EKS-AIM-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph516.01.3E-155352611260
StatusUnreviewed
Ensembl ProteinENSAMEP00000015667
UniProt AccessionG1M8I9;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000014794ENSAMEP00000015661ENSAMET00000016313
ENSAMEG00000014794ENSAMEP00000015659ENSAMET00000016311
ENSAMEG00000014794ENSAMEP00000015667ENSAMET00000016319
OrganismAiluropoda melanoleuca
Functional Description
Protein Length779
Protein Sequence
(FASTA)
GCPSGTFKAN QGDEACTHCP INSRTTSEGA TNCVCRNGYY RADLDPLDMP CTTIPSAPQA 60
VISSVNETSL MLEWTPPRDS GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE 120
PRIYISDLLA HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD 180
SITLSWSQPD QPNGVILDYE LQYYEKELSE YNATAIKSPT NTVTVQGLKA GAIYVFQVRA 240
RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK LPLIIGSSAA GLVFLIAVVV IAIVCNRRRG 300
FERADSEYTD KLQHYTSGHM TPGMKIYIDP FTYEDPNEAV REFAKEIDIS CVKIEQVIGA 360
GEFGEVCSGH LKLPGKREIF VAIKTLKSGY TEKQRRDFLS EASIMGQFDH PNVIHLEGVV 420
TKSTPVMIIT EFMENGSLDS FLRQNDGQFT VIQLVGMLRG IAAGMKYLAD MNYVHRDLAA 480
RNILVNSNLV CKVSDFGLSR FLEDDTSDPT YTSALGGKIP IRWTAPEAIQ YRKFTSASDV 540
WSYGIVMWEV MSYGERPYWD MTNQDVINAI EQDYRLPPPM DCPSALHQLM LDCWQKDRNH 600
RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG INLPLLDRTI PDYTSFNTVD EWLEAGQYKE 660
SFANAGFTSF DVVSQMMMED ILRVGVTLAG HQKKILNSIQ VMRAQMNQIQ SVEAQPPAGR 720
PRAAGRTEQR SSHETSPGIC ATQMMEKKGG QKKTDPGRGR EIQGIFFKED SHKESDHCS 779
Nucleotide Sequence
(FASTA)
GGTTGCCCAT CTGGAACCTT CAAGGCCAAC CAAGGGGACG AGGCCTGCAC GCACTGTCCC 60
ATCAACAGCC GGACCACCTC AGAAGGGGCG ACCAACTGCG TCTGCCGCAA CGGGTACTAC 120
AGAGCAGACC TGGACCCCCT CGACATGCCC TGCACAACCA TCCCCTCCGC GCCCCAGGCC 180
GTGATCTCCA GCGTCAACGA GACCTCCCTC ATGCTGGAGT GGACCCCGCC CCGCGATTCA 240
GGGGGCCGCG AGGACCTGGT CTACAACATC ATCTGCAAGA GCTGTGGCTC GGGCCGGGGC 300
GCCTGCACCC GCTGTGGGGA CAACGTGCAG TACGCGCCCC GCCAGCTGGG CCTGACCGAG 360
CCACGTATCT ACATCAGCGA CCTGCTGGCC CACACGCAGT ACACCTTCGA GATCCAGGCC 420
GTGAACGGCG TCACCGACCA GAGCCCCTTC TCACCTCAGT TCGCCTCCGT GAACATCACC 480
ACCAACCAGG CAGCTCCATC GGCCGTGTCC ATCATGCACC AGGTGAGCCG CACCGTGGAC 540
AGCATCACCC TGTCGTGGTC CCAGCCTGAC CAGCCCAACG GTGTCATCCT GGACTATGAG 600
CTGCAGTACT ATGAGAAGGA GCTCAGTGAG TACAACGCCA CAGCCATAAA AAGCCCCACC 660
AACACGGTCA CTGTGCAGGG CCTCAAAGCC GGCGCCATCT ATGTCTTCCA GGTGCGGGCA 720
CGCACCGTGG CGGGCTACGG GCGCTACAGC GGCAAGATGT ACTTCCAGAC CATGACAGAA 780
GCCGAGTACC AGACAAGCAT CCAGGAGAAG CTGCCTCTCA TCATCGGCTC CTCGGCGGCT 840
GGCCTGGTCT TCCTCATCGC TGTGGTCGTC ATTGCCATCG TGTGCAACAG AAGACGGGGG 900
TTTGAGCGTG CTGACTCGGA GTACACGGAC AAGCTGCAGC ACTACACCAG TGGCCACATG 960
ACCCCAGGCA TGAAGATCTA CATCGACCCT TTCACCTATG AGGACCCCAA TGAGGCAGTG 1020
CGGGAGTTTG CCAAGGAAAT TGACATCTCC TGTGTCAAAA TCGAGCAGGT GATTGGAGCA 1080
GGGGAGTTCG GCGAGGTATG CAGTGGCCAC CTAAAACTGC CAGGCAAGAG AGAGATCTTT 1140
GTAGCCATCA AGACGCTCAA GTCAGGCTAT ACCGAGAAGC AGCGCCGGGA CTTCCTGAGC 1200
GAGGCCTCCA TCATGGGCCA GTTCGACCAC CCCAACGTCA TCCACCTGGA GGGTGTTGTC 1260
ACCAAGAGCA CCCCTGTGAT GATCATCACT GAGTTCATGG AGAACGGCTC CCTGGACTCC 1320
TTCCTCCGGC AAAATGATGG GCAGTTTACA GTCATCCAGC TGGTCGGCAT GCTGCGGGGC 1380
ATCGCGGCCG GCATGAAGTA CCTGGCAGAC ATGAACTACG TCCACCGCGA CCTCGCTGCC 1440
CGCAACATCC TTGTCAACAG CAACCTGGTC TGCAAGGTGT CTGACTTCGG GCTCTCACGC 1500
TTTCTGGAGG ATGATACTTC AGACCCCACC TACACCAGTG CGCTGGGTGG GAAGATCCCC 1560
ATCCGTTGGA CGGCCCCGGA AGCCATCCAG TACCGGAAGT TCACCTCAGC CAGTGATGTA 1620
TGGAGCTATG GTATTGTCAT GTGGGAGGTG ATGTCCTACG GGGAACGACC CTACTGGGAC 1680
ATGACCAACC AGGACGTAAT CAATGCCATA GAGCAGGACT ACCGGCTGCC GCCACCCATG 1740
GACTGCCCCA GTGCCCTGCA CCAGCTCATG CTGGACTGCT GGCAGAAGGA CCGCAACCAC 1800
CGGCCCAAGT TTGGCCAGAT CGTCAACACG TTGGACAAGA TGATCCGAAA CCCCAACAGC 1860
CTCAAAGCCA TGGCACCCCT CTCCTCTGGA ATCAACCTGC CACTGCTGGA CCGCACCATC 1920
CCCGACTACA CCAGCTTTAA CACGGTGGAC GAGTGGCTGG AGGCCGGGCA GTACAAGGAG 1980
AGCTTCGCCA ATGCCGGCTT CACCTCCTTC GATGTTGTGT CACAGATGAT GATGGAGGAC 2040
ATTCTCCGGG TTGGGGTCAC CTTGGCTGGC CACCAGAAAA AAATCCTGAA CAGTATCCAG 2100
GTGATGCGGG CACAGATGAA CCAGATCCAG TCTGTGGAGG CTCAGCCGCC TGCCGGGAGG 2160
CCACGGGCAG CAGGAAGAAC CGAGCAGCGC TCCAGCCATG AGACGTCACC AGGAATATGT 2220
GCAACTCAGA TGATGGAAAA AAAGGGAGGA CAAAAGAAAA CAGATCCTGG GAGGGGGCGG 2280
GAAATACAAG GAATATTTTT TAAAGAGGAT TCTCATAAGG AAAGTGATCA TTGTTCTTAG 2340
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 352   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  411
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 412   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  471
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 472   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  531
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 532   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  591
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 592   DCWQKDRNHRPKFGQIVNTL  611
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Tursiops truncatus"; ?>
EKS-ANC-00003
EKS-BOT-00004
EKS-GOG-00004
EKS-LAC-00003
EKS-PAT-00005
EKS-PTV-00003
EKS-TUT-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0048593; P:camera-type eye morphogenesis
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0007612; P:learning
GO:0050771; P:negative regulation of axonogenesis
GO:0021631; P:optic nerve morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013