EKS-AIM-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	333.9	5.5E-100	53	304	252

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016462

UniProt Accession

G1MAT8;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015604	ENSAMEP00000016462	ENSAMET00000017142

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

RQSAAAPAGG GGLGPGSPCL PRWRAPRLSA APEPRKPHGV KRHHHKHNLK HRYELQETLG 60

KGTYGKVKRA TERFSGRVVA IKSIRKDKIK DEQDMVHIRR EIEIMSSLNH PHIISIYEVF 120

ENKDKIVIIM EYASKGELYD YISERRRLSE RETRHFFRQI VSAVHYCHKN GVVHRDLKLE 180

NILLDDSCNI KIADFGLSNL YQKDKFLQTF CGSPLYASPE IVNGRPYRGP EVDSWALGVL 240

LYTLVYGTMP FDGFDHKNLI RQISSGEYRE PTQPSDARGL IRWMLMVNPD RRATIEDIAN 300

HWWVNWGYKS SVCDCDTLHN SESPLLARII DWHHRSTGLQ AEAEAKIKGL AKPGASEVML 360

ERQRSLKKSK KENDFAQSGQ DSVPESPSKL SSKRPKGILK KRSNSEHRSH STGFIEGVVS 420

PALPAAFKVE PDLCRTAVPL PSSPEAEAPG KLSPKQSATM PKKGILKKTQ QRESGYYSSP 480

ERSESSELLD SNDGLGSGLP SPSPPDPARG TSHGLSCRRK GILKHSSKYS AGTMDPALVS 540

PETPTLESLL EPGVPAEGLS RSYSRPSSVI SDDSVLSSDS FDLLDLQENR PARQRIRSCV 600

SAENFLQIQD FEGLQNQPRP QYLKRYRNRL GDSSFSLLMD MDDVTQVYKK ALEICSKLN 659

Nucleotide Sequence
(FASTA)

CGGCAGAGCG CAGCCGCCCC AGCCGGAGGA GGGGGCCTCG GACCCGGCTC GCCCTGCCTT 60

CCGAGATGGA GGGCGCCGCG GCTCTCGGCG GCCCCGGAGC CCAGGAAGCC GCACGGGGTG 120

AAGCGGCATC ACCACAAGCA CAACTTGAAG CACCGCTACG AGCTGCAGGA GACCCTGGGC 180

AAAGGCACCT ACGGCAAAGT CAAGAGGGCC ACCGAGAGGT TTTCGGGCCG AGTGGTTGCT 240

ATAAAATCCA TTCGTAAGGA CAAAATTAAG GATGAACAAG ACATGGTTCA CATCAGACGA 300

GAGATTGAGA TCATGTCATC CCTCAACCAT CCTCATATCA TCAGTATTTA TGAAGTGTTT 360

GAGAACAAAG ATAAGATTGT GATCATCATG GAGTACGCCA GCAAGGGGGA GCTGTATGAT 420

TACATCAGCG AGCGGAGACG CCTCAGCGAG AGGGAGACCA GACACTTCTT CCGGCAGATC 480

GTGTCCGCCG TGCACTATTG TCACAAGAAC GGCGTGGTCC ACCGGGACTT GAAGCTGGAA 540

AACATCCTGC TGGATGACAG CTGCAATATT AAGATTGCTG ACTTCGGGCT TTCCAACCTG 600

TACCAGAAGG ACAAGTTCTT GCAAACCTTT TGTGGGAGCC CACTCTATGC TTCTCCTGAG 660

ATCGTCAATG GGAGACCTTA CCGGGGGCCG GAGGTGGACA GCTGGGCCCT GGGCGTGTTG 720

CTTTACACTC TCGTTTATGG AACGATGCCC TTCGATGGTT TCGATCACAA AAACCTCATT 780

CGGCAGATCA GCAGCGGAGA GTACCGGGAG CCCACGCAGC CGTCAGACGC CCGAGGACTC 840

ATTCGGTGGA TGCTGATGGT GAACCCCGAT CGCCGGGCCA CCATCGAGGA CATCGCCAAC 900

CACTGGTGGG TGAACTGGGG CTACAAGAGC AGCGTCTGTG ACTGCGACAC GCTCCACAAC 960

TCCGAGTCGC CACTCTTGGC TCGCATCATC GACTGGCACC ACCGTTCCAC GGGGCTGCAG 1020

GCTGAGGCTG AAGCCAAAAT CAAGGGCCTG GCCAAGCCCG GGGCCTCCGA GGTCATGCTG 1080

GAGCGGCAGC GGTCCCTGAA AAAGTCCAAG AAAGAGAACG ATTTTGCGCA GTCCGGCCAG 1140

GACTCGGTAC CCGAGAGCCC ATCCAAGCTG AGTTCCAAGA GGCCCAAAGG GATCTTGAAG 1200

AAGCGGAGCA ACAGCGAACA TCGCTCTCAC AGCACCGGCT TCATCGAAGG CGTCGTGAGC 1260

CCCGCTTTAC CCGCTGCTTT CAAGGTGGAG CCCGACTTGT GCCGGACCGC CGTGCCGCTG 1320

CCGAGCTCCC CCGAGGCGGA GGCGCCAGGC AAGCTCAGCC CCAAGCAGTC GGCCACGATG 1380

CCCAAGAAGG GCATCTTGAA GAAGACACAG CAGAGAGAGT CGGGTTACTA CTCGTCCCCG 1440

GAGCGCAGCG AGTCTTCGGA GCTGTTGGAC AGTAACGACG GGCTGGGCAG CGGCCTCCCT 1500

TCCCCCAGCC CCCCGGACCC TGCCAGGGGG ACGTCCCACG GCCTCTCCTG CCGCAGGAAG 1560

GGCATCTTGA AACACAGCAG CAAGTACTCC GCGGGGACCA TGGACCCGGC CCTTGTCAGC 1620

CCTGAAACGC CCACACTGGA ATCCCTGCTG GAGCCCGGCG TCCCCGCTGA GGGCCTGTCC 1680

CGGAGCTACA GCCGGCCCTC CAGCGTCATC AGTGACGACA GCGTCCTGTC CAGCGACTCC 1740

TTCGACTTGC TGGATTTGCA GGAGAACCGC CCTGCCCGCC AGCGCATCCG CAGCTGTGTC 1800

TCTGCTGAAA ACTTCCTCCA GATCCAGGAC TTTGAGGGGC TCCAGAACCA GCCTCGACCC 1860

CAGTACCTGA AGCGGTACCG GAACCGGCTG GGAGACAGCA GCTTCTCCCT CCTCATGGAC 1920

ATGGACGATG TGACTCAGGT CTACAAGAAA GCGCTGGAGA TCTGCAGCAA GCTGAACTAG 1980

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 53    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPH  112

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 113   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  172

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 173   VHRDLKLENILLDDSCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  232

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 233   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  291

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 292   RATIEDIANHWWV  304

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDSCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013