EKS-AIM-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	540.8	6.1E-163	193	450	258

Status

Unreviewed

Ensembl Protein

ENSAMEP00000016902

UniProt Accession

D2HJ43;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1; PANDA_011298;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000015983	ENSAMEP00000016899	ENSAMET00000017592
ENSAMEG00000015983	ENSAMEP00000016902	ENSAMET00000017595

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

MVNKDMNGFP VKKCSAFQFF KKRVRRWIKS PVVSVDKHQS PSLKYTGPSV MHIPPGEPDF 60

ESSLCPTCLG DHAFQRGVLP PEKESCSWET QPGCEAKEPC NHASILTKPD PRTFWTNDDS 120

AFMKQRRMGL NDFIQKIANN SYACKHPEVQ SILKISQPQE PELMNANPSP PPSPSQQINL 180

GPSSNPHAKP SDFHFLKVIG KGSFGKVLLA RHKAEEAFYA VKVLQKKAIL KKKEEKHIMS 240

ERNVLLKNVK HPFLVGLHFS FQTADKLYFV LDYINGGELF YHLQRERCFL EPRARFYAAE 300

IASALGYLHS LNIVYRDLKP ENILLDSQGH IVLTDFGLCK ENIEHNGTTS TFCGTPEYLA 360

PEVLHKQPYD RTVDWWCLGA VLYEMLYGLP PFYSRNTAEM YDNILNKPLQ LKPNITNSAR 420

HLLEGLLQKD RTKRLGAKDD FMEIKNHVFF SLINWDDLIN KKITPPFNPN VSGPSDLRHF 480

DPEFTEEPVP NSIGRSPDSI LLTASVKEAA EAFLGFSYAP PMDSFL 526

Nucleotide Sequence
(FASTA)

ATGGTAAACA AAGACATGAA TGGATTCCCA GTCAAGAAAT GCTCAGCCTT CCAATTTTTT 60

AAGAAGCGGG TACGAAGATG GATCAAGAGC CCAGTGGTCA GTGTGGACAA GCATCAGAGT 120

CCCAGCCTGA AGTACACGGG CCCCTCGGTC ATGCACATCC CTCCAGGGGA GCCAGATTTT 180

GAGTCTTCCT TGTGTCCAAC GTGCCTGGGA GACCATGCTT TCCAAAGAGG TGTTCTCCCT 240

CCGGAGAAAG AGTCATGTTC GTGGGAAACT CAACCCGGGT GTGAAGCGAA AGAGCCATGT 300

AATCATGCCA GCATCCTGAC CAAGCCTGAC CCAAGAACCT TCTGGACTAA TGATGATTCA 360

GCTTTCATGA AACAGAGGAG GATGGGCCTG AACGACTTTA TTCAGAAGAT TGCCAATAAC 420

TCCTATGCAT GCAAACACCC TGAAGTTCAG TCCATTTTGA AAATCTCCCA ACCTCAGGAG 480

CCTGAGCTTA TGAATGCCAA CCCTTCTCCT CCACCAAGTC CTTCTCAGCA AATCAACCTT 540

GGCCCATCAT CCAATCCTCA CGCTAAACCA TCTGACTTCC ACTTCTTGAA AGTGATTGGG 600

AAAGGCAGTT TTGGGAAGGT TCTTCTAGCA AGACACAAAG CAGAAGAAGC GTTCTATGCA 660

GTCAAAGTTT TACAGAAGAA AGCCATCCTG AAAAAGAAGG AGGAAAAGCA TATTATGTCG 720

GAACGGAATG TTCTACTGAA GAATGTGAAA CACCCTTTCC TGGTGGGCCT TCACTTCTCT 780

TTCCAGACTG CTGACAAATT GTACTTTGTC CTCGACTACA TCAATGGTGG AGAGTTGTTC 840

TACCACCTCC AGAGGGAGCG TTGCTTCCTG GAACCACGGG CTCGTTTCTA TGCTGCTGAA 900

ATAGCCAGTG CCTTGGGTTA CCTGCACTCT CTGAACATCG TCTATAGAGA CTTAAAACCA 960

GAGAATATTC TGCTGGACTC ACAGGGACAC ATTGTCCTTA CTGACTTTGG GCTCTGCAAG 1020

GAGAACATTG AACACAATGG CACGACCTCC ACCTTCTGTG GCACGCCCGA GTATCTTGCA 1080

CCCGAAGTGC TCCATAAGCA GCCTTATGAC AGGACTGTGG ACTGGTGGTG CCTGGGGGCC 1140

GTCTTATATG AGATGCTGTA TGGCCTGCCT CCATTTTACA GCCGAAACAC AGCTGAGATG 1200

TATGACAACA TTCTGAACAA GCCCCTCCAG CTGAAGCCAA ATATCACCAA TTCTGCCAGA 1260

CACCTCCTGG AGGGCCTCCT GCAAAAGGAC AGGACAAAGA GGCTGGGCGC CAAGGACGAC 1320

TTCATGGAGA TTAAGAATCA TGTCTTCTTC TCCCTAATTA ACTGGGATGA TCTCATTAAT 1380

AAGAAGATTA CTCCTCCCTT TAACCCAAAT GTGAGTGGAC CTAGCGACCT GCGGCACTTC 1440

GATCCCGAGT TCACTGAAGA GCCTGTCCCC AACTCCATCG GCAGGTCCCC CGACAGCATC 1500

CTCCTCACAG CCAGCGTCAA GGAAGCGGCC GAGGCCTTCC TAGGCTTCTC CTATGCGCCT 1560

CCCATGGACT CTTTCCTC 1578

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 193   FHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  252

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 253   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  312

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 313   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  372

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 373   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  432

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eiknhvff

Q: 433   KRLGAKDDFMEIKNHVFF  450

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEAFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication
GO:0006974	; P:response to DNA damage stimulus

KEGG

aml:100468926

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013