EKS-AIM-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	345.7	2.0E-103	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSAMEP00000015988

UniProt Accession

G1M9G8;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000014980	ENSAMEP00000015988	ENSAMET00000016655

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

LQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVLF YLSDREPLRL GSGEYTAEEL 60

CIRAAQECCI SPLCHNLFAL YDENTKLWYA PNRTITVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

WFHPNDSGNL LYYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEVLGG QKQFKNFQIE VQKGRYSLHG SDRSFPSLGD LMSHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DIVQGEHLGR GTRTHIYSGT 600

LVDYKDDEGT AEEKRIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSERKP ATEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

YSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPLHCP DEVYQLMRKC WEFQPSNRTT 1140

FQNLIEGFEA LLK 1153

Nucleotide Sequence
(FASTA)

CTACAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCCAAGA AGACCGAGGT GAATCTGGAG GCTCCCGAGC CAGGGGTGGA AGTGCTCTTC 120

TATCTTTCGG ATAGGGAGCC CCTCCGGCTG GGCAGCGGGG AGTACACGGC GGAGGAGCTC 180

TGCATCAGGG CCGCGCAGGA ATGTTGTATC TCTCCTCTGT GTCACAACCT CTTTGCTCTG 240

TATGATGAGA ACACCAAGCT CTGGTATGCC CCGAATCGCA CCATCACTGT TGACGACAAG 300

ACATCGCTCC GGCTCCACTA CCGGATGAGA TTCTATTTCA CCAACTGGCA TGGGACCAAT 360

GATAATGAGC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAA 420

AAAAAAGTCC CAGATGCAAC CCCTCTCCTC GACGCCAGCT CTCTGGAGTA TCTGTTTGCT 480

CAGGGACAAT ATGATTTGGT CAAATGCCTG GCTCCCATTC GAGACCCCAA GACCGAGCAG 540

GATGGGCATG ATATCGAGAA TGAGTGTCTG GGCATGGCAG TCCTGGCCAT CTCCCACTAC 600

GCTATGATGA AGAAGATGCA GTTGCCAGAA CTGCCCAAGG ACATCAGCTA CAAGCGATAT 660

ATTCCAGAAA CATTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720

AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACTATTTG TGACAGCAGC 780

GTATCTACTC ATGACCTGAA GGTGAAATAC CTGGCCACCT TGGAAACTTT GACAAAACAT 840

TATGGCGCTG AAATATTTGA GACTTCCATG TTACTGATTT CATCAGAAAA TGAGATGAAT 900

TGGTTTCATC CGAATGACAG TGGAAACCTT CTCTACTATG AAGTGATGGT AACTGGAAAT 960

CTTGGAATCC AGTGGAGACA GAAACCAAAT GTTGTTCCTG TTGAAAAGGA AAAAAACAAA 1020

CTGAAACGGA AAAAGCTGGA AAATAAACAC AAGAAGGATG AGGAGAAAAA CAAAATCCGG 1080

GAAGAGTGGA ACAATTTTTC TTACTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TCAATAAGCA GGACAACAAA AAAATGGAAC TGAAGCTCTC ATCCCATGAA 1200

GAGGCCTTGT CCTTTGTGTC CCTGGTAGAC GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260

CATTACCTCT GCACCGATGT GGCTCCCCCG TTGATCGTCC ACAACATACA GAATGGTTGT 1320

CACGGTCCAA TCTGCACGGA ATATGCCATC AATAAGTTGC GGCAAGAAGG AAGCGAGGAG 1380

GGGATGTATG TGCTGAGGTG GAGCTGTACC GACTTTGACA ATATCCTCAT GACTGTCACC 1440

TGCTTTGAAA AATCTGAGGT GCTGGGTGGC CAGAAACAGT TCAAGAACTT TCAGATCGAG 1500

GTGCAGAAGG GCCGCTACAG CCTGCACGGC TCGGACCGCA GCTTCCCCAG CCTGGGGGAC 1560

CTGATGAGCC ACCTCAAGAA GCAGATCCTG CGCACAGACA ACATCAGTTT CGTGCTGAAG 1620

CGCTGCTGCC AGCCCAAGCC CCGAGAGATC TCCAATCTGC TTGTGGCTAC TAAGAAAGCC 1680

CAAGAGTGGC AGCCTGTCTA CCCCATGAGC CAGCTGAGTT TTGACCGGAT CCTCAAGAAA 1740

GATATTGTGC AAGGCGAGCA CCTCGGGAGA GGCACACGGA CACACATCTA CTCTGGTACC 1800

CTGGTGGATT ACAAGGATGA CGAAGGAACT GCGGAAGAAA AGAGAATAAA AGTGATCCTC 1860

AAAGTCTTAG ACCCCAGCCA CAGGGACATT TCTCTGGCCT TCTTTGAGGC AGCCAGCATG 1920

ATGAGGCAGG TCTCGCACAA ACACATCGTG TACCTCTATG GCGTCTGTGT CCGAGATGTG 1980

GAGAATATCA TGGTGGAGGA GTTTGTGGAG GGGGGGCCCC TGGATCTCTT CATGCACCGG 2040

AAAAGTGATG TCCTCACCAC ACCATGGAAG TTCAAAGTTG CCAAGCAGCT GGCCAGTGCC 2100

CTGAGTTACT TGGAGGATAA AGACCTGGTC CACGGAAACG TGTGCACGAA AAATCTTCTC 2160

CTGGCCCGCG AGGGCATTGA CAGTGAGTGC GGCCCGTTCA TCAAGCTCAG TGACCCTGGC 2220

ATCCCCATCA CTGTGCTGTC CAGGCAAGAG TGCATAGAAC GAATCCCATG GATTGCTCCA 2280

GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAATGGAG CTTTGGAACC 2340

ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCTCTGA AAGACAAGAC CCTGATTGAG 2400

AAAGAGAGAT TCTACGAAAG CCGGTGCCGG CCAGTGACAC CATCTTGTAA GGAGCTGGCT 2460

GACCTTATGA CCCGCTGCAT GAACTATGAC CCCAACCAGA GACCTTTCTT CCGAGCCATC 2520

ATGAGAGACA TCAATAAACT GGAAGAGCAG AATCCAGACA TTGTTTCTGA AAGAAAGCCG 2580

GCAACCGAAG TGGATCCCAC ACATTTTGAA AAGCGGTTCT TGAAGAGGAT CCGTGACTTG 2640

GGAGAGGGCC ACTTCGGGAA GGTCGAGCTC TGCAGGTATG ACCCTGAGGG GGACAATACT 2700

GGGGAGCAGG TGGCAGTCAA ATCCCTGAAG CCCGAGAGTG GAGGTAACCA CATAGCTGAT 2760

CTGAAGAAGG AAATTGAAAT CCTAAGGAAC CTCTATCACG AGAACATTGT GAAGTACAAA 2820

GGCATCTGTA CCGAAGACGG AGGAAATGGT ATTAAGCTCA TCATGGAATT TCTGCCTTCA 2880

GGAAGCCTTA AGGAATATCT TCCAAAGAAT AAGAACAAAA TTAACCTCAA ACAGCAGTTA 2940

AAATATGCCG TTCAGATTTG TAAGGGGATG GACTATTTGG GTTCTCGTCA GTATGTTCAC 3000

CGGGACTTGG CAGCAAGAAA CGTCCTCGTT GAGAGTGAGC ACCAAGTGAA AATTGGAGAC 3060

TTTGGTTTGA CCAAAGCCAT TGAAACTGAC AAGGAGTACT ACACAGTCAA GGATGATCGG 3120

GACAGCCCTG TGTTTTGGTA TGCTCCCGAA TGTTTAATTC AGTGTAAATT TTATATCGCC 3180

TCTGACGTCT GGTCATTTGG AGTGACTCTG CACGAGCTGC TTACTTACTG TGACTCCGAT 3240

TACAGCCCCA TGGCGTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTC 3300

ACAAGACTTG TGAATACATT AAAAGAAGGA AAACGTTTGC CTTGTCCACT TCACTGTCCA 3360

GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCCAA TCGGACAACT 3420

TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c+++ sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDYSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p  cp+e+++lm++c++ +ps+r++F++++e

Q: 1107  LKEGKRLPCPLhCPDEVYQLMRKCWEFQPSNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDYSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPLHCPDEV YQLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013