EKS-AIM-00314

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00314

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	296.3	2.0E-88	3	225	223

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017073

UniProt Accession

G1MCJ5;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016123	ENSAMEP00000017073	ENSAMET00000017773

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

849

Protein Sequence
(FASTA)

GEDFAVVQQE IIMMKDCKHP NIVAYFGSYL RRDKLWICME FCGGGSLQDI YHVTGPLSEL 60

QIAYVSRETL QKLQGLCYLH SKGKMHRDIK GANILLTDNG HVKLADFGVS AQITATVAKR 120

KSFIGTPYWM APEVAAVERK GGYNQLCDLW AVGITAIELA ELQPPMFDLH PMRALFLMTK 180

SNFQPPKLKD KMKWSNSFHH FVKMALTKNP KKRPTAEKLL QHPFVTQPLT RSLAIELLDK 240

VNNPDHSTYH DFDDDDPEPL VAVPHRIHST SRNVREEKTR SEINFGQVKF DPPLRKETEP 300

HHELPDSDGF LDSSEELYYT ARSNLDLQLE YGQGHQSSYF LGANKSLLKS VEEELHQRGH 360

VAHLEDDEGD DDGSKHSTMK AKVPPPLPPK PKTIFIPQET HSTEDDNQGT IKRCPTSESP 420

AKPSQVPPRP PPPRLPPQKP IALGNGVSSF QLNGEREDSL YQQQNEHRGT NPSRKEKKDV 480

PKPISNGLPP TPKVHMGACF SKVFNGCPLK IHCATSWINP DTRDQYLIFG AEEGIYTLNL 540

NELHETSMEQ LFPRRCTWLY VMNNCLLSIS GKASQLYSHN LPGLFDYARQ MQKLPVSIPA 600

HKLPDRILPR KFAVSAKIPE TKWCQKCCVA LTVRNPYTGH KYLCGALQTS IVLLEWVEPM 660

QKFMLIKHID FPIPCPLRVF EMLVVPEQEY PLVCVGVSRG RDFNQVVRFE TVNPNSTSSW 720

FTESDSPQTS VTHVTQLERD TILVCLDCCI KIVNLQGRLK SSRKLSSELT FDFRIESIVC 780

LQDSVLAFWK HGMQGRSFRS NEVTQEISDN TRIFRLLGSD RVVVLESRPT DNPTANSNLY 840

ILAGHENSY 849

Nucleotide Sequence
(FASTA)

GGAGAAGACT TTGCAGTTGT ACAGCAAGAA ATTATTATGA TGAAAGACTG TAAACACCCA 60

AATATTGTGG CTTATTTTGG AAGCTATCTC AGGAGAGATA AACTTTGGAT TTGCATGGAG 120

TTTTGTGGAG GTGGTTCTTT ACAGGATATT TATCATGTAA CGGGACCTCT GTCAGAACTG 180

CAAATTGCAT ATGTTAGCAG AGAAACACTA CAGAAACTCC AGGGATTATG CTATCTTCAC 240

AGTAAAGGAA AAATGCACAG AGATATAAAG GGAGCTAACA TCCTGTTAAC GGATAATGGT 300

CATGTAAAAT TGGCTGATTT TGGAGTATCT GCACAGATTA CAGCTACAGT TGCCAAACGG 360

AAGTCTTTCA TTGGTACACC ATATTGGATG GCTCCAGAAG TTGCAGCCGT TGAGAGGAAA 420

GGGGGGTACA ATCAGCTCTG TGATCTCTGG GCAGTAGGAA TCACCGCCAT AGAACTCGCG 480

GAGCTTCAGC CGCCTATGTT TGACTTGCAC CCAATGAGAG CATTATTTCT AATGACAAAA 540

AGTAATTTTC AGCCTCCTAA ACTAAAGGAT AAAATGAAAT GGTCAAATAG TTTTCATCAT 600

TTTGTGAAAA TGGCACTTAC CAAAAATCCA AAAAAAAGAC CTACTGCTGA GAAGTTACTA 660

CAGCACCCGT TTGTCACACA ACCTTTGACA CGGTCTTTGG CAATTGAACT GTTGGATAAA 720

GTGAATAATC CAGATCATTC CACTTACCAT GATTTTGATG ATGACGATCC TGAGCCTCTT 780

GTTGCTGTAC CACATAGAAT TCACTCAACA AGTAGAAATG TAAGAGAAGA AAAAACACGC 840

TCGGAGATAA ACTTTGGCCA AGTAAAATTT GATCCACCCT TAAGGAAGGA AACAGAACCA 900

CATCATGAAC TTCCCGACAG TGATGGTTTT TTGGACAGTT CAGAAGAACT ATACTACACT 960

GCAAGATCTA ATCTGGATCT ACAGCTAGAA TATGGACAAG GACACCAAAG TAGTTACTTT 1020

TTGGGTGCAA ACAAGAGTCT TCTGAAGTCT GTTGAAGAAG AATTACATCA GCGAGGGCAT 1080

GTGGCGCATT TAGAAGATGA TGAAGGGGAT GATGATGGAT CTAAACATTC AACCATGAAA 1140

GCGAAAGTTC CACCTCCTTT GCCACCAAAG CCTAAGACCA TATTCATACC ACAGGAAACT 1200

CATTCTACTG AGGATGATAA TCAAGGAACC ATCAAGAGAT GTCCCACGTC AGAGAGCCCA 1260

GCAAAACCAT CCCAAGTTCC GCCTAGACCA CCACCTCCCA GATTACCTCC ACAGAAGCCA 1320

ATTGCTTTAG GAAATGGAGT GAGCTCCTTC CAGTTAAATG GTGAACGAGA GGATTCATTA 1380

TATCAACAAC AGAATGAACA CAGAGGCACA AACCCTTCAA GGAAAGAAAA GAAAGATGTA 1440

CCAAAGCCTA TTAGTAATGG TCTACCCCCA ACACCTAAAG TGCATATGGG TGCATGTTTT 1500

TCGAAGGTTT TTAATGGATG TCCCTTGAAA ATTCACTGTG CAACATCTTG GATAAACCCA 1560

GATACAAGAG ATCAGTACTT GATATTTGGT GCCGAGGAAG GGATTTATAC TTTGAATCTT 1620

AATGAACTTC ATGAAACATC AATGGAACAG CTATTCCCCC GAAGGTGTAC ATGGTTATAT 1680

GTAATGAACA ATTGCTTACT ATCAATATCT GGTAAAGCTT CTCAGCTTTA TTCCCATAAT 1740

TTACCAGGGC TTTTTGATTA TGCAAGACAA ATGCAAAAGT TACCTGTGTC TATTCCAGCA 1800

CACAAACTCC CTGACAGAAT ACTGCCGAGG AAATTTGCTG TATCAGCAAA AATCCCTGAA 1860

ACCAAGTGGT GTCAGAAATG TTGTGTTGCC TTGACAGTGC GAAATCCTTA CACAGGCCAT 1920

AAGTACCTAT GTGGGGCACT TCAGACTAGC ATTGTTTTAT TAGAATGGGT TGAACCAATG 1980

CAGAAATTTA TGTTAATTAA GCACATAGAT TTTCCTATAC CATGTCCACT TAGAGTGTTT 2040

GAGATGCTGG TAGTTCCGGA ACAGGAGTAC CCTTTAGTCT GTGTTGGTGT CAGTAGAGGG 2100

AGAGACTTCA ACCAAGTGGT TCGATTTGAA ACAGTCAATC CAAATTCTAC CTCTTCATGG 2160

TTTACAGAAT CAGATAGCCC ACAGACAAGC GTTACTCATG TAACCCAACT GGAGAGAGAT 2220

ACCATTCTTG TATGCTTGGA CTGTTGTATA AAAATAGTAA ATCTCCAAGG AAGATTAAAA 2280

TCTAGCAGAA AATTATCATC TGAACTCACC TTTGATTTCC GGATTGAATC AATAGTTTGC 2340

CTGCAAGACA GTGTGCTAGC TTTCTGGAAA CACGGAATGC AAGGTAGAAG TTTTAGATCT 2400

AATGAGGTAA CACAAGAAAT TTCAGATAAC ACAAGGATTT TCAGACTGCT TGGATCTGAC 2460

AGGGTCGTGG TTTTGGAAAG TAGGCCTACT GATAACCCCA CGGCAAATAG CAACTTATAC 2520

ATCCTGGCGG GCCATGAGAA CAGTTACTGA 2550

Domain Profile

S: 39    kleelqkeisvlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEe  98

         + + +q+ei ++k++khpniv+y++s+l++++lw++me++ gGsl+d+++  ++ +l+E

Q: 3     DFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSEL  60

         567899********************************************..********

S: 99    qiayilrevl...kaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkr  155

         qiay+ re+l   ++L ylHsk+++Hrdik++niLlt++g+VkL+dfgv+aq+++t++kr

Q: 61    QIAYVSRETLqklQGLCYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATVAKR  120

         *******9962226999*******************************************

S: 156   ktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilk  214

         k+++gtpywmAPEv a+e + gY++ +D+w++GItaielae +pP++dl+p++al++++k

Q: 121   KSFIGTPYWMAPEVAAVErKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTK  180

         *****************98889*********************************99999

S: 215   ne..ppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         ++  ppklk+k k+s++f++fv+ +l+knp+kRp+a++ll+h+F+

Q: 181   SNfqPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV  225

         9888****************************************7

Domain Sequence
(FASTA)

DFAVVQQEII MMKDCKHPNI VAYFGSYLRR DKLWICMEFC GGGSLQDIYH VTGPLSELQI 60

AYVSRETLQK LQGLCYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATVAKRKS 120

FIGTPYWMAP EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN 180

FQPPKLKDKM KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFV 223

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013