EKS-AIM-00218
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00218
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl557.44.0E-168261512252
StatusUnreviewed
Ensembl ProteinENSAMEP00000017165
UniProt AccessionD2H177;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1; PANDA_003253;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000016250ENSAMEP00000017165ENSAMET00000017870
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1150
Protein Sequence
(FASTA)
MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120
AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR 180
SISLRYEGRV YHYRINTASD GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN 240
KPTVYGVSPN YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 300
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL 360
YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF 420
PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP 480
EGCPEKVYEL MRACWQWNPS DRPSFAEIHQ AFETMFQESS ISDEVEKELG KKGVRGVAST 540
LLQAPELPTK TRTSRRAVEH KDPTDVPDTP HSKGLGETDP LDHEPPVSPL LPRKERGPQD 600
GGLNEDERLL PKDKKTNLFS ALIKKKKKTA PTPPKRSSSF REMDGQPERK AASEEEGRET 660
SNGGPALTPS DTAEPAKSPK PSSGAGVPNG AFRETGGAGF RSPHLWKKSS TLTSSRLAAS 720
EEESGSSSSK RFLRSCSASC VPHGARDTEW KSVTLPRDLQ STGRQFDSST FGGHKSEKPA 780
LPRKRASENR SDQVTRGTVT PPPRLVKKTE DAADEVFRDT GESSPGSSPP SLTPKLLRRQ 840
VAGTPSSGLP HKDEAGKSGA LGTPATAEPV PPASRAGPGT SGGASKASTE EPRARRHKPS 900
SESPGRDKGK LSKLKPVPPP PPPASVGKAG KPSQNLSQEA AGEAGTGGKA KATAVVVDAV 960
NSDTVKPGPL GEGVKKPVLP SMPKPQSSSK PAGTPTSPAP TPSTVPSASS ALAGDQPAST 1020
AFIPLISTRV SLRKTRQPPE RIASGTITKG VVLDGTEALC LAISKNSEQM ASHSAVLEAG 1080
KNLFTFCVSY VDSIQQMRNK FAFREAINKL ENNLRELQIC PATAGSGPAA TQDFSKLLSS 1140
VKEISDIVQR 1150
Nucleotide Sequence
(FASTA)
ATGGGGCAGC AGCCTGGAAA AGTTCTTGGG GACCAGAGAA GGCCAAGTTT GCCTGCCCTG 60
CACTTTATCA AAGGAGCAGG GAAGAAGGAA TCATCAAGGC ATGGGGGTCC ACACTGCAAT 120
GTTTTTGTGG AACATGAAGC CCTTCAGAGG CCAGTAGCAT CCGACTTTGA GCCCCAAGGT 180
CTTAGTGAAG CAGCTCGTTG GAACTCCAAG GAAAACCTTC TTGCTGGCCC CAGTGAAAAT 240
GACCCCAACC TTTTCGTTGC ACTGTATGAT TTCGTGGCCA GTGGGGACAA CACCCTAAGT 300
ATAACTAAAG GTGAAAAGCT CCGGGTTTTA GGCTACAATC ACAATGGGGA ATGGTGTGAA 360
GCCCAAACCA AAAATGGCCA AGGGTGGGTC CCAAGCAACT ACATCACACC AGTCAACAGT 420
CTGGAGAAAC ATTCCTGGTA CCATGGGCCT GTGTCCCGCA ACGCGGCCGA ATACCTGCTG 480
AGCAGTGGGA TCAACGGCAG CTTCTTGGTC CGAGAGAGCG AGAGCAGTCC TGGCCAGAGG 540
TCCATCTCGC TGAGATACGA AGGGAGGGTG TACCACTACA GGATCAACAC TGCTTCCGAT 600
GGCAAGCTCT ACGTCTCCTC AGAGAGCCGC TTCAACACTT TGGCTGAGCT GGTTCATCAT 660
CACTCGACTG TGGCGGACGG GCTCATCACC ACTCTCCATT ACCCGGCCCC CAAGCGCAAC 720
AAGCCCACCG TCTACGGCGT GTCCCCCAAC TACGACAAGT GGGAGATGGA GCGCACGGAC 780
ATCACCATGA AGCACAAGCT GGGTGGAGGC CAGTACGGGG AGGTGTACGA AGGCGTGTGG 840
AAGAAATACA GCCTGACGGT GGCTGTGAAG ACCTTGAAGG AGGACACCAT GGAGGTGGAA 900
GAGTTCTTGA AAGAAGCCGC AGTAATGAAA GAGATCAAGC ACCCCAATCT AGTGCAGTTG 960
CTCGGGGTCT GCACCCGGGA ACCCCCATTC TATATAATCA CTGAGTTCAT GACCTATGGG 1020
AACCTGCTGG ATTACCTGAG AGAGTGTAAC CGGCAGGAGG TGAACGCTGT GGTGCTGCTG 1080
TACATGGCCA CTCAGATCTC GTCTGCCATG GAGTACCTGG AGAAGAAGAA CTTCATCCAC 1140
AGAGATCTCG CTGCCCGAAA CTGCCTGGTC GGGGAGAACC ACTTGGTGAA GGTGGCTGAT 1200
TTTGGCCTGA GCAGGTTAAT GACCGGGGAT ACCTACACAG CCCATGCTGG GGCCAAGTTC 1260
CCGATCAAGT GGACGGCGCC GGAGAGCCTG GCCTACAATA AGTTCTCCAT CAAGTCCGAC 1320
GTCTGGGCTT TTGGAGTATT GCTTTGGGAA ATTGCTACCT ATGGCATGTC ACCTTACCCA 1380
GGAATTGACC TGTCCCAGGT GTATGAGCTG CTAGAGAAGG ACTACCGCAT GGAGCGCCCG 1440
GAAGGCTGCC CGGAGAAGGT CTACGAACTC ATGCGAGCAT GTTGGCAATG GAATCCCTCC 1500
GACCGGCCCT CCTTTGCTGA AATCCACCAA GCCTTTGAGA CAATGTTCCA GGAATCCAGC 1560
ATATCAGATG AAGTGGAAAA GGAACTGGGG AAAAAAGGTG TGCGAGGGGT TGCAAGTACT 1620
TTACTGCAGG CCCCAGAGCT GCCCACCAAG ACAAGAACCT CCAGGAGAGC TGTGGAACAC 1680
AAAGACCCCA CTGATGTGCC TGACACACCC CACTCCAAGG GCCTGGGAGA GACCGATCCT 1740
CTGGACCATG AGCCTCCTGT GTCTCCGCTG CTCCCTCGAA AAGAACGAGG TCCCCAGGAT 1800
GGCGGCCTAA ATGAAGATGA GCGCCTTCTC CCCAAAGACA AAAAGACCAA CTTGTTCAGT 1860
GCCTTGATCA AGAAGAAGAA GAAAACAGCC CCAACCCCCC CGAAACGCAG CAGCTCCTTC 1920
CGGGAGATGG ATGGCCAGCC CGAGCGCAAG GCGGCCAGTG AGGAAGAGGG CCGAGAAACC 1980
AGCAACGGGG GGCCAGCCCT CACACCCTCG GACACAGCCG AGCCAGCCAA GTCCCCGAAG 2040
CCCAGCAGCG GGGCTGGTGT CCCCAATGGA GCCTTCCGGG AGACAGGGGG TGCAGGCTTC 2100
CGGTCTCCCC ACCTGTGGAA AAAGTCCAGT ACACTGACCA GCAGCCGCCT GGCAGCCAGT 2160
GAGGAAGAGA GCGGCAGCAG CTCCAGCAAG CGCTTCCTAA GGTCTTGCTC TGCCTCCTGC 2220
GTGCCCCACG GGGCCAGGGA CACAGAGTGG AAGTCTGTCA CACTGCCTCG GGATCTGCAG 2280
TCCACGGGGA GGCAATTCGA CTCGTCCACG TTTGGAGGGC ACAAAAGCGA GAAGCCAGCT 2340
CTGCCTCGGA AGCGAGCAAG TGAGAACAGG TCTGACCAGG TGACCAGAGG CACAGTGACT 2400
CCCCCGCCCA GGCTGGTGAA AAAGACCGAG GATGCAGCGG ATGAGGTCTT CCGAGACACG 2460
GGGGAGTCCA GCCCGGGCTC CAGCCCTCCC AGTCTGACTC CAAAACTCCT CCGCAGGCAG 2520
GTCGCGGGGA CTCCTTCCTC GGGCCTTCCC CACAAGGACG AGGCTGGGAA GTCCGGTGCC 2580
TTGGGGACAC CTGCCACAGC TGAGCCGGTG CCCCCCGCCA GCAGAGCAGG GCCAGGCACG 2640
TCTGGAGGGG CCAGTAAGGC CTCCACCGAG GAGCCCAGAG CGAGGAGGCA CAAGCCCTCC 2700
TCCGAGTCCC CGGGGAGAGA CAAGGGGAAA CTGTCCAAGC TCAAACCTGT CCCGCCACCC 2760
CCGCCACCAG CCTCCGTTGG GAAAGCTGGG AAGCCCTCTC AGAACCTGAG CCAGGAAGCA 2820
GCTGGGGAGG CCGGCACTGG TGGGAAAGCC AAAGCCACGG CTGTGGTTGT GGATGCTGTG 2880
AACAGTGACA CCGTCAAGCC CGGTCCGCTG GGAGAGGGTG TCAAAAAGCC CGTGCTCCCT 2940
TCCATGCCAA AGCCACAGTC GTCCAGCAAG CCGGCGGGGA CCCCGACCAG CCCAGCTCCC 3000
ACCCCTTCCA CCGTGCCATC AGCATCCTCT GCCCTGGCCG GGGACCAGCC AGCCTCCACT 3060
GCCTTCATCC CTCTCATATC AACCCGTGTG TCTCTTCGGA AAACCCGCCA GCCTCCGGAG 3120
CGGATCGCCA GTGGCACCAT CACCAAGGGC GTGGTCCTGG ACGGCACAGA GGCTCTGTGC 3180
CTGGCCATCT CCAAGAACTC CGAGCAGATG GCCAGCCACA GCGCCGTGCT AGAAGCCGGC 3240
AAGAACCTGT TCACGTTCTG CGTGAGCTAT GTGGATTCCA TCCAGCAAAT GAGGAACAAG 3300
TTCGCCTTCC GCGAGGCCAT CAACAAACTG GAGAACAATC TCCGGGAGCT TCAGATTTGC 3360
CCGGCGACAG CAGGGAGCGG CCCGGCGGCC ACTCAGGACT TCAGCAAACT CCTCAGCTCC 3420
GTGAAAGAGA TCAGTGACAT TGTGCAGAGG 3450
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 261   ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  320
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylre++r+ev+avvllymatqissameylekknfih
Q: 321   LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH  380
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 381   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  440
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+w+ps
Q: 441   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS  500
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 501   DRPSFAEIHQAF  512
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00272
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005730; C:nucleolus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0071901; P:negative regulation of protein serine/threonine kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0051353; P:positive regulation of oxidoreductase activity
GO:0051726; P:regulation of cell cycle
GO:2001020; P:regulation of response to DNA damage stimulus
GO:0042770; P:signal transduction in response to DNA damage
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013