGCATC CAGACCATGA GGGCCCAGCT GACGAGCACC 3060
CAGGGGCCCC ACCGG 3075
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc Grl++pg+r+++vaik+lk g+te+qrrdflseasi+Gqfdhp
Q: 660   IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKPGYTERQRRDFLSEASIMGQFDHP  719
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgq+t++qlvgmlrG+++gm ylsd+
Q: 720   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQLTIMQLVGMLRGVGAGMCYLSDL  779
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv+snlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+
Q: 780   GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  839
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 840   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPRALHQLMLDC  899
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         w+kdra+rp+f+qiv +
Q: 900   WHKDRAQRPRFSQIVGV  916
         **************986
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGRL QVPGQRDVPV AIKALKPGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQLTI MQLVGMLRGV GAGMCYLSDL 120
GYVHRDLAAR NVLVDSNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP RALHQLMLDC 240
WHKDRAQRPR FSQIVGV 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043005; C:neuron projection
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0016322; P:neuron remodeling
GO:0043410; P:positive regulation of MAPK cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777; P:protein autophosphorylation
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0006929; P:substrate-dependent cell migration
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013