EKS-AIM-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	340.4	8.9E-102	983	1246	264

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017278

UniProt Accession

G1MD50;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016364	ENSAMEP00000017278	ENSAMET00000017987

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1250

Protein Sequence
(FASTA)

GVEIIVTFPR DVSYSQEMSQ EDLQENNQIT PVRREWAQAH AISLPNEIEM EDFRTKTFTM 60

GPLLLKKEES SKELCDENVG FLLSRPCLEP NISTSVARED VPHFLKGQQR KSEEFSISDT 120

KYSNRRIEFP LPPLSLLSMK PGRHTIPPSH KDQKKRERNI LNFISFVPKL SEPGSRSEEF 180

RPSNRLQEAP FKVFVDQTLR SSDSSIWSRN MCSFWKASHH RQHMEMEENR KSRETEGSDE 240

IAISHLEKGQ SLVSFENCKE SSFPMDREVD IDCLGREMRK AEEENSQHLS SGKKEDSVAR 300

NCKQGCEVGC TMPVKFQEGQ HSEIILSHNE ETRNDQADSK SASVHTGEAV EPNRILEEHT 360

VLNSLSSVVP DGPTEKLPQG HRGMDTNIKI SVAEATKPDM NGMVPLIRIT FPGHGTPKEP 420

SIAKPSLPKR KGTLHNHNSF NILAHPENDG HKMKTHRNKL ESKTKTSNRT PQNFTISTEG 480

SIKPTMHKTS TKTQVFPALG LVDPRPRQSP KIQRRIPQVE KKQSTYRALK PKMQSFPCIC 540

RNPGIKKSSV PFSAQPKEPR LNYLDLKYSD MFKEINSTAN GPGIYEMFGT PVYCHMREAE 600

RHENKYYREI CSAPSGRCIT NKCRSSHSER SSNSRTRFSQ KRPHIKPAKA SLGIKQKNKS 660

LISKEKGYKA IGSNLQGVEN GDGISDPEWQ IKSSGNDFLS SSGEGQPMNL AQPHKRSTAQ 720

NELLPVSDLS TIEEVSMEES ADEGHISNNQ ILATSLRDLH KLEELHHQTP FVLSENSWAV 780

PSEKGSNKHL LPEKQSTASL GKINANQFLI NDIGIKSILD KSETLMSFSF QEKQQRASSQ 840

ADQHWAHSLD HDSLANESIT YHTYGQTLSG ANSISQEILD SVKNEELTDE LLGCLAAELL 900

ALDERENTSC QIMANETGPE NLSLVFSRRG KTTPELGGET TNVKVQRYSN GFRIYNKEEK 960

FLNSNEKKTF SENSSNYEES ILWTKGEILG KGAYGTVYCG LTSQGQLIAV KQVALDTSDK 1020

LATEKEYRKL QEEVDLLKAL KHVNIVAYLG TCLEENIVSI FMEFVPGGSI SSIINRFGPL 1080

PEMVFCKYTR QILQGVAYLH ENCVVHRDIK GNNVMLMPTG IIKLIDFGCA KRLAWAGLNG 1140

THSDMLKSMH GTPYWMAPEV INESGYGRKS DIWSIGCTVF EMATGKPPLA SMDRMAAMFY 1200

IGAHQGLMPP LPEHFSENAA DFVRLCLTRD QHERPSAAQL LKHSFLMRSH 1250

Nucleotide Sequence
(FASTA)

GGTGTTGAGA TTATTGTTAC TTTTCCAAGA GATGTCAGTT ATTCCCAAGA AATGAGCCAA 60

GAAGATTTAC AAGAAAACAA TCAGATAACC CCAGTGCGTC GAGAATGGGC ACAAGCCCAT 120

GCTATTTCTC TCCCAAATGA AATTGAGATG GAGGACTTCC GGACAAAGAC GTTCACCATG 180

GGGCCTTTAC TTCTGAAGAA AGAGGAAAGT TCCAAGGAGC TCTGTGATGA GAATGTGGGC 240

TTTTTGTTGT CAAGACCTTG CTTAGAACCA AACATCTCCA CGTCTGTAGC CAGAGAAGAT 300

GTTCCTCACT TTCTGAAGGG GCAGCAAAGA AAATCTGAAG AGTTTTCTAT TTCTGATACG 360

AAGTACAGTA ACCGAAGAAT CGAGTTTCCT CTGCCACCAT TGTCACTCTT GTCCATGAAA 420

CCTGGTCGTC ATACGATCCC CCCAAGTCAC AAGGATCAAA AAAAGAGAGA AAGAAATATT 480

CTGAACTTCA TATCCTTCGT ACCTAAGCTC TCAGAGCCCG GAAGTCGATC TGAGGAGTTT 540

AGACCATCAA ACAGGCTGCA GGAAGCTCCA TTTAAGGTGT TTGTGGATCA GACGCTCAGG 600

TCCTCTGATA GCTCTATTTG GTCCAGAAAC ATGTGCTCTT TTTGGAAGGC TAGCCATCAC 660

AGACAACACA TGGAGATGGA GGAGAACAGG AAATCCAGGG AAACAGAAGG AAGTGACGAA 720

ATTGCCATCT CTCACCTCGA GAAAGGACAA TCATTGGTGT CCTTTGAGAA TTGTAAGGAA 780

AGCAGTTTTC CTATGGATAG GGAAGTGGAT ATTGACTGCC TTGGTCGTGA AATGAGAAAA 840

GCAGAAGAAG AGAATTCTCA ACATCTTTCA TCAGGAAAGA AAGAGGATTC AGTAGCCAGA 900

AACTGTAAAC AAGGTTGTGA AGTTGGATGT ACCATGCCAG TCAAGTTCCA AGAAGGCCAG 960

CATTCAGAAA TAATTCTCAG CCATAATGAA GAGACTAGAA ATGATCAGGC CGATTCCAAA 1020

AGTGCTTCAG TACATACAGG TGAAGCTGTC GAGCCGAATC GTATTTTAGA AGAGCATACT 1080

GTACTTAACA GTTTGTCCAG TGTGGTCCCT GATGGCCCCA CTGAAAAGCT CCCACAAGGT 1140

CACAGAGGCA TGGACACAAA CATAAAAATA TCAGTAGCAG AGGCCACCAA ACCAGATATG 1200

AATGGAATGG TGCCTCTTAT CCGCATCACT TTCCCTGGAC ATGGAACGCC CAAGGAACCG 1260

TCAATAGCCA AACCAAGCCT CCCAAAAAGA AAGGGTACTC TTCATAACCA CAATAGCTTC 1320

AACATACTTG CACACCCAGA AAATGACGGG CATAAGATGA AAACCCACAG AAATAAGTTG 1380

GAGTCAAAGA CCAAGACCAG TAACAGGACA CCCCAGAATT TCACGATCTC CACTGAAGGT 1440

TCCATTAAGC CTACCATGCA TAAAACCAGC ACAAAAACTC AAGTGTTCCC TGCTTTGGGG 1500

CTTGTTGACC CCAGACCTCG GCAGTCACCC AAGATTCAAA GGCGAATTCC ACAGGTGGAA 1560

AAGAAGCAAT CAACTTACCG GGCTCTGAAA CCTAAAATGC AATCTTTTCC TTGCATCTGT 1620

AGGAATCCAG GAATAAAAAA GTCTTCTGTT CCTTTCTCTG CTCAACCAAA AGAACCAAGA 1680

CTAAATTACT TAGATCTTAA GTATAGTGAC ATGTTCAAAG AAATCAATTC AACTGCTAAT 1740

GGGCCTGGAA TCTATGAAAT GTTTGGGACT CCTGTTTATT GTCACATGAG AGAGGCTGAA 1800

CGTCATGAGA ACAAATATTA CCGAGAGATA TGCTCAGCTC CATCTGGCAG ATGTATTACC 1860

AATAAATGTC GATCTTCACA CAGTGAGAGA AGCAGCAATA GCAGAACAAG ATTTTCTCAG 1920

AAAAGACCAC ATATTAAACC TGCAAAGGCT TCGCTTGGCA TTAAACAAAA GAACAAAAGT 1980

TTAATTTCTA AAGAAAAGGG TTACAAGGCC ATAGGTAGCA ACTTGCAAGG TGTCGAAAAC 2040

GGTGATGGTA TTTCAGATCC AGAGTGGCAG ATAAAGTCTT CAGGAAATGA CTTTCTTTCT 2100

TCCAGTGGTG AAGGTCAGCC CATGAACTTG GCTCAGCCTC ACAAGCGGTC CACTGCACAG 2160

AATGAACTCC TTCCTGTTTC AGATTTGTCC ACCATTGAAG AGGTCTCTAT GGAAGAGTCT 2220

GCTGATGAAG GACACATTTC TAACAATCAA ATACTTGCCA CAAGCCTCAG AGATCTGCAT 2280

AAACTTGAAG AGCTACATCA CCAGACCCCC TTTGTCCTTT CAGAAAATAG CTGGGCAGTG 2340

CCCAGTGAGA AGGGTTCCAA CAAGCATTTA TTGCCAGAAA AGCAGAGTAC AGCATCTCTT 2400

GGTAAAATAA ATGCCAACCA ATTTTTAATT AACGATATAG GGATCAAAAG TATTTTAGAT 2460

AAGTCTGAAA CACTTATGAG TTTCTCTTTC CAAGAGAAAC AACAGAGGGC ATCTTCTCAA 2520

GCAGATCAAC ATTGGGCACA TTCTTTGGAT CATGATAGTT TAGCTAATGA GTCAATTACG 2580

TATCACACAT ACGGACAAAC TTTAAGTGGT GCAAATTCAA TTTCCCAAGA AATTCTAGAT 2640

TCTGTGAAGA ATGAAGAATT GACTGATGAA CTGTTAGGAT GCCTAGCTGC AGAATTATTA 2700

GCTCTTGATG AGAGAGAGAA CACCTCTTGC CAAATAATGG CAAACGAAAC AGGTCCTGAA 2760

AACCTAAGTC TTGTCTTCAG TAGGAGAGGA AAAACCACGC CAGAATTGGG CGGAGAGACA 2820

ACAAATGTTA AAGTACAGAG ATATAGTAAT GGGTTCAGGA TATACAACAA GGAGGAGAAA 2880

TTTCTCAACT CAAATGAAAA GAAGACATTT TCTGAAAATA GTTCAAATTA TGAAGAATCT 2940

ATCCTGTGGA CAAAGGGCGA GATCCTTGGG AAGGGAGCCT ATGGCACAGT ATATTGTGGT 3000

CTTACTAGCC AAGGACAACT AATAGCTGTG AAACAGGTGG CTTTGGATAC CTCTGATAAA 3060

TTAGCTACCG AAAAAGAATA CCGGAAACTG CAGGAAGAAG TAGATTTGCT CAAAGCACTG 3120

AAACATGTCA ATATTGTGGC CTATTTGGGG ACATGTTTGG AAGAAAACAT TGTAAGCATT 3180

TTCATGGAGT TTGTCCCCGG TGGCTCAATT TCTAGTATTA TAAACCGTTT TGGGCCATTG 3240

CCTGAAATGG TGTTCTGTAA ATATACAAGA CAAATTTTGC AAGGTGTTGC TTATCTCCAT 3300

GAGAACTGTG TGGTGCATCG AGATATCAAA GGAAATAATG TCATGCTTAT GCCAACTGGA 3360

ATAATAAAGC TAATTGACTT TGGCTGTGCC AAGCGTTTGG CCTGGGCTGG CTTAAATGGC 3420

ACCCACAGTG ACATGCTTAA GTCCATGCAT GGGACTCCAT ATTGGATGGC CCCAGAAGTC 3480

ATCAATGAGT CTGGCTACGG AAGGAAGTCA GACATCTGGA GCATTGGCTG CACCGTGTTT 3540

GAGATGGCCA CAGGGAAGCC TCCATTGGCT TCCATGGACA GGATGGCAGC CATGTTTTAC 3600

ATTGGAGCAC ACCAAGGGCT GATGCCTCCG TTACCAGAAC ACTTCTCGGA AAACGCAGCA 3660

GACTTTGTGC GTCTGTGCCT AACCAGGGAC CAGCATGAGC GACCTTCTGC TGCCCAGCTC 3720

CTGAAGCACT CCTTCTTGAT GAGAAGTCAC 3750

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 983   WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTsDKLATEKEYRKLQEEVDLLKALK  1041

         89*****************8.89***********8614556778****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee+ ++if+E+v+gGs+ss+++++g+l e+v++kyt+qil+g+ayLHe

Q: 1042  HVNIVAYLGTCLEENIVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHE  1101

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1102  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1161

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++pe++se+

Q: 1162  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHQgLMPPLPEHFSEN  1218

         988..****************************.9*********99879***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa++LLkh+fl

Q: 1219  AADFVRLCLTRDQHERPSAAQLLKHSFL  1246

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LEENIVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTRQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHQGLMPPLP EHFSENAADF 240

VRLCLTRDQH ERPSAAQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013