EKS-AIM-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.3E-167	478	754	277

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016427

UniProt Accession

G1MAQ3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015496	ENSAMEP00000016427	ENSAMET00000017106

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MWGWKGLLFW AVLVTATLCT ARPAPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLVESNRTR ITGEEVEVRD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180

SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240

HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300

GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360

ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIIYKMK SGTKKSDFHS QMAVHKLAKS 420

IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480

GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600

VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660

RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720

KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS VPLDQYSPSF 780

PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR 822

Nucleotide Sequence
(FASTA)

ATGTGGGGCT GGAAGGGCCT CCTTTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60

GCCAGGCCGG CCCCAACCTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC TGGTGACCTG CTGCAGCTCC GCTGTCGGCT GCGGGACGAT 180

GTCCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG TGGAAAGCAA CCGTACCCGC 240

ATCACGGGGG AGGAGGTGGA GGTGCGGGAT TCCGTGCCTG CCGACTCCGG CCTCTACGCT 300

TGTGTGACCA GCAGCCCCTC GGGCAGCGAC ACCACCTACT TCTCCGTCAA TGTCTCAGAT 360

GCTCTCCCCT CCTCGGAGGA CGACGATGAT GATGATGACT CCTCTTCAGA GGAGAAAGAG 420

ACAGATAACA CCAAACCAAA CCGTATGCCC GTGGCTCCGT ACTGGACGTC CCCAGAAAAG 480

ATGGAAAAGA AATTGCACGC AGTGCCGGCT GCCAAGACTG TGAAGTTCAA ATGCCCTTCC 540

AGTGGGACTC CCAACCCCAC GCTGCGCTGG TTGAAAAATG GCAAAGAATT CAAACCTGAC 600

CACAGGATTG GAGGGTACAA GGTCCGTTAC GCCACCTGGA GCATCATCAT GGACTCCGTG 660

GTGCCTTCGG ATAAGGGCAA CTACACCTGC ATCGTGGAGA ACGAGTATGG CAGCATCAAC 720

CACACCTACC AGCTCGACGT CGTGGAGCGG TCCCCTCACC GGCCCATCCT GCAGGCAGGG 780

CTGCCTGCCA ACAAGACCGT GGCCCTGGGC AGCAATGTGG AGTTCATGTG TAAGGTGTAC 840

AGTGACCCAC AGCCCCATAT CCAGTGGCTG AAGCACATCG AGGTGAATGG GAGTAAGATT 900

GGTCCAGACA ACCTGCCTTA TGTCCAGATC TTGAAGACTG CCGGAGTTAA TACCACCGAC 960

AAAGAGATGG AAGTGCTTCA CTTAAGGAAT GTCTCCTTTG AGGACGCGGG GGAGTATACG 1020

TGCTTGGCGG GTAACTCTAT CGGACTCTCC CATCACTCTG CATGGTTGAC CGTTTTGGAA 1080

GCCCTGGAAG AGAGGCCAGC AGTGATGACC TCGCCCCTGT ACCTGGAGAT CATCATCTAC 1140

TGCACGGGGG CCTTCCTCAT CTCCTGCATG GTGGGGTCTG TCATCATCTA CAAGATGAAG 1200

AGTGGCACCA AGAAGAGCGA CTTCCACAGC CAGATGGCCG TGCACAAGCT GGCCAAGAGC 1260

ATCCCTCTGC GCAGACAGGT AACAGTGTCG GCTGATTCTA GCGCGTCCAT GAACTCTGGG 1320

GTTCTGCTGG TTCGGCCCTC ACGTCTCTCC TCTAGTGGAA CCCCCATGCT GGCCGGGGTC 1380

TCTGAATACG AGCTTCCCGA AGACCCTCGC TGGGAGCTGC CTCGAGACAG GCTGGTTTTA 1440

GGCAAACCCC TGGGTGAGGG CTGCTTTGGG CAGGTGGTGT TGGCGGAGGC CATTGGGCTG 1500

GACAAGGACA AACCCAACCG TGTGACCAAA GTGGCTGTGA AGATGCTGAA GTCGGATGCA 1560

ACAGAGAAAG ACCTGTCAGA CCTGATCTCG GAAATGGAGA TGATGAAGAT GATTGGGAAG 1620

CACAAGAACA TCATCAACCT GCTGGGGGCC TGCACGCAGG ACGGTCCTTT GTACGTCATC 1680

GTGGAGTATG CCTCCAAAGG CAACCTGCGG GAGTACCTGC AGGCCCGGCG GCCTCCTGGG 1740

CTGGAGTACT GTTACAACCC CAGCCACAAC CCAGAGGAGC AGCTCTCCTC CAAGGACCTG 1800

GTCTCCTGCG CCTATCAGGT GGCCCGAGGC ATGGAGTATC TTGCCTCCAA GAAGTGCATA 1860

CACCGAGACC TGGCCGCCAG GAACGTGCTG GTGACAGAGG ACAACGTGAT GAAGATCGCA 1920

GACTTCGGCC TCGCACGGGA CATTCACCAC ATCGACTACT ATAAAAAGAC AACCAACGGC 1980

CGGCTGCCTG TGAAGTGGAT GGCCCCCGAG GCCTTGTTTG ACCGGATCTA CACCCACCAG 2040

AGTGACGTCT GGTCTTTTGG GGTGCTCCTG TGGGAAATCT TCACTCTGGG AGGCTCCCCG 2100

TATCCTGGCG TGCCTGTGGA GGAGCTTTTC AAGCTGCTGA AGGAGGGTCA TCGGATGGAC 2160

AAGCCCAGTA ACTGCACCAA TGAGCTGTAC ATGATGATGC GGGATTGCTG GCACGCGGTT 2220

CCCTCTCAGA GACCCACCTT CAAGCAGCTG GTGGAAGACC TGGACCGCAT TGTGGCCTTG 2280

ACCTCCAACC AGGAGTACCT GGACCTGTCC GTGCCCCTGG ACCAGTACTC TCCGAGCTTC 2340

CCCGACACCC GGAGCTCTAC CTGCTCCTCA GGGGAGGATT CCGTCTTCTC TCACGAGCCG 2400

TTGCCCGAGG AGCCCTGTCT GCCCCGACAC CCGGCCCAGC TTGCCAATGG CGGACTCAAA 2460

CGACGC 2466

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 478   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 718   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  754

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013