EKS-AIM-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.8	6.3E-150	401	658	258

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017531

UniProt Accession

G1MDV3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016514	ENSAMEP00000017531	ENSAMET00000018244

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

719

Protein Sequence
(FASTA)

SQNGQQIMDE PMGEEEINPQ TEEGSIKEIA ITHHVKEGHE KADPSQFELL KVLGQGSFGK 60

VFLVKKISGS DARQLYAMKV LKKATLKVRD RVRTKMERDI LVEVNHPFIV KLHYAFQTEG 120

KLYLILDFLR GGDLFTRLSK EVMFTEEDVK FYLAELALAL DHLHSLGIIY RDLKPENILL 180

DEEGHIKLTD FGLSKESIDH EKKAYSFCGT VEYMAPEVVN RRGHTQSADW WSFGVLMFEM 240

LTGTLPFQGK DRKETMTMIL KAKLGMPQFL SPEAQSLLRM LFKRNPANRL GAGPDGVEEI 300

KRHSFFSTID WNKLYRREIH PPFKPATGRP EDTFYFDPEF TAKTPKDSPG IPPSANAHQL 360

FRGFSFVAIT SDDESQAMQT VGVHSIVQQL HRNSIQFTDG YEVKEDIGVG SYSVCKRCIH 420

KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD VYDDGKYVYV VTELMKGGEL 480

LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK PSNILYVDES GNPESIRICD 540

FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI WSLGVLLYTM LTGYTPFANG 600

PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH VDPHQRLTAA LVLRHPWIVH 660

WDQLPQYQLN RQDAPHLVKG AMAATYSALN RNQSPVLEPV GRSTLAQRRG IKKITSTAL 719

Nucleotide Sequence
(FASTA)

TCACAGAATG GACAGCAAAT TATGGATGAA CCTATGGGAG AGGAGGAGAT TAATCCACAA 60

ACTGAAGAAG GCAGTATCAA AGAAATTGCA ATCACACATC ATGTAAAGGA AGGACATGAA 120

AAGGCAGATC CTTCCCAGTT TGAACTTTTA AAAGTATTAG GGCAGGGATC ATTTGGAAAG 180

GTTTTCTTAG TCAAAAAAAT CTCAGGCTCT GATGCTAGAC AGCTTTATGC CATGAAAGTG 240

TTGAAGAAGG CCACATTGAA AGTTCGAGAT CGTGTTCGGA CAAAAATGGA GCGTGATATC 300

TTGGTAGAAG TTAATCATCC TTTTATTGTC AAGTTGCATT ATGCTTTTCA AACTGAAGGG 360

AAGTTGTATC TTATTTTGGA TTTTCTCAGG GGAGGAGATT TGTTTACACG CTTATCCAAA 420

GAGGTGATGT TCACAGAAGA AGATGTCAAA TTCTACTTGG CCGAACTTGC ACTTGCTTTA 480

GACCATCTGC ATAGCCTGGG AATAATCTAT AGAGACTTAA AACCAGAAAA CATACTTCTT 540

GATGAAGAAG GTCACATCAA GTTAACAGAT TTTGGCCTAA GTAAAGAGTC TATTGACCAT 600

GAAAAGAAGG CATATTCTTT CTGTGGAACT GTGGAATACA TGGCTCCCGA AGTAGTTAAT 660

CGTCGAGGTC ATACTCAGAG TGCAGACTGG TGGTCTTTTG GTGTGTTAAT GTTTGAAATG 720

CTCACTGGTA CACTACCTTT CCAAGGAAAA GATCGAAAAG AAACAATGAC TATGATTCTT 780

AAAGCCAAAC TTGGGATGCC ACAGTTTTTG AGTCCTGAAG CCCAGAGTCT TTTACGAATG 840

CTTTTCAAAC GAAATCCTGC TAACAGATTA GGTGCAGGAC CAGATGGAGT TGAGGAAATT 900

AAAAGACATT CATTTTTCTC AACAATAGAC TGGAATAAAC TGTACAGAAG AGAAATTCAT 960

CCACCTTTTA AACCTGCAAC TGGCAGGCCT GAGGATACAT TCTATTTTGA TCCTGAGTTT 1020

ACTGCAAAAA CTCCCAAAGA TTCACCTGGC ATTCCACCTA GTGCTAATGC ACATCAGCTT 1080

TTTCGGGGGT TTAGTTTTGT TGCTATCACC TCAGATGATG AAAGCCAAGC TATGCAGACA 1140

GTTGGTGTGC ATTCAATTGT GCAGCAGTTG CACAGAAACA GTATTCAGTT TACTGATGGA 1200

TATGAAGTAA AAGAAGATAT TGGAGTTGGC TCCTACTCTG TTTGCAAGAG ATGCATACAT 1260

AAAGCTACAA ACATGGAGTT TGCAGTGAAG ATTATTGATA AAAGCAAGAG AGATCCAACA 1320

GAAGAAATTG AAATTCTTCT TCGTTATGGA CAGCATCCAA ACATCATTAC TCTAAAGGAT 1380

GTATATGATG ATGGAAAATA TGTGTATGTA GTGACAGAAC TTATGAAAGG GGGTGAATTG 1440

CTGGATAAAA TTCTTAGACA GAAATTTTTC TCTGAAAGAG AGGCCAGTGC TGTCCTGTTT 1500

ACTATAACCA AAACTGTTGA ATATCTTCAC GCACAAGGGG TGGTTCACAG AGACTTGAAA 1560

CCTAGCAACA TTCTTTACGT GGATGAATCT GGCAATCCAG AATCTATTCG AATTTGTGAT 1620

TTTGGCTTTG CCAAACAGCT AAGAGCAGAA AACGGTCTTC TCATGACTCC TTGTTACACT 1680

GCAAATTTTG TTGCACCAGA GGTTTTAAAA CGACAAGGCT ATGATGCTGC TTGTGATATA 1740

TGGAGTCTTG GTGTCCTCCT CTATACAATG CTTACTGGTT ACACCCCATT TGCAAATGGC 1800

CCTGATGATA CACCAGAGGA AATATTGGCA CGGATAGGCA GCGGAAAATT CTCACTCAGT 1860

GGTGGTTACT GGAATTCTGT TTCAGACACA GCAAAGGACC TGGTATCAAA GATGCTTCAT 1920

GTGGATCCTC ATCAGAGACT GACTGCTGCC CTTGTGCTCA GACATCCTTG GATCGTCCAC 1980

TGGGACCAAC TGCCACAATA CCAACTAAAC AGACAGGATG CACCCCATCT AGTCAAGGGT 2040

GCTATGGCAG CTACATATTC TGCTTTAAAC CGTAATCAGT CTCCAGTTTT GGAACCAGTA 2100

GGCCGCTCTA CTCTTGCTCA GCGGAGAGGT ATTAAAAAAA TCACCTCCAC AGCCCTG 2157

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 401   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  460

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 461   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  520

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 521   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  580

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 581   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  640

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 641   VDPHQRLTAALVLRHPWI  658

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013