EKS-AIM-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	394.5	2.3E-118	46	309	264

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017112

UniProt Accession

G1MCN4;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016190	ENSAMEP00000017112	ENSAMET00000017814

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

970

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGLGSGS SGGGGSTSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INSVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF SFKLLKKECP IPNVQNSPIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPPP QAAGSTNQPG LLASVPQPKT 420

QPQPSQPLPQ SQPKQPQAPP TPQQTPPTPA QALPTPAQAT PQHQQPLFLK QQPQQQQQQP 480

PQQQPPAPQQ PAGTFYQQQQ QQQAQAQQFQ AVHPAAPQPA IAQFPVVSQG SSQQQLIQNY 540

YQQQQQQQQQ QQQQQQLATS LHQQQLLTQQ AALQQKTAVA PAPQPQAPPT AAPQTPGAQQ 600

GSIQAPVRQQ PKVQTTPPPA VQGQKLGSLT PPSSPKTQRA GHRRILSDVT HSAVFGVPAS 660

KSTQLLQAAA AEASLNKSKS ATTTPSGSPR TSQQNVSNAS ESAWNPFDDD NFSKLTAEEL 720

LNKDFAKLGE GKHPEKLGGS AESLIPGFQP THGDAFATPS FSSGTAEKRK GGQPVDSSLP 780

LLSVSDPFIP LQVPDAPEKL IEGLKSPDTS LLLPDLLPMT DPFGSTSDAV IEKADVAVES 840

LIPGLEPPVP QRLPSQTESV TSNRTDSLTG EDSLIDCSLL SNPTTDLLEE FAPIAISAPA 900

HKAAEDSNLI SGFDVPEGSD KVAEDEFDPI PVLITKNPQG GHSRNSSGSS ESSLPNLARS 960

LLLVDQLIDL 970

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 60

AGCGGAGGTG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG GGTCTTTGGC 120

ATTGGGCGAC AGCAGGTCAC TGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATCGTG 180

TTTCTGGTGA GGACAAGCAA TGGAATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGATC TCCAAGTGTG CAAGAGAGAA ATCCAGATAA TGAGAGACCT GTCGGGGCAC 300

AAGAACATCG TTGGTTACAT TGACTCCAGT ATCAACAGTG TGAGCAGCGG TGATGTATGG 360

GAAGTGCTCA TTCTCATGGA CTTCTGTAGG GGAGGCCAGG TGGTCAACCT GATGAATCAG 420

CGCCTGCAAA CAGGTTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA CACCTGCGAA 480

GCCGTTGCCC GCCTGCATCA GTGCAAAACT CCCATTATCC ACCGTGACCT GAAGGTTGAA 540

AATATCCTCT TGCATGACCG AGGCCACTAC GTCCTGTGTG ACTTTGGAAG TGCCACCAAC 600

AAATTTCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 660

ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 720

ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 780

CCATTTGGAG AGAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC CGATAACTCC 840

CGATATTCCC AAGACATGCA CTGCCTAATT AGATATATGT TGGAACCAGA CCCTGATAAA 900

AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAAC TACTCAAGAA AGAATGCCCA 960

ATTCCTAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAGCCAGT GAAAGCCAGT 1020

GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACAACA 1080

GAGACTTCAA TTGCACCCCG TCAGAGGCCT AAGGCTGGGC AGACTCAGCC CAACCCAGGA 1140

ATCCTTCCTA TCCAGCCAGC CCTGACACCT CGAAAGAGGG CCACGGTTCA GCCCCCACCG 1200

CAGGCTGCAG GATCCACCAA TCAGCCCGGC CTTTTAGCCA GTGTTCCCCA GCCAAAAACC 1260

CAGCCCCAAC CCAGCCAGCC TCTACCACAG TCTCAGCCCA AGCAGCCACA GGCTCCACCC 1320

ACCCCACAGC AGACACCGCC CACTCCAGCC CAGGCTCTGC CCACTCCAGC CCAGGCCACG 1380

CCCCAGCACC AGCAGCCCCT CTTCCTCAAG CAGCAGCCAC AGCAGCAGCA GCAGCAACCT 1440

CCCCAGCAAC AGCCGCCAGC TCCCCAGCAG CCCGCGGGCA CGTTTTACCA GCAGCAGCAG 1500

CAGCAACAGG CCCAGGCTCA ACAGTTTCAG GCAGTACACC CAGCAGCCCC GCAACCAGCC 1560

ATCGCCCAGT TCCCCGTGGT GTCGCAAGGA AGCTCTCAGC AGCAGTTGAT ACAGAACTAC 1620

TACCAGCAAC AGCAGCAACA GCAGCAACAG CAGCAGCAGC AGCAGCAGCT GGCCACGAGC 1680

TTGCACCAAC AGCAGCTGCT GACTCAGCAG GCCGCCTTGC AGCAGAAGAC CGCTGTGGCC 1740

CCGGCACCGC AGCCCCAGGC GCCGCCCACC GCGGCCCCGC AGACGCCCGG GGCCCAGCAG 1800

GGCTCCATTC AAGCCCCAGT AAGACAACAG CCAAAGGTTC AAACAACCCC ACCTCCTGCC 1860

GTCCAGGGGC AGAAACTCGG ATCTCTCACT CCTCCGTCAT CCCCCAAGAC CCAACGTGCT 1920

GGGCACAGGC GGATTCTCAG TGACGTAACC CACAGTGCAG TCTTTGGGGT CCCTGCCAGC 1980

AAATCAACCC AGCTGCTCCA GGCAGCTGCA GCTGAGGCCA GCCTCAATAA GTCCAAGTCT 2040

GCAACCACCA CTCCATCAGG CTCTCCTCGG ACCTCCCAAC AGAACGTTTC TAATGCTTCA 2100

GAATCTGCGT GGAATCCCTT CGATGATGAC AATTTCTCCA AACTCACAGC TGAGGAACTG 2160

CTGAACAAGG ACTTTGCCAA GCTGGGGGAA GGCAAACATC CTGAGAAGCT TGGAGGCTCC 2220

GCTGAGAGTT TGATCCCAGG CTTTCAACCA ACTCATGGTG ATGCTTTTGC CACTCCTTCG 2280

TTTTCCTCTG GAACCGCTGA AAAAAGGAAG GGTGGGCAGC CTGTGGATTC TAGCCTCCCA 2340

CTTCTAAGTG TATCTGATCC TTTCATTCCT CTTCAAGTAC CTGATGCACC AGAAAAACTA 2400

ATTGAGGGAC TCAAATCTCC TGACACTTCT CTCCTGCTCC CTGACCTCTT GCCTATGACA 2460

GACCCTTTTG GTAGCACTTC CGATGCTGTG ATTGAAAAAG CTGATGTTGC TGTTGAGAGT 2520

CTCATACCAG GACTGGAGCC CCCAGTGCCC CAGCGCCTTC CATCTCAGAC GGAATCTGTG 2580

ACCTCGAACC GCACAGATTC TCTCACCGGG GAAGATTCCC TGATTGATTG CTCCCTGCTT 2640

TCTAACCCTA CTACTGACCT TCTGGAAGAG TTTGCCCCCA TAGCGATCTC TGCTCCAGCC 2700

CATAAAGCTG CAGAAGATAG TAATCTCATC TCAGGTTTTG ATGTCCCTGA GGGCTCGGAC 2760

AAGGTGGCAG AAGATGAGTT TGACCCTATT CCTGTATTGA TAACCAAAAA CCCACAAGGT 2820

GGGCACTCTA GAAACAGCAG TGGGAGCTCT GAGTCCAGTC TTCCCAACCT AGCCAGGTCT 2880

TTACTGCTGG TGGATCAGCT CATAGACCTG 2910

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINSVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013