EKS-AIM-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKN	478.7	4.4E-144	598	857	260

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016609

UniProt Accession

G1MB81;

Protein Name

Protein Synonyms/Alias

Gene Name

PKN3

Gene Synonyms/Alias

PKN3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015712	ENSAMEP00000016609	ENSAMET00000017295

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

925

Protein Sequence
(FASTA)

FAGPTSQLES QPWREQPDGL AGRGWHPLLG PGADGRPPED EKEVIRRAIQ KELKIKEGVE 60

NLRRVATDRR QLGHVQELLR SSNRRLEQLH GELRALHARI LLPGPGRGLS ALEPVAPGPQ 120

PPAEQPRARL LEALQRQLHV ELKVKQGAEN MTHTYAHGTP KERKLLVAAQ QMLRDSQLKV 180

ALLRMKISSL EASGSPEPGE AGRSGPELLA EELRHRLRIE AAVAEGAKNV VKLLGDRRTQ 240

DRKALAEAQA QLQESSQKLD LLRLALGQLL EGLPSAHPLR GRVARELRTA VSGNPQPSGV 300

LVKPTALTGT LEVRLLGCEQ LLTAVPGRSP AAALAGSPSQ GWLRGRAKPQ RGGGDLATSP 360

ALSSRSRPAA EVLAVLKVDN RVVGQTGWGP VAKQSWDQTF IVPLERAREL EIGVRWRDWR 420

QLCGVAFLRL EDFLDNACHQ LSLSLVPQGL LFAQVTFCDP VIERRPRLRR QKRIFSKRRG 480

QDFLRASQMN LSMAAWGRLV MSLLPPCSSP NTISPPKACP QTPAPPRGAA EPASPSPSAL 540

AAHQTPPHGA QDTSRAVSSG LSHQETAVPG TPNPSPPTPR RGFLCPLSCR KPPRLQDFRC 600

LAVLGRGHFG KVLLVQFKGT GKYYAIKALK KQEVLSRDEM ESLYCEKRIL EAVGRTGHPF 660

LLSLLACFQT SSHACFVTEF APGGDLMMQI HEDVFPEPQA RFYVACVVLG CRRRPPPAML 720

QGDLKLDNLL LDAQGFLKIA DFGLCKEGIG FGDRTSTFCG TPEFLAPEVL TQEAYTRAVD 780

WWGLGVLLYE MLVGECPFPG DTEEEVFDCI VNADAPYPRF LSAQGLELIQ KLLQKCPEQR 840

LGGGEQDAEE IKTQPFFRTT DWQALLARTV QPPFQPLLCG PTDLRYFEGE FTGLPPALTP 900

PDPRCPLTAR QQAAFRDFDF VSEGF 925

Nucleotide Sequence
(FASTA)

TTTGCTGGCC CCACGTCTCA GCTAGAATCG CAGCCTTGGA GAGAGCAGCC TGATGGGTTG 60

GCAGGGAGAG GGTGGCATCC CCTTCTCGGT CCTGGGGCCG ACGGGCGGCC CCCCGAGGAT 120

GAGAAAGAGG TGATCCGCCG GGCCATCCAG AAGGAGCTGA AAATCAAGGA GGGCGTAGAG 180

AACCTGCGGA GGGTAGCCAC AGACCGCCGC CAGCTGGGCC ACGTGCAGGA GCTTCTGCGC 240

TCGTCCAACC GCCGCCTGGA GCAGCTGCAC GGAGAACTGA GGGCGCTGCA CGCACGCATC 300

CTGCTGCCAG GCCCGGGGCG GGGGCTCTCG GCTCTGGAAC CTGTGGCCCC GGGCCCCCAG 360

CCGCCCGCAG AGCAGCCCAG GGCTCGGCTC CTGGAGGCCC TCCAGAGGCA GCTGCACGTG 420

GAGCTGAAGG TGAAGCAGGG GGCAGAGAAC ATGACGCACA CGTATGCCCA TGGCACGCCC 480

AAGGAGCGGA AGCTGCTGGT GGCTGCCCAG CAGATGCTCC GGGACAGCCA GCTGAAGGTG 540

GCCCTGCTAC GAATGAAGAT CAGCAGCTTG GAAGCCAGCG GGTCCCCGGA ACCAGGTGAG 600

GCTGGGAGAA GCGGTCCCGA GCTGCTGGCG GAGGAGCTAA GACATCGGCT CCGCATCGAG 660

GCTGCTGTGG CCGAGGGTGC CAAGAACGTG GTGAAGCTGC TGGGTGACCG GCGAACGCAA 720

GACCGGAAGG CGCTGGCCGA GGCCCAGGCC CAGCTCCAGG AGTCCTCCCA GAAACTGGAC 780

CTCCTGCGGC TGGCCCTGGG GCAGCTGCTG GAGGGACTGC CTTCTGCTCA CCCTCTGCGT 840

GGCAGAGTGG CCCGGGAGCT GCGGACCGCC GTGTCGGGGA ACCCCCAGCC TTCCGGGGTG 900

CTTGTGAAGC CCACCGCCCT GACAGGGACG CTGGAGGTCC GCCTCCTGGG CTGTGAGCAG 960

CTGCTCACAG CAGTGCCTGG ACGGTCCCCG GCGGCTGCGC TGGCCGGGAG CCCCTCCCAG 1020

GGCTGGCTCC GGGGCAGGGC CAAGCCGCAG CGTGGCGGAG GAGATCTGGC CACCTCGCCT 1080

GCCCTGAGCT CCCGGTCTCG CCCCGCAGCC GAGGTGCTGG CTGTGCTGAA GGTGGACAAT 1140

CGTGTCGTGG GCCAGACTGG CTGGGGGCCG GTGGCCAAGC AGTCCTGGGA CCAGACCTTT 1200

ATTGTCCCCC TGGAGCGGGC CCGGGAGCTG GAGATCGGGG TGCGCTGGCG GGACTGGCGG 1260

CAGCTGTGCG GCGTGGCCTT CCTGCGGCTG GAGGACTTCC TGGACAATGC CTGTCACCAG 1320

CTCTCCCTCA GTCTGGTGCC CCAGGGGCTG CTCTTTGCCC AGGTGACCTT CTGTGACCCT 1380

GTCATTGAGA GGAGGCCCCG GCTGCGGAGG CAGAAACGCA TTTTCTCTAA ACGCAGAGGT 1440

CAGGACTTCC TGAGGGCTTC ACAGATGAAC CTCAGCATGG CGGCCTGGGG ACGCTTGGTC 1500

ATGAGCCTGC TGCCCCCCTG CAGCTCCCCG AACACGATCA GCCCTCCCAA AGCGTGCCCC 1560

CAGACCCCGG CCCCACCCCG GGGGGCTGCC GAGCCTGCCT CGCCCAGCCC CTCTGCCCTC 1620

GCAGCGCACC AAACGCCCCC ACATGGAGCC CAGGACACGA GTCGGGCCGT CTCCTCCGGC 1680

CTCAGCCACC AGGAAACTGC TGTCCCAGGA ACCCCCAACC CCTCACCCCC CACCCCCAGG 1740

CGGGGCTTCC TGTGCCCTCT CTCTTGCAGG AAACCCCCCC GGCTTCAGGA CTTCCGCTGC 1800

TTGGCCGTGC TGGGCCGGGG ACACTTTGGG AAGGTCCTCC TGGTCCAGTT CAAGGGGACA 1860

GGGAAGTACT ATGCCATCAA GGCACTCAAG AAGCAGGAGG TGCTGAGCCG AGACGAGATG 1920

GAGAGCCTGT ATTGCGAGAA ACGCATCCTG GAGGCGGTGG GCCGCACGGG GCACCCCTTC 1980

CTGCTCTCCC TCCTTGCCTG CTTCCAGACC TCCAGCCACG CCTGCTTCGT GACCGAGTTT 2040

GCACCCGGTG GTGACCTCAT GATGCAGATC CACGAGGACG TCTTCCCTGA GCCCCAGGCC 2100

CGGTTCTACG TGGCCTGTGT GGTCCTCGGG TGCAGACGCC GCCCTCCTCC TGCGATGCTC 2160

CAGGGGGACC TGAAGTTGGA TAACCTTCTG CTGGATGCCC AGGGTTTCCT GAAGATCGCA 2220

GACTTTGGGC TGTGTAAGGA AGGGATCGGC TTTGGGGACC GGACAAGCAC CTTCTGCGGC 2280

ACCCCGGAGT TCCTGGCCCC GGAAGTGCTG ACCCAGGAGG CCTACACACG GGCTGTGGAC 2340

TGGTGGGGGT TGGGCGTGCT GCTCTACGAA ATGCTGGTGG GCGAGTGCCC ATTCCCGGGG 2400

GACACAGAGG AGGAGGTATT TGACTGCATC GTCAACGCAG ATGCGCCATA TCCCCGCTTT 2460

CTGTCGGCGC AAGGGCTCGA GCTCATTCAG AAGCTCCTGC AGAAGTGCCC GGAGCAGCGC 2520

CTGGGCGGGG GTGAGCAGGA TGCCGAGGAG ATCAAGACCC AGCCTTTTTT CAGGACCACC 2580

GACTGGCAGG CCCTGCTCGC CCGCACCGTC CAGCCCCCCT TCCAGCCCCT GCTCTGCGGC 2640

CCCACGGACC TGCGCTACTT CGAGGGCGAG TTCACGGGGC TGCCGCCGGC CTTAACCCCG 2700

CCTGACCCCC GCTGCCCTCT GACTGCCCGC CAGCAGGCCG CCTTCCGAGA CTTTGACTTT 2760

GTGTCAGAGG GATTC 2775

Domain Profile

S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60

         fr+lavlgrghfgkvll+++k+tg++yaikalkk+++l+rde+esl+cekrileav++++

Q: 598   FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEMESLYCEKRILEAVGRTG  657

         9***********************************************************

S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120

         hpfl++llacfqt++h+cfv+e+a+ggdlm++ihedvf+ep+a fy+acvvlg

Q: 658   HPFLLSLLACFQTSSHACFVTEFAPGGDLMMQIHEDVFPEPQARFYVACVVLGCRRRPPP  717

         ************************************************************

S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180

          ++  dlkldnllld++g++kiadfglckeg+g+gdrtstfcgtpeflapevlt+++ytr

Q: 718   AMLQGDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTR  777

         ************************************************************

S: 181   avdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsveaieilrrllrknp  240

         avdwwglgvllyemlvge+pfpgd+eeevfd+ivn++++yprfls++++e++++ll+k+p

Q: 778   AVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNADAPYPRFLSAQGLELIQKLLQKCP  837

         ************************************************************

S: 241   ekrlgaserdaedvkkqpff  260

         e+rlg +e+dae++k+qpff

Q: 838   EQRLGGGEQDAEEIKTQPFF  857

         *******************9

Domain Sequence
(FASTA)

FRCLAVLGRG HFGKVLLVQF KGTGKYYAIK ALKKQEVLSR DEMESLYCEK RILEAVGRTG 60

HPFLLSLLAC FQTSSHACFV TEFAPGGDLM MQIHEDVFPE PQARFYVACV VLGCRRRPPP 120

AMLQGDLKLD NLLLDAQGFL KIADFGLCKE GIGFGDRTST FCGTPEFLAP EVLTQEAYTR 180

AVDWWGLGVL LYEMLVGECP FPGDTEEEVF DCIVNADAPY PRFLSAQGLE LIQKLLQKCP 240

EQRLGGGEQD AEEIKTQPFF 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0010631	; P:epithelial cell migration
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF02185	; HR1; 3.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00742	; Hr1; 3.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013