EKS-AIM-00180
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00180
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK447.81.2E-134322589268
StatusUnreviewed
Ensembl ProteinENSAMEP00000016291
UniProt AccessionG1MAB7;
Protein Name
Protein Synonyms/Alias
Gene NameLIMK1
Gene Synonyms/Alias LIMK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000015431ENSAMEP00000016291ENSAMET00000016965
OrganismAiluropoda melanoleuca
Functional Description
Protein Length632
Protein Sequence
(FASTA)
AGSELPVCAS CGQRIYDGQY LQALNADWHA DCFRCCECSA SLSHQYYEKD GQLFCKRDYW 60
ARYGESCHGC SEHITKGLVM VAGELKYHPE CFICLTCGTF IGDGDTYTLV EHSKLYCGHC 120
YYQTVVTPVI EQILPDSPGS RLPHTVTLVS IPASTHGKRG LSVSIDPPHG LPGCSTEHSH 180
TVRVQGVDPG CMSPDVKNSI HVGDRILEIN GTPIRNVPLD EIDLLIQETS RLLQLTLEHD 240
PHDTLGHGPG PEPSLLFSPT HTPSGEVGSS SRQKPVLRSY STDRSPGAGS LGSPASQRKD 300
LGRSESLRVV CRPHRIFRPS DLIHGEVLGK GCFGQAIKVT HRETGEVMVM KELIRFDEET 360
QRTFLKEVKV MRCLEHPNVL KFIGVLYKDK RLNFITEYIK GGTLRGIIKS MPTGLPPWPR 420
WPILALLSAP SGQAYLHSMN IIHRDLNSHN CLVRENKNVV VADFGLARLM VEEKTQPEDL 480
RSLKKADRKK RYTVVGNPYW MAPEMINGRS YDEKVDVFSF GIVLCEIIGR VNADPDYLPR 540
TMDFGLNVRG FLDRYCPPNC PPSFFPITVR CCDLDPEKRP SFVKLEQWLE TLRMHLAGHL 600
PLGPQLEQLD RGFWETYRRG ESGLPAHPEV PD 632
Nucleotide Sequence
(FASTA)
GCAGGAAGTG AGTTGCCCGT GTGTGCAAGC TGCGGCCAGA GGATCTATGA TGGCCAGTAC 60
CTCCAGGCCC TGAATGCTGA CTGGCACGCA GATTGCTTCA GGTGTTGTGA ATGCAGTGCC 120
TCCCTCTCAC ACCAGTACTA CGAGAAGGAT GGGCAGCTCT TCTGCAAGAG GGACTACTGG 180
GCCCGCTATG GAGAGTCCTG CCACGGGTGC TCAGAGCACA TCACCAAGGG GCTGGTCATG 240
GTGGCCGGGG AGCTAAAATA CCACCCCGAG TGCTTCATCT GCCTCACGTG CGGGACCTTC 300
ATCGGGGACG GGGACACCTA CACGCTGGTG GAACACTCCA AGCTGTACTG TGGGCACTGC 360
TACTATCAGA CCGTGGTGAC CCCCGTTATC GAGCAGATCC TGCCCGACTC CCCCGGCTCC 420
CGCCTGCCCC ACACAGTTAC CCTAGTATCC ATCCCAGCCT CGACTCATGG CAAACGTGGC 480
CTCTCAGTCT CCATCGACCC CCCACACGGT CTGCCGGGCT GCAGCACAGA GCACTCCCAC 540
ACCGTCCGTG TCCAGGGGGT GGACCCAGGC TGCATGAGCC CCGATGTGAA GAATTCCATC 600
CATGTCGGAG ACCGGATCCT GGAAATCAAT GGCACACCCA TCCGGAATGT GCCCCTGGAT 660
GAGATTGACC TGCTGATCCA GGAAACCAGC CGCCTACTCC AGCTAACTCT TGAGCACGAT 720
CCCCACGACA CGCTGGGTCA CGGGCCGGGT CCTGAGCCCA GCCTCCTGTT CTCCCCAACT 780
CACACTCCCA GTGGGGAGGT GGGCAGCTCT TCACGGCAGA AGCCTGTCCT GAGGAGCTAC 840
AGCACCGACA GGTCTCCGGG TGCCGGCTCA CTGGGCTCCC CAGCCTCCCA GCGCAAGGAC 900
CTGGGGCGCT CCGAATCCCT CCGCGTGGTC TGCCGGCCGC ACCGCATCTT CCGGCCGTCA 960
GACCTCATCC ATGGGGAGGT GTTGGGCAAG GGCTGCTTCG GCCAGGCCAT CAAGGTGACG 1020
CACCGGGAGA CGGGCGAGGT GATGGTGATG AAGGAGCTGA TCCGGTTCGA CGAAGAGACC 1080
CAAAGGACAT TCCTCAAGGA GGTGAAGGTC ATGAGATGCC TGGAGCACCC CAACGTGCTC 1140
AAGTTCATCG GGGTGCTCTA TAAGGACAAG AGGCTCAACT TCATCACAGA GTACATCAAG 1200
GGGGGCACCC TGCGGGGCAT CATCAAGAGC ATGCCAACCG GTCTGCCACC GTGGCCCCGT 1260
TGGCCCATCC TGGCCCTTCT CTCCGCCCCC TCAGGACAGG CCTACCTTCA CTCCATGAAC 1320
ATCATCCACC GGGACCTCAA CTCCCACAAC TGCCTGGTCC GAGAGAACAA GAACGTGGTG 1380
GTGGCCGACT TTGGGCTGGC CCGGCTCATG GTGGAAGAAA AGACACAACC TGAAGACCTG 1440
CGAAGCCTCA AGAAGGCAGA CCGCAAAAAG CGCTACACGG TGGTGGGTAA CCCGTACTGG 1500
ATGGCGCCCG AGATGATCAA TGGCCGCAGC TACGACGAGA AGGTGGACGT GTTTTCCTTT 1560
GGAATCGTCC TGTGCGAGAT CATTGGGCGG GTGAATGCGG ACCCTGACTA CCTGCCCCGC 1620
ACCATGGACT TTGGCCTCAA TGTGCGAGGC TTCCTGGACC GTTACTGCCC CCCAAACTGC 1680
CCGCCGAGCT TTTTCCCCAT CACTGTGCGC TGCTGTGATC TGGACCCTGA GAAGAGGCCC 1740
TCCTTCGTGA AGCTGGAGCA GTGGCTGGAG ACCCTCCGCA TGCACTTGGC CGGCCACCTG 1800
CCACTGGGCC CGCAGCTGGA GCAGCTGGAC AGGGGCTTCT GGGAGACCTA CCGCCGTGGC 1860
GAGAGTGGAC TGCCTGCTCA CCCCGAGGTC CCCGACTGA 1899
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk
Q: 322   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  381
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes..lpwtqrvrlak.diasGlsylhskgi  117
         fiGvl+kdk+l+++teyi+gGtl+ ++ks+ +   pw++   la     sG +ylhs++i
Q: 382   FIGVLYKDKRLNFITEYIKGGTLRGIIKSMPTglPPWPRWPILALlSAPSGQAYLHSMNI  441
         ******************************99845799988888625669**********
S: 118   ihrdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywm  177
         ihrdlns+nclvre+k+vvvadfGlarl+vee++++e+lrslkk drkkr+tvvG+Pywm
Q: 442   IHRDLNSHNCLVRENKNVVVADFGLARLMVEEKTQPEDLRSLKKADRKKRYTVVGNPYWM  501
         ************************************************************
S: 178   aPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcP  237
         aPe+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++ +cP
Q: 502   APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCP  561
         ************************************************************
S: 238   eaflklavvccdldpesrpsfeelekkl  265
         ++f++++v+ccdldpe+rpsf++le++l
Q: 562   PSFFPITVRCCDLDPEKRPSFVKLEQWL  589
         **************************97
Domain Sequence
(FASTA)
LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60
FIGVLYKDKR LNFITEYIKG GTLRGIIKSM PTGLPPWPRW PILALLSAPS GQAYLHSMNI 120
IHRDLNSHNC LVRENKNVVV ADFGLARLMV EEKTQPEDLR SLKKADRKKR YTVVGNPYWM 180
APEMINGRSY DEKVDVFSFG IVLCEIIGRV NADPDYLPRT MDFGLNVRGF LDRYCPPNCP 240
PSFFPITVRC CDLDPEKRPS FVKLEQWL 268
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00185
EKS-BOT-00191
EKS-CAF-00197
EKS-CAP-00216
EKS-DAR-00492
EKS-DIO-00098
EKS-DRM-00101
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00189
EKS-MAM-00192
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00195
EKS-MYL-00196
EKS-OCP-00125
EKS-ORN-00242
EKS-ORA-00170
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-PES-00169
EKS-POA-00188
EKS-RAN-00185
EKS-SAH-00188
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00242
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005925; C:focal adhesion
GO:0043005; C:neuron projection
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0051444; P:negative regulation of ubiquitin-protein ligase activity
GO:0032233; P:positive regulation of actin filament bundle assembly
GO:0045773; P:positive regulation of axon extension
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF00595; PDZ; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 2.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 2.
PS50023; LIM_DOMAIN_2; 2.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013