EKS-AIM-00363

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00363

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.7	5.3E-104	1329	1587	259

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016838

UniProt Accession

G1MBW0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015908	ENSAMEP00000016838	ENSAMET00000017529

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1594

Protein Sequence
(FASTA)

RAVLAHLSPQ PAVASTQNSI NSRNCTPALP LQSSCCSGSA FRRQECTLGD SACKNSESDP 60

EDFSDETNPE NLYGTSPPST PRQMKRMSAK HQRNNVGRPA SRSGLKVEKM NAPNQPPHKD 120

TGKTVENVEE YSYKQEKKIR ATLRTTERDH KKNVQCSFML DSVGGSLPKK SIPDVDLNKP 180

YLSLGCSNAK LPVSVPMPIA RTARQTSRTD CPADRLKFFE TLRLLLKLTS VSKKKDREQR 240

GQENTSAFWF NRSNELIWLE LQAWHAGRTI NDQDLFLYTA RQAIPEIINE ILTFKVNYGS 300

FAFVRNGASF NGTSVEGQCR APHGTKMGGY STYHEHLQRQ RVSFEQVKRI MELLEYIEAL 360

YPSLQALQKD YEKYAAKDFQ DRVQALCLWL NITKDLNQKL RIMGTVLGIK NLSDIGWPVF 420

EIPSPRSSKG NEPEDEGDDT EGDLKELESS ADESEEEQLS GPRAPEPTQP TDSSFNAHSR 480

DCVPKKLERL ESEDDSVGWG TPDCSTEAGF SRHCLTSIYR PFVDKALKQM GLRKLILRLH 540

KLMDGSLQRA RIALVKSDRP VEFSEFPDPM WGSDYVQLSR TPPSSEQKCS TVSWDELQSM 600

DLPSFEPAFL VLCRVLLNVI HECLKLRLEQ RPAGEPSLLS IKQLVRECKE VLKGGLLMKQ 660

YYQFMLHEVL DHLDKTDCNI DAFEEDLHKM LMVYFDYMRS WIQMLQQLPQ ASHSLKNLLE 720

EEWNFTKEIT HYIRGGEAQA GKLFCDIAGM LLKSTGSFLE FGLQESCAEF WTSADDSNAS 780

DEIRRSVIEI SRALKELFHE ARERASKALG FAKMLRKDLE IAAEFILSAP VRDLLDVLKS 840

KRYVKVQIPG LENLQMFVLD TLAAEKNIIL QLLNAAAGKD CSKESDDELI DACLLLTKHS 900

DRARDSEDSW ATWEAQPVKI VPQVETVDTL RSMQVDNLLL VVVQSAHLTS QRKAFQQSIE 960

GLMTLRQEQT SSQPVIARAL QQLKNDALEL CNRISDAIDR VDHMFTSEFD AEVDESESVT 1020

LQQYYREAMI QGYNFGFEYH KEVVRLMSGE FRQKIGDKYI SFARKWMNYV LTKCESGRGT 1080

RPRWATQGFD FLQAIEPAFI SALPEDDFLS LQALMNECIG HVIGKPHSPV TAIHRNSPRP 1140

VKVPRCHSDP PNPHLIIPTP EGFSTRSVPS DARSHGSPAA VSVTAAAAGR PGPSGSDSAP 1200

PKPISSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT EERDEPAYPK GDSSGSARRS 1260

WELRTLISQT KDSASKQGPI EAIQKSVRLF EEKRYREMRR KNIIGQVCDT PKSYDNVMHV 1320

GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF 1380

EGIKHPNLVR YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL 1440

HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI 1500

TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI MYKVGMGHKP PIPERLSPEG 1560

KDFLSHCLES EPRMRWTASQ LLDHSFVKVC TDEE 1594

Nucleotide Sequence
(FASTA)

AGGGCTGTAT TGGCCCACTT GTCCCCCCAA CCTGCAGTGG CTAGCACACA AAATTCTATC 60

AACAGCAGAA ACTGCACACC AGCTCTGCCC CTGCAATCCT CCTGTTGCTC GGGGTCAGCC 120

TTTCGTAGGC AAGAGTGCAC ATTGGGAGAT TCAGCATGCA AGAATTCTGA GTCTGATCCA 180

GAGGACTTTT CAGATGAAAC CAATCCGGAG AACCTTTATG GCACCTCTCC CCCCAGCACA 240

CCTCGGCAGA TGAAACGCAT GTCTGCCAAG CACCAGAGGA ATAACGTAGG GAGGCCTGCC 300

AGTCGATCTG GTTTGAAAGT AGAAAAAATG AATGCACCAA ACCAGCCTCC ACACAAAGAC 360

ACTGGAAAAA CTGTGGAGAA TGTGGAAGAA TACAGCTATA AGCAGGAGAA AAAGATCCGA 420

GCAACTCTTA GGACAACAGA GCGCGATCAT AAGAAAAATG TGCAGTGCTC GTTCATGTTG 480

GACTCAGTGG GTGGGTCTTT GCCCAAAAAA TCAATTCCAG ATGTGGATCT TAATAAGCCT 540

TACCTCAGTC TTGGCTGCAG CAATGCTAAG CTTCCGGTAT CCGTGCCCAT GCCTATAGCC 600

AGAACTGCAC GCCAGACTTC TAGGACTGAC TGTCCAGCAG ATCGCTTAAA GTTTTTTGAG 660

ACTTTAAGAC TTCTGCTAAA GCTTACCTCA GTCTCAAAGA AGAAGGACAG GGAGCAAAGA 720

GGACAGGAAA ATACGTCTGC TTTCTGGTTT AACCGATCTA ATGAACTGAT CTGGTTAGAG 780

CTACAAGCCT GGCATGCAGG ACGGACCATT AACGACCAGG ACCTCTTTTT ATATACAGCC 840

CGTCAAGCCA TCCCAGAGAT TATCAATGAA ATCCTTACTT TCAAAGTTAA TTATGGGAGC 900

TTTGCCTTTG TTAGAAATGG AGCTAGTTTT AATGGTACTT CAGTAGAAGG GCAGTGCAGA 960

GCCCCTCACG GAACAAAGAT GGGGGGTTAC TCAACGTATC ATGAGCATCT CCAACGCCAG 1020

AGGGTGTCAT TTGAGCAGGT AAAGCGGATA ATGGAGCTGC TGGAGTACAT AGAAGCACTT 1080

TATCCATCGT TGCAAGCTCT TCAAAAGGAC TATGAAAAAT ATGCTGCAAA AGACTTCCAG 1140

GACAGGGTGC AGGCACTCTG TTTGTGGTTA AACATCACAA AAGACTTAAA TCAGAAGTTG 1200

AGGATTATGG GCACTGTTTT GGGCATCAAG AATTTATCAG ACATTGGCTG GCCAGTGTTT 1260

GAAATCCCTT CTCCTCGATC ATCCAAAGGC AATGAGCCAG AAGATGAGGG TGATGACACA 1320

GAAGGGGACT TGAAAGAGCT GGAAAGTAGC GCAGATGAGA GTGAAGAAGA GCAGCTCTCA 1380

GGTCCAAGGG CACCGGAACC CACACAGCCC ACTGACAGCA GTTTCAACGC CCATTCGCGG 1440

GATTGCGTAC CTAAGAAGCT TGAGAGGCTT GAATCTGAGG ACGATTCTGT TGGTTGGGGC 1500

ACACCAGACT GCAGCACAGA AGCAGGCTTT AGTAGACATT GTCTGACTTC TATTTATAGA 1560

CCATTTGTAG ACAAAGCACT GAAGCAAATG GGGTTAAGAA AGTTAATTTT AAGACTTCAC 1620

AAGCTGATGG ACGGTTCCTT GCAAAGGGCA CGTATAGCAC TGGTAAAGAG TGACCGTCCA 1680

GTGGAGTTTT CTGAATTTCC AGACCCCATG TGGGGTTCCG ATTACGTGCA GTTATCCAGG 1740

ACGCCCCCTT CATCGGAGCA GAAGTGCAGC ACTGTGTCGT GGGATGAGCT GCAGTCCATG 1800

GACTTGCCGT CCTTCGAGCC CGCCTTCCTG GTGCTCTGTC GTGTCCTCCT GAACGTGATC 1860

CATGAGTGTC TCAAGTTAAG ACTGGAACAG AGACCTGCTG GCGAACCATC TCTCTTGAGT 1920

ATTAAGCAGC TGGTGAGGGA GTGTAAAGAG GTGCTCAAGG GCGGCCTGCT GATGAAGCAG 1980

TACTACCAGT TCATGCTGCA CGAGGTGCTG GACCACCTGG ACAAGACCGA CTGCAACATC 2040

GACGCCTTCG AGGAGGACCT GCACAAGATG CTCATGGTGT ATTTTGATTA CATGAGAAGC 2100

TGGATCCAGA TGCTGCAGCA GTTACCTCAA GCCTCCCATA GTCTAAAAAA CCTGTTAGAA 2160

GAAGAATGGA ATTTCACCAA AGAAATAACT CATTACATCC GAGGAGGAGA AGCACAGGCT 2220

GGAAAACTTT TCTGTGACAT CGCGGGGATG CTGCTGAAGT CGACAGGAAG TTTTTTAGAG 2280

TTTGGCTTGC AGGAGAGCTG TGCGGAGTTC TGGACCAGCG CTGACGACAG CAACGCCTCA 2340

GATGAAATCA GGAGATCTGT TATAGAGATT AGTCGAGCAC TGAAGGAGCT CTTTCATGAA 2400

GCTAGAGAAA GAGCCTCTAA GGCACTTGGA TTTGCTAAAA TGTTGAGAAA GGACCTGGAA 2460

ATAGCAGCAG AGTTCATACT TTCAGCCCCA GTTAGAGACC TTCTGGATGT TCTGAAATCA 2520

AAACGATATG TTAAGGTACA GATTCCTGGC TTAGAAAACT TGCAGATGTT TGTTCTAGAC 2580

ACTCTTGCTG CAGAGAAGAA CATTATTTTG CAGTTACTCA ATGCAGCCGC AGGAAAGGAT 2640

TGCTCGAAAG AGTCGGATGA TGAACTGATT GACGCCTGTC TCCTGCTAAC CAAGCACAGT 2700

GATCGCGCTC GGGATTCAGA AGACAGCTGG GCCACGTGGG AAGCACAGCC TGTCAAAATT 2760

GTGCCTCAGG TCGAGACTGT TGATACCCTG AGAAGCATGC AGGTGGATAA TCTTTTACTT 2820

GTGGTCGTGC AGTCTGCCCA TCTCACCAGC CAGAGAAAAG CTTTCCAGCA GTCCATTGAG 2880

GGACTCATGA CTCTGCGCCA GGAGCAGACA TCCAGTCAGC CGGTCATCGC CAGAGCTTTG 2940

CAGCAGCTGA AGAATGATGC ACTAGAGCTT TGCAACAGAA TAAGCGATGC CATTGACCGA 3000

GTGGACCACA TGTTCACCTC AGAATTTGAT GCTGAAGTTG ATGAATCGGA GTCTGTCACG 3060

TTGCAGCAGT ACTACCGAGA AGCAATGATT CAGGGCTACA ACTTTGGGTT CGAGTATCAT 3120

AAAGAAGTTG TTCGTTTGAT GTCTGGAGAG TTTAGACAGA AGATAGGAGA CAAATATATA 3180

AGCTTTGCCC GGAAATGGAT GAACTATGTC CTAACTAAAT GTGAGAGTGG TCGAGGTACA 3240

AGACCCAGGT GGGCAACCCA AGGTTTTGAC TTTCTACAAG CCATTGAGCC TGCCTTTATT 3300

TCAGCTTTGC CAGAAGATGA CTTCTTGAGT CTTCAAGCCT TGATGAATGA GTGCATTGGC 3360

CACGTGATAG GAAAGCCACA CAGTCCTGTT ACAGCTATTC ATCGGAACAG CCCCCGTCCT 3420

GTGAAGGTGC CGCGATGCCA CAGTGACCCT CCCAACCCAC ATCTCATCAT CCCGACGCCA 3480

GAGGGTTTCA GCACTCGGAG CGTGCCTTCG GATGCACGGA GCCACGGCAG CCCCGCTGCT 3540

GTTTCTGTCA CTGCTGCTGC CGCCGGTCGC CCCGGCCCCT CCGGCAGCGA CTCTGCACCA 3600

CCCAAACCCA TCAGCAGTGC CCATGATACC AGGGGTTCCA GCGTCCCTGA GAACGACCGA 3660

TTGGCTTCCA TAGCCGCCGA GTTACAGTTT CGGTCCCTGA GCCGCCACTC AAGCCCCACT 3720

GAGGAGCGTG ACGAACCAGC ATATCCAAAA GGTGATTCAA GTGGGTCAGC TCGAAGAAGC 3780

TGGGAACTTC GGACACTTAT CAGTCAGACG AAGGACAGCG CTTCCAAACA AGGACCCATA 3840

GAAGCTATCC AGAAGTCAGT CCGGTTGTTT GAAGAAAAGA GGTATCGAGA AATGAGGAGA 3900

AAGAATATCA TTGGTCAAGT TTGTGATACC CCTAAATCTT ACGATAACGT TATGCACGTA 3960

GGCTTGAGGA AGGTGACCTT CAAGTGGCAA AGAGGAAACA AAATTGGGGA GGGGCAGTAT 4020

GGGAAGGTCT ACACCTGTAT CAGTGTCGAC ACCGGCGAGT TGATGGCTAT GAAGGAGATT 4080

CGATTTCAAC CTAATGACCA TAAAACTATC AAGGAAACTG CAGACGAATT GAAAATCTTT 4140

GAGGGCATCA AACACCCCAA TCTGGTTCGG TATTTTGGTG TGGAGCTTCA TAGAGAAGAA 4200

ATGTACATCT TCATGGAGTA CTGTGACGAA GGGACGTTAG AAGAGGTGTC AAGGCTGGGA 4260

CTTCAGGAAC ATGTCATTAG GCTGTATTCA AAGCAGATCA CCATTGCAAT CAATGTCCTC 4320

CATGAGCATG GCATAGTTCA CCGTGACATC AAAGGTGCCA ACATCTTCCT CACCTCCTCG 4380

GGGCTCATCA AGCTGGGGGA TTTCGGATGC TCAGTAAAGC TTAAGAACAA CGCGCAGACC 4440

ATGCCGGGCG AAGTGAACAG CACGCTGGGG ACAGCAGCAT ACATGGCTCC TGAAGTCATC 4500

ACTCGCGCAA AAGGAGAAGG CCATGGGCGT GCGGCAGACA TCTGGAGTCT GGGCTGCGTC 4560

GTCATAGAGA TGGTGACCGG CAAGAGGCCT TGGCATGAAT ATGAACACAA CTTTCAGATT 4620

ATGTATAAAG TGGGAATGGG GCACAAGCCA CCGATCCCTG AAAGATTAAG CCCGGAAGGA 4680

AAGGACTTCC TTTCTCACTG CCTTGAAAGT GAGCCCAGGA TGAGGTGGAC AGCCAGCCAG 4740

CTCCTCGACC ATTCCTTCGT CAAGGTCTGC ACAGATGAAG AATGA 4785

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1329  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1385

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1386  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1443

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1444  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1503

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1504  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1562

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1563  FLSHCLESEPRMRWTASQLLDHSFV  1587

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESEPRMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013