EKS-AIM-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	263.9	1.6E-78	195	445	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017214

UniProt Accession

D2HR59;

Protein Name

Protein Synonyms/Alias

Gene Name

ILK

Gene Synonyms/Alias

ILK; PANDA_014448;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016283	ENSAMEP00000017214	ENSAMET00000017920

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLT RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAG GGTAACGCGG TGGCCGTTCG CCTGTGGCTG 60

GACAACACGG AGAACGACCT CAACCAGGGG GATGATCATG GCTTCTCCCC CTTGCACTGG 120

GCTTGCCGAG AGGGCCGTTC TGCTGTGGTT GAGATGTTGA TCATGCGGGG GGCACGAATC 180

AATGTGATGA ACCGTGGGGA TGACACCCCC CTGCACCTGG CAGCCAGCCA TGGACACCGT 240

GATATTGTGC AGAAGCTGCT GCAGTACAAA GCTGACATCA ATGCAGTGAA CGAGCATGGA 300

AATGTGCCCC TGCACTATGC CTGTTTTTGG GGCCAAGATC AGGTTGCAGA GGACCTGGTA 360

GCTAACGGGG CCCTTGTCAG CATTTGTAAC AAGTATGGAG AGATGCCTGT GGACAAAGCC 420

AAGGCACCCC TGAGAGAGCT CCTCCGAGAG CGGGCAGAGA AGATGGGCCA GAACCTTACC 480

CGTATTCCAT ACAAGGACAC ATTCTGGAAG GGAACCACCC GCACTCGGCC CCGAAATGGG 540

ACTCTGAACA AACACTCCGG CATTGACTTC AAACAGCTCA ACTTTCTGGC AAAGCTCAAC 600

GAGAATCACT CTGGAGAGCT ATGGAAGGGC CGTTGGCAGG GCAATGACAT CGTCGTGAAG 660

GTGCTAAAGG TTCGAGACTG GAGTACAAGG AAGAGCAGGG ACTTCAACGA GGAGTGTCCC 720

CGTCTCAGGA TTTTCTCGCA TCCAAATGTG CTCCCAGTGC TAGGTGCCTG TCAGTCTCCA 780

CCTGCTCCTC ACCCCACCCT CATCACACAC TGGATGCCAT ATGGATCCCT GTACAATGTA 840

TTACACGAAG GCACCAATTT CGTTGTGGAC CAGAGCCAGG CTGTGAAGTT TGCGTTGGAC 900

ATGGCAAGGG GCATGGCCTT CCTACACACA TTAGAGCCCC TCATCCCACG ACATGCACTC 960

AATAGCCGCA GTGTAATGAT TGATGAGGAC ATGACTGCTC GAATCAGCAT GGCCGACGTC 1020

AAGTTCTCCT TCCAATGCCC TGGGCGCATG TATGCACCTG CCTGGGTGGC GCCTGAAGCT 1080

CTGCAGAAGA AGCCTGAAGA TACAAACAGA CGCTCAGCAG ACATGTGGAG TTTTGCAGTG 1140

CTTCTGTGGG AACTGGTGAC ACGGGAGGTA CCCTTTGCTG ACCTCTCCAA CATGGAGATA 1200

GGAATGAAGG TGGCACTGGA AGGCCTCCGG CCTACCATCC CACCAGGCAT TTCCCCCCAT 1260

GTGTGTAAGC TCATGAAGAT CTGCATGAAT GAAGACCCTG CTAAGCGGCC CAAGTTTGAC 1320

ATGATTGTGC CTATCCTAGA GAAGATGCAG GACAAGTAG 1359

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         +  +++++++g+++k++w++++++vK l++++++++k++++++e+ +l+ +shpn++ +l

Q: 195   FLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVL  254

         667899******************************************************

S: 63    Gvcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         G+c+++p+   +l+++++++gsL+nvlhe ++ ++d++++v++al++ArGma+Lh+ +p

Q: 255   GACQSPPAphPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL  314

         ******99745**********************************************997

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs.  178

          i ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 315   -IPRHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDt  368

         .*************.**********.88888...78999998**************9998

S: 179   ..eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkec  236

           +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c

Q: 369   nrRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKIC  428

         8899********************************************************

S: 237   wnedpekRpsfseivks  253

         +nedp+kRp+f++iv +

Q: 429   MNEDPAKRPKFDMIVPI  445

         **************986

Domain Sequence
(FASTA)

FLAKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRI FSHPNVLPVL 60

GACQSPPAPH PTLITHWMPY GSLYNVLHEG TNFVVDQSQA VKFALDMARG MAFLHTLEPL 120

IPRHALNSRS VMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD 180

MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 240

KRPKFDMIVP I 251

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001658	; P:branching involved in ureteric bud morphogenesis
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0008284	; P:positive regulation of cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0042327	; P:positive regulation of phosphorylation
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

aml:100473650

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013