EKS-AIM-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	400.9	4.6E-120	2686	3016	331

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017701

UniProt Accession

G1MEC3;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016741	ENSAMEP00000017701	ENSAMET00000018422

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

3058

Protein Sequence
(FASTA)

MSLALNDLLI CCRHLEHDRA TERRKEVEKF KRLIRDPETV QHLDRHSDSK QSKYLNWDAV 60

FRFLQKYVQK ETECLRTAKP SVSASTQATR QKKMQEISSL VKYFIKCANK RAPRLKCQEL 120

LNYIMDTVKD SSNGPVYGAD CSNILLKDIL SVRKYWCEIS QQQWLELFSV YFGLYLKPAQ 180

DINRVLVARI IHAVTKGCCS QTDGLNAKFL DFFSKAIQHA RQEKSSAGLN HILAAFIIFL 240

KTLAVNFRIR VCQLGDEILP TLLYIWTQHR LNDSLKEVII ELFQLQIYVH HPKGAKTQEK 300

GAYESSKWKS ILYNLYDLLI NEISHIGSRG KYSSGSRNVA VKENLIELMA DICHQIFNED 360

TRSLEISQSY TTTQRELNDY STPCKKKKIE LGWEVIKDHL QKSQSDFDLV PWLQITTQLI 420

SKYPSSLPNC ELSPLLVILY QLLPQHRHGE RTPYVLRCLT EVALCQGKKS NLEVSQKSDL 480

LKFWIKIWSL TFRGISSEQI QAENFGLLGA IIQGSLIEVD REFWKLFTGS ACRPSCPAVC 540

CLTLAMTVCV VPETVKTGVE HSLCEVNRSC SLKELIMKWL LLYHLEDDFE DGTELPPVLH 600

SNFPHLAVEK ILVSLTMKNC KAAMNFLQRV PECEQHQKDQ EEPPFSEVEE LFLQTTFDKM 660

GFLTIVKECA VEKHQSTVGF SVHQNLKESL DRYLLGLSEQ LLHNYSSETT NAETLIRCSS 720

LLVGVLGCYC YVGVIAEEEA YRSELFQKAK SLMQCAGESI TLFKSKTNEE SRIASLRNMM 780

NLCTSCLCNC TKPSPNKIAS RFFLRLLTSK LMNDIADICR SLASFIRKPS DFGEVESLED 840

EADENLMEVE DQSSMTLFSD YPPGSSSDAP MSGDGQSTFG AMNPLAEEHL SKQDLLFLDM 900

LKFLCVCVTT AQTSPVSFRA ADIRRKLLML IDTSMLDPTK SLHLHMYLLL LKELPGEEYP 960

LPMEEVVELL KPLSNVCSLY RRDQDVCKTL LNHFVHIVRN LCQGDMDAEN ARDAQGQFLT 1020

VIGAFWHLAK EGKCTFSVRM ALVKCLKTLL ETDPYSKWAI LNVMGKDFPV NEVFPHFLAD 1080

NHHQVSMLAA ESINRLFQDM KHRGSSTLWK ALPLKLQQTA FENAYLQAQE GMREVSHRAK 1140

NPELLDEIYN RKSVLLMTIA VVLCCSPVCE KQALFALCKS VKENGLEPHL VKKVLGKVSE 1200

TFGYRRLEDF MASHLDYLVL EWLNLQDTEH SLYSFPFILL NYTTVEDFYR SCYKVLIPHL 1260

VIRSRFDEVK SIANQIEEDW KSLLTHCFPK ILVNILPYFA YEGTGDSGMA QQRETATKVY 1320

DMLKDENLLG KQIDHLFLSN LPEIVVELLM TLHEPAAAGT SQSTDLCDFS GDLDPAPNPP 1380

HFPSHVIKAT FAYISNCHKT KLKSILEILS KSPDSYQKIL LAICEQAAET NNVYKKHRIL 1440

KIYHLFVTLL LKDIKSALGG AWAFVLRDVI YTLIHYINKK PSRFVDVSSR SFSLCCDLLS 1500

RVCHTAVTYC KDALENHLHV IVGTLIPLVD DQMEVQGQVL DLLKYLVIDN KDNENLYMTI 1560

KLLDPFPDHD VFKDLRITQQ KIKYSKGPFS LLEEINHFLS VSAYDALPLT RLEGLKDLRR 1620

QLAQHKDQMA GLMRASKDNP QDGIMVKLIV SLLQLCKMAV NHTGEIEVLE AVGSCLGEVG 1680

PVDFSTIALQ HSGDTSSTKA PELFKDKELQ WTFITLTYLN NTLVEDCVKV RSAAATCLKS 1740

ILATKTGHSF WEIYKTTPDP MLIYLQPFRT SKKKFLEVPR LEKESPLEGL DDMSLWIPQN 1800

ENHDIWIKRL TCAFLDSGGT KSEILRLLKP MCEVKTDFCQ AVLPYLIHDI LLQDTEESWR 1860

NLLSAHIQGF FTNCFRHSSP PSRSTTPANL DSESEHLFRC CVDKKSQRTM LAVVDYMRRQ 1920

KRPSLGTVFD DAFWLELNYL EVAKVAQSCA AHFTALLYAE IYADKKSMED QDKRSLTFEE 1980

ASQSTAISSL SEKSKEETGI SLQDLLLEIY RSIGEPDSLY GCGGGKLLQP LTRLRTYEHE 2040

AMWGKALVTY DLETAISPST RQAGIIQALQ NLGLCHILSV YLKGLDHENK ERCAELQELH 2100

YQAAWRNMQW DHCLSVNKGV EGTNYHESLY NAVQSLRDRE FSTFYESLRY ARVKEVEELC 2160

KGGLESVYSL YPTLSRLQAI GELENIGELL ARSGTDSRQP SEVYAKWRKH SQLLKDSDFS 2220

FQEPIMALRT VILEILMEKE MENSQKECFR DILTKHLVEL SILARTVKNT QLPERAMFQI 2280

KQYNPASCGV SEWQLEEAQV FWAKKEQSLA LSILKQMIKK LDASCAENDP DLRLIYAECL 2340

RVCGTWLAET CLENPAVIMQ TYLEKAVEVA RNYDGESSDE LKNGKMKAFL SLARFSDTQY 2400

QRIENYMKSS EFENKQALLK RAKEEVGLLR EHKIQTNRYT VKVQRELELD ECALRALKED 2460

RKRFLCKAVE NYISCLLSGE GHDMWIFRLC SLWLENSGVS EVNGMMKIDG MKIPSYKFLP 2520

LMYQLAARMG TKMMGGLGFH EVLNNLISRI AMDHPHHTLF IILALANANK DEFLTKPEAA 2580

GRNRITKNAP KQSSPLDEDR TEAANRIIHT IRSRRPQMVR SVEALCDAYI ILANLDAAQW 2640

RAQRKGISIP ADQPITKLKN LEDVVVPTME IKVDPTGEYR NLVTIQSFKA EFRLAGGLNL 2700

PKIIDCLGSD GKERRQLVKG RDDLRQDAVM QQVFQMCNML LQRNTETRKR KLTICTYKVV 2760

PLSQRSGVLE WCTGTVPIGE FLVNNENGAH KRYRPKDFSA LHCQKKMMDV QKKSFEEKYK 2820

TFMDVCQKFQ PVFRYFCMEK FLDPAVWFEK RLAYTRSVAT SSIVGYILGL GDRHVQNILI 2880

NEQSAELVHI DLGVAFEQGK ILPTPETVPF RLTRDIVDGM GITGVEGVFR RCCEKTMEVM 2940

RSSQETLLTI VEVLLYDPLF DWTMNPLKAL YLQQRPEDDT ELHSTPGGED QECRRSLSDT 3000

DQSFNKVAER VLMRLQEKLK GVEEGTVLSV GGQVNLLIQQ AMDPKNLSRL FPGWKAWV 3058

Nucleotide Sequence
(FASTA)

ATGAGCTTAG CACTTAATGA TCTGCTTATT TGCTGCCGTC ATCTAGAACA TGATAGAGCT 60

ACAGAACGAA GGAAAGAAGT TGAGAAATTT AAGCGCCTGA TTCGGGATCC TGAAACTGTT 120

CAACATTTAG ATCGACATTC AGATTCCAAA CAAAGCAAAT ATTTGAACTG GGATGCTGTT 180

TTTAGATTTT TACAGAAATA TGTTCAGAAA GAAACAGAAT GTCTGCGAAC AGCGAAACCA 240

AGCGTATCAG CCTCAACACA AGCCACTAGG CAGAAAAAGA TGCAAGAAAT CAGTAGTTTG 300

GTCAAGTACT TCATCAAATG TGCAAATAAA AGAGCACCCA GACTAAAATG TCAAGAACTC 360

TTGAATTATA TCATGGATAC AGTGAAAGAT TCATCTAATG GTCCCGTTTA TGGAGCGGAT 420

TGTAGCAACA TTCTGCTCAA GGACATTCTC TCAGTGAGGA AATATTGGTG TGAAATATCT 480

CAGCAACAGT GGCTAGAATT GTTCTCTGTG TACTTTGGTC TGTACCTTAA ACCTGCACAA 540

GACATTAATA GAGTTTTAGT GGCTAGAATA ATTCATGCTG TGACCAAAGG ATGCTGTTCA 600

CAAACCGATG GATTAAATGC CAAATTTTTG GATTTCTTTT CCAAGGCTAT TCAGCATGCA 660

AGACAGGAGA AGAGCTCTGC AGGTCTAAAT CACATCTTAG CAGCGTTTAT TATCTTCCTC 720

AAGACGTTGG CTGTAAACTT TCGAATTCGA GTGTGTCAAT TAGGAGATGA AATTCTTCCT 780

ACCTTGCTTT ATATTTGGAC CCAACATAGA CTTAACGATT CCTTAAAAGA AGTAATTATT 840

GAATTATTTC AACTGCAGAT TTATGTGCAT CATCCAAAGG GAGCTAAAAC CCAAGAAAAA 900

GGTGCTTATG AATCAAGTAA ATGGAAAAGT ATCTTGTATA ACTTATATGA TCTGCTAATT 960

AACGAGATCA GTCATATAGG AAGCAGAGGG AAATATTCTT CAGGATCTCG TAATGTTGCT 1020

GTCAAGGAAA ACTTGATTGA GTTGATGGCA GATATTTGTC ACCAGATTTT TAATGAGGAT 1080

ACTAGATCTT TGGAGATTTC TCAGTCTTAC ACTACCACCC AAAGAGAACT TAATGATTAC 1140

AGCACGCCTT GCAAAAAGAA GAAAATAGAA TTAGGCTGGG AGGTGATAAA AGATCATCTT 1200

CAGAAGTCAC AGAGTGATTT TGATCTTGTG CCTTGGTTAC AGATCACAAC CCAGTTAATA 1260

TCCAAATATC CTTCAAGTTT ACCTAACTGT GAGTTGTCAC CATTACTGGT GATACTATAC 1320

CAGCTTCTGC CTCAACATCG ACATGGGGAG CGCACGCCGT ATGTGTTACG ATGCCTTACA 1380

GAAGTTGCAT TGTGTCAAGG GAAGAAATCC AACCTAGAAG TCTCACAGAA GTCAGATTTA 1440

TTGAAATTCT GGATTAAAAT TTGGTCTCTT ACCTTTCGTG GTATAAGTTC TGAGCAAATA 1500

CAAGCTGAAA ACTTTGGTTT ACTTGGAGCT ATAATTCAAG GCAGTTTAAT TGAGGTTGAT 1560

AGAGAATTCT GGAAGTTATT TACTGGGTCA GCCTGCAGAC CATCATGTCC TGCAGTATGC 1620

TGCTTGACTC TGGCAATGAC CGTCTGTGTG GTTCCAGAAA CTGTAAAAAC AGGAGTGGAG 1680

CACAGTCTGT GTGAAGTAAA TAGAAGTTGT TCTTTAAAGG AATTGATAAT GAAATGGCTC 1740

TTACTCTATC ATTTAGAGGA TGACTTTGAA GACGGTACAG AGCTGCCTCC AGTTCTTCAC 1800

AGTAATTTTC CTCATCTTGC AGTGGAGAAA ATTCTTGTGA GTCTCACTAT GAAAAATTGT 1860

AAAGCTGCAA TGAATTTTCT CCAAAGAGTG CCAGAATGTG AACAACACCA AAAAGATCAA 1920

GAAGAGCCTC CATTCTCAGA AGTTGAAGAA CTGTTTCTTC AGACAACTTT TGACAAGATG 1980

GGTTTTTTAA CCATTGTGAA AGAATGTGCT GTAGAAAAGC ACCAGTCCAC CGTAGGCTTT 2040

TCTGTCCACC AGAACCTCAA GGAATCACTG GATCGCTATC TTCTGGGATT ATCAGAGCAG 2100

CTTTTACATA ACTACTCATC TGAGACTACA AATGCAGAAA CGCTTATCCG GTGTTCAAGT 2160

CTTTTGGTGG GTGTTCTTGG CTGCTATTGT TATGTGGGAG TAATAGCTGA AGAGGAAGCA 2220

TATAGATCAG AACTATTCCA GAAAGCCAAG TCTCTAATGC AGTGTGCGGG AGAAAGTATC 2280

ACTCTGTTCA AAAGTAAGAC CAATGAGGAA TCTAGGATTG CTTCCCTGAG AAATATGATG 2340

AATCTCTGTA CCAGTTGCTT GTGTAATTGT ACCAAGCCCA GTCCAAATAA GATTGCATCT 2400

AGATTTTTCC TACGATTGTT GACATCAAAG CTCATGAATG ATATTGCAGA TATTTGTAGA 2460

AGTTTGGCGT CCTTTATCAG AAAGCCATCT GACTTTGGAG AAGTAGAATC GCTGGAAGAT 2520

GAGGCTGATG AAAATCTGAT GGAGGTGGAG GATCAGTCAT CCATGACCCT GTTCAGTGAC 2580

TACCCTCCTG GCAGCTCCAG TGATGCCCCC ATGTCTGGAG ATGGCCAGAG TACTTTTGGT 2640

GCCATGAATC CTTTAGCTGA AGAACATCTG TCAAAGCAAG ATCTGCTCTT TTTAGACATG 2700

CTCAAGTTCT TGTGTGTGTG CGTAACTACA GCTCAGACCA GTCCAGTGTC ATTTAGAGCA 2760

GCGGACATTC GGAGGAAGTT GTTAATGTTA ATTGATACTA GCATGCTAGA CCCTACTAAA 2820

TCCCTCCACC TACACATGTA TCTACTGCTT TTAAAGGAGC TTCCTGGAGA AGAATATCCT 2880

TTGCCCATGG AAGAGGTTGT TGAACTTCTA AAACCACTCT CCAATGTGTG TTCTTTGTAT 2940

CGCCGTGACC AGGATGTTTG TAAAACACTT TTAAACCACT TTGTTCATAT AGTGAGGAAC 3000

CTGTGTCAAG GGGATATGGA TGCTGAAAAC GCAAGGGATG CTCAAGGGCA GTTTCTGACA 3060

GTGATTGGAG CATTCTGGCA CCTAGCAAAG GAGGGGAAAT GCACATTCTC TGTAAGAATG 3120

GCACTAGTGA AGTGCCTTAA AACTTTGCTT GAGACCGATC CTTATTCAAA ATGGGCTATT 3180

CTTAATGTAA TGGGAAAAGA CTTTCCTGTA AACGAAGTAT TTCCACATTT TCTTGCTGAT 3240

AACCATCATC AAGTTAGCAT GTTGGCAGCA GAGTCAATCA ACAGATTATT CCAGGATATG 3300

AAACACAGAG GTTCGTCCAC ATTATGGAAA GCACTTCCTT TGAAGCTTCA GCAAACAGCT 3360

TTTGAAAATG CATACTTGCA AGCTCAGGAA GGAATGAGAG AAGTGTCCCA CAGAGCTAAG 3420

AACCCTGAAC TTTTGGATGA GATTTATAAC AGAAAATCTG TTTTACTGAT GACGATAGCT 3480

GTGGTTTTAT GCTGTAGCCC AGTCTGTGAA AAACAGGCTT TGTTTGCGCT GTGCAAGTCT 3540

GTAAAAGAGA ATGGATTAGA ACCTCACCTT GTTAAAAAGG TTTTAGGGAA AGTTTCTGAA 3600

ACTTTTGGAT ACAGACGTTT AGAAGACTTT ATGGCTTCTC ATTTGGATTA TCTGGTTTTG 3660

GAATGGCTAA ATCTTCAAGA TACTGAACAT AGCTTATATT CTTTTCCTTT TATTTTACTA 3720

AACTATACAA CCGTTGAGGA TTTCTATAGA TCATGTTACA AGGTTTTGAT CCCACATCTA 3780

GTGATTAGAA GTCGTTTTGA TGAGGTGAAG TCCATTGCTA ATCAGATCGA AGAGGATTGG 3840

AAAAGTCTTC TAACACACTG CTTTCCAAAG ATTCTTGTAA ATATTCTTCC TTACTTCGCC 3900

TACGAGGGTA CAGGAGACAG TGGGATGGCA CAGCAGAGAG AGACTGCTAC CAAAGTCTAC 3960

GATATGCTTA AAGATGAAAA TTTACTAGGA AAACAGATTG ATCATTTATT CCTTAGTAAT 4020

TTGCCGGAGA TCGTTGTGGA GTTATTGATG ACGTTACATG AGCCCGCAGC TGCAGGCACC 4080

AGCCAAAGCA CGGACCTGTG TGACTTTTCA GGGGATTTGG ATCCTGCACC TAACCCACCT 4140

CATTTTCCTT CACATGTGAT TAAAGCAACG TTTGCCTACA TCAGCAATTG CCATAAAACC 4200

AAGCTTAAAA GCATTTTAGA AATTCTTTCC AAAAGCCCTG ATTCCTATCA GAAAATTCTT 4260

CTAGCCATAT GTGAGCAAGC TGCTGAGACA AATAATGTTT ATAAAAAGCA CAGAATTCTT 4320

AAAATATATC ACCTGTTTGT TACTTTATTA CTGAAAGATA TTAAAAGTGC CTTAGGAGGA 4380

GCTTGGGCCT TTGTTCTTCG AGATGTTATC TATACTTTGA TTCATTATAT CAACAAAAAG 4440

CCTTCTCGTT TCGTGGATGT GTCGTCACGG AGCTTCTCCC TGTGTTGTGA CCTGTTAAGC 4500

CGGGTTTGCC ACACGGCAGT CACTTACTGT AAGGACGCTC TGGAAAATCA TCTCCACGTG 4560

ATTGTTGGCA CACTTATACC CCTTGTGGAC GATCAGATGG AGGTGCAGGG ACAGGTGTTG 4620

GACTTGTTGA AATACTTAGT GATAGATAAC AAGGATAATG AAAACCTCTA TATGACAATT 4680

AAACTTTTAG ATCCTTTTCC TGACCATGAT GTCTTTAAGG ATTTGCGCAT TACTCAGCAG 4740

AAAATTAAAT ACAGTAAAGG ACCCTTTTCG CTTTTGGAGG AAATAAATCA TTTTCTCTCT 4800

GTGAGTGCTT ATGATGCCCT TCCCCTGACA AGGCTGGAAG GCCTGAAGGA TCTCCGCAGA 4860

CAGCTAGCTC AGCATAAGGA CCAGATGGCC GGCCTCATGA GAGCATCTAA GGATAACCCG 4920

CAGGACGGCA TAATGGTGAA GCTCATTGTC AGCTTGTTGC AGTTATGCAA GATGGCGGTG 4980

AACCACACTG GTGAAATAGA AGTTTTAGAG GCTGTTGGAA GCTGCCTGGG AGAAGTGGGT 5040

CCTGTCGATT TCTCCACGAT AGCTCTGCAG CACAGTGGAG ATACGTCTTC TACCAAGGCC 5100

CCTGAGTTGT TTAAGGATAA GGAACTTCAG TGGACCTTCA TAACCCTGAC CTACCTGAAT 5160

AACACGCTGG TAGAAGACTG TGTCAAAGTG CGATCGGCTG CTGCTACCTG TTTGAAAAGC 5220

ATTTTAGCCA CAAAGACTGG ACATAGTTTC TGGGAGATTT ATAAGACGAC ACCTGATCCC 5280

ATGCTGATCT ACCTACAGCC TTTCAGAACA TCAAAAAAAA AGTTTTTAGA AGTCCCCAGA 5340

CTGGAGAAAG AAAGTCCATT AGAAGGCCTG GATGATATGA GCCTGTGGAT TCCTCAAAAT 5400

GAAAATCATG ACATTTGGAT AAAGAGGCTG ACTTGCGCCT TTTTGGATAG TGGAGGCACG 5460

AAAAGTGAAA TTCTTCGATT ATTAAAGCCA ATGTGTGAAG TGAAAACTGA CTTTTGTCAG 5520

GCTGTGCTTC CATACTTGAT TCACGATATT TTACTCCAAG ATACAGAGGA ATCCTGGAGA 5580

AATCTGCTTT CTGCGCACAT TCAGGGATTT TTCACTAACT GTTTCAGACA CTCCTCACCA 5640

CCGAGCCGAT CCACGACCCC TGCCAATTTG GATTCAGAGT CAGAGCACCT GTTCCGATGC 5700

TGTGTGGACA AAAAATCACA GAGAACGATG CTTGCTGTTG TGGACTACAT GAGGAGACAA 5760

AAGAGACCTT CCCTAGGAAC AGTTTTCGAT GATGCTTTCT GGCTGGAGTT GAATTATCTA 5820

GAGGTTGCCA AGGTGGCTCA GTCTTGTGCT GCTCACTTTA CGGCACTGCT CTACGCAGAA 5880

ATCTACGCAG ATAAGAAAAG CATGGAAGAC CAAGACAAAA GAAGTCTTAC GTTTGAAGAA 5940

GCAAGCCAGA GTACAGCTAT TTCTAGTTTG AGTGAAAAAA GTAAAGAAGA AACTGGAATA 6000

AGTTTGCAGG ATCTGCTCTT AGAAATCTAC AGAAGTATAG GAGAGCCCGA CAGTCTGTAT 6060

GGCTGTGGTG GAGGGAAACT GCTACAGCCC CTCACTAGAC TGCGCACATA TGAACATGAA 6120

GCAATGTGGG GAAAAGCCCT GGTGACATAT GACCTTGAGA CGGCCATATC CCCATCAACC 6180

CGCCAGGCAG GGATAATCCA GGCCTTGCAG AATTTGGGAC TCTGCCATAT TCTTTCCGTC 6240

TATTTAAAAG GACTAGATCA TGAAAATAAG GAGCGGTGCG CTGAGCTGCA GGAGCTCCAC 6300

TACCAGGCAG CTTGGAGGAA CATGCAGTGG GACCACTGCC TTTCCGTCAA CAAAGGTGTG 6360

GAAGGAACCA ATTACCACGA ATCATTGTAC AATGCTGTGC AGTCTCTGAG AGATAGAGAA 6420

TTCTCCACAT TTTACGAAAG TCTCAGATAT GCCAGGGTGA AAGAAGTGGA GGAGCTGTGC 6480

AAGGGGGGGC TCGAGTCTGT GTACTCCCTG TACCCCACAC TCAGCAGGCT GCAGGCCATT 6540

GGTGAGCTCG AGAACATCGG GGAGCTGCTC GCCAGATCAG GCACGGATAG TAGGCAGCCC 6600

TCTGAAGTAT ACGCTAAGTG GCGGAAACAC TCCCAGCTTC TCAAAGACAG TGATTTCAGT 6660

TTTCAGGAGC CCATCATGGC TCTCCGCACA GTCATTTTGG AGATCCTGAT GGAAAAGGAA 6720

ATGGAGAACT CCCAGAAAGA ATGTTTTAGG GACATTCTCA CCAAGCACCT TGTAGAACTC 6780

TCCATACTAG CCCGAACTGT CAAGAACACT CAGCTCCCTG AAAGGGCAAT GTTTCAAATT 6840

AAACAGTATA ATCCAGCTAG TTGTGGAGTC TCTGAGTGGC AGCTGGAGGA AGCCCAAGTA 6900

TTTTGGGCAA AAAAGGAGCA GAGTCTTGCC CTGAGTATTC TCAAGCAGAT GATCAAGAAG 6960

TTGGATGCCA GTTGTGCAGA GAATGATCCC GACCTAAGAC TTATATACGC AGAATGTCTG 7020

CGAGTTTGCG GCACCTGGTT AGCAGAAACT TGCCTAGAAA ACCCTGCGGT CATCATGCAG 7080

ACTTATCTAG AAAAGGCAGT GGAAGTTGCT AGAAATTATG ATGGAGAAAG CAGTGATGAG 7140

CTTAAAAATG GAAAAATGAA AGCATTTCTC TCATTAGCAC GGTTCTCGGA CACGCAGTAC 7200

CAGAGAATTG AAAACTACAT GAAATCGTCA GAGTTTGAAA ACAAGCAGGC TCTTCTGAAA 7260

AGGGCCAAAG AAGAAGTGGG CCTTCTTAGG GAACATAAAA TCCAGACCAA CAGATACACA 7320

GTAAAGGTCC AGCGGGAGCT GGAGCTGGAT GAATGTGCAC TCCGTGCACT GAAAGAGGAC 7380

CGTAAACGTT TCCTATGTAA AGCAGTTGAA AATTACATCA GTTGCTTACT GAGTGGAGAA 7440

GGACACGATA TGTGGATATT CCGTCTTTGT TCTCTCTGGC TTGAAAATTC CGGAGTTTCC 7500

GAAGTCAATG GCATGATGAA GATCGATGGA ATGAAGATTC CATCCTACAA ATTTTTGCCC 7560

CTTATGTACC AGTTGGCTGC TAGAATGGGG ACCAAAATGA TGGGAGGCCT CGGATTTCAT 7620

GAAGTCCTCA ATAATCTTAT CTCTAGAATT GCAATGGATC ACCCCCATCA CACTTTGTTT 7680

ATTATACTGG CCTTAGCAAA TGCAAACAAA GATGAATTTT TGACCAAACC AGAGGCAGCA 7740

GGAAGGAACA GAATAACTAA AAATGCACCT AAACAAAGCT CTCCGCTCGA TGAGGATCGA 7800

ACCGAGGCTG CAAATAGAAT AATACATACT ATCAGAAGTA GGAGACCTCA GATGGTCAGA 7860

AGTGTGGAGG CGCTCTGTGA TGCTTATATC ATATTAGCAA ACTTAGACGC TGCTCAGTGG 7920

AGGGCTCAGA GAAAAGGCAT AAGTATCCCA GCAGACCAGC CAATTACTAA ACTGAAGAAT 7980

TTAGAAGATG TCGTTGTTCC AACTATGGAA ATTAAGGTGG ACCCTACCGG AGAATACAGA 8040

AATCTGGTGA CTATACAGTC ATTTAAAGCA GAATTTCGTT TAGCAGGAGG TTTAAATTTA 8100

CCTAAAATAA TAGACTGTCT GGGCTCTGAT GGCAAGGAAA GGAGACAGCT CGTCAAGGGC 8160

CGTGACGACC TGAGACAGGA CGCGGTCATG CAGCAGGTTT TCCAGATGTG TAATATGTTA 8220

CTGCAGAGGA ACACGGAGAC CAGGAAGAGG AAACTGACCA TCTGCACATA CAAGGTGGTC 8280

CCGCTTTCTC AGCGAAGTGG AGTCCTTGAA TGGTGCACAG GAACTGTCCC CATTGGTGAG 8340

TTCCTTGTGA ACAACGAGAA CGGTGCTCAT AAGAGATACA GGCCGAAGGA CTTCAGCGCC 8400

CTTCACTGCC AGAAGAAAAT GATGGATGTA CAAAAGAAGT CTTTTGAAGA GAAATATAAA 8460

ACGTTCATGG ATGTCTGCCA GAAATTTCAA CCGGTTTTCC GTTACTTCTG CATGGAAAAA 8520

TTCTTGGACC CAGCTGTTTG GTTCGAGAAG CGACTGGCTT ATACTCGCAG CGTGGCTACT 8580

TCCTCTATCG TTGGTTACAT ACTTGGACTT GGTGATCGAC ATGTACAGAA TATCTTGATA 8640

AATGAGCAGT CTGCAGAACT TGTACATATA GATTTGGGAG TTGCTTTTGA GCAGGGTAAG 8700

ATCCTCCCTA CTCCCGAAAC GGTTCCTTTC AGACTCACCA GAGATATTGT GGATGGGATG 8760

GGCATTACTG GTGTTGAAGG TGTCTTCAGA AGGTGCTGTG AAAAAACCAT GGAGGTTATG 8820

AGAAGCTCTC AGGAAACCCT GCTAACCATT GTGGAGGTTC TCCTCTACGA CCCCCTGTTT 8880

GACTGGACCA TGAATCCTCT GAAAGCTCTG TATTTACAGC AGAGGCCGGA AGATGACACT 8940

GAGCTGCACT CCACTCCCGG CGGAGAGGAC CAGGAATGCA GACGCAGTCT CAGTGACACC 9000

GACCAGAGCT TCAACAAAGT AGCGGAACGC GTGTTGATGA GACTACAAGA GAAACTGAAA 9060

GGAGTGGAGG AGGGAACGGT GCTCAGTGTT GGGGGGCAGG TGAATCTGCT CATACAGCAA 9120

GCCATGGACC CCAAAAATCT CAGCCGACTT TTCCCAGGAT GGAAAGCTTG GGTG 9174

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

         ++f+ +  +   ++ pk +  +Gsdgke+++Lvkg++Dlrqd++++q+f+++N lL++++

Q: 2686  QSFKAEFRLAGGLNLPKIIDCLGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNMLLQRNT  2745

         566666666667788999******************************************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

         et++rkL+i+tykVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr+kd+s

Q: 2746  ETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFL---VNNENGAHK---RYRPKDFS  2799

         *************************************...799999999...********

S: 122   tvqarkpklkhlkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrs  177

         +  ++k++++++k+s    ++ f++v+++++p  +++++++ekf++p++wfe+r aytrs

Q: 2800  ALHCQKKMMDVQKKSfeekYKTFMDVCQKFQP--VFRYFCMEKFLDPAVWFEKRLAYTRS  2857

         ********************************..9*************************

S: 178   lAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrni  237

         +A++s+vgyiLgLgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRLTr+i

Q: 2858  VATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDI  2916

         ********************************************.***************

S: 238   vnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk......kkktsk  291

         v+++g+tgveGvfr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++

Q: 2917  VDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRP  2976

         ******************************************************9*****

S: 292   eteeelaekakaealkikkllskvekaenavatrdlllle  331

         e+++el+++   e++++ + ls+ ++++n+va+r+l++l+

Q: 2977  EDDTELHSTPGGEDQECRRSLSDTDQSFNKVAERVLMRLQ  3016

         ***********************************99987

Domain Sequence
(FASTA)

QSFKAEFRLA GGLNLPKIID CLGSDGKERR QLVKGRDDLR QDAVMQQVFQ MCNMLLQRNT 60

ETRKRKLTIC TYKVVPLSQR SGVLEWCTGT VPIGEFLVNN ENGAHKRYRP KDFSALHCQK 120

KMMDVQKKSF EEKYKTFMDV CQKFQPVFRY FCMEKFLDPA VWFEKRLAYT RSVATSSIVG 180

YILGLGDRHV QNILINEQSA ELVHIDLGVA FEQGKILPTP ETVPFRLTRD IVDGMGITGV 240

EGVFRRCCEK TMEVMRSSQE TLLTIVEVLL YDPLFDWTMN PLKALYLQQR PEDDTELHST 300

PGGEDQECRR SLSDTDQSFN KVAERVLMRL Q 331

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005819	; C:spindle
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0007420	; P:brain development
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0007292	; P:female gamete generation
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0007507	; P:heart development
GO:0071044	; P:histone mRNA catabolic process
GO:0016572	; P:histone phosphorylation
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0042159	; P:lipoprotein catabolic process
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0043066	; P:negative regulation of apoptotic process
GO:0030889	; P:negative regulation of B cell proliferation
GO:0051402	; P:neuron apoptotic process
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:0002331	; P:pre-B cell allelic exclusion
GO:0090399	; P:replicative senescence
GO:0001756	; P:somitogenesis
GO:0000723	; P:telomere maintenance

KEGG

aml:100480638

;

InterPros

IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013