EKS-AIM-00324
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00324
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack354.92.5E-106116362247
StatusUnreviewed
Ensembl ProteinENSAMEP00000017587
UniProt AccessionG1ME09;
Protein Name
Protein Synonyms/Alias
Gene NameTNK1
Gene Synonyms/Alias TNK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000016650ENSAMEP00000017587ENSAMET00000018302
OrganismAiluropoda melanoleuca
Functional Description
Protein Length652
Protein Sequence
(FASTA)
MLPEASSLWL LRLLRDIQLA QFYRPILEEL NVTRPEHFDF VRPEDLDGIG MGRPAQRRLA 60
EALKKHRSGL KSKNWVYKIL GGFAPEQKET TPPSDSHLSL PEPEGGLKCL IPDGAVCRGE 120
LLGSGCFGVV HRGLWTLPSG QSVPVAVKSL RVGPEGPVGT ELGDFLREVS IMMNLEHPHV 180
LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPIPGAMAY LGARGLVHRD LATRNLLLAS 240
PRTIKVADFG LVRPLRGARG RYVMGGPRPI PYAWCAPESL RQGAFSSASD VWMFGVTLWE 300
MFSGGEEPWA GVPPYLILQR LEQDRARLPR PPLCSRALYS LALRCWAPHP ADRPSFSYLE 360
GLLQEAWPPE GRCVRDVTEP GALRMQTGDP VTIIEGSASS HSPDSATWKG QNGRTFKVGS 420
FPASAVTLAD AGVSPATRPV HRVSPAQGER HQGNVDGDRG KAKLRDVPPA RAGRRNVPLQ 480
RMKVISKSLE SVLSLGPRPT GGGSSPPELR HARAVPQGPP GLPSRPPFAS SPSQPGQPPR 540
ERPPWPKREP PHSHPSGAPG ASKATVPSGG LLPDPELQRR IMEVELGVHG VTHQECQAAL 600
RATGGDVVSA IRNLKVDQLF HLSSRSRADC RRILEHYQWD LSAASRYVLA RP 652
Nucleotide Sequence
(FASTA)
ATGCTCCCCG AGGCGAGCTC GCTGTGGCTG CTTCGGCTGC TCCGAGACAT CCAGCTGGCC 60
CAGTTTTACC GCCCCATCCT TGAGGAACTT AATGTTACCC GGCCGGAGCA CTTTGACTTC 120
GTCAGGCCCG AGGACCTGGA CGGCATCGGC ATGGGCCGGC CTGCCCAGCG CAGACTGGCC 180
GAAGCTCTGA AGAAGCACCG TTCGGGGCTC AAGTCAAAGA ACTGGGTCTA CAAGATCCTT 240
GGGGGTTTTG CCCCTGAGCA GAAGGAGACC ACCCCACCTT CGGACAGCCA CCTGTCCCTC 300
CCTGAGCCGG AGGGGGGACT CAAGTGTCTG ATCCCGGATG GTGCCGTGTG CAGAGGGGAG 360
CTGCTGGGCT CCGGCTGCTT TGGAGTGGTG CACCGAGGGC TGTGGACACT GCCCAGCGGC 420
CAGAGCGTCC CAGTGGCTGT CAAGTCCCTC CGGGTGGGTC CTGAAGGGCC CGTGGGCACA 480
GAGCTGGGGG ACTTCCTTCG AGAGGTGTCC ATCATGATGA ACTTGGAGCA CCCACACGTG 540
CTGCGTCTGC ACGGCCTCGT GCTGGGCCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCC 600
CTGGGATCCT TGCACGCGCG CCTGACCGCC CCGGCCCCGA TACCGGGGGC CATGGCATAC 660
CTGGGGGCCC GCGGGCTGGT GCACCGAGAC CTCGCCACGC GCAACCTGCT GCTGGCCTCC 720
CCGCGCACCA TCAAGGTGGC CGACTTCGGG CTGGTGCGGC CGCTGCGCGG CGCCCGGGGC 780
CGCTACGTCA TGGGCGGGCC CCGCCCCATC CCCTACGCCT GGTGTGCGCC AGAGAGCCTG 840
CGCCAGGGGG CCTTCTCTTC TGCGTCGGAC GTGTGGATGT TTGGGGTGAC GCTGTGGGAG 900
ATGTTCTCCG GGGGCGAGGA GCCCTGGGCA GGGGTCCCGC CGTACCTCAT CCTGCAGCGG 960
CTGGAACAGG ACCGGGCCCG GCTGCCTCGG CCTCCCCTCT GCTCCAGGGC ACTCTACTCC 1020
CTCGCCTTGC GCTGCTGGGC CCCCCACCCC GCCGACCGGC CTAGCTTTTC CTACCTGGAG 1080
GGGCTGCTCC AAGAGGCCTG GCCGCCGGAG GGACGTTGTG TGCGGGATGT GACAGAGCCA 1140
GGCGCCCTAA GGATGCAGAC TGGCGACCCC GTCACCATCA TCGAGGGCAG TGCCTCTTCC 1200
CACAGCCCCG ACTCCGCAAC CTGGAAGGGC CAGAATGGCC GCACATTCAA AGTGGGCAGC 1260
TTCCCAGCCT CGGCGGTGAC GCTGGCAGAC GCGGGGGTCT CACCAGCCAC CCGTCCAGTC 1320
CACAGGGTCT CCCCTGCCCA GGGAGAGCGA CACCAGGGAA ACGTAGATGG GGACAGAGGG 1380
AAGGCAAAGC TGCGGGATGT ACCTCCAGCA CGGGCCGGGA GAAGGAACGT GCCCCTGCAG 1440
AGAATGAAAG TCATTTCCAA GAGTCTGGAG TCCGTCCTGT CCCTGGGCCC CCGCCCCACA 1500
GGGGGTGGTT CGAGCCCCCC CGAACTTCGC CATGCCAGAG CTGTGCCTCA GGGACCCCCA 1560
GGCCTGCCAT CCCGCCCTCC CTTTGCCTCC AGCCCTTCTC AGCCCGGCCA GCCCCCCAGG 1620
GAGCGGCCTC CCTGGCCCAA GAGAGAACCC CCCCACAGTC ATCCCTCAGG AGCACCTGGA 1680
GCTAGCAAAG CCACCGTCCC CTCCGGAGGC CTCCTGCCCG ACCCCGAGTT GCAGAGGAGG 1740
ATTATGGAGG TGGAGCTGGG CGTGCACGGA GTCACGCACC AGGAGTGCCA GGCAGCACTA 1800
AGGGCCACTG GGGGAGACGT GGTTTCTGCC ATCCGGAACC TCAAGGTGGA CCAGCTCTTC 1860
CATCTGAGTA GCCGGTCCAG AGCGGACTGC CGACGCATCC TGGAGCACTA CCAGTGGGAC 1920
CTCTCCGCTG CCAGTCGCTA TGTCCTGGCC CGGCCCTGA 1959
Domain Profile
S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58
         ++++e+lG+G+fgvv+rg W+ psg+sv+vavk+l+  ++  ++tel+dflrevs++++l
Q: 116   VCRGELLGSGCFGVVHRGLWTLPSGQSVPVAVKSLRvgPEGPVGTELGDFLREVSIMMNL  175
         56889******************************9999*********************
S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118
         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a                i  ++ay
Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAP---------------IPGAMAY  220
         ************************************99...............889****
S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178
         l+++ lvhrdla+rnlllas++++k++dfGlvr+l  ++++yv+  ++++P+aWcaPesl
Q: 221   LGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLRGARGRYVMGGPRPIPYAWCAPESL  280
         ************************************************************
S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238
         r+ +fssasdvW+fGvtlWemfs GeePW+g++++ il++++++++rl++P++c++++ys
Q: 281   RQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEQDRARLPRPPLCSRALYS  340
         ************************************************************
S: 239   lllkcWakkpadrpkfsalkek  260
         l+l+cWa +padrp+fs l++ 
Q: 341   LALRCWAPHPADRPSFSYLEGL  362
         *****************99876
Domain Sequence
(FASTA)
VCRGELLGSG CFGVVHRGLW TLPSGQSVPV AVKSLRVGPE GPVGTELGDF LREVSIMMNL 60
EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPIP GAMAYLGARG LVHRDLATRN 120
LLLASPRTIK VADFGLVRPL RGARGRYVMG GPRPIPYAWC APESLRQGAF SSASDVWMFG 180
VTLWEMFSGG EEPWAGVPPY LILQRLEQDR ARLPRPPLCS RALYSLALRC WAPHPADRPS 240
FSYLEGL 247
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>
EKS-BOT-00346
EKS-CAJ-00352
EKS-CAF-00351
EKS-CAP-00380
EKS-ECT-00058
EKS-EQC-00338
EKS-ERE-00047
EKS-FEC-00334
EKS-GOG-00343
EKS-HOS-00353
EKS-ICT-00327
EKS-LOA-00355
EKS-MAM-00347
EKS-MUM-00378
EKS-MUP-00341
EKS-MYL-00347
EKS-NOL-00316
EKS-OCP-00065
EKS-ORC-00325
EKS-OTG-00351
EKS-PAT-00328
EKS-POA-00336
EKS-PRC-00058
EKS-PTV-00087
EKS-RAN-00361
EKS-SUS-00306
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030308; P:negative regulation of cell growth
GO:0046580; P:negative regulation of Ras protein signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013