EKS-AIM-00253

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00253

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	436.8	5.0E-131	221	517	297

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016532

UniProt Accession

G1MB05;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015666	ENSAMEP00000016532	ENSAMET00000017213

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

638

Protein Sequence
(FASTA)

SATVFRPASS SCRTNMDAKK PRNYSLTTFP ILKARKKQNL HPGKVESKPL VQAQKPSSKL 60

KNLRMTQFLP KNPNTSITAL PFVDTKGKKN MVNLPHISNK ILLKPPLLYQ ENQSHNQIPA 120

SELKASEMPF HSSSKTEDPK PEEKPPKRHK VPLTAAEALR FFKNQLSSYE QSEILGYTEL 180

WFLGLEAEKL HVTPEKFSKT SFDDEHGSYL KVLHDHIAYR YEVLEMIGRG SFGQVAKCLD 240

HKNNELVALK IIRNKKRFHH QALVELKILE ALRRKDKDNT HNVVHMKDFF YFRNHLCITF 300

ELLGINLYEL MKNNSFQGFS LSIVRRFTLS VLKCLQMLYV EKIIHCDLKP ENIVLYQKGQ 360

VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYNM AIDMWSLGCI MAELYTGYPL 420

FPGENEVEQL ACIMEVLGLP PTHFIQTASR RQTFFDSKGF PKNMTNNRGK KRYPDSKDLT 480

MVLKTCDTSF LDFLRRCLVW EPSLRMTPDQ ALKHAWIHEP RNLKPRSRPQ TLRKASLCLP 540

SEARKSKVQG HHHLDIKEVI IKAATIDKIK GGTTKQVQNS GDQQGSLQHA ADVVQLPQLT 600

EASGKPEAVV GTEDSKTSPG KQSKNSSPKN MNILPPIV 638

Nucleotide Sequence
(FASTA)

TCAGCCACTG TTTTTAGGCC TGCCTCTTCC TCTTGCAGGA CTAACATGGA TGCTAAAAAA 60

CCAAGGAACT ATAGTTTGAC AACCTTCCCA ATTTTGAAAG CAAGAAAGAA ACAGAATCTC 120

CACCCTGGGA AGGTTGAGAG TAAGCCTTTG GTTCAAGCCC AGAAGCCATC TTCCAAGCTC 180

AAGAACCTCA GAATGACTCA ATTCTTGCCT AAGAATCCAA ACACCAGCAT TACTGCACTC 240

CCTTTTGTGG ATACCAAGGG GAAGAAGAAC ATGGTTAACC TCCCACACAT CAGCAACAAA 300

ATCTTGCTAA AGCCACCCCT GCTGTATCAG GAGAATCAAA GTCACAATCA GATACCAGCC 360

TCTGAACTCA AGGCTTCAGA AATGCCTTTC CATTCAAGCA GTAAAACCGA AGATCCCAAG 420

CCAGAGGAGA AACCACCAAA AAGGCACAAG GTGCCTCTGA CAGCGGCAGA GGCCCTAAGG 480

TTTTTTAAGA ACCAGCTATC TTCATATGAG CAAAGTGAAA TCCTGGGCTA CACGGAGCTA 540

TGGTTCCTGG GGCTTGAAGC AGAGAAGCTC CACGTGACTC CTGAGAAGTT CAGTAAAACA 600

AGTTTCGATG ATGAACACGG CTCCTATCTG AAGGTCCTGC ATGATCACAT TGCCTACCGC 660

TATGAGGTTT TGGAGATGAT CGGGAGAGGG TCCTTTGGAC AGGTGGCCAA GTGCTTGGAT 720

CACAAAAACA ATGAGTTGGT GGCCTTGAAA ATCATCAGGA ACAAGAAGAG ATTTCACCAT 780

CAGGCGCTGG TGGAGCTGAA GATCCTGGAA GCTCTCAGAA GGAAGGACAA AGACAACACC 840

CACAATGTGG TGCACATGAA GGACTTTTTC TATTTTCGCA ATCATCTCTG CATCACCTTT 900

GAACTCCTGG GAATCAACTT ATATGAGTTG ATGAAGAATA ATAGCTTTCA AGGCTTCAGT 960

CTGTCAATAG TTCGGCGCTT CACCCTCTCT GTTTTGAAGT GTTTGCAAAT GCTTTATGTA 1020

GAGAAAATCA TTCACTGTGA TCTCAAGCCC GAGAATATAG TGTTATACCA AAAGGGCCAA 1080

GTCTCTGTTA AAGTCATTGA CTTTGGATCA AGCTGTTATG AACACCAGAA AGTATACACC 1140

TACATCCAAA GCCGGTTCTA TAGATCCCCA GAGGTGATTC TGGGCCATCC CTACAACATG 1200

GCCATTGATA TGTGGAGCCT GGGCTGCATC ATGGCCGAGT TGTACACAGG CTACCCTCTG 1260

TTCCCCGGGG AGAATGAAGT GGAGCAGCTG GCCTGCATCA TGGAGGTGCT GGGCCTGCCA 1320

CCAACCCACT TCATTCAGAC GGCCTCCAGG AGACAGACAT TCTTTGATTC CAAAGGTTTT 1380

CCTAAAAATA TGACCAACAA CAGGGGGAAA AAAAGATACC CGGATTCGAA GGATCTCACG 1440

ATGGTGCTGA AAACCTGCGA CACCAGCTTC CTGGACTTTC TCAGAAGGTG TTTGGTATGG 1500

GAACCTTCTC TTCGCATGAC CCCTGACCAG GCCCTCAAAC ATGCTTGGAT TCATGAGCCA 1560

CGGAATCTCA AACCACGGTC CAGACCCCAG ACCCTGAGGA AAGCCAGTCT CTGTCTCCCC 1620

TCTGAGGCTC GGAAGTCCAA GGTTCAGGGG CATCATCATT TGGACATAAA AGAGGTGATC 1680

ATCAAAGCAG CGACCATAGA CAAAATAAAA GGTGGCACCA CTAAACAGGT TCAGAATTCA 1740

GGTGATCAGC AGGGCTCTCT ACAGCATGCA GCTGATGTTG TCCAGCTGCC TCAACTAACA 1800

GAAGCTTCTG GAAAGCCAGA GGCAGTTGTT GGAACAGAAG ACTCCAAGAC CTCCCCAGGA 1860

AAACAAAGTA AAAACTCCTC ACCCAAGAAC ATGAATATTT TACCACCTAT TGTATGA 1917

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+ig+GsfgqV+k+ld+k++e va+kii+nkkrf++qa  E++iLe+l++kdk+++

Q: 221   YEVLEMIGRGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNT  280

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nvv+++++f+frnhlc++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L++L+

Q: 281   HNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFQGFSLSIVRRFTLSVLKCLQMLYV  340

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++y+

Q: 341   EKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYN  399

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc++aEl+tG+pLfpGenev+qla+i+evlglpp++++++a+++++ff++k+

Q: 400   MAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPTHFIQTASRRQTFFDSKG  459

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk ++                ++  k+++p sk+l+++lk+++++ f d+l+r+l ++p

Q: 460   FPKNMT----------------NNRGKKRYPDSKDLTMVLKTCDTS-FLDFLRRCLVWEP  502

         999655................445567899*********999888.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 503   SLRMTPDQALKHAWI  517

         *************97

Domain Sequence
(FASTA)

YEVLEMIGRG SFGQVAKCLD HKNNELVALK IIRNKKRFHH QALVELKILE ALRRKDKDNT 60

HNVVHMKDFF YFRNHLCITF ELLGINLYEL MKNNSFQGFS LSIVRRFTLS VLKCLQMLYV 120

EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYNM 180

AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PTHFIQTASR RQTFFDSKGF 240

PKNMTNNRGK KRYPDSKDLT MVLKTCDTSF LDFLRRCLVW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013