EKS-AIM-00370
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00370
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl547.64.7E-165563827265
StatusUnreviewed
Ensembl ProteinENSAMEP00000017177
UniProt AccessionD2HPH1;
Protein Name
Protein Synonyms/Alias
Gene NameMERTK
Gene Synonyms/Alias MERTK; PANDA_013676;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000016223ENSAMEP00000017177ENSAMET00000017882
OrganismAiluropoda melanoleuca
Functional Description
Protein Length970
Protein Sequence
(FASTA)
AVAEVREATK PDPPLPGGLQ ADHTPFSLPH TSGYQPALTS SPPQLGRPHT GNAAHPGVTS 60
SGSKLLPPLA FNHTIGHIIL SEHKDVKFNC SINIPNMYQD IAVISWWKDG KELLGAHHAI 120
MQFYSDDEVT AIIASFSITS VQRSDNGSYI CKMKINNEEI VSDPIYIEVQ GLPHFIRQPE 180
SMNVTRNTAF NLTCQAVGPP EPVNIFWVQN SSRVNEQPEK SPSVLTVPGL TETAVFSCEA 240
HNDKGLTVSK GVQINIKAIP SPPTEVRVYN STAHSVLISW VPGFDGYSPF RNCSVQVKEV 300
DPLSNGSVMV FNTSASPHLY QIKQLQALAN YSIGVSCMNE IGWSAMSPWI LASTTEGAPS 360
VAPSNVTVFL NESSHKVDVR WIKPPIKRQD GELLGYRISH MWQSADTSKE LSEEVGQNGS 420
RAQISVQVHN ATCTVRIAAI TRGGVGPFSD PVKMFIPAHG WVDFAPSSTP APGNTDPVLI 480
ILGCFCGFVL IGSILYISLI IRKRIQETKF GNAFTEEDSE LVVNYIAKKS FCRRAIELTL 540
RSLGVSEELQ NKLEDVVIDR NLLILGKILG EGEFGSVMEG NLKQQDGTSQ KVAVKTMKLD 600
NFSQREIEEF LSEAACMKDF NHPNVIGLLG VCIEMSSQGI PKPMVILPFM KYGDLHTYLL 660
YSRLETGPKH IPLQTLLKFM VDIAQGMEYL SNRNFLHRDL AARNCMLRDD MTVCVADFGL 720
SKKIYSGDYY RQGRIAKMPV KWIAIESLAD RVYTSKSDVW AFGVTMWEIA TRGMTPYPGV 780
QNHEMYDYLL HGHRLKQPED CLDELYEIMH SCWRAEPLDR PTFSVLRLQL EKLLESLPEV 840
QDKAEVIYIN TQFPESCEDP GEGPTLAQLD MNIDLDSIIG SCTPSAAVSV VTAEVHENRP 900
HEERYILNGG SEEWGDLASA APGKNCVLPE DRLVKNGVSW SQSSTLPLGS PSPDGLLFAD 960
DSSEDSEVLI 970
Nucleotide Sequence
(FASTA)
GCTGTTGCAG AGGTGAGGGA AGCAACCAAG CCTGACCCAC CATTGCCAGG AGGCCTGCAA 60
GCTGACCACA CGCCATTTTC CCTTCCTCAC ACCAGTGGGT ACCAGCCTGC CTTGACGTCT 120
TCACCACCCC AGCTTGGACG ACCGCATACA GGGAATGCAG CCCATCCAGG GGTGACCTCT 180
TCTGGGTCAA AGCTCCTTCC GCCTCTTGCA TTTAATCATA CAATTGGCCA CATAATACTT 240
TCTGAACATA AAGATGTCAA GTTCAATTGC TCCATCAATA TACCTAATAT GTACCAGGAC 300
ATTGCAGTTA TTTCTTGGTG GAAAGATGGG AAGGAGTTGC TTGGGGCACA TCATGCCATT 360
ATGCAGTTTT ATTCGGATGA CGAAGTCACA GCAATAATCG CCTCCTTCAG CATAACCAGC 420
GTGCAGCGTT CAGACAACGG CTCATATATC TGTAAGATGA AAATAAACAA CGAAGAGATT 480
GTGTCTGACC CCATCTACAT TGAGGTGCAA GGACTTCCTC ACTTTATTAG ACAGCCCGAG 540
AGCATGAATG TCACAAGAAA CACGGCCTTC AACCTCACCT GTCAAGCTGT GGGCCCTCCT 600
GAGCCTGTCA ACATTTTCTG GGTTCAGAAC AGCAGCCGTG TTAATGAACA GCCAGAAAAG 660
TCCCCCTCTG TTCTGACCGT TCCTGGTCTG ACCGAGACAG CAGTCTTCAG TTGTGAGGCC 720
CACAATGACA AAGGGCTGAC CGTGTCCAAG GGTGTGCAGA TCAACATCAA AGCAATTCCC 780
TCCCCACCAA CTGAAGTCCG TGTCTACAAT AGCACCGCAC ACAGCGTGCT GATCTCCTGG 840
GTCCCGGGTT TTGATGGATA CTCCCCGTTC AGGAATTGCA GCGTTCAGGT CAAGGAAGTT 900
GATCCGCTGA GTAATGGCTC GGTCATGGTT TTTAACACCT CTGCCTCACC ACATCTGTAT 960
CAAATCAAGC AGCTGCAAGC TCTGGCTAAT TACAGCATCG GTGTGTCGTG CATGAATGAA 1020
ATTGGCTGGT CTGCAATGAG CCCTTGGATT CTGGCCAGCA CGACTGAAGG AGCTCCCTCA 1080
GTAGCACCTT CGAATGTCAC TGTGTTTCTG AATGAATCTA GTCATAAGGT GGATGTCAGA 1140
TGGATCAAGC CTCCAATTAA GCGGCAGGAT GGGGAACTGC TGGGCTACCG GATATCTCAC 1200
ATGTGGCAGA GTGCGGACAC TTCTAAAGAA CTGTCTGAAG AAGTTGGCCA GAATGGCAGC 1260
CGTGCTCAGA TTTCTGTTCA AGTCCACAAT GCCACGTGCA CAGTGAGGAT TGCCGCCATC 1320
ACCAGGGGGG GAGTCGGGCC TTTCAGTGAC CCAGTGAAAA TGTTCATCCC TGCACACGGT 1380
TGGGTAGATT TTGCCCCCTC GTCCACCCCA GCACCTGGCA ACACGGATCC TGTGCTCATC 1440
ATCCTTGGTT GCTTTTGTGG ATTTGTTTTG ATTGGGTCGA TTTTATATAT TTCTCTGATC 1500
ATCAGAAAAC GAATCCAGGA GACAAAGTTT GGGAATGCCT TCACAGAGGA GGATTCGGAA 1560
TTAGTCGTCA ATTATATTGC AAAGAAGTCC TTCTGTCGGC GAGCCATCGA ACTCACCTTG 1620
CGTAGCTTGG GAGTCAGTGA GGAACTACAA AATAAACTGG AAGATGTTGT GATTGACAGG 1680
AATCTATTAA TTCTCGGAAA AATCCTGGGG GAAGGAGAGT TTGGGTCTGT GATGGAAGGA 1740
AATCTTAAGC AGCAAGATGG GACCTCTCAG AAAGTGGCCG TGAAGACCAT GAAGTTGGAC 1800
AACTTTTCTC AGCGAGAGAT TGAGGAGTTC CTCAGTGAGG CTGCGTGCAT GAAAGACTTC 1860
AACCACCCCA ACGTCATCGG ACTCCTAGGT GTATGTATAG AAATGAGCTC TCAAGGCATC 1920
CCAAAGCCCA TGGTGATTTT ACCCTTCATG AAGTACGGGG ATCTGCATAC CTACTTACTC 1980
TATTCCCGAC TAGAGACAGG ACCCAAGCAT ATTCCTCTGC AGACACTACT GAAGTTCATG 2040
GTGGACATCG CCCAGGGAAT GGAGTATCTG AGCAACAGGA ATTTTCTTCA TCGAGATTTA 2100
GCTGCTCGAA ACTGCATGTT ACGAGACGAT ATGACCGTCT GTGTCGCGGA CTTTGGCCTC 2160
TCTAAAAAGA TCTACAGTGG TGATTACTAC CGCCAAGGCC GCATCGCTAA AATGCCTGTG 2220
AAATGGATCG CCATAGAGAG TCTCGCGGAC CGAGTCTACA CAAGTAAAAG TGACGTGTGG 2280
GCATTTGGCG TGACCATGTG GGAAATAGCA ACACGAGGAA TGACTCCCTA CCCGGGAGTC 2340
CAAAACCACG AAATGTACGA CTATCTTCTC CACGGCCACA GGCTGAAGCA GCCCGAGGAC 2400
TGCCTGGATG AACTGTATGA AATAATGCAC TCTTGCTGGA GAGCTGAGCC CTTGGACCGA 2460
CCTACCTTTT CAGTGTTGAG ACTGCAGCTA GAAAAGCTCT TGGAAAGTTT GCCTGAAGTT 2520
CAGGACAAAG CTGAGGTCAT TTACATCAAC ACACAGTTTC CTGAGAGCTG TGAGGACCCT 2580
GGAGAGGGCC CCACACTTGC TCAGCTGGAC ATGAATATTG ATCTTGACTC TATCATTGGC 2640
TCTTGTACTC CCAGCGCTGC CGTCAGCGTG GTCACTGCAG AAGTTCACGA GAACAGACCT 2700
CATGAGGAAA GGTACATCCT GAATGGGGGC AGTGAAGAAT GGGGAGATCT GGCTTCTGCT 2760
GCCCCGGGAA AGAACTGTGT TTTACCAGAG GACAGACTTG TAAAAAATGG AGTCTCCTGG 2820
TCCCAATCCA GCACACTGCC CTTGGGGAGC CCATCACCAG ATGGACTTTT ATTTGCCGAC 2880
GATTCCTCAG AAGACTCAGA AGTCCTCATA TGA 2913
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lgk+lgegefgsvmeg+lkq+dg+++kvavkt+kld+++++eieeflseaacmk+f+h
Q: 563   LILGKILGEGEFGSVMEGNLKQQDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNH  622
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvi l+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv
Q: 623   PNVIGLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  681
         ****************9.******************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk
Q: 682   DIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  741
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc
Q: 742   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  801
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ldely++m++cw+a+p drp+fsvlr
Q: 802   LDELYEIMHSCWRAEPLDRPTFSVLR  827
         *************************9
Domain Sequence
(FASTA)
LILGKILGEG EFGSVMEGNL KQQDGTSQKV AVKTMKLDNF SQREIEEFLS EAACMKDFNH 60
PNVIGLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120
IAQGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240
DELYEIMHSC WRAEPLDRPT FSVLR 265
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00383
EKS-BOT-00400
EKS-CAJ-00403
EKS-CAF-00399
EKS-CAP-00426
EKS-DAR-00776
EKS-EQC-00388
EKS-GAM-00236
EKS-GAG-00337
EKS-GAA-00487
EKS-GOG-00385
EKS-HOS-00401
EKS-ICT-00376
EKS-LAC-00414
EKS-LOA-00404
EKS-MAM-00397
EKS-MEG-00328
EKS-MOD-00384
EKS-MUM-00430
EKS-MUP-00389
EKS-MYL-00395
EKS-NOL-00363
EKS-ORN-00510
EKS-ORC-00375
EKS-OTG-00400
EKS-PAT-00373
EKS-PES-00354
EKS-POA-00390
EKS-RAN-00412
EKS-TAG-00470
EKS-TAR-00501
EKS-TAS-00047
EKS-TEN-00499
EKS-XET-00510
EKS-XIM-00502
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016028; C:rhabdomere
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001779; P:natural killer cell differentiation
GO:0051250; P:negative regulation of lymphocyte activation
GO:0030168; P:platelet activation
GO:0050766; P:positive regulation of phagocytosis
GO:0043491; P:protein kinase B signaling cascade
GO:0060041; P:retina development in camera-type eye
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013