EKS-AIM-00237

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00237

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	236.1	4.1E-70	957	1212	256

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017599

UniProt Accession

G1ME21;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016638	ENSAMEP00000017599	ENSAMET00000018314

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1268

Protein Sequence
(FASTA)

ESPAARTASE PSASLSSAHR HLSRRNGLSK LCQSRMGLSE DRWNTYCLSS LAAQNICTSK 60

LHCLVAPEQT ELAGSLGSMS CCSLLRGLSL GWSTPLLPTP VCNPNKAVFT VDARTTEILV 120

ANDKACQLLG HSSHDLIGQK LTQFFLKPDS DVVKALSEEH VEADGHAAVV FGTVVDVVSR 180

SGEKIPVSVW MKKVKQDHSL CCVVVLEPVE RVSAWVAFQS DGTVTSCDSL FALLHGYASG 240

EEVLGQHITD LIPSVQLPPP GEPVPQNLKI QRSVGRARDG TTFPLSLKLK SESSSEMVED 300

SSAVSEWGYS ASVWVFSTIS GLITLLPDGT IYGINHSFAL MLFGYGKTEL LGKNITFLIP 360

SFFHYMGLAR DSSLPLPNLA DCLDIGNQSG PGKTSVGPQQ GRNLAGTATD PRANSALVGD 420

HVLPRGETLE PVGSQEDFAG TQAQADAGGR LPSSLLGLPT PGVDSIPESR PPAQEWSSPE 480

DQLSTLLEKE EPAAPESLRQ DLVGASGSDP VDTRMSASRE GSEDRSRHTE MCGLYQEWTS 540

LSNARNSNRR AESIKPKPHA TGQPAGEGPL MPCPGYGGEH STPSGSPPGT AQLPFSTPTL 600

DEPWVAVEND REELQTCLIK EQLSKLSLMG PRGGSYTELA PAEHPRGSAP VSLCGPGSRG 660

RCRRAGSSSA YYALATDLPG VLGAVQAQEA DGNSFSWNLK ELFFNERTDR TSSSCSCTAS 720

ELAGSPSASL AGSDVDVSGL HGRRSDVLDD RELLLLTGTY FDLGEARQFH ESRLGPDQAE 780

PSETGLVSSE HYEVSGRESP ACVLPTSGAG PVDACPSEEP RLSFQVTSTP VRGDSLVTPG 840

PVRVQQEIQE GTYAGSCYHR DGAQLSVQFE VKRVELQGSA TLFCCWLVKD LLHSHQDSAT 900

RTRLLLASLP SSSHSMLELS GSSVGEMLRS KPWFEEPPKA VELEGLAACE GAYSHKYSTL 960

SPLGSGAFGF FCSRWSSVAV SNLREVVVKF IKKEKVLEDC WIEDPKLGKV TLEIAILSRV 1020

DHANIIKVLD VFENQAFFQL VMEKHGSGLD LFAFIDRHPS LDEPLASYIF RQLVSAVGYL 1080

RSQSIIHRDI KDENIVIAED FTIKLIDFGS AAYLEKGRLF HTFCGTIEYC APEVLMGNPY 1140

KGPELEMWSL GVTLYTLIFE ENPFCELEET MEAMIHPPYL VSEDLMELMS GLLQPVPEQR 1200

TTLEKLVADP WVTQPVNLAN YTWDEVCRVN KPESGALSGV SLETESRCTR EVAWALEPCG 1260

ALCPRGGP 1268

Nucleotide Sequence
(FASTA)

GAGAGCCCGG CTGCGCGGAC TGCCTCCGAG CCCAGCGCGT CCCTGTCCTC GGCCCACAGA 60

CACCTGAGCA GAAGGAATGG GCTTTCCAAG CTCTGCCAGA GCAGGATGGG CCTCTCCGAA 120

GACAGATGGA ACACCTACTG CCTGTCGTCC CTGGCTGCCC AGAATATTTG CACCAGCAAA 180

CTGCACTGCC TGGTGGCACC GGAGCAGACG GAACTGGCTG GGTCCCTGGG CAGCATGTCC 240

TGCTGCTCCC TGCTGCGGGG CTTGTCCTTG GGGTGGTCCA CGCCCCTGCT GCCGACCCCT 300

GTGTGCAACC CGAACAAGGC TGTGTTCACC GTGGATGCCA GGACCACAGA GATCCTGGTT 360

GCCAACGACA AGGCTTGCCA GCTCCTGGGG CACAGCAGCC ATGACCTAAT TGGCCAGAAG 420

CTCACGCAGT TCTTCCTGAA GCCCGATTCC GACGTGGTGA AGGCCCTCAG CGAAGAGCAC 480

GTGGAGGCTG ACGGCCATGC CGCTGTCGTG TTCGGCACAG TGGTGGACGT CGTGAGCCGC 540

AGTGGGGAGA AGATCCCGGT TTCCGTGTGG ATGAAGAAGG TGAAGCAGGA CCACAGCCTG 600

TGCTGCGTGG TCGTGCTGGA GCCTGTGGAG CGTGTGTCGG CCTGGGTCGC TTTCCAGAGC 660

GATGGCACCG TAACATCCTG TGACAGCCTG TTTGCTCTCC TGCACGGGTA CGCGTCTGGG 720

GAGGAGGTGC TCGGGCAGCA CATCACAGAC CTGATCCCTT CCGTGCAGCT CCCTCCCCCC 780

GGTGAGCCTG TCCCACAGAA TCTCAAGATT CAGAGGTCTG TTGGGAGAGC CAGAGATGGC 840

ACCACCTTCC CTCTGAGCTT AAAACTGAAG TCTGAGTCCA GTAGCGAGAT GGTGGAAGAC 900

AGCAGCGCAG TCTCCGAGTG GGGTTACTCG GCATCCGTCT GGGTGTTCTC CACCATCAGC 960

GGCCTCATCA CCCTCCTGCC CGACGGGACC ATCTACGGCA TCAACCACAG CTTTGCGCTG 1020

ATGCTGTTTG GTTACGGGAA GACGGAGCTC CTGGGCAAGA ATATCACTTT CCTGATCCCC 1080

AGCTTCTTCC ACTACATGGG CCTTGCGCGT GACAGTTCTT TACCGCTGCC CAACCTGGCC 1140

GACTGCTTGG ATATTGGCAA CCAGAGTGGG CCTGGGAAGA CAAGTGTGGG CCCCCAGCAG 1200

GGCCGGAACC TGGCTGGCAC AGCCACGGAT CCAAGGGCTA ACAGCGCACT TGTTGGAGAC 1260

CACGTTTTGC CACGAGGGGA GACCCTAGAG CCAGTGGGAA GCCAAGAAGA CTTCGCCGGC 1320

ACACAGGCCC AAGCAGACGC TGGAGGCCGC CTCCCTTCTT CCCTCCTGGG TCTGCCCACC 1380

CCAGGGGTAG ACAGCATCCC AGAAAGCAGG CCACCAGCCC AGGAATGGTC ATCACCCGAG 1440

GACCAGCTGA GTACTCTCTT GGAGAAGGAG GAACCTGCAG CCCCAGAGAG CCTCAGACAG 1500

GACCTCGTGG GAGCAAGCGG GTCTGACCCA GTGGACACAC GGATGTCTGC TTCCCGTGAA 1560

GGATCTGAGG ACAGGAGCAG GCACACTGAA ATGTGCGGCC TGTATCAGGA GTGGACAAGC 1620

TTGAGTAATG CCCGCAATTC AAACCGTCGG GCTGAGTCCA TCAAGCCCAA GCCCCATGCC 1680

ACAGGCCAGC CGGCAGGGGA GGGCCCCCTG ATGCCCTGTC CTGGATATGG GGGTGAGCAC 1740

AGCACGCCGT CAGGAAGCCC CCCCGGGACA GCACAGCTCC CGTTCTCGAC GCCTACCCTG 1800

GATGAGCCGT GGGTGGCGGT GGAGAATGAC CGAGAGGAGC TACAGACCTG CTTAATTAAG 1860

GAGCAGCTGT CCAAGTTGAG CCTCATGGGA CCCCGGGGTG GCTCTTACAC TGAGCTGGCC 1920

CCAGCGGAGC ATCCCCGAGG CTCTGCCCCC GTGTCCTTGT GCGGCCCGGG AAGCAGAGGC 1980

CGGTGCCGCC GTGCGGGCAG CTCCTCAGCC TACTATGCTC TGGCCACAGA CCTCCCTGGT 2040

GTCCTGGGTG CCGTGCAGGC CCAGGAGGCT GATGGGAATT CATTTTCCTG GAACCTCAAG 2100

GAACTCTTTT TCAATGAACG GACAGATCGA ACTTCTTCCA GCTGTTCCTG CACCGCGTCC 2160

GAGCTTGCGG GGTCGCCGTC TGCTTCGCTG GCCGGCTCTG ATGTAGATGT GAGTGGTCTG 2220

CACGGGCGGA GATCAGATGT TCTAGATGAC CGAGAACTGT TGCTCCTGAC CGGCACTTAC 2280

TTCGATCTTG GGGAGGCCCG GCAGTTTCAC GAGAGCCGTC TGGGGCCCGA TCAAGCAGAG 2340

CCCTCCGAGA CGGGTCTGGT GTCCTCAGAA CACTATGAAG TGAGTGGCAG AGAGAGCCCA 2400

GCCTGCGTCC TTCCCACGTC AGGGGCCGGC CCCGTAGATG CGTGCCCATC AGAGGAGCCC 2460

AGGCTGAGTT TCCAGGTCAC TTCCACGCCT GTGAGAGGGG ACAGCTTGGT GACACCTGGG 2520

CCCGTCCGCG TGCAGCAGGA GATCCAGGAG GGGACCTACG CCGGCAGCTG CTACCACCGG 2580

GACGGAGCGC AGCTGAGTGT GCAGTTTGAG GTGAAGCGGG TGGAGCTCCA GGGCTCCGCG 2640

ACCCTGTTCT GCTGCTGGCT CGTGAAAGAC CTGCTGCACA GCCACCAGGA CTCGGCCACG 2700

CGGACCCGCC TGCTCCTGGC CAGCCTGCCC AGCTCCAGCC ACTCCATGCT CGAGCTTTCT 2760

GGATCCAGCG TGGGGGAGAT GCTCAGAAGC AAACCCTGGT TTGAGGAGCC CCCCAAGGCT 2820

GTGGAGCTGG AGGGGCTGGC GGCCTGCGAG GGCGCATACT CCCACAAGTA CAGCACGCTG 2880

AGCCCGCTGG GCAGTGGGGC CTTTGGCTTC TTCTGTTCTC GATGGAGTTC TGTTGCTGTT 2940

TCTAATCTCC GTGAGGTGGT GGTGAAGTTT ATTAAGAAGG AGAAGGTTTT GGAGGATTGT 3000

TGGATCGAGG ATCCCAAACT TGGAAAAGTT ACTTTAGAGA TTGCAATTCT GTCCAGGGTG 3060

GACCATGCCA ATATCATCAA GGTGTTGGAT GTATTTGAAA ACCAAGCGTT CTTTCAGCTT 3120

GTGATGGAGA AGCACGGCTC CGGCCTGGAC CTCTTTGCAT TCATTGACCG CCATCCCAGC 3180

CTTGACGAGC CCCTGGCGAG TTACATCTTC CGACAACTGG TGTCGGCAGT GGGTTACCTG 3240

CGCTCGCAGA GCATCATTCA CCGGGACATC AAGGACGAGA ACATCGTGAT TGCGGAGGAC 3300

TTCACCATCA AGCTGATCGA CTTCGGCTCC GCCGCCTACT TGGAGAAGGG CAGGCTGTTT 3360

CACACGTTCT GTGGGACGAT CGAGTACTGT GCACCCGAAG TCCTCATGGG AAACCCGTAC 3420

AAGGGGCCGG AGCTGGAGAT GTGGTCGCTG GGGGTCACGC TGTACACACT GATCTTTGAG 3480

GAGAACCCCT TCTGTGAGCT GGAGGAGACC ATGGAGGCCA TGATCCACCC CCCGTACCTG 3540

GTGTCAGAAG ATCTCATGGA ACTCATGTCT GGGCTGCTGC AACCTGTCCC CGAGCAGCGG 3600

ACCACCCTGG AGAAGCTGGT GGCAGACCCC TGGGTGACAC AGCCCGTGAA TCTTGCTAAC 3660

TACACCTGGG ATGAGGTGTG TCGCGTCAAC AAGCCAGAAA GCGGAGCTCT GTCCGGTGTG 3720

AGCCTGGAGA CAGAAAGCAG GTGTACCAGG GAAGTGGCCT GGGCTCTGGA GCCCTGCGGG 3780

GCCTTGTGCC CCCGGGGAGG GCCCTGA 3807

Domain Profile

S: 1     ykllktlGegsfgkVklakhk...etkekvavKiikkkkl......seeslekikrEiei  51

         y++l+ lG+g+fg     +++   ++ ++v+vK+ikk+k+      ++ +l k++ Ei+i

Q: 957   YSTLSPLGSGAFGFFCSRWSSvavSNLREVVVKFIKKEKVledcwiEDPKLGKVTLEIAI  1016

         788999*******998877776668899***********99999998899**********

S: 52    lkklkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsa  110

         l++++h niik+l+v+e++ +++lv+e + sg +Lf  i ++ +l+e  a+ +f+qlvsa

Q: 1017  LSRVDHANIIKVLDVFENQAFFQLVMEkHGSGLDLFAFIDRHPSLDEPLASYIFRQLVSA  1076

         ***************************888899***************************

S: 111   vkYlhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellk  170

         v Yl+s++i+HrD+K eN+++ ++ +ik++DFG a+++++g+l++tfcG+++Y+aPe+l+

Q: 1077  VGYLRSQSIIHRDIKDENIVIAEDFTIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLM  1136

         ************************************************************

S: 171   gkkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230

         g++Y+gp++++WslGv+Ly+l++++ Pf e       e++++  ++ p+ +s++l++L++

Q: 1137  GNPYKGPELEMWSLGVTLYTLIFEENPFCEL------EETMEAMIHPPYLVSEDLMELMS  1190

         ****************************998......678889999999***********

S: 231   klLvvdpekRatieeilkhewl  252

          lL+  pe+R+t+e++++++w+

Q: 1191  GLLQPVPEQRTTLEKLVADPWV  1212

         *********************7

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFFCSRWS SVAVSNLREV VVKFIKKEKV LEDCWIEDPK LGKVTLEIAI 60

LSRVDHANII KVLDVFENQA FFQLVMEKHG SGLDLFAFID RHPSLDEPLA SYIFRQLVSA 120

VGYLRSQSII HRDIKDENIV IAEDFTIKLI DFGSAAYLEK GRLFHTFCGT IEYCAPEVLM 180

GNPYKGPELE MWSLGVTLYT LIFEENPFCE LEETMEAMIH PPYLVSEDLM ELMSGLLQPV 240

PEQRTTLEKL VADPWV 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:2000505	; P:regulation of energy homeostasis
GO:0070092	; P:regulation of glucagon secretion
GO:0043576	; P:regulation of respiratory gaseous exchange

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091

; PAS; 3.

Prosites

PS50112	; PAS; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013